Removal Of Molars Research Articles

Learning Curve in the Extraction of Impacted Lower Third Molars: A Prospective Cohort Study.

Third molar removal is one of the most common surgical procedures in dentistry. Therefore, it is important to evaluate the learning curve of dentists undergoing surgical training. Thus, the aims of this study were to assess the performance of oral surgery residents in third molar extractions based on operative time and the occurrence of incidents/complications, and to determine which variables are associated with surgical difficulty. A prospective cohort study was carried out in adults requiring an impacted lower third molar extraction. All procedures were performed by residents of a master's degree in Oral Surgery and Implantology. The outcome variables were operative time and surgeon-reported difficulty. A descriptive, bivariate and multivariate analysis was performed. One hundred and 74 patients were operated on by six students. Similar performance was observed among the surgeons. Although a significant improvement in operative time was seen after 10 cases, a non-significant decreasing trend of incidents was also found. The multivariate analysis revealed an association between difficulty with crown/root sectioning and impaction against the second molar. At least 10 lower impacted third molar extractions performed by postgraduate students with experience in tooth extractions are required to improve the operative time. Incidents seem to decrease slightly with the number of procedures performed. Surgical difficulty seems to be related to the need for crown/tooth sectioning and greater impaction against the second molar. Further studies are required to confirm these findings.

Evaluation of patient comfort and satisfaction after the surgical removal of mandibular impacted molars using a piezo-electric technique: A randomized double-blind clinical trial.

This is a double clinical trial conducted to study the patient satisfaction and comfort during and after surgical removal of impacted mandibular 3rd molar using Piezo electric tips. Two groups of 25 each [14 (56%) males and 11 (44%) females] and [18 (72% males and 07 (28%) females] represented the Rotary and Piezo groups respectively with bilateral impactions. one side of the patient is operated by piezo and the other side by rotary instrument after a gap of 2-3 week between the procedures. The variables considered are pain, swelling, trismus, patient satisfaction and comfort. The readings were taken on base line,3rd day,7th and 14th day. Descriptive statistical analysis was performed using means and standard deviations for continuous variables and percentages for categorical variables. The level of significance was set at p<0.05. The surgery time taken was more in the Piezo group (26.96±12.201) in comparison with the Rotary group (21.32±12.786- (p=0.011∗). Satisfaction was rated better in the Piezo group (3.18±0.909 vs 2.88±0.881) (p=0.013∗). Tactile sensation was less in the Piezo group (1.24±0.436) vs (2.28±0.678) (p=0.001). Less pain was reported in the piezo group patients and the difference between the two groups was statistically significant only during the third day follow up (p=0.001). The overall patient satisfaction and comfort was better in piezo in spite of longer duration of surgery. It provides better quality of life as the patients experienced less pain and the total number of analgesics taken is significantly less compared to rotary group.

FREQUENCY OF POST-OPERATIVE COMPLICATIONS IN PATIENTS ASSOCIATED WITH IMPACTED MANDIBULAR THIRD MOLAR REMOVAL

Objectives: To determine the frequency of postoperative complications associated with impacted mandibular third molar removal in patients presenting to a tertiary care hospital (Hayatabad Medical Complex, Peshawar) Material and Methods: A descriptive Cross-sectional study was conducted on 132 patients with post-op complications after third molar removal. Both genders and patients ages 17 to 60 were added. Patients with missing clinical history, radiographs, and fractured mandibles were excluded from the study. Postoperative complications were recorded on a predesigned proforma. Results: Mild pain was found in 49 (37.1%) patients, moderate pain was found in 71 (53.8%) patients, and severe pain was recorded in 12 (9.1%) patients. Dry socket was found in 16 (12.1%) patients. Infection was found in 5 (3.8%) patients. Inferior alveolar nerve (IAN) damage was found in 3 (2.3%) patients and Lingual nerve damage was found in 6 (4.5%) patients. Conclusion: In our study, the postoperative complications of concerns in patients associated with impacted mandibular third molar removal were dry socket in 12.1% of patients, infection in 3.8% of patients, IAN nerve damage in 2.3% of patients, and lingual nerve damage that was found in 4.5% patients. Key Words: Complications, mandible, third molar surgery

INFLUENCE OF METHODS OF AUGMENTATION OF THE ALVEOLAR PROCESS DURING TOOTH EXTRACTION OPERATION ON THE STABILITY OF DENTAL IMPLANTS

