Months Of Clinical Use Research Articles

Role of Obeticholic Acid, a Farnesoid X Receptor Agonist, in Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis.

Background. Obeticholic acid (OCA) has emerged as a promising drug in the management of nonalcoholic fatty liver disease (NAFLD). This meta-analysis aimed to analyse the therapeutic effect of OCA on NAFLD. Methods. Randomized controlled trials (RCTs) involving patients with NAFLD receiving OCA in the intervention arm and placebo in the control arm were searched throughout the electronic databases. The primary outcomes were changes in non-invasive markers of hepatic fibrosis and liver histology. The secondary outcomes included changes in liver enzymes, metabolic parameters from baseline and adverse events (AEs). Results. Four RCTs involving 1,278 subjects met the inclusion criteria. Over 6 weeks to 18 months of clinical use, OCA outperformed placebo in resolving definite nonalcoholic steatohepatitis (odds ratio [OR] 1.60, 95% confidence interval [CI] [1.04-2.48], p=0.03) and improving fibrosis (OR 2.23, 95% CI [1.56-3.20], p<0.0001), hepatocellular ballooning (OR 1.83, 95% CI [1.35-2.47], p<0.0001) and lobular inflammation (OR 1.62, 95% CI [1.13-2.32], p=0.009). OCA did not improve the enhanced liver fibrosis score and steatosis better than placebo, and demonstrated superior efficacy compared with the placebo in reducing serum alanine aminotransferase, aspartate aminotransferase and gamma-glutamyl transferase levels. Although a favourable effect of OCA over placebo was seen in body-weight reduction, the OCA use was associated with adverse changes in lipid parameters. Except for the greater risk of pruritus and constipation, the AE profile was comparable between the OCA and placebo groups. Conclusions. OCA has a favourable efficacy in improving liver histology and liver enzymes. However, the worsening of lipid parameters and other AEs with the OCA use warrants further investigation.

Development, validation and long-term evaluation of a liquid chromatography-tandem mass spectrometry method for simultaneous quantification of amiodarone, desethylamiodarone and mexiletine in human plasma and serum

Amiodarone and mexiletine are used for ventricular arrhythmias, for which a combination therapy of both anti-arrhythmic drugs (AADs) is not uncommon. Therapeutic drug monitoring (TDM) can be beneficial for clinical guidance of therapy, especially to correctly identify adverse events. Desethylamiodarone, the active metabolite of amiodarone, accumulates over time and is associated with serious adverse events. Therefore, simultaneous TDM for amiodarone, desethylamiodarone and mexiletine is advantageous in clinical practice. The presented LC-MS/MS method was validated for selectivity, matrix effect, linearity, accuracy, precision, carry-over and stability. The method was continuously evaluated during eight months of clinical use. The method was shown to be linear within the measured range of 0.1 to 10 mg/L for each component. The matrix effect was considered negligible. No interfering responses were found for amiodarone, desethylamiodarone and the isotopic-labeled internal standards. A constant and reproducible within-run contribution of 45.3 %, originating from the system, was identified for mexiletine. The systemic contribution to the peak area of the lowest quantifiable concentration of mexiletine affected the selectivity and carry-over effect measurements. Multiple measurements showed that regression adjusted concentrations were accurate and reproducible, indicating calibration correction was applicable. Sample stability was found to be within limits for all storage conditions and freeze–thaw cycles. Furthermore, long-term method evaluation with external controls resulted in stable measurements with a percentage coefficient of variance between 1.3 % and 6.3 %. The presented practical and reliable method is applicable for clinical TDM and will allow clinical practitioners to guide drug therapy of amiodarone and mexiletine.

