An imaginary-time method was developed for calculating the probability of particle transmission through smooth barriers variable with time. Within the imaginary-time method, the tunneling process is described by using classical equations of motion written in terms of an imaginary time (t → it), while the probability of tunneling is determined by the imaginary part of the action functional, this imaginary part being calculated along the subbarrier particle trajectory. The fundamentals of the imaginary-time method are surveyed, and its applications in the theory of atomic-state ionization under the effect of constant electric and magnetic fields that have various configurations, in the field of intense monochromatic laser radiation and of an ultrashort electromagnetic pulse, in the process of Lorentz ionization of atoms and ions during their motion in a strong magnetic field, etc., are outlined. The applications of the imaginary-time method in relativistic cases—for example, in the theory of ionization of levels of multiply charged ions whose binding energy is commensurate with the electron rest energy—and in quantum field theory (Schwinger effect, which consists in the production of electron-positron pairs from a vacuum by a superstrong external field) are briefly described. Particular attention is given to methodological issues and details of the imaginary-time method that are of importance in solving specific physics problems, but which are usually skipped in original publications.