Blue Spots Research Articles

Infall Motions in the Hot Core Associated with the Hypercompact H ii Region G345.0061+01.794 B

We report high angular resolution observations, made with the Atacama Large Millimeter Array in band 6, of high excitation molecular lines of CH3CN and SO2 and of the H29α radio recombination line toward the G345.0061+01.794 B HC H ii region in order to investigate the physical and kinematical characteristics of its surroundings. Emission was detected in all observed components of the J = 14 →13 rotational ladder of CH3CN and in the 304,26–303,27, and 324,28–323,29 lines of SO2. The peak of the velocity-integrated molecular emission is located ∼0.″4 northwest of the peak of the continuum emission. The first-order moment images and channel maps show a velocity gradient of 1.1 km s−1 arcsec−1 across the source and a distinctive spot of blueshifted emission toward the peak of the zero-order moment. The rotational temperature is found to decrease from 252±24 K at the peak position to 166±16 K at its edge, indicating that our molecular observations are probing a hot molecular core that is internally excited. The emission in the H29α line arises from a region of 0.″65 in size, where its peak coincides with that of the dust continuum. We model the kinematical characteristics of the “central blue spot” feature as due to infalling motions, suggesting a central mass of 172.8±8.8 M ⊙. Our observations indicate that this HC H ii region is surrounded by a compact structure of hot molecular gas, which is rotating and infalling toward a central mass, that is most likely confining the ionized region. The observed scenario is reminiscent of a “butterfly pattern” with an approximately edge-on torus and ionized gas roughly parallel to its rotation axis.

Advancements in Laser Therapies for Dermal Hyperpigmentation in Skin of Color: A Comprehensive Literature Review and Experience of Sequential Laser Treatments in a Cohort of 122 Indian Patients.

The heightened awareness of ethnic dermatology aligns with the growing prevalence of skin of color communities globally, where hyperpigmentation disorders pose a common dermatological challenge. Effectively addressing dermal pigmentation is challenging due to its resistance to conventional therapies and its association with impaired quality of life. This underscores the need for effective treatments and a thorough grasp of laser advancements. A relevant literature search spanning the last 7 years across the PubMed database reveals core studies, challenges, and the evolution of laser technologies tailored for various forms of congenital and acquired dermal hyperpigmentation in skin of color. This comprehensive review explores the mechanisms, applications, and recommendations for pigmentary laser technologies, highlighting the key role of Q-switched lasers in their established millisecond/ nanosecond forms and emerging picosecond lasers, fractional non-ablative and ablative lasers, Intense Pulsed Light, etc. The summary of evidence includes studies on dermal melanocytosis (nevus of Ota and Hori's nevus), tattoos, acquired dermal macular hyperpigmentation, etc., and also entities with mixed epidermal-dermal components, such as melasma and post-inflammatory hyperpigmentation. The review offers valuable insights for clinicians to make informed decisions based on diagnosis, skin type, and the latest technologies to optimize results and minimize complications, especially in darker Fitzpatrick skin types. In their five-year study with 122 Indian patients, the authors applied specific laser combinations for diverse dermal melanoses, including tattoos, dermal/mixed melasma, acquired dermal macular hyperpigmentation, and dermal nevi. Substantial pigmentation reduction, subjectively assessed by both physicians and patients, was observed across all groups. A one-way ANOVA indicated a significant difference in mean improvement scores across various pigmentary conditions (F = 3.39, p = 0.02), with melasma patients exhibiting a significantly higher improvement score than tattoos (p = 0.03). The results affirmed the safety and efficacy of sequential laser therapy for dermal pigmentation in skin of color, advocating for flexibility in approach while maintaining the rationale behind the laser sequences. Despite advancements, challenges persist, and gaps in the current literature are identified. In conclusion, this summary highlights the ongoing pursuit of optimal protocols in dermatological laser treatments for dermal melanoses, offering valuable insights for future research and clinical practice.

