Static self‐assembly resides in thermodynamically stable global minima of the energy landscape, whereas dynamic self‐assembly occupies local minima of the energy profile and remain in the ordered state for a limited time via dissipation of energy to surroundings. This makes the spatiotemporal control over assembly and disassembly mechanism easily controllable in case of dynamic self‐assembly. But due to higher thermal stability of static self‐assembly, it is very challenging to perform reverse engineering upon these types of systems. Herein we report growth reaction based reversal of static silver cubes obtained via cucurbit[8]uril (CB[8]) crosslinked self‐assembly of silver nanoparticles (AgNP). The AgNP building units with variable CB[8] surface coverage have been used as seed onto which deposition of gold via growth reaction has been performed. The disassembly of supracube structure has been controlled by the formation of [AuCl4]¯‒CB[8] complex and successive reduction of [AuCl4]¯ to Au0 on the surface of seed. The resulting monodispersed isotropic nanoparticles, formed from the CB[8] based cubic self‐assembly after growth, exhibit Au‐Ag bimetallic nature. Quenching of the fluorogenic response from the hydrophobic dye coumarin‐7, added after growth, suggests direct interaction with the metallic nanoparticle surface after disassembly and thereby confirms successful growth reaction mediated reversal of self‐assembly.