Beam Monitoring Research Articles

A novel fiber-optic beam monitor

A novel beam monitor based on Ce-doped silica optical fibers is being presented. Four fibers are mounted on the outside of a beam transport pipe, at the location of a beam stop at a proton cyclotron. The secondary radiation caused by the proton beam interaction with the beam stop is measured by the optical fibers via Radiation-Induced Emission (RIE). The light signal in the individual fibers is correlated to the proton flux closest to the fiber and can therefore be used as a detector to monitor the position of the proton beam in the beam stop. Initial testing shows that monitoring of a 150 nA beam of 18 MeV protons into a beam dump is possible. The monitor can measure relative beam current and beam displacement in X and Y as a function of magnetic steering.

Employing finite element analysis for assessing the condition monitoring of sandwich beams

In engineering and transportation, beams are frequently utilized as structural elements for both static and dynamic loads. This paper focuses on a smart structure method that incorporates ANSYS software for modeling and simulation. Piezoelectric transducers are employed for actuation and sensing throughout the structure. The governing equation of a finite element that converts the mechanical energy of the structure into the electric energy of the piezoelectric material is derived using Hamilton's principle. Debonding of piezoelectric sensors/actuators is caused by structural alterations in sandwich beams, and this leads to a notable fluctuation in both static and dynamic responses. It has been shown that Finite Element Modeling with ANSYS software yields accurate numerical solutions over a broad range of related parameters. The results are displayed and vibration modes are animated by utilizing the graphical post processing capabilities. It has been observed that the material and structural alterations are what cause the increase in natural frequencies. With an input of 1 V, the load is adjusted between 0 and 5000 Hz for every material configuration.

AE-Based Health Monitoring of Full-scale RC Beams Strengthened with FRCM Composites

Using fiber-reinforced cementitious matrix (FRCM) offers several advantages, making it a potential replacement for conventional fiber-reinforced polymers (FRP). Integrating mechanical anchorage enhances the robustness and cost-effectiveness of the FRCM system. This research study primarily focuses on the comprehensive flexural strengthening of reinforced concrete (RC) beams using FRCM. To achieve this, three RC beams were intentionally partially damaged, and subsequently, two layers of FRCM were applied with three distinct strengthening strategies, including options with and without mechanical anchorage. These beams were then subjected to a monotonic four-point bending loading test. Monitoring of the front face of the beam is carried out using the Digital Image Correlation (DIC) technique, while the bottom and back faces were equipped with three acoustic sensors, each with a frequency range of 20-1000 kHz. It was observed that the FRCM strengthening strategy involving mechanical anchorage proved highly effective in increasing the load capacity of the beam by approximately 20% when compared to other strategies using a similar percentage of fabric reinforcement. The analysis of acoustic emission (AE) data involved the assessment of parameters such as AE cumulative hits, Cumulative signal strength, event rate, RA-AF, and historical index. These metrics helped identify different test phases based on changing trends in event rate and RA-AF over time. The historical index revealed the patterns of significant events.

Observation of Beam Emittance Reduction due to Gas Sheet Injection for Beam Profile Measurement

In a high intensity ion accelerator, a non-destructive beam monitor is required to realize a continuous measurement of the beam for improving the beam quality in operation for users. We have developed a non-destructive 2-D beam profile monitor detecting photons produced by interaction between a beam and a sheet-shaped gas. Though the developed monitor is a non-destructive type, the injected gas sheet should induce scattering of the beam particles which makes the beam emittance large. We have measured a beam current and a phase space distribution of the J-PARC 3 MeV, 60 mA H− beam with change of the gas sheet flux. It was found that the beam current reduction was in linear relation and the root mean square emittance was constant or decreased by up to 4.5% in y-y′ plane and did not change in x-x′ plane against a rise in the gas sheet flux. These result indicate that the developed monitor can be utilized as a non-destructive one depending on the gas sheet flux condition.