Machine learning and lean six sigma for targeted patient-specific quality assurance of volumetric modulated arc therapy plans

Background and purposeRadiotherapy plans with excessive complexity exhibit higher uncertainties and worse patient-specific quality assurance (PSQA) results, while the workload of measurement-based PSQA can impact the efficiency of the radiotherapy workflow. Machine Learning (ML) and Lean Six Sigma, a process optimization method, were implemented to adopt a targeted PSQA approach, aiming to reduce workload, risk of failures, and monitor complexity. Materials and methodsLean Six Sigma was applied using DMAIC (define, measure, analyze, improve, and control) steps. Ten complexity metrics were computed for 69,811 volumetric modulated arc therapy (VMAT) arcs from 28,612 plans delivered in our Institute (2013–2021). Outlier complexities were defined as >95th-percentile of the historical distributions, stratified by treatment. An ML model was trained to predict the gamma passing rate (GPR-3 %/1mm) of an arc given its complexity. A decision support system was developed to monitor the complexity and expected GPR. Plans at risk of PSQA failure, either extremely complex or with average GPR <90 %, were identified. The tool’s impact was assessed after nine months of clinical use. ResultsAmong 1722 VMAT plans monitored prospectively, 29 (1.7 %) were found at risk of failure. Planners reacted by performing PSQA measurement and re-optimizing the plan. Occurrences of outlier complexities remained stable within 5 %. The expected GPR increased from a median of 97.4 % to 98.2 % (Mann-Whitney p < 0.05) due to plan re-optimization. ConclusionsML and Lean Six Sigma have been implemented in clinical practice enabling a targeted measurement-based PSQA approach for plans at risk of failure to improve overall quality and patient safety.

The Impact of Intracranial Pressure Telesensors: An Observational Propensity-Matched Control Analysis of Service Demand and Costs.

Implantable telemetric intracranial pressure (ICP) sensors (telesensors) enable routine, noninvasive ICP feedback, aiding clinical decision-making and attribution of pressure-related symptoms in patients with cerebrospinal fluid shunt systems. Here, we aim to explore the impact of these devices on service demand and costs in patients with adult hydrocephalus. We performed an observational propensity-matched control study, comparing patients who had an MScio/Sensor Reservoir (Christoph Miethke, GmbH & Co) against those with a nontelemetric reservoir inserted between March 2016 and March 2018. Patients were matched on demographics, diagnosis, shunt-type, and revision status. Service usage was recorded with frequencies of neurosurgical admissions, outpatient clinics, scans, and further surgical procedures in the 2 years before and after shunt insertion. In total, 136 patients, 73 telesensors, and 63 controls were included in this study (48 matched pairs). Telesensor use led to a significant decrease in neurosurgical inpatient admissions, radiographic encounters, and procedures including ICP monitoring. After multivariate adjustment, the mean cumulative saving after 2 years was £5236 ($6338) in telesensor patients (£5498 on matched pair analysis). On break-even analysis, cost-savings were likely to be achieved within 8 months of clinical use, postimplantation. Telesensor patients also experienced a significant reduction in imaging-associated radiation (4 mSv) over 2 years. The findings of this exploratory study reveal that telesensor implantation is associated with reduced service demand and provides net financial savings from an institutional perspective. Moreover, telesensor patients required fewer appointments, invasive procedures, and had less radiation exposure, indicating an improvement in both their experience and safety.

3D EVALUATION OF MICROGAPS AT THE IMPLANT-ABUTMENT CONNECTION BEFORE AND AFTER THERMODYNAMIC CYCLING.

To analyze the microgap changes between hybrid-abutment crowns made of two materials and three internal taper connec9on implants with different connection designs before and after thermodynamic loading. A total of 30 implants-10 each of Straumann Bone Level Implant-RC (STR); GC AADVA Implant (AAD); and Astra-Tech OsseoSpeed EV (AST)-were included in this laboratory study. Each implant had an internal taper connection, but their designs were slightly different. Five hybrid-abutment crowns were fabricated using a lithium disilicate ceramic (LD), and five were fabricated using polymethylmethacrylate (PMMA) with CAD/CAM technologies for each implant system, providing six sample groups STR-LD, AAD-LD, AST-LD, STR-PMMA, AAD-PMMA, and ASTPMMA. The microgap volume was measured using micro-CT images obtained before and after thermodynamic loading equivalent to 4 months of clinical use. Student t test, one-way ANOVA, and Tukey test were used for comparisons. The greatest microgap volume increase was recorded (3.405% ± 1.567%) in the AST-LD group, and the lowest increase (0.45% ± 0.373%) was in the STR-PMMA group. A statistically significant difference in microgap increase was not detected among PMMA and LD groups: for STR-LD/STR-PMMA (t test: P = .273); for AAD-LD/AAD-PMMA (t test: P = .374); and for AST-LD/AST-PMMA (t test: P = .268). However, the difference in the microgap increase between the different implant systems was statistically significant. The microgap between hybrid-abutment crowns and implants increased after short-term thermodynamic cycling. Hybrid-abutment crowns with different elastic modulus showed similar microgap increase. The geometric shape of the connection influenced the microgap increase.

