Proliferation Of Monoclonal Plasma Cells Research Articles

Transient IgA1-λ Paraproteinemia During Treatment of Acute Myelomonoblastic Leukemia

Monoclonal plasma cell proliferation with secretion of IgA-lambda and free lambda light chains during a phase of bone marrow aplasia following intensive chemotherapy was observed in a patient suffering from acute myelomonoblastic leukemia. The clonal expansion and regression was investigated at the cellular level by immunofluorescence using an antiserum against the idiotype of the paraportein. Although a large panel of common antigens was used for testing, no antibody activity of the paraprotein could be demonstrated.

GAUCHER'S DISEASE AND BENIGN MONOCLONAL GAMMAPATHY

A case of chronic non-neuronopathic Gaucher's disease is presented. The diagnosis was based on the finging of typical Gaucher cells in the bone marrow spleen. The patient also had a benign monoclonal gammapathy. Immunofluorescence studies of bone marrow and spleen were performed using monospecif antisera against immunoglobulin heavy and light chains. The results indicate a monoclonal plasma cell proliferation in the bone marrow, whereas the distribution of plasma cells in the spleen was polyclonal. The combination of chronic Gaucher's disease and monoclonal gammapathy was also found in the patient's brother.

“PARANEOPLASTIC” SYNDROMES ASSOCIATED WITH MONOCLONAL LYMPHOCYTE AND PLASMA CELL PROLIFERATION*

Annals of the New York Academy of SciencesVolume 230, Issue 1 p. 228-239 “PARANEOPLASTIC” SYNDROMES ASSOCIATED WITH MONOCLONAL LYMPHOCYTE AND PLASMA CELL PROLIFERATION* Sydney E. Salmon, Sydney E. Salmon Department of Medicine University of Arizona College of Medicine Tucson, Arizona 85724Search for more papers by this author Sydney E. Salmon, Sydney E. Salmon Department of Medicine University of Arizona College of Medicine Tucson, Arizona 85724Search for more papers by this author First published: March 1974 https://doi.org/10.1111/j.1749-6632.1974.tb14453.xCitations: 19 * This work was supported by United States Public Health Service Grants CA 14102 and CA 14087 and Contract NIH-NCI-C-73-3713. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Citing Literature Volume230, Issue1Paraneoplastic SyndromesMarch 1974Pages 228-239 RelatedInformation