Performance of LGAD strip detectors for particle counting of therapeutic proton beams

Objective. The performance of silicon detectors with moderate internal gain, named low-gain avalanche diodes (LGADs), was studied to investigate their capability to discriminate and count single beam particles at high fluxes, in view of future applications for beam characterization and on-line beam monitoring in proton therapy. Approach. Dedicated LGAD detectors with an active thickness of 55 μm and segmented in 2 mm2 strips were characterized at two Italian proton-therapy facilities, CNAO in Pavia and the Proton Therapy Center of Trento, with proton beams provided by a synchrotron and a cyclotron, respectively. Signals from single beam particles were discriminated against a threshold and counted. The number of proton pulses for fixed energies and different particle fluxes was compared with the charge collected by a compact ionization chamber, to infer the input particle rates. Main results. The counting inefficiency due to the overlap of nearby signals was less than 1% up to particle rates in one strip of 1 MHz, corresponding to a mean fluence rate on the strip of about 5 × 107 p/(cm2·s). Count-loss correction algorithms based on the logic combination of signals from two neighboring strips allow to extend the maximum counting rate by one order of magnitude. The same algorithms give additional information on the fine time structure of the beam. Significance. The direct counting of the number of beam protons with segmented silicon detectors allows to overcome some limitations of gas detectors typically employed for beam characterization and beam monitoring in particle therapy, providing faster response times, higher sensitivity, and independence of the counts from the particle energy.

Quasi-real-time range monitoring by in-beam PET: a case for 15O

A fast and reliable range monitoring method is required to take full advantage of the high linear energy transfer provided by therapeutic ion beams like carbon and oxygen while minimizing damage to healthy tissue due to range uncertainties. Quasi-real-time range monitoring using in-beam positron emission tomography (PET) with therapeutic beams of positron-emitters of carbon and oxygen is a promising approach. The number of implanted ions and the time required for an unambiguous range verification are decisive factors for choosing a candidate isotope. An experimental study was performed at the FRS fragment-separator of GSI Helmholtzzentrum für Schwerionenforschung GmbH, Germany, to investigate the evolution of positron annihilation activity profiles during the implantation of ^{14}O and ^{15}O ion beams in a PMMA phantom. The positron activity profile was imaged by a dual-panel version of a Siemens Biograph mCT PET scanner. Results from a similar experiment using ion beams of carbon positron-emitters ^{11}C and ^{10}C performed at the same experimental setup were used for comparison. Owing to their shorter half-lives, the number of implanted ions required for a precise positron annihilation activity peak determination is lower for ^{10}C compared to ^{11}C and likewise for ^{14}O compared to ^{15}O, but their lower production cross-sections make it difficult to produce them at therapeutically relevant intensities. With a similar production cross-section and a 10 times shorter half-life than ^{11}C, ^{15}O provides a faster conclusive positron annihilation activity peak position determination for a lower number of implanted ions compared to ^{11}C. A figure of merit formulation was developed for the quantitative comparison of therapy-relevant positron-emitting beams in the context of quasi-real-time beam monitoring. In conclusion, this study demonstrates that among the positron emitters of carbon and oxygen, ^{15}O is the most feasible candidate for quasi-real-time range monitoring by in-beam PET that can be produced at therapeutically relevant intensities. Additionally, this study demonstrated that the in-flight production and separation method can produce beams of therapeutic quality, in terms of purity, energy, and energy spread.

Design of Nupix-A2, a Monolithic Active Pixel Sensor for heavy-ion physics

The High Intensity heavy-ion Accelerator Facility (HIAF) is being constructed to generate intense beams of primary and radioactive ion for a wide range of research fields. Hence, a Monolithic Active Pixel Sensor (MAPS) named Nupix-A2 has been developed in a 130-nm High Resistivity CMOS process. The Nupix-A2 can simultaneously measure the particle hit' energy, arrival time, and position. It consists of a 128 × 128 pixel array, a digital-to-analog converter array, and a digital control module. The Nupix-A2 can measure energy deposition from 300 e- to over 50 ke- and time duration from 13 μs to 140 μs. This sensor also offers full readout mode and fast readout mode. In full-readout mode, all pixels measure arrival time and energy, suitable for real-time beam monitoring and image reconstruction. In fast-readout mode, only particle hit's positions are detected and read out. This paper presents the design of the Nupix-A2.

