Density functional theory (DFT) was used to investigate the hydrogen evolution reaction (HER) on monolayer VSe2 doped by transition metal (TM) (Sc, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Rh, Ir), in which Se or V is replaced by TM atoms (denoted as TM@Se or TM@V). Introducing transition metals (TMs) into the VSe2 monolayer can alter its electronic structure and catalytic properties. The choice of transition metal dopants and their configurations can significantly impact the catalytic performance of the material. It is illustrated that the TM@V systems are more stable than TM@Se configurations. Moreover, Co@V, Cu@V, Fe@V Zn@V and Cu@Se exhibit the lower ΔGH* values of 0.07, 0.09, 0.10, 0.12 and −0.1 eV, respectively, and ΔGH* values are very close to the ideal value of zero and are superior to precious metal Pt (ΔGH* = −0.1eV). Based on the scaling relationship of ΔGH* of H* intermediate, the volcano diagram and exchange current density diagram are established. It is predicted that Cu@V, Co@V, Fe@V, Zn@V structures could provide large exchange current of −1.6, −1.22, −1.7, −2 i0/(Acm−2), respectively.