Molecular Recognition Effect Research Articles

Influence of polymer morphology on the ability of imprinted network polymers to resolve enantiomers

Network copolymers imprinted with l-phenylalanine anilide ( l-PheNHPh) exhibit an affinity for the print molecule. The binding of l-PheNHPh to the polymer can be quantitatively evaluated by employing the material as a stationary phase in a HPLC experiment. The degree of separation of the d and l enantiomers of PheNHPh (α value) is used to establish the influence of polymer morphology on polymer performance. Factors that promote stabilization of the template-polymerizable monomer complex prior to polymerization results in polymers with stronger and more selective binding of the substrate. Interestingly, a gel-like non-porous polymer performed similarly to a mesoporous polymer. Performance is also improved upon heat treatment of the polymers and various ways to inhibit the molecular recognition effect are demonstrated.

Chiral Polypeptide Monolayers from Self-Condensation of Amphiphilic Amino Acid Ester. Effect of Chirality on the Membrane Structure

Abstract A Chiral polypeptide monolayer was prepared by self-condensation of an amphiphilic (S)-serine phenyl ester on an aqueous subphase. The monolayer film gave a two-dimensional structure markedly different from that of racemic analogues, reflecting the effect of molecular recognition of chirality in the lateral self-condensation process.

Solvent effects in molecular recognition

Abstract

Recent developments in the synthesis and functionalization of conducting poly(thiophenes)

AbstractThe mechanism of the electropolymerization of thiophene derivatives has been investigated by varying the electrosynthesis conditions and the monomer structure. The results of these analyses led to the definition of optimized electrosynthesis conditions allowing the control of the electrical and electrochemical properties of poly(thiophenes). On the basis of these results, the properties of these polymers have been modified by means of a new one‐step electrosynthesis of conducting composite materials and by the direct electropolymerization of tailor‐made functionalized monomers. For this purpose, the steric conditions associated to the various possibilities of covalent derivatization have been analyzed, leading to the definition of a “functionalization space”, compatible with the preservation of high conductivity and electrochemical reversibility in the resulting polymers. This concept has been applied to the synthesis of highly conducting chiral poly(thiophenes) on which an effect of enantioselective molecular recognition has been demonstrated for the first time.

Recent developments in the synthesis and functionalization of conducting poly(thiophenes)

AbstractThe mechanism of the electropolymerization of thiophene derivatives has been investigated by varying the electrosynthesis conditions and the monomer structure. The results of these analyses led to the definition of optimized electrosynthesis conditions allowing the control of the electrical and electrochemical properties of poly(thiophenes). On the basis of these results, the properties of these polymers have been modified by means of a new one‐step electrosynthesis of conducting composite materials and by the direct electropolymerization of tailor‐made functionalized monomers. For this purpose, the steric conditions associated to the various possibilities of covalent derivatization have been analyzed, leading to the definition of a “functionalization space”, compatible with the preservation of high conductivity and electrochemical reversibility in the resulting polymers. This concept has been applied to the synthesis of highly conducting chiral poly(thiophenes) on which an effect of enantioselective molecular recognition has been demonstrated for the first time.