Long-term Prostate Cancer–specific Mortality After Prostatectomy, Brachytherapy, External Beam Radiation Therapy, Hormonal Therapy, or Monitoring for Localized Prostate Cancer

BackgroundThe optimal treatment of localized prostate cancer (PCa) remains controversial. ObjectiveTo compare long-term survival among men who underwent radical prostatectomy (RP), brachytherapy (BT), external beam radiation therapy (EBRT), primary androgen deprivation therapy (PADT), or monitoring (active surveillance [AS]/watchful waiting [WW]) for PCa. Design, setting, and participantsThis is a cohort study with long-term follow-up from the multicenter, prospective, largely community-based Cancer of the Prostate Strategic Urologic Research Endeavor (CaPSURE) registry. Men with biopsy-proven, clinical T1–3aN0M0, localized PCa were consecutively accrued within 6 mo of diagnosis and had clinical risk data and at least 12 mo of follow-up after diagnosis available. Outcome measurements and statistical analysisPCa risk was assessed, and multivariable analyses were performed to compare PCa-specific mortality (PCSM) and all-cause mortality by primary treatment, with extensive adjustment for age and case mix using the Cancer of the Prostate Risk Assessment (CAPRA) score and a well-validated nomogram. Results and limitationsAmong 11 864 men, 6227 (53%) underwent RP, 1645 (14%) received BT, 1462 (12%) received EBRT, 1510 (13%) received PADT, and 1020 (9%) were managed with AS/WW. At a median of 9.4 yr (interquartile range 5.8–13.7) after treatment, 764 men had died from PCa. After adjusting for CAPRA score, the hazard ratios for PCSM with RP as the reference were 1.57 (95% confidence interval [CI] 1.24–1.98; p < 0.001) for BT, 1.55 (95% CI 1.26–1.91; p < 0.001) for EBRT, 2.36 (95% CI 1.94–2.87; p < 0.001) for PADT, and 1.76 (95% CI 1.30–2.40; p < 0.001) for AS/WW. In models for long-term outcomes, PCSM differences were negligible for low-risk disease and increased progressively with risk. Limitations include the evolution of diagnostic and therapeutic strategies for PCa over time. In this nonrandomized study, the possibility of residual confounding remains salient. ConclusionsIn a large, prospective cohort of men with localized PCa, after adjustment for age and comorbidity, PCSM was lower after local therapy for those with higher-risk disease, and in particular after RP. Confirmation of these results via long-term follow-up of ongoing trials is awaited. Patient summaryWe evaluated different treatment options for localized prostate cancer in a large group of patients who were treated mostly in nonacademic medical centers. Results from nonrandomized trials should be interpret with caution, but even after careful risk adjustment, survival rates for men with higher-risk cancer appeared to be highest for patients whose first treatment was surgery rather than radiotherapy, hormones, or monitoring.

Ionoacoustic monitoring of relativistic heavy ion beams

The performance of ionoacoustic detectors is investigated with respect to application of high-precision range and energy loss measurements for relativistic heavy ions. The technique is based on the generation of a pressure wave when a microsecond-pulsed relativistic ion beam is stopped in a water container. The acoustic signal from individual ion pulses is registered by a piezoelectric detector and analyzed in the time/frequency domain to identify the location of pressure wave generation. The experiments were performed at the SIS18 synchrotron at GSI Helmholtzzentrum (Darmstadt, Germany) with Xe, Pb and U ions of energies between 200 MeV/u and 1 GeV/u. We show that the signal amplitude of the acoustic pressure pulse has a linear correlation with the beam intensity within a range of at least 104 to 109 particles/spill.By determining the delay time of the primary and reflected acoustic signal in the water reservoir, the ionoacoustic technique provides information on ion ranges of 1 % accuracy. By an energy-range calibration in combination with a simulation code such as FLUKA, the range data can be used to determine the beam energy. As demonstrated, inserting targets of known thickness in front of the detector is a simple approach for measuring the energy loss of relativistic ions. The advantage of the ionoacoustic technique is the rather simple experimental setup, the huge dynamic range, the information available online by means of only a single pulse and its radiation hardness. Ionoacoustic detectors have great potential as intensity and energy monitor for short-pulsed light and heavy ion beams at existing or future high-energy ion facilities.