The issues of functional and aesthetic optimum are extremely important in the field of providing dental care to the population nowadays. Different materials are used to solve the issue of bone atrophy after tooth extraction: bone substitutes (autografts, allografts, xenografts or alloplastic materials), resorbable and nonresorbable membranes, etc. The aim of the study was to determine the influence of the type of healing of the alveola of the removed mandibular molar on the effectiveness of dental implantation. Materials and methods. The study enrolled 75 patients aged 25 to 45 years who were indicated for removal of a single mandibular molar with subsequent planning of dental implantation. The results. Patients were enrolled into three clinical groups depending on the method of alveolar process augmentation. Before the surgical stage of dental implantation, which corresponded to the 90th day after the tooth extraction operation, the lowest indicator of the optical density of bone tissue was noted in patients of the control group, where the healing of the socket of the removed tooth took place traditionally under a blood clot. In the first and second clinical groups, on the 90th day after the installation of the implant, a higher optical density of bone tissue in the area of the installed dental implant, compared to the control group, continued to be observed by 20.3% and 57.0%, respectively. Conclusion. The combined use of granules of bone substitute of animal origin and keratoxenoimplant after the operation of removal of the mandibular molar leads to the optimal formation of newly formed bone tissue in the area of the socket of the removed tooth, which contributes to the processes of osseointegration of the intraosseous dental implant.

Effectiveness of Lidocaine with Epinephrine Irrigation in Reducing Acute Pain from Surgical Removal of Mesioangular-Impacted Third Molars.

Anesthetic irrigation is an effective treatment for postoperative pain suppression in patients after molar extraction, but exerts a short period of extraction. The study aimed to evaluate the effect of lidocaine with epinephrine irrigation on acute pain relief in healthy volunteers with inferior alveolar nerve block (IANB) injection for the surgical removal of mesioangular (MA)-impacted third molars. A total of 28 patients (56 samples) with bilateral MA-impacted third molars were recruited. This study was a split-mouth, double-blind, randomized clinical trial. Surgical procedures were conducted over two separate appointments. Each patient randomly received 2% lidocaine with 1:100,000 epinephrine for the irrigation of the extraction site after surgery on one side of the mouth and normal saline solution on the other side. The postoperative visual analog scale (VAS) as a pain indicator was recorded and statistically analyzed for both treatments. The VAS levels at 3 and 4 h after surgery in the lidocaine group were significantly lower than those of the normal saline group. Increases in pain scores were recorded five hours after surgery in both groups. No complications were recorded during this study. Continuous local anesthetic irrigation appears to be effective in reducing acute postoperative pain in patients with IANB for MA-impacted third molar surgery. Reference number ISRCTN13866362, Date: 1 October 2024.

Flapless extraction of impacted mandibular third molars: A contemporary surgical approach

The aim of this review is to evaluate the clinical outcomes of flapless extraction of impacted mandibular third molars compared to traditional flap-based techniques, with a focus on patient satisfaction, complication rates, and overall surgical efficiency. The extraction of impacted mandibular third molars (wisdom teeth) is a common procedure in oral and maxillofacial surgery, traditionally performed using a flap-based technique. While this method provides clear access to the impacted tooth, it is often associated with significant postoperative morbidity, such as pain, swelling, and extended recovery time. Recent innovations have introduced flapless extraction as a minimally invasive alternative, aiming to minimize tissue trauma and preserve periosteal integrity. This technique, however, presents its own set of challenges, including limited visibility and technical demands.This review analyzes the current literature on flapless extraction techniques, drawing from retrospective studies, randomized controlled trials, and clinical case reports. The data include comparisons of postoperative outcomes between flapless and traditional methods, emphasizing factors such as operative time, postoperative discomfort, and the frequency of complications. Findings indicate that flapless extraction generally results in reduced postoperative pain, swelling, and faster recovery times compared to traditional flap-based techniques. Patients who undergo flapless extraction report higher satisfaction due to less postoperative discomfort and a quicker return to normal function. However, the technique poses challenges in cases of deeply impacted teeth, where the lack of a flap may hinder complete access and increase the risk of complications. Flapless extraction represents a promising evolution in the surgical removal of impacted mandibular third molars, offering several advantages over traditional methods, particularly in reducing postoperative morbidity. However, the technique requires precise surgical skill and is not suitable for all cases. Careful case selection is crucial, and continued research is needed to further validate its efficacy and safety in complex scenarios.

