Mohammad Hoesin Hospital Palembang Research Articles

The Influence of Progressive Muscle Relaxation (PMR) On The Improvement Of Body Composition, Depression Status And Quality of Life of Breast Cancer Patients During Chemotherapy In Dr. Mohammad Hoesin Hospital (RSMH) Palembang

ABSTRAK
 The breast cancer progression and chemotherapy side effects not only cause problems in mental status, but also the patient's physical status. This is related to a deteriorating quality of life and a worse prognosis. Physical exercise can improve physical status, mental status, and quality of life.
 Experimental pre- and post intervention research with a control group was conducted on breast cancer patients to determine the effect of progressive muscle relaxation on the improvement of body composition, depression status, and quality of life for breast cancer patients during chemotherapy at RSMH on February 2019 - February 2020.
 Progressive muscle relaxation (PMR) can improve body composition (p = 0.000), reduce the degree of depression (p = 0.000), improve global health status (p = 0.013), physical functioning (p = 0.002), emotional functioning (p = 0.009), social functioning (p = 0015), body image (0,000), sexual function (p = 0.05), future perspective (p = 0.006), and decreased fatigue (p = 0.00), nausea and vomiting (p = 0.002 ), pain (0,000), insomnia (0.002), appetite loss (p = 0,000), breast symptoms (p = 0,000), arm symptoms (p = 0,000), hair loss (p = 0,000), and therapy side effects (p = 0.000).

Comparison of Scar Modified Radical Mastectomy Surgery Using Songket Technique and Standard Technique at Mohammad Hoesin Hospital in Palembang

Abstract
 Introduction. Lateral ear dogs and loss of anterior axillary fold are side effects of modified radical mastectomy (MRM) operations and are cosmetically unpleasant. Songket technique is expected to reduce the side effects of MRM surgery. This study compared the Modified Radical Mastectomy surgery scar using Songket and standard techniques.
 Methods. This research is a clinical randomized trial. With anterior chest thoracic data of postoperative patients and assessed by the patient's family and medical professionals using a likert scale on wound length, wound width, wound angle and armpit folding. This study was performed in the Department of Surgery Mohammad Hoesin Hospital Palembang from January 2020 to April 2020.
 Result. A total of 32 research subjects participated with the average Likert scale score on medical and family assessments between the Songket and standard technique groups with p values ​​of 0.605 and 0.984, respectively.
 Conclusion. There was no difference in comparison of scar Modified Radical Mastectomy operations using Songket techniques and standard techniques at Mohammad Hoesin Hospital in Palembang.

Predictor Factors of Difficult Laparoscopic Cholecystectomy in Cholelithiasis Patients at Mohammad Hoesin Hospital, Palembang

Abstract
 Laparoscopic cholecystectomy is the gold standard for cholecystectomy and can be performed by trained general surgeons. However, the percentage of complications that occur from cholecystectomy laparotomy is approximately 20 percent. So, it is necessary to research risk factors for complications.
 This research is an analytic observational study with a cross-sectional design using preoperative data and intraoperative findings of laparoscopic cholecystectomy. Age, gender, body mass index, history of cholecystitis, number of stones, and location of stones are identified as predictors that affect the difficulty of laparoscopic cholecystectomy. The data collection was performed at the Mohammad Hoesin Hospital Palembang Department from July 2019- July 2020.
 Of the 67 research samples, a Chi-square test was performed, and the factors that had a significant relationship were the body mass index (P-Value 0,000), history of cholecystitis (P-Value 0,000), number of stones (P-Value 0.049), and stone location. (P-Value 0.002). The backward stepwise logistic regression using the four variables showed that the history of cholecystiti

Fiberoptic Endoscopic Examination of Swallowing (FEES) Evaluation in Post Stroke Patients