A neutron beam monitor based on ceramic gas electron multiplier with high spatial resolution for low flux measurements.

Neutron scattering instruments play an important role in studying the inner structure of materials. A neutron beam monitor is a detector commonly used in a neutron scattering instrument. The detection efficiency for most neutron beam monitors is quite low (10-4-10-6). However, in some experiments with a low neutron flux, such as small angle neutron scattering (SANS) and inelastic neutron scattering experiments, a neutron beam monitor with a higher detection efficiency (∼1% for thermal neutrons) is required to reduce the duration of the experiment. To meet this requirement, a ceramic gas electron multiplier-based neutron beam monitor equipped with a 1 µm 10B4C neutron converter was developed in this study. Its performance was determined both experimentally and in simulations. The detection efficiency in the wavelength range of 1.8-5.5 Å was measured experimentally and was confirmed by the simulation results. An algorithm based on event selection and position reconstruction was developed to improve the spatial resolution to about 1mm full-width-half-maximum. The wavelength spectrum was measured in beamline 20 (BL20) and agreed well with the results obtained using a commercial monitor. The maximum counting rate was 1.3MHz. The non-uniformity over the whole 100 × 100mm2 active area was determined to be 1.4%. Due to the excellent performance of this monitor, it has been used in several neutron instruments, such as the SANS and the High-Energy Direct-Geometry Inelastic Spectrometer instruments in the China spallation neutron source.

Feasibility and Clinical Implementation of Electron FLASH Radiation Therapy in the Yorkshire Swine Model

Preclinical studies have shown FLASH radiation therapy (RT) increases the therapeutic index through reduction in normal tissue toxicity but with retained tumor control compared to conventional dose rate (CONV) RT. Dosimetry in FLASH beams is challenging and complex as beam monitoring and proper dosimetry analysis remain uncertain and under investigation. Despite these limitations, clinical translation of FLASH RT has already begun. For translation of FLASH RT from the preclinical stage, it is critical that robust clinical workflows and dosimetry methods be confidently established to ensure patient safety. Here, we present the clinical workflow for the Yorkshire pig, an animal that resembles the body dimension, weight, and biology of a human patient, with the goal to establish standard operating procedures to ensure a safe and robust clinical translation in our upcoming phase I study in cutaneous tumors. The study determines feasibility and safety while finding incidence of dose-limiting toxicities and maximum tolerable dose for future Phase II trials. All procedures were approved by the institutional animal care and use committee. 6 pigs (40-50 kg) were placed under general anesthesia and underwent CT imaging for radiation therapy simulation purposes. The skin was first shaven, and targets on the dorsolateral flanks were marked with tattoos and BBs for CT visualization. Vacloc immobilization was used to allow for reproducible setup on the treatment couch. A treatment planning model was established for treatment planning and dose evaluation purposes. CONV and FLASH single and fractionated dose regimens were prescribed to the 90% isodose line in a 9 MeV beam. Skin collimation and bolus minimized beam penumbra and increased skin dose. Treatment time and pulse repetition frequency were constant between all FLASH fields. Prescription levels were varied via dose per pulse. Calibration and verification of these settings were performed utilizing a multi-dosimeter method for verification in solid water. Output of the beam was verified on the day of the treatment using beam current transformers. This same multi-dosimeter method was used as in-vivo dosimetry on treatment day and compared to the dose verification ensure full dose was received. Variation between the three dosimeter methods was found to be within 5% among all pigs within the study. The maximum percent difference between dose verification and dose delivery was 6%. Consideration must be taken in dosimeter readout error due to the surface of the pig skin. FLASH and CONV toxicity results are currently under evaluation and will be published upon completion of the study. Establishing guidelines and protocols for electron FLASH clinical translation is important to instill confidence in patient safety with this new technique. This study has further optimized and developed dosimetry tools and setup to be used in future clinical trials.