Clinical and Molecular Impact of Advanced Platelet-Rich Fibrin on Pain, Swelling, and Distal Periodontal Status of Mandibular Second Molars After Mandibular Third-Molar Extraction.

Background and Objectives: This study aimed to evaluate the role of A-PRF (advanced platelet-rich fibrin) in the enhancement of wound healing and protecting the periodontal health of mandibular second molars after the extraction of mandibular third molars. Additionally, the study assessed the levels of pro-inflammatory cytokines in the gingival crevicular fluid (GCF) of mandibular second molars as markers of inflammation. Materials and Methods: Twenty-five systemically healthy adult patients with bilateral removal of impacted mandibular third molars were included. Each patient received A-PRF in one extraction site, while the contralateral site served as a control. Periodontal parameters of the adjacent second molar, including probing depth (PD) and clinical attachment level (CAL), were measured in distal-vestibular (DV) and distal-lingual (DL) sites. Pain, swelling, and overall healing were subjectively evaluated. Levels of tumor necrosis factor-alpha (TNF-α), interleukin 1 beta (IL-1β), and interleukin 6 (IL-6) in the GCF were analyzed. Evaluations occurred at baseline and three months post-surgery. Results: A-PRF significantly improved PD (from 4.69 ± 0.61 mm to 3.85 ± 0.34 mm in DV, and from 4.71 ± 0.65 mm to 3.79 ± 0.27 mm in DL, respectively) and CAL (from 2.41 ± 0.25 mm to 1.82 ± 0.21 mm in DV, and from 2.40 ± 0.36 mm to 1.75 ± 0.19 mm in DL, respectively) of the adjacent second molar, compared to control sites, three months post-surgery. Pain and swelling scores were notably lower on the 7th postoperative day in the A-PRF group. A-PRF also reduced pro-inflammatory cytokines in GCF, significantly more than in control sites, at three months post-surgery. Conclusions: A-PRF enhances the periodontal and inflammatory status of adjacent teeth and wound healing after the extraction of mandibular third molars.

EP052 A maxillary artery pseudoaneurysm: A rare complication following upper third molar removal

EP052 A maxillary artery pseudoaneurysm: A rare complication following upper third molar removal

37 A maxillary artery pseudoaneurysm: A rare complication following upper third molar removal

37 A maxillary artery pseudoaneurysm: A rare complication following upper third molar removal

Minimally Invasive Technique for removal of impacted 3rd mandibular molar and periodontal status of 2nd molar. Clinical study.

Minimally Invasive Technique for removal of impacted 3rd mandibular molar and periodontal status of 2nd molar. Clinical study.

Analysing inflammatory responses after mandibular third molar extraction: a comparison of suture-less and multiple suture techniques.

This study aims to compare the outcomes of suture-less and multiple suture closure methods on postoperative pain, swelling, and trismus, and associated complications. This prospective, randomized clinical trial was conducted at the Department of Oral & Maxillofacial Surgery, Goa Dental College & Hospital. Inclusion criteria encompassed subjects aged between 17 and 55 years, classified as American Society of Anaesthesiologists (ASA) I, with asymptomatic impacted third molars falling within the moderately difficult impaction range (Pederson's difficulty index: 5-7). Study excluded individuals classified as ASA II, III, or IV, those with known or suspected allergies to the anaesthetic solution, immunocompromised patients, and individuals taking medications that could affect healing. Pregnant or lactating females and those with a history of bleeding disorders were also excluded. Wound closure methods were compared: Group A underwent primary closure with silk sutures, while Group B had suture-less closure. Subjects were allocated to the specific groups using a simple randomization method. This involved using a lottery-based random sequence to assign each participant to either Group A or Group B. Pain intensity, facial swelling, and trismus were key outcomes. Secondary outcomes included lingual nerve sensation and postoperative complications. Demographics factors, surgical details, radiographic and perioperative data, and physiological parameters were considered. Non-parametric tests and parametric test (repeated measure ANOVA) were employed. Statistical significance was set at P < 0.05. Among 101 participants, both closure techniques exhibited similar outcomes in pain, swelling, and lingual nerve function. However, suture-less closure resulted in significantly less trismus and fewer cases of delayed wound healing. Suture-less method after surgical removal of third molar may reduce trismus compared to multiple sutures. While pain, swelling, and lingual nerve function management were comparable.

