High triglyceride levels can increase the risk of heart disease, so finding effective ways to manage them is important. Traditional yoga practices, especially Shatkarma, are being looked at for their potential benefits on cardiovascular health. This present case report explores one-month Shatkarma intervention on hypertriglyceridemia of a middle-aged male. A 58-year-old man with very high triglycerides (598.77 mg/dl) was admitted to Patanjali Ayurveda Hospital, based on his pre-examination he was transferred to Shatkarma department for further procedure. He then participated in a one-month Shatkarma program, which included Shankha Prakshalana (done once), Kunjal Kriya (twice a week), and Jal Neti and Trataka (alternate day). After the month-long program, his triglyceride levels dropped significantly from 598.77 mg/dl to 114.5 mg/dl. This case shows that Shatkarma practices can significantly lower triglyceride levels. The results suggest that combining traditional yoga practices with conventional treatments could be a helpful way to manage high triglycerides. However, since everyone’s body responds differently; more research is needed to fully understand how these practices work and their long-term benefits.