Electron contamination suppression in transmission detectors for radiotherapy.

Higher energy and intensity radiotherapy beams are being used, in part, due to the increased spatial accuracy of treatments. However, higher intensity beams can result in a larger total dose error, motivating the increasing need for real-time dose monitoring. We are developing a thin, real-time upstream Monolithic Active Pixel Sensor based system for beam monitoring with excellent precision on measuring the beam shape. Here we present a method to additionally provide dosimetry by adding thin conversion material in strips to the surface of the detector, a grating structure. &#xD;Approach: By modulating the thickness of the conversion material to minimally disturb the contamination electron signal while enhancing the photon signal, the difference in these signals can be used to extract a photon-only signal, and hence dose. The simulation software Gate, based on Geant4, is utilised to study whether well functioning gratings can be better made from aluminium or copper and to optimise the thickness of a copper grating. &#xD;Main results: It is possible to enhance the photon signal by a factor 6.7 (7.7) compared to the bare sensor for a 5.8 (6.7) MV beam, without modulation of the signal due to beam electrons. &#xD;Significance: The grating can be used to perform dosimetry in real-time using a thin upstream detector.

Detection of transverse cracks in steel beams using damage location coefficients and artificial neural networks

Structural health monitoring plays a crucial role in ensuring the integrity and safety of engineering structures such as steel beams. This research paper presents a comprehensive methodology for detecting transverse cracks in beams with a constant section and any boundary conditions. The proposed approach utilizes the normalized squared modal curvature of the beam, the damage severity, and the natural frequency of the undamaged beam. By analyzing the natural frequencies of both the undamaged and damaged states, Relative Frequency Shift (RFS) values are obtained. Subsequently, the Damage Location Coefficients (DLC) are calculated by normalizing the RFS values. These DLC values are then employed to establish a comprehensive database of known damage signatures, enabling the training of an artificial neural network (ANN) in MATLAB. The trained ANN can predict the locations of damages for new scenarios by utilizing DLC values obtained from measurements. To validate the effectiveness of the ANN, extensive simulations using Finite Element Method (FEM) and experimental measurements are conducted on a steel cantilever beam. The results demonstrate the ANN’s capability to accurately predict the locations of transverse cracks, showcasing its potential as a reliable tool for structural health monitoring of steel beams.

Dosimetry for radiobiological in vivo experiments at laser plasma-based proton accelerators

Objective. Laser plasma-based accelerators (LPAs) of protons can contribute to research of ultra-high dose rate radiobiology as they provide pulse dose rates unprecedented at medical proton sources. Yet, LPAs pose challenges regarding precise and accurate dosimetry due to the high pulse dose rates, but also due to the sources’ lower spectral stability and pulsed operation mode. For in vivo models, further challenges arise from the necessary small field dosimetry for volumetric dose distributions. For these novel source parameters and intended applications, a dosimetric standard needs to be established. Approach. In this work, we present a dosimetry and beam monitoring framework for in vivo irradiations of small target volumes with LPA protons, solving aforementioned challenges. The volumetric dose distribution in a sample (mean dose value and lateral/depth dose inhomogeneity) is provided by combining two independent dose measurements using radiochromic films (dose rate-independent) and ionization chambers (dose rate-dependent), respectively. The unique feature of the dosimetric setup is beam monitoring with a transmission time-of-flight spectrometer to quantify spectral fluctuations of the irradiating proton pulses. The resulting changes in the depth dose profile during irradiation of an in vivo sample are hence accessible and enable pulse-resolved depth dose correction for each dose measurement. Main results. A first successful small animal pilot study using an LPA proton source serves as a testcase for the presented dosimetry approach and proves its performance in a realistic setting. Significance. With several facilities worldwide either setting up or already using LPA infrastructure for radiobiological studies with protons, the importance of LPA-adapted dosimetric frameworks as presented in this work is clearly underlined.

