Alcohol Molecules Research Articles

Directing the Rate-Enhancement for Hydronium Ion Catalyzed Dehydration via Organization of Alkanols in Nanoscopic Confinements.

Alkanol dehydration rates catalyzed by hydronium ions are enhanced by the dimensions of steric confinements of zeolite pores as well as by intraporous intermolecular interactions with other alkanols. The higher rates with zeolite MFI having pores smaller than those of zeolite BEA for dehydration of secondary alkanols, 3‐heptanol and 2‐methyl‐3‐hexanol, is caused by the lower activation enthalpy in the tighter confinements of MFI that offsets a less positive activation entropy. The higher activity in BEA than in MFI for dehydration of a tertiary alkanol, 2‐methyl‐2‐hexanol, is primarily attributed to the reduction of the activation enthalpy by stabilizing intraporous interactions of the Cβ‐H transition state with surrounding alcohol molecules. Overall, we show that the positive impact of zeolite confinements results from the stabilization of transition state provided by the confinement and intermolecular interaction of alkanols with the transition state, which is impacted by both the size of confinements and the structure of alkanols in the E1 pathway of dehydration.

Directing the Rate‐Enhancement for Hydronium Ion Catalyzed Dehydration via Organization of Alkanols in Nanoscopic Confinements

AbstractAlkanol dehydration rates catalyzed by hydronium ions are enhanced by the dimensions of steric confinements of zeolite pores as well as by intraporous intermolecular interactions with other alkanols. The higher rates with zeolite MFI having pores smaller than those of zeolite BEA for dehydration of secondary alkanols, 3‐heptanol and 2‐methyl‐3‐hexanol, is caused by the lower activation enthalpy in the tighter confinements of MFI that offsets a less positive activation entropy. The higher activity in BEA than in MFI for dehydration of a tertiary alkanol, 2‐methyl‐2‐hexanol, is primarily attributed to the reduction of the activation enthalpy by stabilizing intraporous interactions of the Cβ‐H transition state with surrounding alcohol molecules. Overall, we show that the positive impact of zeolite confinements results from the stabilization of transition state provided by the confinement and intermolecular interaction of alkanols with the transition state, which is impacted by both the size of confinements and the structure of alkanols in the E1 pathway of dehydration.

Insight of organic molecule dissolution and diffusion in cross-linked polydimethylsiloxane using molecular simulation

Polymeric membranes have gained an immense importance for the pervaporation (PV) of biofuels. The PV performance is influenced by several complex elements and significant understanding is empirically fairly difficult. Furthermore, it is essential to specify membrane swelling in different solvents prior to the PV. A molecular dynamics simulation protocol was applied to examine the swelling of cross-linked PDMS membranes in 1-butanol, ethanol, acetone, and water, the dissolution of organic molecule in dilute aqueous solution in PDMS, the PV through these swollen membranes and dissolution rate of guest molecules in membranes. The agglomeration effects of water as well as organic molecules inside cross-linked PDMS membrane during sorption and diffusion processes were also investigated. The effects of predicted cross-linked PDMS on separation performance of membranes, interactions of the guest molecules on the swelling degree and diffusion coefficients follow the experimental trend. The predicted dissolution and diffusion, the diffusion selectivity and mean square displacement of different agglomerated forms of water and alcohol molecules through cross-linked membrane fairly matches the reported experimental results. Moreover, their reliability on the interaction between solvent and polymer, void size distribution and temperature were investigated. The micro level insights into the swelling of cross-linked polymer membranes, dissolution and diffusion of organic molecules and understanding of mass transfer were provided by simulation, which are valuable for making new membranes for high PV performance.

Langmuir Films of Perfluorinated Fatty Alcohols: Evidence of Spontaneous Formation of Solid Aggregates at Zero Surface Pressure and Very Low Surface Density.

