Non-equilibrium exsolution dynamics of a carbon dioxide/propane solvent mixture in heavy oil phase have been studied through a series of micro-optical visualization tests and continuum numerical simulations. The micro-optical visualization tests include bulk-phase Constant-Composition-Expansion (CCE) pressure depletion tests, and bubble-scale exsolution tests from nucleation sites. The CCE tests are aimed to investigate three main parameters of non-equilibrium exsolution dynamics, namely, the total gas phase volume ratio (Vg%), the relative volume of the solvent/heavy oil system (RV), and the solvent molar ratio in free gas phase (e.g., CO2 mol%). The experimental methodology has successfully validated the deviations of the targeting parameters between non-equilibrium and equilibrium state, providing a feasible way to characterize the definition of non-equilibrium. For bubble-scale exsolution tests, two operating schemes have been applied as continuous and segmental depletion. By capturing the growth of bubbles under different depletion schemes, logarithmic relationships have been found between kinetic reaction rate frequency factors (RRFs) of bubble growth and prevailing system pressure. A larger pressure differential from live oil saturation pressure yielded higher kinetic frequency factors. Through all tests, the pseudo-bubble point pressure (where the first batch of gas bubbles were observed) of the solvent/heavy oil system has been determined at ΔP =450∼550kPa from the live oil saturation pressure, which is consistent in terms of the values among different depletion schemes. This has indicated the experimental feasibility in determining the shifting/delay of the bubble point pressure. Numerically, a continuum numerical simulator has been developed to determine the relationship between RRFs and pressure by segmentally history matching Vg%, RV and CO2 mol% of the depletion tests. Similar to the experimental findings, the segmentally optimized RRFs have found to be in logarithmic relationships with pressure. This logarithmic relationship between RRFs and pressure have both been experimentally and numerically verified, and the feasibility of the logarithmic relationship developed from bubble exsolution to be implemented as numerical inputs in continuum reservoir simulation has been validated.