A number of researchers have proposed different scales for calculating the various atomic descriptors. Atomic descriptors viz. electronegativity and hardness, react differently to varied pressures as demonstrated by a recent study. This work explores the complex interplay in the field of molecular interactions involving pressure, electronegativity, chemical hardness and electrophilicity index. Although it is known that pressure plays a vital role in adjusting the electrical features of molecules, a little is known about how pressure specifically affects basic chemical ideas. After a thorough analysis, we have revealed the complex impact of pressure on the atomic electrophilicity index. The principles of equalisation for hardness, electronegativity and electrophilicity under various pressures (0, 200 and 500 GPa) have been analysed and presented in a novel way. This study advances our understanding of pressure's effect on molecular characteristics. The knowledge gathered from this research has a wide range of usage in scientific fields, which include materials science and chemical reactivity in harsh environments. It also lays the groundwork for future works pertaining to pressure-driven molecular design and application developments.