Monosperma Flower Research Articles

Isoputrin and Butrin, the Antihepatotoxic Principles ofButea monospermaFlowers1

Since an extract from the flowers of BUTEA MONOSPERMA, a plant drug used in India for the treatment of liver disorders, showed significant activity in different models of liver damage, the extract was fractionated by solvent partitioning and HPLC, and activity monitored by means of CCl 4 - and GalN-induced liver lesion IN VITRO. The antihepatotoxic principles isolated consisted of two known flavonoids, isobutrin (3, 4, 2′, 4′-tetrahydroxychalcone-3, 4′-diglucoside), and the less active butrin (7, 3′, 4′-trihydroxyflavanone-7, 3′-diglucoside). For qualitative and quantitative analysis of isobutrin and butrin in extracts of BUTEA MONOSPERMA flowers a HPLC system was developed.