Characterisation of the UK high energy proton research beamline for high and ultra-high dose rate (FLASH) irradiation

Objective. This work sets out the capabilities of the high energy proton research beamline developed in the Christie proton therapy centre for Ultra-High Dose Rate (UHDR) irradiation and FLASH experiments. It also characterises the lower limits of UHDR operation for this Pencil Beam Scanning (PBS) proton hardware. Approach. Energy dependent nozzle transmission was measured using a Faraday Cup beam collector. Spot size was measured at the reference plane using a 2D scintillation detector. Integrated depth doses (IDDs) were measured. EBT3 Gafchromic film was used to compare UHDR and conventional dose rate spots. Our beam monitor calibration methodolgy for UHDR is described. A microDiamond detector was used to determine dose rates at zref. Instantaneous depth dose rates were calculated for 70–245 MeV. PBS dose rate distributions were calculated using Folkerts and Van der Water definitions. Main results. Transmission of 7.05 ± 0.1% is achieveable corresponding to a peak instantaneous dose rate of 112.7 Gy s−1. Beam parameters are comparable in conventional and UHDR mode with a spot size of σ x = 4.6 mm, σ y = 6.6 mm. Dead time in the beam monitoring electonics warrants a beam current dependent MU correction in the present configuration. Fast beam scanning of 26.4 m s−1 (X) and 12.1 m s−1 (Y) allows PBS dose rates of the order tens of Grays per second. Significance. UHDR delivery is possible for small field sizes and high energies enabling research into the FLASH effect with PBS protons at our facility. To our knowledge this is also the first thorough characterisation of UHDR irradiation using the hardware of this clinical accelerator at energies less than 250 MeV. The data set out in this publication can be used for designing experiments at this UK research facility and inform the possible future clinical translation of UHDR PBS proton therapy.

Ultrathin four-quadrant silicon photodiodes for beam position and monitor applications: Characterization and radiation effects

Ultrathin semiconductor photodiodes are of interest for beam position and monitoring in X-ray synchrotron beamlines and particle therapy medical applications. In this work, single and four-quadrant diodes have been fabricated on ultrathin Si films with thicknesses of 10 μm, 5 μm and 3 μm from silicon on insulator (SOI) substrates. Physical and electrical characterization of the devices has been carried out. Good functional electrical characteristics have been obtained for the devices fabricated on the different silicon thicknesses. The impact of electron, neutron and proton irradiations on the electrical characteristics has been studied for the 10 μm-thick devices. In spite of the observed diode leakage current increase and positive charge trapping in interquadrant isolation oxide, functional operation as radiation detector is verified upon illumination with a pulsed laser beam transient current technique.

Phenomena and Laws of Stochastic Electron Optics Use for the Formation and Monitoring of Charged Particles Beams

Phenomena and Laws of Stochastic Electron Optics Use for the Formation and Monitoring of Charged Particles Beams

Real-time monitoring of ultra-high dose rate electron beams using bremsstrahlung photons

Recently, as the clinically positive biological effects of ultra-high dose rate (UHDR) radiation beams have been revealed, interest in flash radiation therapy has increased. Generally, FLASH preclinical experiments are performed using UHDR electron beams generated by linear accelerators. Real-time monitoring of UHDR beams is required to deliver the correct dose to a sample. However, it is difficult to use typical transmission-type ionization chambers for primary beam monitoring because there is no suitable electrometer capable of reading high pulsed currents, and collection efficiency is drastically reduced in pulsed radiation beams with ultra-high doses. In this study, a monitoring method using bremsstrahlung photons generated by irradiation devices and a water phantom was proposed. Charges collected in an ionization chamber located at the back of a water phantom were analyzed using the bremsstrahlung tail on electron depth dose curves obtained using radiochromic films. The dose conversion factor for converting a monitored charge into a delivered dose was determined analytically for the Advanced Markus® chamber and compared with experimentally determined values. It is anticipated that the method proposed in this study can be useful for monitoring sample doses in UHDR electron beam irradiation.