One-year experience with latanoprostene bunod ophthalmic solution 0.024% in clinical practice: A retrospective observational study.

We evaluated the IOP-lowering efficacy and safety of latanoprostene bunod (LBN) ophthalmic solution 0.024% (Vyzulta®), the first topical nitric oxide-donating prostaglandin analog (PGA), in clinical practice. A retrospective medical chart review from July 2021 to July 2023 of patients with open-angle glaucoma receiving LBN with at least 1 year follow-up was conducted. All included patients received LBN 0.024% as a replacement for a PGA, with examinations at 1-, 3-, 6-and 12-months follow-up. Main outcome measures were IOP, retinal nerve fiber layer thickness, visual fields before/after LBN use and adverse effects. Subgroup analysis with glaucoma types and PGA use were performed for additional IOP reduction after LBN use. Among 78 included patients, 47 patients (81 eyes), 60% with open-angle glaucoma (OAG) remained on LBN throughout 12-month follow-up. Baseline IOP was 18.2±4.2 mm Hg, and Prostaglandin analog (PGA)-IOP was 14.4 ± 3.0 mm Hg (21% mean IOP reduction). After switched to LBN, mean additional IOP reduction was 1.0 mm Hg at month 1, and the greatest reduction was 1.6 mm Hg (8.8% additional mean IOP reduction) at month 12 (P<0.0001). Subgroup analysis (NTG, 73%) showed that mean additional IOP reduction at month 12 was 1.3±2.0 mm Hg in NTG group and 2.1±3.2 mm Hg in POAG group (7.7% vs. 8.7% additional IOP reduction rates, P = 0.23). Subgroup analysis of PGA use at month 12 was 1.8±2.3 mm Hg in tafluoprost group and 0.5±1.7 mm Hg in travoprost group (9.5% vs.2.6% additional IOP reduction rates, P = 0.02). Tolerable ocular adverse effects included irritation (n = 16, 19.8%), mild conjunctival hyperemia (n = 11, 13.6%), dark circles (n = 4, 4.9%) and blurred vision (n = 2, 2.5%). There were no significant visual field and retinal nerve fiber layer thickness changes after 12 months of treatment with LBN 0.024%. Although high intolerable adverse effects including conjunctival hyperemia and eye irritation happened in the first month, remaining sixty percent of patients exhibited statistically significant additional IOP reductions in the replacement of other PGAs during 12 months of clinical use of LBN 0.024%.

Impact of effervescent denture cleaning tablets on color and surface characteristics of additively manufactured and hand-cast splint materials.

This study is to evaluate the color stability, surface roughness, and hardness of additively manufactured and hand-cast splint materials after a 6-month commercially available denture cleaning tablet immersion simulation. Disc-shaped additively manufactured and hand-cast auto polymerizing acrylic resin specimens were prepared (N = 40 each). All specimens were exposed to coffee solution totally 2days. Thereafter, all specimens were immersed into three different effervescent solutions that simulated 6months of clinical use. The total color change (ΔE*ab), surface roughness (Ra), and Vickers hardness (Vh) were measured at baseline and after immersion protocols. A two-way ANOVA and Bonferroni's post hoc test were used for color change. The dependent t-test and ANOVA were used for roughness and hardness evaluation. Additively manufactured splint materials were more affected by coffee immersion. It was observed that all denture cleaning tablets induced a noticeable alteration in color of the specimens (p < 0.05). Roughness and hardness measurement changes after solution immersions were statistically significant for both splint groups (p < 0.05). On the other hand, distilled water and denture cleaning tablets created similar roughness and hardness measurements at baseline and after immersion. After 6months use of tested cleaning tables, the color stability, surface roughness, and hardness of both groups were affected. The evaluation of the surface properties of splint materials could be recommended to the dentists in periodic controls during splint treatments. The use effervescent denture cleaning tablets altered the surface characteristics of tested splint materials over time with nonsignificant difference between each other. After 6months, awareness should be raised about surface characteristics of splint materials.