Introduction. Complications caused by post-stroke dysphagia increase the morbidity and mortality of patients. Although it has a significant effect on the functional abilities and worsening of the patient's prognosis, post-stroke dysphagia is still under-noticed and often undiagnosed. The importance of knowing the incidence of post-stroke dysphagia, not only to determine its relationship to the pathology of the disease but also to determine treatment plans or follow-up interventions. This study aims to determine the incidence of FEES findings in post-stroke dysphagia both hemorrhagic and non-hemorrhagic stroke.
 Methods. Forty post-stroke patients in the Inpatient and Outpatient Installation of the THTKL Section and the Neurology Section of Dr. Hospital. Mohammad Hoesin Palembang conducted a FEES examination to see leakage, residue, penetration, and aspiration after being given six different types of food boluses ranging from filter porridge, rice porridge, oatmeal, water, milk, and biscuits. The results of the assessment are recorded and analyzed descriptively.
 Results. From 40 research subjects found 25 people experiencing dysphagia, where subjects with non-hemorrhagic stroke types were 21 people (52.5%), while hemorrhagic stroke types were four people (10%). The occurrence of leakage of filter porridge was 5 findings, leakage of rice porridge was eight findings, oatmeal leakage, water, and milk were seven findings each, and biscuit leakage was two findings. The incidence of filtered pulp residues was 12 findings, rice porridge residues were 14 findings, oatmeal residues were 15 findings, water and milk residues were five findings each, and biscuit residues were eight findings. The incidence of penetration of filter porridge, rice porridge, and biscuits was one finding each, oatmeal penetration was not found, while water and milk penetration were six events each. The aspirations of filter porridge, rice porridge, oatmeal, and biscuits were not found, while water and milk aspirations were seven findings.
 Conclusion. The incidence of dysphagia in post-stroke patients both hemorrhagic and non-hemorrhagic in the Inpatient and Outpatient Installation of the THTKL Section and the Neurology Section of the Mohammad Hoesin Hospital Palembang Palembang is quite high at 62.5%. The occurrence of food residues is the most FEES findings. While aspirations are the fewest findings.

Effects of Neo-Adjuvant Chemotherapy on CD8 + Serum Levels in Local Advanced Stage Breast Cancer Patients

Introduction.CD8 + CTLs are important components of tumor specific cellular adaptive immunity in breast cancer. Chemotherapy can increase the response of cytotoxic lymphocytes and provide anti-tumor immunity. Therefore, chemotherapy can cause cell death and trigger tumor antigens that are processed by APC and activate CD8 + cells to destroy tumor cells. Evaluation of the immune system before treatment can predict chemotherapy response. The purpose of this study was to assess the effect of neo-adjuvant chemotherapy on serum CD8 + levels in patients with locally advanced breast cancer.Methods.Non-comparative clinical trials were conducted at Dr. Mohammad Hoesin Hospital Palembang from October 2017 to June 2018.The sample of this study was 30 breast cancer patients who met the inclusion criteria. All samples underwent FAC neo-adjuvant chemotherapy and data were analyzed with SPSS version 21. Results.The mean age of advanced breast cancer patients was 45.97 ± 10,526 years with an age range of 30-66 years. Serum CD8 + levels after chemotherapy decreased significantly compared to before chemotherapy (p = 0.000). The value of serum CD8 + before chemotherapy has a sensitivity of 42.86% and specificity of 43.48% with a cut of point of 660.7 cells / mm3.Conclusion.Neo-adjuvant chemotherapy significantly decreases serum CD8 + levels in local advanced breast cancer patients.Keyword: CD8 +, locally advanced breast cancer, immune system, neo-adjuvant chemotherapy