Contributions of Jupiter's Deep‐Reaching Surface Winds to Magnetic Field Structure and Secular Variation

AbstractNASA's Juno mission delivered gravity data of exceptional quality. They indicate that the zonal winds, which rule the dynamics of Jupiter's cloud deck, must slow down significantly beyond a depth of about 3,000 km. Since the underlying inversion is highly non‐unique additional constraints on the flow properties at depth are required. These could potentially be provided by the magnetic field and its Secular Variation (SV) over time. However, the role of these zonal winds in Jupiter's magnetic field dynamics is little understood. Here we use numerical simulations to explore the impact of the zonal winds on the dynamo field produced at depth. We find that the main effect is an attenuation of the non‐axisymmetric field, which can be quantified by a modified magnetic Reynolds number Rm that combines flow amplitude and electrical conductivity profile. Values below Rm = 3 are required to retain a pronounced non‐axisymmetric feature like the Great Blue Spot (GBS), which seems characteristic for Jupiter's magnetic field. This allows for winds reaching as deep as 3,400 km. A SV pattern similar to the observation can only be found in some of our models. Its amplitude reflects the degree of cancellation between advection and diffusion rather than the zonal wind velocity at any depth. It is therefore not straightforward to make inferences on the deep structure of cloud‐level winds based on Jupiter's SV.

Acquired dermal melanocytosis on the nasal mucosa treated with Q-switch Nd:YAG laser: a case report

Acquired dermal melanocytosis on the nasal mucosa treated with Q-switch Nd:YAG laser: a case report

High-temperature thermal disturbance elimination method based on multi-channel extraction and correction.

Digital image correlation (DIC) technology has been widely used in high-temperature measurement fields. However, due to the complexity of high-temperature environments, there are many interference factors that limit the development of high-temperature DIC technology, among which thermal disturbance is one of the most significant factors that severely affects the measurement accuracy of high-temperature DIC. In this paper, a multi-channel separation technique combined with a low-cost laser speckle device is proposed to eliminate thermal disturbance errors in high-temperature DIC measurements. First, a blue laser speckle generation system is independently designed to produce the most suitable speckle particles, and the best laser speckle is determined and projected onto the blue background white spot pattern. Then a green LED illuminates the sample to provide illumination for the sample's own grayscale characteristics. A color camera collects photos, and the obtained images are processed with channel separation to extract and calculate the displacement of different channels. Finally, the displacement fields of the green and blue channels are subtracted to separate the thermal disturbance error and correct the measurement values. In this paper, a laser speckle projection system is first assembled, followed by a comprehensive evaluation of the projected speckle and, finally, a DIC experimental system is constructed for verification experiments at both room temperature and high temperature, and the corrected values are compared with the true values. The results show that the corrected values are highly consistent with the true values, which verifies the reliability of the proposed method.

GM1 and GM2-Gangliosidosis: Clinical Features, Neuroimaging Findings and Electroencephalography.

Gangliosidosis is one of the hereditary metabolic diseases caused by the accumulation of Gangliosid in the central nervous system, leading to severe and progressive neurological deficits. Regarding phenotype, GM1 and GM2-Gangliosidosis are divided into Infantile, Juvenile, and Adult. In this study, thirty-seven patients with GM1 and GM2-Gangliosidosis were referred to the neurology department of Mofid Children's Hospital in Tehran, Iran, whose disease was confirmed from September 2019 to December 2021. This study assessed age, sex, and developmental status before the onset of the disease, clinical manifestations, brain imaging, and electroencephalography. 97.20% of patients were the result of family marriage. Approximately 80% of juvenile patients were developmentally normal before the onset of the disease. Developmental delay was more common among infantile GM1-Gangliosidosis than infantile GM2-Gangliosidosis, but in total, more than 50% of GM1&GM2-Gangliosidosis patients had reached their developmental milestone before the onset of the disease. With the onset of disease symptoms, 100% of patients regressed in terms of movement, 97.20% of them mentally, and 75% of them had seizures during the disease. The most common clinical findings were cherry-red spot, Mongolian spot, macrocephaly, organomegaly, hyperacusis, and scoliosis. The most common brain imaging findings included bilateral thalamus involvement, brain atrophy, PVL, and delayed myelination. The most common finding in electroencephalography was background low voltage with abnormal sharp waves. This study concluded that most of the patients are the result of family marriage, and most of the juvenile patients are developmentally normal before the onset of the disease. In addition, more than 50% of infantile patients reach their developmental milestones before the onset of the disease. The most common clinical findings of these patients are seizures, cherry-red spot, macrocephaly, hyperacusis, Mongolian spot, and bilateral involvement of the thalamus.