Properties of Superelastic Nickel-Titanium Wires after Clinical Use.

The aim of the present study was to describe and determine changes in the superelastic properties of NiTi archwires after clinical use and sterilization. Ten archwires from five different manufacturers (GAC, 3M, ODS, GC, FOR) were cut into two segments and evaluated using a three-point bending test in accordance with ISO 14841:2006. The center of each segment was deflected to 3.1 mm and then unloaded to 0 N to obtain a load-deflection curve. Deflection at the end of the plateau and forces at 3, 2, 1 and 0.5 mm on the unloading curve were recorded. Plateau slopes were calculated at 2, 1 and 0.5 mm of deflection. Data obtained were statistically analyzed to determine differences (p < 0.001). Results showed that the degree of superelasticity and exerted forces differed significantly among brand groups. After three months of clinical use, FOR released a greater force for a longer activation period. GC, EURO and FOR archwires seemed to lose their mechanical properties. GC wires released more force than other brand wires after clinical use. Regarding superelasticity after sterilization, GAC, 3M and FOR wires recovered their properties, while EURO archwires lost more.

Comparative Evaluation of Wear of Natural Enamel Antagonist Against Glazed Monolithic Zirconia Crowns and Polished Monolithic Zirconia Crowns: An In Vivo Study.

To comparatively evaluate the amount of wear of natural enamel against a glazed full coverage monolithic zirconia crown and a polished monolithic zirconia crown at 6 and 12 months. Thirty subjects within the age range of 18 to 35 years participated in this study. The subjects received a total of 60 single crowns, which were divided into two groups: (1) 30 glazed monolithic zirconia crowns opposed by natural enamel (group A); and (2) 30 polished monolithic zirconia crowns opposed by natural enamel (group B). Each subject received a crown from both groups, placed bilaterally in endodontically treated maxillary or mandibular first molars. An impression was made of the opposing arch at 24 hours, 6 months, and 12 months. The resulting casts were scanned with a 3D optical scanner. The recall scans were superimposed and compared to baseline scans using 3D AutoCAD software. A control group was included to compare the wear values to natural enamel against natural enamel. No significant difference (P = .855) was found in enamel wear between groups A (42.80 μm) and B (42.50 μm) after 6 months of use. However, a significant difference (P < .05) in enamel wear was found between group A (81.87 μm) and group B (71.43 μm) after 12 months of use. Glazed monolithic zirconia crowns cause more wear to the opposing enamel than polished monolithic zirconia crowns after 12 months of clinical use.

Thermo-flexible resin for the 3D printing of occlusal splints: A randomized pilot trial

ObjectivesTo compare the clinical performance of occlusal splints printed from thermo-flexible resin with milled splints. MethodsA parallel two-arm pilot trial was initiated. Forty-seven patients (n women=38) were recruited from a tertiary care center and randomized using an online tool (sealed envelope). Inclusion criterion was an indication for treatment with a centric relation occlusal splint due to bruxism or any form of painful temporomandibular disorder. Patients were excluded if they were younger than 18 years, unable to attend follow-up appointments, or required another type of splint therapy. Patients received either, a 3D-printed (intervention group, V-print splint comfort, VOCO) or a milled splint (control group, ProArt CAD splint, Ivoclar). Construction software Ceramill M-splint (AmannGirrbach), 3D-printer MAX UV 385 (Asiga) and milling unit PrograMill PM7 (Ivoclar) were used. Follow-up assessments were conducted after 2 weeks and 3 months. Outcome measures were survival, adherence, technical complications, patient satisfaction on a 10-point Likert scale, and maximum wear using superimposition of optical scans. ResultsAfter 3 months, 20/23 intervention group and 18/24 control group participants were assessed. All splints survived. Minor complications were small crack formations on 6 printed and 4 milled splints. Mean patient satisfaction was 8 (SD 1.7) for printed, and 8.1 (SD 2.3) for milled splints (r = 0.1, p = .52). Median maximum wear was highly dispersed with 153 (IQR 140) in posterior and 195 (IQR 537) in frontal segments of printed, and 96 (IQR 78) respectively, 123 (IQR 155) of milled splints, (both: r = 0.31, p = .084). ConclusionsWithin the limitations of a pilot trial, 3D-printed and milled splints performed similarly in terms of patient satisfaction, complication rates and wear behavior. Clinical significanceThermo-flexible material was proposed for 3D printing of occlusal splints to overcome mechanical weaknesses of previously available resins. This randomized pilot study provides evidence that this material is a viable alternative to milled splints for at least three months of clinical use. Further evidence on long-term use should be obtained.