Dermatologic Lesions in Geriatric Patient with Diabetes Mellitus

Introduction: In geriatrics, there are changes in structure and function results in histopathological, physiological and clinical skin changes. The conditions can cause morbidity and decreases the quality of life of patients. This study was the first study that provide the characteristics of geriatric skin disorders in Dr. Mohammad Hoesin Hospital Palembang.
 Methods: This study was descriptive observational with cross-sectional design using total sampling method performed among patients in Geriatric Outpatient Clinic, Dermatology and Venereology Outpatient Clinic and geriatric inpatient room in Dr. Mohammad Hoesin Hospital on July-September 2019.
 Results: Physiological skin changes in geriatrics include xerosis cutis (13,95%), seborrheic keratosis (13,17%), guttate hypomelanosis (8,5%), senile lentigen (6,97%), freckle (2,32%), periorbital hyperpigmentation (1,55%), senile purpura (0,77%) and poikiloderma civatte (0,77%). The most skin disorder found were lichen simplex chronicus (11,1%), pressure ulcers (9,25%), senile pruritus (8,32%), asteatotic dermatitis (6.47%) and candidiasis (3,7%). The most common comorbid condition were diabetes mellitus in 16 patients (22,5%), CVD in 7 patients (9,9%), hypertension in 6 patients (8,5%), AKI in 6 patients (8,5 %), and HHD in 4 patients (5,6%). Diabetes mellitus was significantly associated with xerosis cutis (p = 0,0007), senile pruritus (p = 0,015), and guttate hypomelanosis (p = 0,016).
 Conclusion: The most physiological skin changes found in geriatric patients in Dr. Mohammad Hoesin Hospital were xerosis cutis, seborrheic keratosis, and guttate hypomelanosis, while skin disorder were lichen simplex chronicus, pressure ulcer, and senile pruritus. Diabetes mellitus was significantly associated with skin disorders.

SAT-247 RISK FACTORS OF INSOMNIA IN CHRONIC HEMODIALYSIS PATIENT IN MOHAMMAD HOESIN HOSPITAL PALEMBANG INDONESIA

Insomnia is the inability to fall asleep or stay asleep and wake up earlier characterized by poor sleep quality and could cause poor quality of life. A recent survey has shown that insomnia is still a very common problem in maintenance hemodialysis patients. There are many factors involved in insomnia. This research aimed to identify and analyze factors that may affect insomnia on chronic hemodialysis patients in Mohammad Hoesin Hospital Palembang. This research used analytic observational method with cross-sectional approach. The sample of the research was chronic hemodialysis patients in Mohammad Hoesin Hospital Palembang within period of November-December 2018 that fulfilled the inclusive criteria. Data were analyzed using univariate analysis and presented as frequency distribution table. Data were also analyzed using bivariate and multivariate analysis to gain the understanding of involving factors. This study involved 71 chronic hemodialysis patients that meets the inclusion criteria, 62 (87.3%) of them experienced insomnia. The bivariate analysis showed significant results between chronic pain, hemodialysis schedule and stress (p = 0,000; p = 0,013; p = 0,007. Based on multivariate analysis showed that chronic pain (p = 0.017) had a significant effect on the occurrence of insomnia (p <0.05), while stress (p = 0.239), hemodialysis schedule (p <0.217). The hemodialysis schedule has a significant relationship with the occurrence of insomnia and morning hemodialysis schedule, Chronic pain, and stress are risk factor for the occurrence of insomnia on chronic hemodialysis patients

SAT-101 THE ASSOCIATION BETWEEN ADIPONECTIN SERUM LEVEL AND CAROTID INTIMA MEDIA THICKNESS IN CHRONIC HEMODIALYSIS PATIENTS

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in chronic kidney disease (CKD) patients. The most important underlying mechanism is progressive atherosclerosis. Measurement of carotid intima-media thickness (CIMT) is considered as a method for detecting subclinical cardiovascular disease. Adiponectin is a collagen like protein produced by fat cells that have anti-inflammatory and antiatherogenic effects, so it is cardioprotective. But the effect of adiponectin protection against hemodialysis (HD) patients is still controversial. The research design is correlative analytic with cross sectional approach. This research was conducted at Hemodialysis unit of Mohammad Hoesin Hospital Palembang from July 2016 until July 2017. The subjects were more than 18 years old CKD patients who underwent routine HD for a least 3 months. Maximum CIMT measurement were performed along distal of communic carotid artery about 5 cm before carotid bifurcation using carotid doppler ultrasound. Serum adiponectin levels are examined shortly before HD session. Of the 34 subjects, the average age was 45.56 12.26 years. The median level of adiponectin was 6.36 (0.77 – 104.38 g/ml). The mean of maximum CIMT of this research was 0.810 0.190 mm. There were 15 subjects with increased of CIMT and plaque was found in 8 subjects. Spearman correlation test showed no correlation between adiponectin and CIMT (r: -0,195; p: 0,264). Multivariate linear regression test of CIMT related factors was found that age, blood sugar and body mass index have relationship with CIMT. There was no significant association between serum adiponectin level and CIMT. CIMT is affected by age, blood sugar and body mass index.