Morphology and Phylogenetic Position of the Sargassum Nudibranch Scyllaea fulva Quoy & Gaimard, 1824 (Nudibranchia: Scyllaeidae): First Record in Hong Kong.

Scyllaeidae is a small group of nudibranchs comprising three genera (Scyllaea, Notobryon, and Crosslandia) with striking morphological similarities, making their identification challenging based on external features alone. Previous studies have highlighted the significance of central radular teeth in distinguishing Notobryon from Scyllaea and Crosslandia. The genus Scyllaea, commonly known as the sargassum nudibranch, currently consists of only two valid species, Scyllaea pelagica and Scyllaea fulva. These species inhabit seaweed Sargassum spp., feeding on hydroids. During a biodiversity survey conducted in April 2023, seven sargassum nudibranch individuals were collected from the seaweed Sargassum spp. at a depth of 2 meters in Tai She Wan through SCUBA diving. Initially, the specimens were misidentified based on their resemblance to Notobryon wardi and previous local records. However, thorough morphological and molecular examinations confirmed them to be Scyllaea fulva, representing the first record of this species in Hong Kong. Notably, our specimens lacked the blue spots observed in specimens from Thailand and the West Pacific Ocean, as reported in previous studies. Internally, a pineapple-like structure formed a honeycomb pattern on the surface of the masticatory edge of the jaw flap, with the presence of central radular teeth. A Maximum Likelihood tree analysis revealed Crosslandia to be the sister group of Scyllaea. Comparative analysis of intra-specific distances between individuals from the Philippines, French Polynesia, and Hong Kong indicated a close relationship between the Hong Kong specimens and those from the Philippines. Furthermore, we provide a detailed description of the external and internal morphology of Scyllaea fulva in this paper, integrating valuable morphological information for future species identification purposes.

Impact of optical brightening agents on alkali‐based inks in packaging: A comparative study on color accuracy

AbstractAccurately assessing the color quality of printed products becomes intricate when optical brightening agents (OBAs) are introduced in papers, as diverse interactions occur among different ink pigments and papers containing OBAs due to variations in ink formulation chemistries. Specifically, alkali‐based pigments, commonly used as spot colors, are carefully formulated to ensure consistency across production batches. The presence of OBAs, which absorb ultraviolet light and emit it in the visible spectrum, significantly affects color perception and accuracy on paper when interacting with these inks. This research marks an initial investigation into how OBAs in paper influence the color accuracy of five distinct alkali‐based spot color paste inks using a Little Joe ink proofer. The research examines the physical, optical, and colorimetric characteristics of two paper samples‐one with OBA and one without‐ and analyzes the colorimetric changes occurring during the ink drying process. The results indicate that reflex blue, purple, and violet spot colors achieved acceptable delta E (ΔE00) value of below 3 on non‐OBA paper, with rubine red being on the borderline at 3.1 after 48 h. In contrast, purple, rhodamine red and violet achieved acceptable ΔE00 below 3 on high OBA paper. The distinct behavior exhibited by certain inks led to the conclusion that achieving a consistent proofing procedure across diverse alkali‐based ink formulations is impractical.