In this work, Langmuir films of two highly fluorinated fatty alcohols, CF3(CF2)12CH2OH (F14OH) and CF3(CF2)16CH2OH (F18OH), were studied. Atomic Force Microscopy (AFM) images of the films transferred at zero surface pressure and low surface density onto the surface of silicon wafers by the Langmuir-Blodgett technique revealed, for the first time, the existence of solid-like domains with well-defined mostly hexagonal (starry) shapes in the case of F18OH, and with an entangled structure of threads in the case of F14OH. A (20:80) molar mixture of the two alcohols displayed a surprising combination of the two patterns: hexagonal domains surrounded by zigzagging threads, clearly demonstrating that the two alcohols segregate during the 2D crystallization process. Grazing Incidence X-ray Diffraction (GIXD) measurements confirmed that the molecules of both alcohols organize in 2D hexagonal lattices. Atomistic Molecular Dynamics (MD) simulations provide a visualization of the structure of the domains and allow a molecular-level interpretation of the experimental observations. The simulation results clearly showed that perfluorinated alcohols have an intrinsic tendency to aggregate, even at very low surface density. The formed domains are highly organized compared to those of hydrogenated alcohols with similar chain length. Very probably, this tendency is a consequence of the characteristic stiffness of the perfluorinated chains. The diffraction spectrum calculated from the simulation trajectories compares favorably with the experimental spectra, fully validating the simulations and the proposed interpretation. The present results highlight for the first time an inherent tendency of perfluorinated chains to aggregate, even at very low surface density, forming highly organized 2D structures. We believe these findings are important to fully understand related phenomena, such as the formation of hemi-micelles of semifluorinated alkanes at the surface of water and the 2D segregation in mixed Langmuir films of hydrogenated and fluorinated fatty acids.

Nanoporous Crystalline Composite Aerogels with Reduced Graphene Oxide.

High-porosity monolithic composite aerogels of syndiotactic polystyrene (sPS) and poly(2,6-dimethyl-1,4-phenylene oxide) (PPO) containing reduced graphene oxide (r-GO) were prepared and characterized. The composite aerogels obtained by supercritical carbon dioxide (scCO2) extraction of sPS/r-GO and PPO/r-GO gels were characterized by a fibrillar morphology, which ensured good handling properties. The polymer nanoporous crystalline phases obtained within the aerogels led to high surface areas with values up to 440 m2 g−1. The role of r-GO in aerogels was studied in terms of catalytic activity by exploring the oxidation capacity of composite PPO and sPS aerogels toward benzyl alcohol in diluted aqueous solutions. The results showed that, unlike sPS/r-GO aerogels, PPO/r-GO aerogels were capable of absorbing benzyl alcohol from the diluted solutions, and that oxidation of c.a. 50% of the sorbed benzyl alcohol molecules into benzoic acid occurred.

Catalytic transformations of (+)-aromadendrene: Functionalization and isomerization reactions in the presence of the heteropoly acid catalyst H3PW12O40

Transformations of the naturally occurring compound (+)-aromadendrene (1) were performed in the presence of the heteropoly acid catalyst H3PW12O40, a technologically efficient homogeneous catalyst, which, in principle, can be recovered from polar solutions by precipitation using a nonpolar solvent. In solutions of n-butanol and ethanol, there was the formation of (+)-ledene resulting from isomerization of the double bond in the carbon chain of the substrate and the ether produced by nucleophilic addition of the alcohol molecule to the exocyclic double bond of 1. In ethanol solution, in addition to formation of (+)-ledene and the ether product derived from ethanol, there was also the formation of a product formed by the addition of a water molecule to the (+)-aromadendrene double bond. The products, alone or mixed, presented pharmacological properties and have the potential for commercial application. The simple catalytic process developed in this work is a technologically attractive route, which employs a renewable substrate for the production of compounds with potential uses in the fine chemical industry.

Water/Alcohol Mixture Adsorption in Hydrophobic Materials: Enhanced Water Ingress Caused by Hydrogen Bonding.

Microporous crystalline porous materials such as zeolites, metal–organic frameworks, and zeolitic imidazolate frameworks (ZIFs) have potential use for separating water/alcohol mixtures in fixed bed adsorbers and membrane permeation devices. For recovery of alcohols present in dilute aqueous solutions, the adsorbent materials need to be hydrophobic in order to prevent the ingress of water. The primary objective of this article is to investigate the accuracy of ideal adsorbed solution theory (IAST) for prediction of water/alcohol mixture adsorption in hydrophobic adsorbents. For this purpose, configurational bias Monte Carlo (CBMC) simulations are used to determine the component loadings for adsorption equilibrium of water/methanol and water/ethanol mixtures in all-silica zeolites (CHA, DDR, and FAU) and ZIF-8. Due to the occurrence of strong hydrogen bonding between water and alcohol molecules and attendant clustering, IAST fails to provide quantitative estimates of the component loadings and the adsorption selectivity. For a range of operating conditions, the water loading in the adsorbed phase may exceed that of pure water by one to two orders of magnitude. Furthermore, the occurrence of water–alcohol clusters moderates size entropy effects that prevail under pore saturation conditions. For quantitative modeling of the CBMC, simulated data requires the application of real adsorbed solution theory by incorporation of activity coefficients, suitably parameterized by the Margules model for the excess Gibbs free energy of adsorption.

