Changes of total moisture mass above an aquifer such as snow accumulation, soil moisture, and storage at the water table, represent changes of mechanical load acting on the aquifer. The resulting moisture-loading effects occur in all observation well records for confined aquifers. Deep observation wells therefore act as large-scale geological weighing lysimeters, referred to as “geolysimeters”. Barometric pressure effects on groundwater levels are a similar response to surface loading and are familiar to every hydrogeologist dealing with the “barometric efficiency” of observation wells. Moisture-loading effects are small and generally not recognized because they are obscured by hydraulic head fluctuations due to other causes, primarily barometric pressure changes. For semiconfined aquifers, long-term moisture-loading effects may be dissipated and obscured by transient flow through overlying aquitards. Removal of barometric and earth tide effects from observation well records allows identification of moisture loading and comparison with hydrological observations, and also comparison with the results of numerical models that can account for transient groundwater flow.