Microcrack monitoring and fracture evolution of polyolefin and steel fibre concrete beams using integrated acoustic emission and digital image correlation techniques

The use of polymer and steel fibres in plain concrete appears to be an excellent solution for limiting crack propagation and improving the post-ductility performance of concrete structures. Based on this premise, this study investigated the fracture evolution of polyolefin fibre-reinforced concrete (PFRC) and steel fibre-reinforced concrete (SFRC) specimens through the integrated application of two diagnostic techniques, acoustic emission (AE) and digital image correlation (DIC), under three-point bending tests. Based on the processing of AE signals, different AE statistical parameters such as the cumulative number of hits, amplitude distribution, and some representative analysis methods including the b-value method, Ib-value method, and AE intensity analysis methods were selected to analyse the early detection of cracking and post-cracking behaviour in PFRC vs SFRC specimens during mechanical degradation. Simultaneously, the DIC technique was used to validate the fracture evolution of the AE results. Furthermore, to verify the reliability of the AE and DIC results, the damage localisation and fracture evolution of the PFRC versus SFRC specimens were confirmed by integrating the AE fracture energies and DIC outcomes. The tests and analysed results showed that the addition of steel fibres to plain concrete significantly improved the ability to restrict crack propagation and provided higher post-cracking resistance compared to PFRC specimens owing to their stronger fibre–matrix bonding, effective fibre bridging, and crack-arresting mechanism. The present study indicates that the combined AE and DIC techniques are highly effective for the early detection of damage and ductility performance in fibre-reinforced concrete structures.

Hydrogenated amorphous silicon high flux x-ray detectors for synchrotron microbeam radiation therapy

Objective. Microbeam radiation therapy (MRT) is an alternative emerging radiotherapy treatment modality which has demonstrated effective radioresistant tumour control while sparing surrounding healthy tissue in preclinical trials. This apparent selectivity is achieved through MRT combining ultra-high dose rates with micron-scale spatial fractionation of the delivered x-ray treatment field. Quality assurance dosimetry for MRT must therefore overcome a significant challenge, as detectors require both a high dynamic range and a high spatial resolution to perform accurately. Approach. In this work, a series of radiation hard a-Si:H diodes, with different thicknesses and carrier selective contact configurations, have been characterised for x-ray dosimetry and real-time beam monitoring applications in extremely high flux beamlines utilised for MRT at the Australian Synchrotron. Results. These devices displayed superior radiation hardness under constant high dose-rate irradiations on the order of 6000 Gy s−1, with a variation in response of 10% over a delivered dose range of approximately 600 kGy. Dose linearity of each detector to x-rays with a peak energy of 117 keV is reported, with sensitivities ranging from (2.74 ± 0.02) nC/Gy to (4.96 ± 0.02) nC/Gy. For detectors with 0.8 μm thick active a-Si:H layer, their operation in an edge-on orientation allows for the reconstruction of micron-size beam profiles (microbeams). The microbeams, with a nominal full-width-half-max of 50 μm and a peak-to-peak separation of 400 μm, were reconstructed with extreme accuracy. The full-width-half-max was observed as 55 ± 1 μm. Evaluation of the peak-to-valley dose ratio and dose-rate dependence of the devices, as well as an x-ray induced charge (XBIC) map of a single pixel is also reported. Significance. These devices based on novel a-Si:H technology possess a unique combination of accurate dosimetric performance and radiation resistance, making them an ideal candidate for x-ray dosimetry in high dose-rate environments such as FLASH and MRT.