Simple preparation of nitrogen-doped TiO2 and its performance in selective oxidation of benzyl alcohol and benzylamine under visible light

N-doped TiO2, denoted as T_400, was prepared simply by the facile thermal hydrolysis of TiOSO4 using NH4OH as both a precipitating agent and a nitrogen source. Compared to TiO2 without nitrogen doping, T_400 provides superior photocatalytic activity toward the selective oxidation of benzyl alcohol and benzylamine under visible light irradiation, with > 85 % conversion and > 95 % selectivity to benzaldehyde and N-benzylidenebenzylamine products, respectively. The increased photoactivity of T_400 is ascribed to enhanced visible-light absorption and efficient photogenerated charge transfer and separation as supported by UV–vis DRS, photoelectrochemical and VB-XPS results. The catalyst can tolerate the presence of substituent groups in benzyl alcohol and benzelamine molecules as > 80 % conversion and > 95 % selectivity are still achieved, which expands the scope of substrates and catalyst utilization. Band energy level of N-doped TiO2 compared to that of undoped TiO2 is determined using Mott-Schottky and UV–vis DRS measurements. Possible mechanisms for the formation of benzaldehyde and N-benzylidenebenzylamine over N-doped TiO2 are proposed. This work presents a simple synthesis of N-doped TiO2, using a low-cost and easily handled inorganic titanium salt instead of air/moisture-sensitive alkoxide precursors and reveals its potential application toward photocatalytic synthesis of organic fine chemicals under visible light.

Molecular dynamics simulations of aqueous solutions of short chain alcohols. Excess properties and the temperature of maximum density

The excess enthalpy hE and excess volume vE of the binary systems {methanol, ethanol, 1-propanol, 2-propanol, and tert-butanol + water} over the whole composition range at 298.15 K and the temperature of maximum density, TMD, in the alcohol diluted region were studied by MD simulations at atmospheric pressure. Our model systems were defined using the flexible version of the TIP4P/2005 model of water, the OPLS-AA for alcohols, and the geometric combining rule for all the Lennard-Jones cross interactions, with the exception of those between oxygen sites of water and alcohol molecules. These latter values were fitted to reproduce the experimental excess properties of the mixtures. This new parameterization allows for an appropriate description of the excess thermodynamics of these short-chain alcohol/water systems over the whole composition range. The changes in the temperature of maximum density of water induced by the addition of small amounts of alcohol concentration are, however, not adequately reproduced by our models. In all instances we observe a pronounced decrease of the simulated TMDs when alcohol concentration increases. This is in sharp contrast with the experimental behavior, which at very high dilution displays slight increases in the TMD right before the decreasing regime sets in for higher alcohol concentrations. For similar alcohol mole fractions, the simulated decrease of the TMDs grows in parallel with the size of the alkyl group of the alcohol. A similar situation is found experimentally for concentrations higher than those that increase the TMD. These differences disappear when the TMD change is expressed in terms of the mass concentration of alcohol. This leads to very similar Despretz constants for all solutions studied in this work.

Unusual swelling of acrylate based crosslinked polymer networks in linear primary alcohols: Experimental and modeling aspects

The present investigation focuses on analysis of swelling behavior of systems composed of linear primary alcohols and photo-chemically crosslinked poly (butyl prop-2-enoate) (PABu). For this purpose, reactive blends composed of monofunctional (n-ABu) and difunctional (1-prop-2-enoyloxyhexyl prop-2-enoate) monomers as well as a standard photoinitiator were exposed to ultraviolet-visible (UV–vis) irradiation to induce free radical crosslinking polymerization. Experimental swelling studies of the obtained optically transparent PABu networks in methanol, ethanol, propan-1-ol, butan-1-ol, pentan-1-ol, hexan-1-ol and heptan-1-ol were performed by gravimetric sorption measurements. Among the various models available to rationalize the swelling kinetics of these PABu-alcohol systems, the second order approach was found to agree well with the experimental data.In particular it was observed that swelling properties strongly depend on the length of the linear alkyl chain of the primary alcohols. Swelling of PABu network at equilibrium increases from methanol to butan-1-ol where it reaches a maximum and subsequently decreases from butan-1-ol to heptan-1-ol. To understand this unusual behavior, polymer-solvent solubility parameters were considered, which could not account for the swelling maximum detected in the case of butan-1-ol. Molecular simulations performed on model systems composed of a linear primary alcohol molecule set and a reproduced PABu network revealed that their mutual interaction energy times the molar mass of the alcohol show a trend very similar to that of the observed swelling behavior.