Submucosal Infiltration versus Intravenous Administration of Dexamethasone in Decreasing Post-operative Inflammatory Sequelae after Third Molar Surgery - A Comparative Study

Abstract Introduction: Surgical removal of lower third molar is one of the most common surgical procedures and is quite stressful for many patients. In this study, two different routes of administration of dexamethasone 8 mg (intravenous [IV] vs. submucosally infiltrated) were used to evaluate the role of dexamethasone in reducing the post-operative inflammatory sequelae following lower third molar removal. Materials and Methods: Sixty patients who had to undergo surgical removal of mandibular third molars were randomly divided into two groups, each group consisting of 30 patients. One group of patients was administered 8 mg dexamethasone submucosally five min before the surgery. Another group of patients received 8 mg dexamethasone intravenously five min before the surgery. Facial swelling and pain were measured on the 2nd, 4th and 7th post-operative days. Results: The results of this study revealed that both the routes were effective in controlling post-operative pain and swelling. IV route of dexamethasone showed higher efficacy compared to submucosal (SM) route of dexamethasone in reducing the post-operative inflammatory sequelae in the surgical removal of impacted lower third molar teeth. Discussion: It was seen that IV dexamethasone (8 mg) and submucosal dexamethasone (8 mg) had equivalent ratings in terms of reduction of swelling and pain. Although the results of this study showed both the routes are effective in controlling post-operative swelling and pain after third molar surgery, the study concluded that certain benefits of submucosal route make the sm route to be a valuable alternative to iv dexamethasone.

Dental-dedicated magnetic resonance imaging in the follow-up of lower third molar removal.

The objective is to present a dental-dedicated magnetic resonance imaging (ddMRI)-based follow-up of inferior third molar removal over 12months. A 30-year-old female presented with recurrent pain and bleeding from her lower right third molar. With adding diagnostic information from a panoramic image, the tooth was referred for removal. The patient underwent ddMRI using a dental coil with a proton density (PD) weighed turbo spin echo (TSE) sequence and a PD-TSE-STIR with fat suppression to highlight possible inflammatory processes. The scans were performed pre-operatively, immediately post-operatively, and in a rigorous follow-up (weekly basis for the first 6weeks, bi-weekly from 7 to 12weeks, and once at 6 and 12months post-operatively). Using ImageJ software, circular ROIs were selected in the extraction alveolus coronary, middle, and apical regions. Mean grey values (MGVs) and standard deviation (SD) were obtained. A trend of decreasing MGVs in the PD (TSE) pulse sequence was observed over time, irrespective of the root third. Considering the PD-STIR (TSE), no trend was observed. ddMRI is feasible in the follow-up assessment of inferior third molar removal. Further clinical trials with larger samples are needed to define the usability of follow-up with ddMRI, considering a potential added diagnostic value.

Evaluation of Knowledge and Perception of the Third Molar Extraction Procedure Among Patients in the Eastern Province, Saudi Arabia: A Cross-Sectional Study

Background Third molar extraction is one of the most common oral surgical procedures globally. This study assessed patients’ knowledge of third molar extraction procedures. Methods A self-administered questionnaire was administered to patients (N=384) of the dental hospital at Imam Abdulrahman bin Faisal University in the eastern province. The questionnaire covered demographic data, knowledge of third molar extraction, and patients’ perception questions. SPSS Version 24 was used for statistical analysis. Chi-square and Fisher’s Exact test were used. P-values less than or equal to 0.05 were considered statistically significant. Results According to the demographical characteristics of the patient who received 3rd molar removal surgery. As per the history of the extraction, 45% had previous 3rd molar extraction experience, whereas 55% had no previous dental surgical experience. There was no significant difference between the groups with the knowledge about the extraction (p-0.187). Patients with no previous history were more aware of the correct time for 3rd molar extraction at 27% vs 19%, respectively (P=0.046*). Patients with a previous history of third molar extraction showed significant results of knowledge in terms of taking medication prior to 3rd molar surgical procedure. Conclusion The patient with previous experience with third molar extraction showed low misconceptions. However, further studies should consider increasing the knowledge and correcting the patients’ perceptions.

A prospective split-mouth clinical study: comparison of the effect of lornoxicam and etodolac on postoperative sequels following lower third molar surgery.