Photochemical Screening and Antifungal Activity of Faidherbia albida Roots

Photochemical Screening and Antifungal Activity of Faidherbia albida Roots

Comprehensive anti-corrosion study of electrodeposited graphene oxide-alumina composite with nickel matrix in NaCl solution

In this work, a matrix of nickel composite coating is embedded with graphene oxide and alumina. This work developed a matrix of nickel composite coating embedded with graphene oxide and alumina (GO-Al2O3) at various concentrations using an electrodeposition process. Fourier transforms infrared spectroscopy (FTIR) and Energy-dispersive X-ray spectroscopy (EDAX) confirmed further incorporation of GO and GO-Al2O3 within nickel coating. The calculated crystal size of the nickel coating was 19.46 nm; however, it reduced to 11.58 nm in the Ni-GO-Al2O3 (1.5 g/L) coating. The surface morphology of Ni-GO-Al2O3 coating using Field emission Scanning electron microscopy (FE-SEM) showed fine grain size; however, nickel had cubic-shaped crystals and was significantly larger. Contact angle measurements reveal the hydrophobic characteristic of the Ni-GO-Al2O3 coating, which was 110.8° compared to nickel (71.4°). Tafel and electrochemical impedance showed maximum polarization resistance for Ni-GO-Al2O3 (1.5 g/L) coating. The developed Ni-GO-Al2O3 coating was put through short, long-term immersion tests and showed less weight loss than Ni and Ni-GO coating. pH change was the least for Ni-GO-Al2O3 coating due to its compact shape, which prevented the transport of corrosion-causing ions to the metal and consequently reduced metal oxidation. Ni-GO-Al2O3 coating shows the least blue spot, indicating negligible rupture after immersion. Atomic force microscopy study revealed that Ni-GO-Al2O3 has a smoother surface, which did not significantly change even after immersion. Nickel coating showed cracks, producing high corrosion products and more pits, showing its inability for long-term inhibition; however, Ni-GO-Al2O3 coating with the least cracks and pits showed negligible corrosion products on its surface even after one month of exposure. Fe and O are higher in Ni and Ni-GO after immersion and least in Ni-GO-Al2O3, making it more protective. Compared to pure Ni coatings, the composite coating electrode containing 1.5 g/L of GO-Al2O3 had the best corrosion resistance due to the abovementioned characteristics.

What is dermal melanocytosis?

Dermal melanocytosis is a common type of birthmark. These birthmarks used to be called “Mongolian spots”. They appear as a flat, blue‐to‐gray patch.Dermal melanocytosis birthmarks are often on the back or buttocks. They can also be seen on other parts of the body. These spots are usually present at birth. They tend to fade over the first few years of life.

GNAQ/GNA11 Mosaicism Is Associated with Abnormal Serum Calcium Indices and Microvascular Neurocalcification

Mosaic mutations in genes GNAQ or GNA11 lead to a spectrum of diseases including Sturge-Weber syndrome and phakomatosis pigmentovascularis with dermal melanocytosis. The pathognomonic finding of localized "tramlining" on plain skull radiography, representing medium-sized neurovascular calcification and associated with postnatal neurological deterioration, led us to study calcium metabolism in a cohort of 42 children. In this study, we find that 74% of patients had at least one abnormal measurement of calcium metabolism, the commonest being moderately low serum ionized calcium (41%) or high parathyroid hormone (17%). Lower levels of ionized calcium even within the normal range were significantly associated with seizures, and with specific antiepileptics despite normal vitamin D levels. Successive measurements documented substantial intrapersonal fluctuation in indices over time, and DEXA scans were normal in patients with hypocalcemia. Neurohistology from epilepsy surgery in five patients revealed not only intravascular, but perivascular and intraparenchymal mineral deposition and intraparenchymal microvascular disease in addition to previously reported findings. Neuroradiology review clearly demonstrated progressive calcium deposition in individuals over time. These findings and those of the adjoining paper suggest that calcium deposition in the brain of patients with GNAQ/GNA11 mosaicism may not be a nonspecific sign of damage as was previously thought, but may instead reflect the central postnatal pathological process in this disease spectrum.