Mitigation of Intensity Modulated Radiation Therapy and Stereotactic Body Radiation Therapy Treatment Planning Errors on the Novel RefleXion X1 System Using Failure Mode and Effect Analysis Within Six Sigma Framework

The aim of this study was to apply the Six Sigma methodology and failure mode and effect analysis (FMEA) to mitigate errors in intensity modulated radiation therapy (IMRT) and stereotactic body radiation therapy (SBRT) treatment planning with the first clinical installation of RefleXion X1. The Six Sigma approach consisted of 5 phases: define, measure, analyze, improve, and control. The define, measure, and analyze phases consisted of process mapping and an FMEA of IMRT and SBRT treatment planning on the X1. The multidisciplinary team outlined the workflow process and identified and ranked the failure modes associated with the plan check items using the American Association of Physicists in Medicine Task Group 100 recommendations. Items with the highest average risk priority numbers (RPNs) and severity ≥7 were prioritized for automation using the Eclipse Scripting Application Programming Interface (ESAPI). The "improve" phase consisted of developing ESAPI scripts before the clinical launch of X1 to improve efficiency and safety. In the "control" phase, the FMEA ranking was re-evaluated 1 year after clinical launch. Overall, 100 plan check items were identified in which the RPN values ranged from 10.2 to 429.0. Fifty of these items (50%) were suitable for automation within ESAPI. Of the 10 highest-risk items, 8 were suitable for automation. Based on the results of the FMEA, 2 scripts were developed: Planning Assistant, used by the planner during preparation for planning, and Automated Plan Check, used by the planner and the plan checker during plan preparation for treatment. After 12 months of clinical use of the X1 and developed scripts, only 3 errors were reported. The average prescript RPN was 138.0, compared with the average postscript RPN of 47.8 (P < .05), signifying a safer process. Implementing new technology in the clinic can be an error-prone process in which the likelihood of errors increases with increasing pressure to implement the technology quickly. To limit errors in clinical implementation of the novel RefleXion X1 system, the Six Sigma method was used to identify failure modes, establish quality control checks, and re-evaluate these checks 1 year after clinical implementation.

Changes in the properties of pure cotton surgical gowns and drapes with clinical use and reprocessing.

The impact of repeated in-hospital reprocessing on 100% cotton fabric continues to be debated. We analyzed the properties of surgical gowns and drapes over 15 months of clinical use. The amount of linting fibers and the water absorption rate increased significantly, but microbial and blood penetration was preserved.

Development of an assessment form for the performance of public transportation use in individuals with stroke

Purpose To develop a new assessment form that is assessed by therapists for the performance of public transportation use for stroke survivors through content validation. Materials and Methods The items for the tentative assessment form were selected using hierarchical clustering analysis on previous records of 76 field-based training sessions for public transportation use for stroke survivors. After the modification of the tentative form based on 6 months of clinical use, the final form was developed through content validation using the Delphi method by 71 therapists who had been working at the hospital for more than 2 years and had experience with training for public transportation use. Results The Public Transportation use Assessment Form (PTAF) for stroke was successfully developed through three validation processes. It consists of four categories (plan for going out, mobility, using trains, and using buses) including 15 items that cover various tasks of public transportation use. The scoring for each was as follows: 3, independent; 2, requires supervision of verbal assistance; 1, requires assistance; and N, not applicable. Conclusion The PTAF, developed through content validation, could assess the ability of public transportation use, and identify specific problems for each stroke survivor in clinical setting. IMPLICATIONS FOR REHABILITATION We developed the Public Transportation use Assessment Form (PTAF) to assess the ability of stroke survivors to use public transportation. The PTAF could identify specific problems related to public transportation use for stroke survivors and aid in planning rehabilitation programs based on the results. The PTAF could share information about which task need support in public transportation use and could augment the hospital discharge plan.