Surprising peculiarities of the shear viscosity for water and alcohols

This work is devoted to the discussion of surprising behavior of the kinematic shear viscosities for water, methanol and ethanol properties ethanol – one of monohydric alcohols of methanol series. We will show that the application of the standard activation approach to them is conjugated with insuperable difficulties. In order to describe the behavior of the shear viscosity in them the approach, developed for low-molecular argon-like liquids is used. The non-spherical shape of alcohol molecules is taken into account. The special attention is focused to the shear viscosity of aqueous solutions of ethanol, demonstrating a strong dependence on alcohol concentration. A new approach, generalizing that for one-component liquids, is proposed. The careful comparison with experimental data supports our main assumptions.

Preferential Orientations and Anomalous Interfacial Tensions in Aqueous Solutions of Alcohols.

Literature studies on interfacial tension versus temperature between normal alcohols and water show that it increases with temperature and exhibits a maximum value at a given temperature depending on the molecular weight of the alcohol. This very unusual behavior is supposedly accompanied by the formation of monolayers of alcohol molecules oriented preferentially at the interface, a structural issue not confirmed until now. We use molecular-based models for water and alcohols in combination with molecular dynamics simulations to provide physical insights, from a molecular perspective, into the structural and thermodynamic behavior at the liquid-liquid interfaces of aqueous solutions of alcohols.

Antibiotic-induced disruption of commensal microbiome linked to increases in binge-like ethanol consumption behavior

Research focusing on the gut-brain axis is growing, but the interplay of ethanol (alcohol molecule), the gut microbiome, the brain and behavior is poorly understood. In the current study, we remodeled the gut microbiota by providing adult male C57BL/6J mice with a non-absorbable antibiotic cocktail (ABX) in the drinking water and tested ethanol consumption behavior in a binge-like “Drinking in the Dark” model. Notably, 2 weeks of ABX pre-treatment significantly increased ethanol consumption during the 6 weeks of ethanol exposure in the DID paradigm. ABX treatment also appeared to prevent anxiety-like behavior during ethanol withdrawal period. ABX-treated mice expressed reduced bacterial diversity and modified microbiota compositions within cecal samples. There were drastically reduced levels of commensal Firmicutes and increases in the Bacteroidetes and Verrucomicrobia populations. Importantly, the relative abundance of Firmicutes inversely correlated to ethanol intake levels regardless of antibiotic treatment, whereas Bacteroidetes and Verrucomicrobia populations negatively correlated to ethanol intake levels. This is the first report demonstrating that ABX-induced disruption of the gut commensal microbiota leads to increased ethanol consumption in mice. This work reveals an important relationship between the gut microbiota and ethanol consumption behavior and supports the use of microbial-targeted approaches to study gut-brain interactions during alcohol use disorder.

Probing effects of thermal and chemical coupling method on decomposition of methane hydrate by molecular dynamics simulation

Methane hydrate, being a potential alternative energy source has attracted the attention of many researchers. Here, we investigated the decomposition of methane hydrate with and without alcohols at different temperatures. The results showed that the hydroxyl group of alcohol molecules close to methane hydrate tends to reorient toward methane hydrate. The formation of hydrogen bonds between alcohol and water in methane hydrate cages destabilises the (methane hydrate) structure, thus leading to its decomposition. We also studied the effects of temperature on alcohols used during methane hydrate decomposition by comparing the variations in total potential energy with temperature. We observed that 300 K is the turning point, when the temperature is lower than 300 K, the accelerating effect of alcohol on methane hydrate decomposition is more pronounced. Additionally, the effect of temperature was found to vary with alcohols. For methanol, temperature mainly affects the rate of diffusion; a high rate of diffusion accelerates the decomposition of methane hydrate. For glycerol, temperature mainly affects the interaction energy between glycerol and water, which can accelerate the decomposition of methane hydrate. Our work provides a theoretical basis for future researches into exploitation of methane hydrate by combining thermal stimulation and alcohol.