Pediatric Logistic Organ Dysfunction 2 Scoring System in Predicting the Prognosis of Death in Pediatric Patients with Clinical Sepsis

ABSTRACT&#x0D; Introduction. Sepsis is still one of the main causes of mortality and morbidity in children in industrialized and developing countries. Pediatric Logistic Organ Dysfunction 2 (PELOD 2) score aims to assess the degree of organ system disorder. In addition, PELOD score 2 also has a close relationship with death and can detect any organ dysfunction even in patients with low mortality. This study aims to determine the relationship between PELOD 2 score with the death of patients in pediatric surgical cases with clinical sepsis at Dr. Mohammad Hoesin Hospital (RSMH) Palembang.&#x0D; Methods. An observational analytic study with a cohort design was conducted at the Mohammad Hoesin Hospital in Palembang from August 2017 to December 2017. There were 30 samples of pediatric patients with clinical sepsis who met the inclusion criteria. Data frequency and distribution are explained in tabular form. The relationship between PELOD 2 score (Pediatric Logistic Organ Dysfunction 2) with death was analyzed by the Fisher Exact test. Survival rates are obtained by analyzing survival using Kaplan meier. Data analysis uses SPSS version 18.0.&#x0D; Results. In this study, the results showed that there were no differences in age, weight, height and sex between groups with mortality and life outcomes (p&gt; 0.05). With the Fisher Exact test, it was found that there was a significant relationship between PELOD 2 score and mortality in pediatric patients with clinical sepsis (RR = 13; RR&gt; 2; p = 0.000; p&gt; 0.05). Of 30 pediatric patients with clinical sepsis, there were 13 deaths (43.3%) of pediatric patients with clinical sepsis where 13 out of 15 people (86.7%) in the risk group and the comparison group did not get any deaths.&#x0D; Conclusions. It can be concluded that there is a significant relationship between PELOD 2 score (Pediatric Logistic Organ Dysfunction 2) with the death of patients in pediatric surgical cases with clinical sepsis at Dr. Mohammad Hoesin Hospital (RSMH) Palembang.

Relationship Between IPSS (International Prostatic Symptomatic Score) and Quality of Life in Patients with LUTS (Lower Urinary Tract Symptoms)

ABSTRACT&#x0D; Introduction. Lower urinary tract symptoms (LUTS) is the most common problem in men with age and can reduce quality of life due to various complaints on micturition.&#x0D; &#x0D; Method. This study was a cross sectional study conducted in May-July 2018 at the Urology Outpatient Clinic, Dr. Mohammad Hoesin Hospital Palembang and 36 samples were obtained. The technique of data collection was done by filling out the questionnaire. Analysis of data in the form of descriptive for general characteristics and correlation analysis used is the Spearman Rank test correlation.&#x0D; &#x0D; Results: The most prevalence of benign prostate hyperplasia (BPH) occurred in the age group 71-80 years as many as 12 patients (33.3%). BPH patients who came with the most LUTS experienced severe degrees of International Prostatic Symptomatic Score (IPSS) (24 patients, 66.7%). There were 16 patients (44.4%) felt their quality of life was very poor. Spearman Rank correlation test showed no significant relationship between IPSS with the quality of life of patients with BPH with LUTS (p&gt; 0.05, r = 0.073)&#x0D; &#x0D; Conclusion. There was no significant relationship between IPSS with the quality of life of BPH patients with LUTS.

Profile of Photic Driving Inelectroence Phalography Records at Mohammad Hoesin Hospital Palembang

Photic driving (PD) is a normal electroencephalography phenomenon in the parietooccipital region during intermittent photic stimulation (IPS). The PD response is an indicator that is sensitive to age, brain maturity, certain abnormalities, changes in brain signal and brain complexity. Currently, there is not much data about the PD response based on individual characteristics. Methods: It is a cross-sectional study with secondary data from EEG and medical records, from January to December 2017. Result: Of 536 records, only 444 EEG records fulfilled the research criteria. PD response was more common in women (61.4%) and age group between 20-60 years (78.6%). Normal EEG result was 71.4%. PD responses were most commonly diagnosed with epilepsy etiology (33.8%). Only 28.6% of PD responses were found in abnormal EEG results. Conclusion: Distribution showed that the response of PD decreased in older age. The PD response is more common in patients with normal EEG results. The more abnormal results of EEG, PD response rarely arise.

