There is no French National Report on acute poisonings. Knowledge about the causes of acute drug poisonings should be extended using data collected in French monocentric studies or in other countries. In spite of continuous efforts since 30 years, the annual number of acute drug poisonings and drug-induced deaths at the best has plateaued, at the worst has increased. Interventions of medical emergency service related to acute drug poisonings remain frequent with a trend towards an increase. The annual number of expositions to antidepressants, whatever the pharmacological classes, seems unchanged with a progressive decline in exposure to polycyclic antidepressants while there is an increase in exposures to serotonin selective re-uptake inhibitors (SSRI). Deaths are related to polycyclic antidepressants while some SSRIs, including venlafaxine and citalopram, may also be associated with deaths. There is a progressive increase in exposure to neuroleptics as well as to cardiotropic drugs requiring attention to these trends. Acute poisonings related to drugs used in the treatment of heroin addiction have been reported. The mechanisms of toxicity are not clearly understood: overdose with methadone, drug-drug interaction of buprenorphine and benzodiazepines. Anyway, the annual mortality rate of opioid-related overdoses has steadily decreased. Ecstasy is largely used in France. However, ectasy-induced serotonin syndrome remains quite rare.