The carboxylative cyclization of propargyl alcohol and carbon dioxide catalyzed by organocatalysts

Carbon dioxide (CO2), as a cheap, non-toxic, and abundant C1 resource, can be transformed into high value-added chemicals by constructing C−C, C−O, C−N, and C−S bonds, which is in agreement with the requirements of green chemistry and sustainable development. For example, CO2 can not only be transformed into fuel-related formic acid, methanol etc., but also serves as raw materials for the synthesis of fine chemicals such as carbonates, carbamates and salicylic acid. However, CO2 has the disadvantage of thermodynamic stability and chemical inertness, which can hinder its chemical conversion and utilization. It has become one of the research hotspots to develop efficient catalysts of activating CO2 and reducing the reaction energy barrier in the field of CO2 conversion. Under the continuing efforts of chemists, a series of highly efficient catalysts have been developed and applied in the catalytic conversion of CO2. The carboxylative cyclization of propargyl alcohol to prepare α-alkylidene cyclic carbonates is one of desired chemical reaction in CO2 fixation, which presents 100% atomic utilization and meets the requirements of green chemistry. Now, investigations on the carboxylative cyclization of propargyl alcohol and CO2 have been developing rapidly, and a series of novel reaction systems have been reported. In the carboxylative cyclization, transition metals are extensively studied. Various transition-metal catalytic systems, including silver (AgI), copper (CuI), zinc (ZnII), are closely investigated in the carboxylative cyclization. The transition-metal salts can effectively activate the carbon-carbon triple bond in the propargyl alcohol structure, facilitating the subsequent attack of carbon-carbon triple bonds by alkyl carbonate anions to generate the target products. Although the transition metals are efficient catalysts in this cyclization reaction, their disadvantages, such as high cost and transition-metal residues, are not favourable. Recently, transition metal-free organocatalysts have been becoming one hotspot in the catalysis field, and found wide applications in the field of CO2 conversion, burgeoning in the literature. A series of organocatalysts, such as ionic liquids (ILs), organic strong bases, phosphines and CO2 adducts, have been reported in this carboxylation cyclization reaction. Herein, an overview about the research progresses of organocatalyst-catalyzed carboxylative cyclization is provided, with a particular emphasis on the application of ionic liquids, CO2 adducts and phosphines, and their corresponding mechanisms. Rationally designed CO2-reactive site-containing ILs could activate CO2 effectively, in which the anion is the main contributor, while the cations make a lower contribution. By introducing one or more CO2-reactive sites into the anion structure of ILs, linear CO2 molecules can transformed into active carbonate anions and carbamate anions, thereby achieving the effect of activating CO2. In virtue of CO2-reactive sites, ILs-catalyzed carboxylation cyclization is realized under mild conditions. Strong nucleophiles are found to easily react with CO2 molecule to generate CO2 adducts, such as N -heterocyclic carbenes-CO2 adducts (NHC-CO2), N-heterocyclic olefins-CO2 adducts, alkylated N -heterocyclic olefins CO2-adducts (ANHO-CO2), carbodicarbenes-CO2 adducts (CDCs-CO2), alkoxide-functionalized imidazolium betaines CO2-adducts(AFIB-CO2) and so on, which can serve as efficient organocatalysts in the carboxylative cyclization reaction. Phosphines also present strong nucleophilicity, can activate CO2 and propargyl alcohol molecules by nucleophilic addition to CO2 and carbon-carbon triple bonds of propargyl alcohols. Furthermore, chiral phosphines can act as chiral organocatalysts to afford optically active functionalized cyclic carbonates. Taken together, these rationally designed organocatalysts exhibited excellent performance, obtaining a series of α-alkylidene cyclic carbonates in good yields. In this paper, the mechanisms of the carboxylative cyclization promoted by organocatalysts are closely discussed, hoping to pave a way for the design of more efficient and green organocatalysts.

Periodic Elastic Motion in a Self-Assembled Monolayer under Spontaneous Oscillations of Surface Tension: Molecules in a Scrum Push Back a Marangoni Flow

Regularly recurring phenomena are a common and important part of life. Such rhythmic behaviors are often seen in nonliving systems under far-from-equilibrium conditions. The study of simple nonliving systems provides clues for improving our understanding of the origin of biological rhythms. Here, we focus on the spontaneous oscillation of surface tension associated with an intermittent Marangoni convective flow generated by two types of surfactants, those that are partially soluble (long chain alcohols) and insoluble (lipids) in water. In this system, we find that the collective motions of two surfactants interact with each other in a systematic manner to control a stable periodic motion: the alcohol molecules (donor) produce a Marangoni flow, and the lipid molecules (acceptor) in a monolayer push the flow back. The shape of the surface tension oscillation can be explained by the viscoelastic properties of the acceptor surfactant, whereas the period of the surface tension oscillation has been explained by the physical properties of the donor surfactant. A recently developed time-resolved X-ray surface scattering technique enables the dynamic structure of the water surface under flow to be determined. We have repeatedly observed that lipid molecules at the air-water interface become regularly oriented normal to the surface at every onset of the Marangoni convective flow.

