Since January 1, 2022 last year, many countries outside Africa have begun to have outbreaks of Monkeypox (Mpox) virus. The first case of Mpox transfusion was confirmed on 16 September 2022 Chinese mainland. In order to prevent major public health events, the aim of this study is to predict which populations in China are more susceptible to Mpox virus infection. There are two main research methods used in this paper: literature research method and statistical analysis method. The proportion of male cases in different groups was mainly analyzed separately, and the proportion of the data was determined by a 95% confidence interval. Second, analyze the true proportions of these factors through demographic information. Semen samples and rectal swabs of the type from the confirmed case are then transmitted to determine how Mpox virus is transmitted. Finally, sex-age (proportion hospitalized) was counted. The results of the experiment are: the proportion of male cases is the highest, and the true proportion of male sex and sexual transmission ratio of the influencing factors is the highest. The main types of transmission are: sexual contact, other, and between people. Men in the 18-49 age group and women in the 18-59 age range had the greatest hospitalization rates, respectively. The conclusion is that men who have sex with men, sex actors, HIV-positive patients, women aged 18-59 and men aged 18-49 are the main target groups in China and are susceptible to Mpox virus.