High-fluence 1064nm Q-switched Nd:YAG laser treatment for ectopic Mongolian spot

Q-switched neodymium-yttrium aluminum-garnet (Q-switched Nd:YAG) laser has been reported as an effective treatment for nevus of Ota and acquired bilateral nevus of Ota-like macules (ABNOM). Data on ectopic Mongolian spots have rarely been reported.The present study was performed to investigate the treatment efficacy of a high-fluence 1064 nm Q-switched Nd:YAG laser without tissue whitening in ectopic Mongolian spots.We included 61 patients with ectopic Mongolian spots, and 70 lesions were examined. Thirty-three lesions were treated with a high-fluence 1064 nm Q-switched Nd:YAG laser, and 38 lesions were observed without treatment. The results were assessed using a 5-quantile grading scale and melanin index using a Mexameter®.Mean follow-up duration was 14.1 ± 6.8 months for the treatment group and 17.8 ± 10.0 months for the observation group. Mean 5-quintile grading scale at final follow-up was statistically different (p < 0.001) between the two groups (treatment: 2.85 ± 1.00, observation: 0.49 ± 0.73). There was a significant difference (p < 0.001) in the Δ melanin index (initial melanin index – final melanin index) between the observation (7.1 ± 62.7) and treatment (156.7 ± 78.4) groups.High-fluence Q-switched Nd:YAG laser without tissue whitening showed good results and was well-tolerated in treating ectopic Mongolian spots.

First report of leaf spot disease caused by Alternaria tenuissima on Lonicera caerulea L. in Heilongjiang Province, China.

Blue honeysuckle (Lonicera caerulea L.) is a perennial plant of the Caprifoliaceae family and Lonicera genus, the largest genus in the plant kingdom. Between September 2021 and September 2022, a leaf spot disease was observed on ~20% of blue honeysuckles of the 'Lanjingling' cultivar grown in a 3.33 ha field at the Xiangyang base (126.96°E, 45.77°N) of the Northeast Agricultural University, Harbin (Heilongjiang Province, China). Leaf spots first presented black mildew centers, gradually covering large areas of the leaf until it eventually fell off. Small 3-4 mm segments of infected tissue from 50 randomly selected leaves were surface sterilized with 75% ethanol and 5% sodium hypochlorite, rinsed in sterile distilled water, and transferred to 9 cm Petri dishes containing potato dextrose agar (PDA) after drying. Finally, two isolated pathogens were obtained through single spore culture on PDA; they appeared as gray-black colonies and were named LD-12 and LD-121. The observed LD-12 and LD-121 conidia displayed a morphology consistent with Alternaria spp. They were obpyriform and dark brown, with 0-6 transverse and 0-3 longitudinal septa, measuring 6.00-17.70 μm × 9.30-42.30 μm and 5.70-20.70 μm × 8.40-47.70 μm for LD-12 and LD-121, respectively (n = 50). Genomic DNA was extracted from the two isolates for molecular verification, and PCR amplification was performed with ITS1/ITS4 (White et al. 1990), GPD1/GPD2 (Woudenberg et al. 2015), EFl-728F/EF1-986R (Carbone and Kohn 1999), RPB2-5F2/RPB2-7CR (Liu et al. 1999), and Alt-for/Alt-rev (Hong et al. 2005) primers. Sequences of LD-12 ITS (OQ607743), GPD (OQ623200), TEF (OQ623201), RPB2 (OQ658509), and ALT (OQ623199) revealed 99-100% of identity with Alternaria tenuissima sequences (KC584567, MK451973, LT707524, MK391051, and ON357632). Sequences of LD-121 ITS (OQ629881), GPD (OQ850078), TEF (OQ850075), RPB2 (OQ850076), and ALT (OQ850077) revealed 99-100% identity with A. alternata sequences (MN826219, ON055384, KY094927, MK637444, and OM849255). Nine two-year-old healthy plants from the 'Lanjingling' cultivar were selected for a pathogenicity test. Three plants were inoculated with either the LD-12 or LD-121 conidial suspension (1 × 106 spores/ml) or with clean water as an experimental control condition (Mirzwa-Mróz et al., 2018; Liu et al., 2021). All plants were cultured in a greenhouse at 28℃ under a 12-h light/dark cycle, and each experiment was performed three times. Typical leaf spot symptoms were observed on inoculated leaves after 10 d. The same pathogens reisolated from infected leaves displayed the same morphological and molecular traits. They were again identified as A. tenuissima and A. alternata, confirming Koch's postulate. A. tenuissima and A. alternata were previously reported on Orychophragmus violaceus (Liu et al., 2021) and L. caerulea (Yan et al., 2022) in China. This study is the first report of a blue honeysuckle leaf spot caused by A. tenuissima in China. In the future, effective biological and chemical control should be used to prevent blue honeysuckle leaf spots in China.