Density, viscosity and electrical conductivity of alcohol solutions of 2,2-diethyl-1,1,3,3-tetramethylguanidinium bis(trifluoromethylsulfonyl)imide

Density, viscosity and electrical conductivity are measured for the methanol and ethanol solutions of the ionic liquid (IL), 2,2-diethyl-1,1,3,3-tetramethylguanidinium bis(trifluoromethylsulfonyl)imide ([TMG(C2)2][NTf2]), at the molality up to 3 mol·kg−1, and the interactions are explored at the molecular level. The concentration dependence of the physicochemical properties is evaluated by empirical models including the Redlich–Kister, the Jones–Dole and the Casteel–Amis equations. The obtained interaction coefficients from viscosity measurements indicate the structure making effect in both systems, by which alcohol molecules gather around the ionic moieties through significant ion–dipole interactions. According to the calculated apparent molar volume and molar conductivity, ion aggregation occurs to form ion pairs when a specific concentration (c0) is reached. The IL behaves as a weak electrolyte in alcohols, and ethanol is more efficient to dissociate IL with a higher value of c0.

A MODEL OF HYDROGEN BOND FORMATION BETWEEN THE MOLECULES IN VAPOR AND LIQUID

A model for the interaction between neutral molecules in amorphous isotropic environment is considered. The intermolecular interaction energy contains three independent groups of quantities describing non-polar forces, polar forces, and hydrogen bonds. Respectively, each of the forces is represented by its own molecular descriptor: generalized charge, dipole moment, and two numbers showing the ability of the molecule to be the donor or the acceptor of the H-bond. The H-bond contribution to the total energy of intermolecular interaction is described as a product of some quantum-mechanical threshold value and the probability of correct arrangement of interacting molecules. The accuracy of the model is verified by applying it to the estimations of the energies of dimers composed of water, alcohol, and carbon acid molecules. The accuracy and convenience of the model are evidently manifested in a priori calculations of the vaporization heat of water, alcohols, and carbon acids.

Crystal structure and Hirshfeld surface analysis of 1-methyl-4-(2-methyl-10H-benzo[b]thieno[2,3-e][1,4]diazepin-4-yl)piperazin-1-ium 2,5-di-hydroxy-benzoate propan-2-ol monosolvate.

The asymmetric unit of the title salt, C17H21N4S+·C7H5O4 -·C3H7OH, consists of an olanzapinium cation, an independent 2,5-di-hydroxy-benzoate anion and a solvent isopropyl alcohol mol-ecule. The central seven-membered heterocycle is in a boat conformation, while the piperazine ring displays a distorted chair conformation. The dihedral angle between the benzene and thiene rings flanking the diazepine ring is 52.58 (19)°. In the crystal, the anions and cations are connected by N-H⋯O and O-H⋯O hydrogen bonds, forming a three-dimensional network.

Alcohol solvent treatment of PEDOT:PSS hole transport layer for optimized inverted perovskite solar cells

Poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) is widely used as a hole transport materials in perovskite solar cells, due to a variety of suitable properties. However, the existence of the insulated PSS chain leads to the low electrical conductivity, which should be improved for the further development of inverted perovskite solar cells. In this study, three alcohol solvents were proposed for post-treatment of PEDOT:PSS thin films, which utilized the electrostatic shielding effect of alcohol molecules to promote phase separation of the PEDOT chain and the PSS chain. At the same time, The insulated PSS chain was removed by dissolving in highly hydrophilic alcohols. In the end, we successfully improved the conductivity of PEDOT:PSS thin films. By ethanol solvent treatment, the short-circuit current density of the perovskite solar cell based on glass/ITO/PEDOT:PSS was increased from 15.64 to 17.45 mA/cm2, the power conversion efficiency (PCE) reached 11.36%, which was 25% higher than the traditional structure. For flexible devices, a preliminary PCE of 9.20% was achieved.