This study aims to compare the efficacy of two non-steroidal anti-inflammatory agents (NSAIDs), namely lornoxicam and etodolac for controlling pain, edema and trismus after removal of lower impacted third molars. A total of 20 patients comprised of both genders with bilateral impacted lower impacted third molars (in similar positions) was included in the present study. Patients were randomly assigned either to the lornoxicam group (8mg of lornoxicam) or to the etodolac group (400mg of etodolac). The drugs prescribed were handed out immediately after tooth extraction. Postoperative pain was assessed using visual analog scale (VAS). Edema was evaluated using reference lines on the face. Trismus was assessed using a caliper at maximum mouth opening (mm). There was no significant difference in postoperative pain, trismus, and edema between lornoxicam and etodolac group (p > 0.05). Based on the results obtained in the present study, ıt has been verified that both lornoxicam and etodolac were adequately effective in the management of pain following third molar surgery. Lornoxicam and etodolac had similar impacts on pain, edema and trismus after impacted lower third molar surgical extractions.

Enhancing Lower Third Molar Surgery: Using The Piezoelectric Technique for Superior Postoperative Outcomes and Complication Prevention.

Background: The surgical removal of impacted mandibular third molars is routine in oral and maxillofacial surgery and common postoperative complications are widely reported in the literature. Therefore, this prospective split-mouth study aims to compare the postoperative sequelae of piezoelectric surgery versus conventional surgery of the lower third molar, focusing on pain and swelling. Methodology: In total, 41 patients were treated under local anesthesia and surgical removal on one side of their mouth was performed using conventional rotary surgery (micromotor) while the other side's was by piezosurgery, with an interval of 15 days from the previous procedure (82 extraction sites); in addition, pain and swelling analyses were conducted. Results: The pain analysis demonstrated a median of one day of pain in patients treated with piezoelectric surgery compared to two days with conventional surgery (p < 0.001). The probability of not feeling pain was greater in sites treated with experimental surgery on the first and second days (p < 0.001). The swelling was worse in places treated with the conventional method, with the most significant difference being the distance between the angle of the mandible and the upper lip vermilion on both days and the more subtle difference between the angle of the mandible and the anterior nasal spine on the seventh day. Conclusions: When a piezosurgical unit is used, according to the literature, is well known that it takes more time to perform the surgical extraction of third molars. Despite that, our results show that it causes less pain postoperatively, with faster improvement and a quicker reduction in swelling compared to conventional surgery.

Comparison of the efficacy of aescin and diclofenac sodium in the management of postoperative sequelae and their effect on salivary Prostaglandin E2 and serum C-reactive protein levels after surgical removal of impacted mandibular third molar: a randomized, double-blind, controlled clinical trial.

Surgical removal of an impacted third molar is one of the most common oral surgical procedures performed in dental offices. The postoperative phase is often associated with severe inflammation. Non-steroidal anti-inflammatory drugs (NSAIDs) are usually prescribed to manage postoperative discomfort. NSAIDs have been associated with gastrointestinal bleeding, renal function disturbances, and platelet count reductions. Thus, the present study demonstrates the utility of aescin in managing postoperative discomfort after the surgical removal of impacted mandibular third molars.This study aimed to correlate and compare the impact of aescin and diclofenac on salivary PGE2 levels and serum C-reactive protein levels after surgical extraction of the mandibular third molar. The study will also evaluate and compare the effectiveness of individual drug therapy in managing postoperative pain, swelling and mouth opening. The planned study is a single-center, double-blind, randomized, parallel, prospective clinical trial. Each patient will be prescribed either diclofenac sodium 150 mg/day or aescin (escin) 120 mg/day to be taken orally in divided doses for five days after surgically removing the impacted mandibular third molar.Pain will be assessed using a visual analog scale. Facial swelling and mouth opening will be recorded using a metric scale with standardized reference points. ELISA (enzyme-linked immunosorbent assay (ELISA) will be employed to measure salivary Prostaglandin E2 and serum C-reactive protein levels. All parameters will be recorded preoperatively (T0) on the second postoperative day (T1) and fifth postoperative day (T2). The proposed study is expected to show a clinically acceptable response to the administration of aescin for the management of postoperative discomfort compared to diclofenac sodium after third molar surgery.The proposed study is expected to positively manipulate the levels of salivary Prostaglandin E2 and serum C-reactive protein, which are reliable inflammatory markers.The outcome of this study may provide an efficacious and safe alternative to conventional nonsteroidal anti-inflammatory drugs for managing postoperative discomfort following third molar surgery.