Extensive Telangiectasias and Mongolian Spots

Extensive Telangiectasias and Mongolian Spots

Linear shrinkage and the methylene blue spot test in the analysis of plasticity of granulometrically stabilized laterites

Linear shrinkage and the methylene blue spot test in the analysis of plasticity of granulometrically stabilized laterites

A New Species of the Genus &lt;i&gt;Darevskia&lt;/i&gt; Arribas, 1999 from South Ossetia (Reptilia: Sauria: Lacertidae)

A new species of rock lizards of the genus Darevskia Arribas, 1999 — Darevskia arribasi sp. nov. is described from vicinity of Ertso Lake in South Ossetia. In comparison of Darevskia arribasi sp. nov. with other species of the «saxicola-brauneri» complex [D. lindholmi (Szczerbak, 1962), D. saxicola (Eversmann, 1834), D. brauneri (Mehely, 1909) (including D. b. brauneri, D. b. myusserica Doronin, 2011, D. b. darevskyi (Szczerbak, 1962), and D. szczerbaki (Lukina, 1963)], the new species is characterized by the smallest body size among all representatives of this complex L♂♂ — 55 – 62 mm; ♀♀ — 58 – 63 mm. The number of scales around the middle of the body (Sq.) in D. arribasi sp. nov. (52 – 58, more often 54 – 56) also significantly less than for D. saxicola sensu lato in generally. Along the throat from ear to ear fold there are 36 – 42 scales, less than in D. saxicola sensu lato. Two large preanal shields present in front of the anal shield in half of the individuals examined; in a quarter of individuals on both sides of the small central preanal there are by one enlarged lateral preanal shield, in another quarter all preanal shields are of the same size. Central temporal (Massetericum) always developed; always six pair of mandibulars, three in contact; collar straight, extremely rarely slightly serrated; ribs on the caudal scales are expressed to some extent; rostral usually separated from frontonasal by nasal shields. The coloration of adult males is olive-lettuce, or olive-brown from above; adult females are grey-brown; juvenile coloration coffee-brown with the blue and black spots on the edge of the outer ventral shields at the middle of trunk. Taxonomical status of new species is well supported with result of analysis of the mitochondrial cytochrome b data.

Mongolian spots in a sick patient-A diagnosis of infantile GM1 gangliosidosis.

Mongolian spots in a sick patient-A diagnosis of infantile GM1 gangliosidosis.

First report of Didymella glomerata causing leaf spot on Lonicera caerulea L. in Heilongjiang province, China.

