Objectives: To report a correlation of IL-6 of pancreatic cancer and cancer progression in three pancreatic cancer patients.Method: Three pancreatic cancer patients were monitored for changes in IL-6 levels, tumor markers (CEA, CA19-9), and clinical outcomes over their treatment period.Results: Patient 1’s IL-6 levels rose with liver metastasis and tumor progression, coinciding with increases in tumor markers. Patient 2’s IL-6 levels remained elevated during chemotherapy, correlating with tumor growth. Patient 3’s IL-6 levels spiked prior to cancer progression.Conclusion: Elevated IL-6 levels were observed in advancing pancreatic cancer patients, suggesting IL-6 as a potential biomarker for monitoring cancer progression in pancreatic cancer. Regular IL-6 monitoring could improve prognostic evaluations and treatment strategies.