A numerical simulation of an unsteady gas flow containing inert solid particles in a shock tube is carried out using the interpenetrating continuum model. The gas and dispersed phases are characterized by governing equations that express the concepts of mass, momentum, and energy conservation as well as an equation that shows the change of the volume fraction of the dispersed phase. Using a Godunov-type approach, the hyperbolic governing equations are solved numerically with an increased order of accuracy. The working section of the shock tube containing air and solid particles of various sizes is considered. The shock wave structure is discussed and computational results provide the spatial and temporal dependencies of the particle concentration and other flow quantities. The numerical simulation results are compared with available experimental and computational data.