China has the largest blue honeysuckle (Lonicera caerulea L.) cultivation area globally. In June 2022, leaf spots were observed on approximately 10% of blue honeysuckle (cv. 'Lanjingling') leaves in a 0.03-ha field in Harbin (127.66°E, 45.61°N), Heilongjiang Province, China. The leaves of the affected plants displayed chlorotic to tan dieback with a darker brown margin along the leaftip and leave margins. Cross-sectional segments of approximately 3 mm were cut from 50 typical infected plant leaves. Their surfaces were sterilized with 75% ethanol for 30 s followed by 3 min in 5% sodium hypochlorite (NaOCl), rinsed three times with sterile water, and transferred to 9-cm Petri dishes containing 15 ml of sterile PDA growth medium. Five purified cultures with similar culture characteristics were finally obtained and their colonies were dark brown on the PDA plates. The pycnidia were subglobular and deep black and measured avg. 215.48 (135.30-331.20) μm × avg. 170.28 (99.90-282.90) μm (n = 50) (Chen et al., 2015; Huang et al., 2018). Conidia were single-celled, hyaline, and ellipsoidal and measured avg. 6.22 (5.40-7.20) µm × avg. 3.42 (2.70-3.90) µm (n = 50). For molecular verification, genomic DNA was extracted from a representative isolate, LD-75. The internal transcribed spacer region (ITS), the second-largest subunit of RNA polymerase II (rpb2), the partial 28S large subunit rDNA (LSU), beta-tubulin (TUB), and actin (ACT) genes were amplified with the primers ITS1/ITS4, RPB2f/RPB2r, LROR/LR7, TUB2Fd/TUB4Rd, and ACT512f/ACT783R, respectively (White et al. 1990; Carbone and Kohn, 1999; Staats et al., 2005; de Gruyter et al., 2009; Chen et al., 2015). BLAST results indicated that the genes of LD-75 (GenBank OP218870, OP264863, OQ561448, OQ597233, and OQ597232) shared 99%-100% identity with those of Didymella glomerata (OK485138, GU371781, EU754185, MZ073910, and MW963190, respectively). Therefore, based on morphological characteristics and molecular phylogeny, LD-75 was identified as D. glomerata. Six two-year-old healthy plants from the 'Lanjingling' cultivar were selected for a pathogenicity test. The leaves were surface disinfested with 75% ethanol and then wiped with sterilized water three times. All plants were cultured in a greenhouse at 28℃ under a 12-h light/dark cycle. Whole plants sprayed with conidial suspension of isolate LD-75 (106 spores/mL) (n = 3) displayed leaf spot symptoms after 14 d, while no symptoms were detected on whole plants sprayed with sterile water (n = 3). The same isolate, reisolated from infected leaves and with the same morphological and molecular traits, was also identified as D. glomerata, confirming Koch's postulate. The fungus was previously reported in Cornus officinalis in Nanyang City, China (Huang et al., 2018). To our knowledge, this is the first report of blue honeysuckle leaf spot caused by D. glomerata in China. Reducing blue honeysuckle production losses caused by leaf spots is crucial for growers, and we hope that researchers will develop efficient control strategies for managing this emerging plant disease.

Extensive mongoloid spots in mucopolysaccharidosis Type I Hurler syndrome

Lysosomal storage diseases are inherited metabolic disorders that are caused by enzyme deficiencies within the lysosomes. The most common lysosomal storage disorder associated with Mongolian spots (MSs) is GM1 gangliosidosis Type-1. We are reporting a case of Hurler disease with extensive MS. A 9-month-old girl, born to a consanguineously married couple, presented with a developmental delay with uneventful birth history. The presence of multiple mongoloid spots over the lumbosacral region and lateral abdominal wall was noticed since birth. Examination showed coarse facies with a depressed nasal bridge and a low-set ear. Multiple mongoloid macules were noted in the lumbosacral region. Serum enzyme assay level had decreased activity of alpha-L-iduronidase (IDUA). Exome sequencing revealed a homozygous mutation in exon 8 of the IDUA gene. Extensive MS can be seen in mucopolysaccharidosis (MPS) Type 1 in addition to commonly described GM1 gangliosidosis. The early diagnosis helps to start enzyme replacement therapy in MPS Type I, compared to currently no specific treatment available for GM1 gangliosidosis.