The Effect of Denture Cleansing Solutions on the Retention of Precision Attachments: An In Vitro Study.

This study aimed to investigate the effect of different cleansing solutions on the retention of precision attachments. A precision attachment patrix was embedded into acrylic resin and the matrix was placed onto the patrix. The red (high retention, 8 N), yellow (regular retention, 6 N), and green (reduced retention, 4 N) plastic matrixes of the attachments (n = 32) were soaked in three different denture cleansing solutions (sodium laureth sulfate, sodium bicarbonate-sodium perborate, sodium bicarbonate) for a duration simulating 6 months of clinical use. The control group was soaked in tap water. A universal testing machine was used to measure the retention values of attachments after they were soaked in denture cleansers. The retention values were compared among the groups with repeated-measures analysis of variance followed by the Tukey HSD test (p = 0.05). Yellow attachments were affected by sodium laureth sulfate, sodium bicarbonate-sodium perborate, and water (p = 0.012). Green attachments’ retention increased after immersion in sodium laureth sulfate (p = 0.04) and water (p = 0.02). Red attachments’ retention increased after immersion in sodium laureth sulfate or sodium bicarbonate-sodium perborate (p = 0.045). Water did not affect the retention of red attachments. Because sodium bicarbonate tablets did not affect the retention of attachments, clinicians may recommend their use as a cleanser. Clinicians also may inform patients using fixed and removable partial prostheses with precision attachments of a possible increase in retention after the use of sodium laureth sulfate or when using sodium bicarbonate-sodium perborate with yellow and red attachments.

Detection of the effects of the various denture cleansing methods on overdenture retentive attachments with a scanning electron microscope

Background/Aim: The purpose of this in vitro study was to evaluate the effect of mechanical and chemical denture cleansing methods on dental attachments of varying retention with a scanning electron microscope. Material and Methods: An implant analog and a male part of a dental attachment were embedded into an acrylic block, and an abutment was screwed onto the analog. Different locator attachments with varying retention were tested using different denture cleansing methods and tap water for a time simulating 12 months of clinical use. A pull-out test was performed for each attachment, followed by analysis of the samples with a scanning electron microscope. Results: For the blue attachment group, there was no statistically significant difference between the retention values of control and chemical and mechanical denture cleansing groups (p&gt;0.05). The clear and pink attachments were affected by chemical and mechanical denture cleansing, and had significantly decreased retention values compared to the control group (p&lt;0.05). For both types of attachments, the mechanical cleansing group exhibited the lowest retention loss value. Scanning electron microscopy results showed that surface irregularities, scratch lines, and deformations were detected in chemical and mechanical denture cleansing groups for all types of retentive attachments. Conclusions: Both attachment systems with different retentions were influenced by the denture cleansing method. Considering the results, clinicians could recommend the most appropriate method to patients, one that does not adversely affect the properties of the retainer parts. Clinicians should not advise using mechanical and chemical denture cleansing methods to protect the long-term retention of pink and clear attachments.

FRACTURE RESISTANCE UNDER CYCLIC LOADING OF LITHIUM DISILICATE VONLAYS VERSUS ROSETTA VONLAYS RESTORING PREMOLARS (IN VITRO STUDY)