Effectiveness of platelet-rich fibrin in third molar extractions: a randomized controlled split-mouth study

ObjectivesTo date, studies have only investigated the use of platelet-rich fibrin (PRF) after removal of third molars from the mandible or maxilla. Removal of the upper and lower third molars is typically combined into one session per side; therefore, this study aimed to investigate influence on PRF.Materials and methodsThis prospective, single-blinded, randomized controlled, clinical trial (split-mouth design) included 25 patients. After third molar removal, the test group’s sockets were treated with solid PRF clots, whereas the control group’s sockets were conventionally treated. The primary outcome was swelling, which was measured digitally and analogously. Secondary outcomes included trismus, pus, hematoma, and clinical attachment loss (CAL) of the second molars on days 1, 3, 7, and 14. Patient-centered outcome measures and the consumption of painkillers and antibiotics were recorded on days 0–7. The t-test for paired samples, Wilcoxon test, and Chi-Square test were used for statistical analyses.ResultsSwelling was significantly lower on day 14 in the test group (p < 0.05). No statistically significant differences were observed in pain, trismus, and CAL. In the test group, the number of painkillers taken and the number of days of intake were significantly lower (p < 0.05).ConclusionsPRF caused a reduction of painkiller consumption and in the days painkillers were needed. PRF significantly considerably reduced swelling after 14 days. Owing to the lack of differences in other parameters, the integration of PRF application into routine wisdom tooth removal is critical.Clinical relevancePRF affects the long-term outcomes of third molar removal by reducing swelling and reducing as well as shortening painkiller consumption.Trial registrationclinicaltrials.gov (NCT05089812).

Mandibular third molar coronectomy in older adults and its effects on oral health-related quality of life.

The purpose of this study was to investigate the effect of coronectomy on postoperative quality of life in older adults. Coronectomy is an alternative to complete surgical removal of a mandibular third molar that lies close to the inferior alveolar nerve. This prospective study included patients >60 years old who had an indication for coronectomy of a mandibular third molar. Patients were asked to complete the Dutch version of the Oral Health Impact Profile-14 (OHIP-14) daily during the first postoperative week. Postoperative pain, swelling, limited mouth opening, chewing ability and infection were also recorded. Furthermore, the effect of the impaction pattern, state of eruption, presence of preoperative pathology, patient health status according to the American Society of Anaesthesiologists score, gender, smoking on the postoperative OHIP-14 and pain scores were investigated. Thirty patients (16 males, 14 females) with a mean age of 71.2 (SD 8.3, range 60-91) years were included in the study. OHIP-14 and pain scores were highest on the first postoperative day and gradually declined during the first postoperative week. Patients who underwent coronectomy of a fully impacted mandibular third molar had significantly higher OHIP-14 scores on the first postoperative day than those who underwent coronectomy on a (partially) erupted mandibular third molar. We did not observe any postoperative complications up to 1 year after the surgery. Mandibular third molar coronectomy seems to present a valid treatment option in older adults.

Pregabalin as an Effective Adjunct in Postoperative Care following Third Molar Removal

Background: The surgical removal of impacted mandibular third molar is probably the most commonly performed procedure in oral &amp; maxillofacial surgery. This study aimed to evaluate the effectiveness of pregabalin as an adjunct to standard analgesia for managing postoperative pain, facial swelling, and trismus following mandibular third molar extraction.  Methods: A total of 136 patients undergoing bilateral extractions were included. Each patient served as their own control, receiving pregabalin with standard analgesia for one extraction and only standard analgesia for the other. Postoperative pain was assessed using the Visual Analogue Scale (VAS) at various intervals, while facial swelling and interincisal distance (IID) were measured on Days 1, 3, 7, and 14.  Results: VAS scores were higher in the control group; however, it was not statistically significant (P = 0.000) at any time interval. % facial swelling was significantly lower in the test group on postoperative day 1[2.32(1.77- 2.95) test; 2.32 (1.82-3.60) control; P = 0.009] and day 3 [6.67 (5.17-8.44) test; 7.49 (5.77-9.43) control; P = 0.004]. However, no significant differences were seen on postoperative day 7 and day 14. Similarly, no significant differences in mouth opening measurements were found.  Conclusion: Pregabalin is effective as an adjuvant therapy in reducing pain and facial swelling after third molar surgery. However, multicenter, randomized, double- blinded studies are recommended to confirm these findings.