MON Group Research Articles

옻나무 급여기간이 한우육의 냉장저장 중 품질특성에 미치는 영향

This study was carried out to investigate the effect of feeding periods of dietary Rhus verniciflua Stokes (RVS) on the quality characteristics of Hanwoo beef during refrigerated storage. Hanwoo steers were fed a 4% RVS-contained diet for 0 (control), 3, 4, 5, or 6 mon prior to slaughter (28 mon of age). The M. semitendino년 from carcasses were stored at for 7 d. The crude fat content was lower in the 4 and 5 mon groups than in the other groups (p

Elevated adipogenesis of marrow mesenchymal stem cells during early steroid-associated osteonecrosis development

BackgroundIncreased bone marrow lipid deposition in steroid-associated osteonecrosis (ON) implies that abnormalities in fat metabolism play an important role in ON development. The increase in lipid deposition might be explained by elevated adipogenesis of marrow mesenchymal stem cells (MSCs). However, it remains unclear whether there is a close association between elevated adipogenesis and steroid-associated ON development.ObjectiveThe present study was designed to test the hypothesis that there might be a close association between elevated adipogenesis and steroid-associated ON development.MethodsON rabbit model was induced based on our established protocol. Dynamic-MRI was employed for local intra-osseous perfusion evaluation in bilateral femora. Two weeks after induction, bone marrow was harvested for evaluating the ability of adipogenic differentiation of marrow MSCs at both cellular and mRNA level involving adipogenesis-related gene peroxisome proliferator-activated receptor gamma2 (PPARγ2). The bilateral femora were dissected for examining marrow lipid deposition by quantifying fat cell number, fat cell size, lipid deposition area and ON lesions. For investigating association among adipogenesis, lipid deposition and perfusion function with regard to ON occurrence, the rabbits were divided into ON+ (with at least one ON lesion) group and ON- (without ON lesion) group. For investigating association among adipogenesis, lipid deposition and perfusion function with regard to ON extension, the ON+ rabbits were further divided into sub-single-lesion group (SON group: with one ON lesion) and sub-multiple-lesion group (MON group: with more than one ON lesion).ResultsLocal intra-osseous perfusion index was found lower in either ON+ or MON group when compared to either ON- or SON group, whereas the marrow fat cells number and area were much larger in either ON+ or MON group as compared with ON- and SON group. The adipogenic differentiation ability of MSCs and PPARγ2 expression in either ON+ or MON group were elevated significantly as compared with either ON- or SON group.ConclusionThese findings support our hypothesis that there is a close association between elevated adipogenesis and steroid-associated osteonecrosis development.

Cost of asthma rescue and anti-allergy medications among asthmatic children with prior anti-allergy prescriptions initiating asthma controller therapy

Rationale Evaluate the effect of asthma-controller initiation (montelukast [MON] vs. inhaled corticosteroids [ICS]) on asthma-rescue and anti-allergy medication costs among children with asthma and allergic rhinitis [AR]. Methods A 24-month retrospective, pre-post cohort study using large pharmacy claims database included children (<16 years) with ≥2 consecutive asthma-controller prescriptions (2/1/99-1/31/00) and ≥1 anti-allergy prescription (within 3 months prior to initial controller prescription). Children on ICS and MON were matched 1:1 on age, days of prior AR therapy supply, duration of controller therapy and propensity score. Pre-post differences in mean per-member-per-month costs of rescue/acute medications [RAM] (short-acting beta agonist [SBA], antibiotics, oral corticosteroids [OCS]), prescription anti-allergy medications [AAM] (antihistamines, nasal steroids), and other respiratory medications [ORM] (xanthines, mast cell stabilizers, other anti-leukotrienes) were calculated. Results 1,236 of the 4,005 children were matched into ICS and MON groups (n=618 each). MON patients had a smaller cost increase overall compared to ICS group (combined cost for RAM, AAM and ORM: $5.55 vs $12.08, p=0.0003). Cost increase for RAM ($0.94 vs $3.82, p=0.0026) was significantly lower in MON group, driven by smaller increases in costs for SBA ($1.79 vs $3.34, p=0.008). Antibiotics (−$0.65 vs $0.51, p=0.1) and OCS (−0.20 vs −0.04, p=0.1) costs decreased in MON group. Cost increase for AAM ($5.29 vs $10.06, p<0.0001) was also significantly lower in MON group with both antihistamines ($4.44 vs 7.43, p=0.0037) and nasal steroids ($0.85 vs $2.63, p<0.0001) contributing. Mean cost of ORM decreased in both groups. Conclusions Among asthmatic children with AR, initiating MON resulted in lower costs of asthma-rescue and anti-allergy medications compared with initiating ICS.

Materials on the Ethnography of the Mountain Peoples of Nge-An Province (Democratic Republic of Vietnam)

In the west of Nge-An Province, in the mountains along the river Ka and its tributary, the Nam Mo, dwell people of various racial strains and ethnographic groups, closely related in language and culture to the peoples of Laos and North Vietnam. On the map, "Peoples of Indo-China," drafted in 1958, this area is depicted as ethnically quite homogeneous. Only Thai peoples were noted, with the exception of a small enclave of mountain Mons to the north of Myong Sen. In addition, the Mon group of Thai Pongs was incorrectly classed among the mountain Thais. Field studies in 1962 showed that 13 peoples totalling 20,000 persons live in Ki-shon County, Nge-An Province. The most numerous among them are the Meo (over 8,000 persons); the following Thai ethnographic groups: Hang Tong (5,000), Thai Myoi, Man Thanh, Lao; and the mountain Mons: Thai Hai, Thai Hat, and Thai Pong.