The aim of the study was to assess fracture resistance under cyclic loading of Rosetta®SM CAD vs. IPS e.max CAD (control) vonlays restoring maxillary premolars. According to the sample size calculation, a total of 20 samples will be selected and then divided into two equal groups; 10 sample each based on the material type: Group (A): Ten vonlays (n=10) manufactured from IPS e. max CAD blocks (control). Group ( B): Ten vonlays (n=10) manufactured from Rosetta®SM CAD blocks (intervention). A natural tooth presenting an upper first premolar was prepared in accordance with the ceramic onlay restorations preparation guidelines with an occlusal box with half of the bucco-lingual distance and a 2 mm depth from the cusp tip to pulpal floor, gingival seat with 1 mm depth from pulpal floor, occlusal reduction of 2 mm of the functional cusp with extending the preparation at the palatal surface by 2 mm in the cervical direction, occlusal reduction of 1.5 mm of non-functional cusp and 12º divergence angle. The preparation was then extended to the labial surface, with a 0.5 mm chamfer finish line. All line angles were finally rounded, and all margins were finished. For duplication of the natural tooth; the epoxy dies were constructed. Base and catalyst of the epoxy resin material were mixed as instructed by the manufacturer at a rate of 200r/min and then was poured into the silicon mould under vibration to eliminate any air voids, then was allowed to set completely following the manufacturer instructions for 24 hours, this procedure was repeated 20 times for creating 20 epoxy resin dies which replicating the prepared natural tooth. The die was then scanned by optical scanning using Medit i500 oral scanner. Milling of Vonlays was achieved using Sirona MCX5 milling machine using IPS e. max CAD blocks and Rosetta SM CAD blocks: 10 IPS e.max CAD blocks with block size C14 and 10 Rosetta®SM CAD blocks with block size C14 were used. Vonlays were then seated on their corresponding dies and cemented with dual cured self-adhesive resin cement (Variolink, Ivoclar Vivadent). Cementation procedures were performed by keeping each sample under a constant pressure of 5Kg using a custom designed cementation device for standardization the applied load during cementation process. All samples were mechanically aged (cyclic loading) to simulate 6 months of clinical use. Following that, all samples were subjected to fracture resistance testing under a compressive load to the center of their long axis using computer controlled universal testing machine with a load cell of 5 Kilo newton (K N) with a computer software used for data recording (Instron® Bluehill Lite Software). The mean values ± SDs values for e.max group were (502.39 ±102.89 N) with minimum value (338.16 N) and maximum value (721.29 N). The mean values ± SDs values. Rosetta group were (468.76 ± 67.54 N) with minimum value (367.11 N) and maximum value (648.48 N). Failure modes were determined under stereomicroscope and classified into repairable and catastrophic in both groups and showed that 60% of e.max group exhibited repairable failure while 40% of specimens showed catastrophic failure while in Rosetta group, 90% of the specimens exhibited repairable failure. Only 10% displayed catastrophic failure. Then a fractured part within each group was examined under scanning electron microscope (SEM) to reveal and compare their microstructure.

PO-1718 Variations in MR linac beam performance – daily EPID-based results from 22 months of clinical use

PO-1718 Variations in MR linac beam performance – daily EPID-based results from 22 months of clinical use

Glass Ionomer Versus Self-adhesive Cement and the Clinical Performance of Zirconia Coping/Press-on Porcelain Crowns.

This split-mouth clinical study investigated the effect of luting cement on the performance of veneered yttrium-stabilized tetragonal zirconia polycrystal (Y-TZP) zirconia crowns. A total of 60 crowns prepared with Y-TZP coping and press-on porcelain were made with a split-mouth design in 30 participants. The crowns were cemented either with glass ionomer cement (GIC) (Meron, Voco) or with self-adhesive resin cement (Bifix-SE, Voco). The restorations were assessed immediately after treatment and after 6, 12, 24, 36, and 48 months using the modified United States Public Health Service criteria. The parameters analyzed were retention, color stability, marginal discoloration, marginal adaptation, surface roughness, anatomic form, and secondary caries. The differences between the groups were analyzed by the Fisher exact test in each period of evaluation. The survival rate was analyzed with the Kaplan-Meier and log-rank test (α=0.05). After 48 months, 20 participants attended the recall. During the period of evaluation, 1 crown cemented with glass ionomer cement and 1 crown cemented with resin cement lost retention. Color match, marginal discoloration and adaptation, surface roughness, and anatomic form did not change in any of the periods evaluated, and no secondary caries was observed. No significant differences were found between the 2 luting cements for any of the clinical parameters analyzed, nor for the survival rates during the study. The type of cement did not influence the performance of the crowns after 48 months of clinical use. Both cements resulted in adequate retention rates, aesthetic and functional outcomes, and biological response.

Assessing seizure burden in pediatric epilepsy using an electronic medical record-based tool through a common data element approach.

Improvement in epilepsy care requires standardized methods to assess disease severity. We report the results of implementing common data elements (CDEs) to document epilepsy history data in the electronic medical record (EMR) after 12months of clinical use in outpatient encounters. Data regarding seizure frequency were collected during routine clinical encounters using a CDE-based form within our EMR. We extracted CDE data from the EMR and developed measurements for seizure severity and seizure improvement scores. Seizure burden and improvement was evaluated by patient demographic and encounter variables for in-person and telemedicine encounters. We assessed a total of 1696 encounters in 1038 individuals with childhood epilepsies between September 6, 2019 and September 11, 2020 contributed by 32 distinct providers. Childhood absence epilepsy (n=121), Lennox-Gastaut syndrome (n=86), and Dravet syndrome (n=42) were the most common epilepsy syndromes. Overall, 43% (737/1696) of individuals had at least monthly seizures, 17% (296/1696) had a least daily seizures, and 18% (311/1696) were seizure-free for >12months. Quantification of absolute seizure burden and changes in seizure burden over time differed between epilepsy syndromes, including high and persistent seizure burden in patients with Lennox-Gastaut syndrome. Individuals seen via telemedicine or in-person encounters had comparable seizure frequencies. Individuals identifying as Hispanic/Latino, particularly from postal codes with lower median household incomes, were more likely to have ongoing seizures that worsened over time. Standardized documentation of clinical data in childhood epilepsies through CDE can be implemented in routine clinical care at scale and enables assessment of disease burden, including characterization of seizure burden over time. Our data provide insights into heterogeneous patterns of seizure control in common pediatric epilepsy syndromes and will inform future initiatives focusing on patient-centered outcomes in childhood epilepsies, including the impact of telemedicine and health care disparities.

Effects of denture cleaning solutions on the retention of Hader bar clips

Statement of problemThe clinical performance of implant-retained overdentures (IODs) with plastic bar clips made of different materials in the same design and dimensions may vary according to the patient’s daily home care procedures. However, information about the effects of denture cleaning solutions on the retention of Hader bar clips is lacking. PurposeThe purpose of this in vitro study was to evaluate the retention of Hader bar clips made of different polymers after being soaked in denture cleaning solutions. Material and methodsNinety Hader bar clips made of polyamide (PA, n=30), polytetrafluoroethylene (PTFE, n=30), and polyetherketoneketone (PEKK, n=30) materials were tested. Two multiunit abutments were screwed onto the implant analogs and embedded into an acrylic resin block in a standardized position. The digital scanning of the abutments was acquired, and the bar patrix of each material system milled from a cobalt-chromium (Co-Cr) alloy disk by using computer-aided design and computer-aided manufacturing (CAD-CAM). After the milled bar patrices were screwed onto abutments and the metal housings of the bar clips were embedded into acrylic resin blocks, they were connected passively at the same angulation to a universal testing machine. The initial retention values of all Hader bar clips were measured, and each material system was divided into 3 subgroups (n=10) before soaking in the cleaning solutions: distilled water (DW), 5% sodium hypochlorite (NaOCl), or sodium bicarbonate-sodium perborate (SBSP). Each material was soaked for the equivalent of 3 months of clinical use. The final retention values of each Hader bar clip were measured. The data were statistically analyzed by using a 2-way analysis of variance (ANOVA), the Tukey honestly significant difference (HSD) test, and the paired sample t test (α=.05). ResultsThe 2-way ANOVA showed that the denture cleaning solution, the clip material, and their interactions led to significantly different retention values (P<.001). A decrease was observed for the retention values of all test groups after soaking in the cleaning solutions (P<.05). No retention was observed for the PTFE clips after soaking in the 5% NaOCI solution. ConclusionsThe denture cleaning solutions negatively affected the retention of Hader bar clips, regardless of the type of solution and clip material. The 5% NaOCI solution not only decreased the retention of PTFE clips but also completely degraded it. It is recommended that 5% NaOCI solution be avoided for the daily care of IODs with PTFE clips.