Factors that influence cognitive function in epilepsy patients at neurology clinic Mohammad Hoesin Hospital Palembang

Background Epilepsy is a clinical manifestation of brain disorder due to various etiologies that needs appopriate treatment. Lack of therapy leade to cognitive impairment. This research aims to evaluate cognitive function profile and analyze factors that influence cognitive function in epilepsy patient. Method This is a cross sectional study of epilepsy patient in Mohammad Hoesin Hospital Palembang between January–May 2018 that fullfilled inclusion and exclusion criterias assesed by MOCA-Ina and questionnaire. Data was analyzed with SPSS 20.0 Chi-square, ANOVA and correlation for bivariate and double linear regression for multivariate. Result Samples consists 39 subjects. The prevalence of cognitive impairment in epilepsy patients was 69.2%. Level of education >9 years was mostly recorded from the samples with MOCA-Ina score that shows cognitive impairment. In multivariate analysis with multiple linear regression tests of 8 variables (age, sex, education level, age of onset, type of epilepsy syndrome, type of drug, duration of seizure, and frequency of seizures), three variables (gender, level of education, duration of seizure) had significant relationship with cognitive function of epilepsy patients. There was also a positive correlation between gender (0,333), education level (0,542) on cognitive function and a negative correlation (−0,334) between the duration of seizure and cognitive function. Conclusion The prevalence of cognitive impairment was 69.2% in epilepsy patients at Mohammad Hoeasin hospital Palembang. Level of education, gender and duration of seizure influence cognitive function in epilepsy patient.

Association between size and type of ventricular septal defect and nutritional status in children

Ventricular septal defect (VSD) is often associated with malnutrition. Nutritional status in VSD is affected by inadequate energy intake or increase energy requirement. The objective of this study to assess the association between size and type of VSD and nutritional status. A cross-sectional study was conducted at Dr. Mohammad Hoesin Hospital Palembang. Data were collected from medical record and statistical analysis Chi square. All of 401 VSD patients were 68.1% perimembranous outlet, 25.7% doubly committed subarterial, 2.7% perimembranous outlet extension to inlet, 2.5% muscular and 1% inlet. The size of VSD were 133 (33.2%) small, 219 (54.6%) moderate, 49 (12.2%) large. There were 43 (10.7%) severely underweight, 278 (69.3%) underweight, 80 (20%) well nourished; 41 (10.2%) stunting, 360 (72%) normal height; 18 (4.5%) severely wasting, 242(60.3%) wasting and 141 (35.2%) well-nourished based on WAZ, HAZ and WHZ measurement respectively. There were a significant association between size of VSD and underweight (OR 18.147; 95% CI 9.47 to 34.76; p=0.00) and wasting (OR 25.09; 95% CI 14.55 to 43.26; p=0.00). There was a significant association between type of VSD and stunting (p=0.02). Our conclusion that significant association between size, underweight and wasting, also between type and stunting.

Comparison of leptin serum levels between systemic lupus erythematosus (SLE) and non-SLE patients at Mohammad Hoesin Hospital Palembang

Systemic lupus erythematosus (SLE) is an autoimmune disease, in which immune system mistakenly attacks healthy tissues such as joint, skin, kidneys, brain, and other organs. The dysregulation occurs in the immune system and produces various inflammatory autoantibodies and cytokines in SLE patients. Leptin plays a role in the immune system’s reaction to autoimmune diseases related to the inflammatory response, therefore it acts as a potential target in the development of therapy in the autoimmune disease. Serum leptin levels in SLE patients may be elevated, and are associated with the involvement of lupus nephritis, although it still unclear. A cross sectional study was conducted with a number of 70 subjects, each group consisted 35 SLE and 35 non-SLE patients who were treated as outpatient in the period of April - November 2016 at internal medicine Mohammad Hoesin hospital Palembang. We found that, leptin serum levels in the SLE group were higher than the non-SLE group but showed no significantly different.

Pre and intraoperative findings of chronic otitis media

Chronic otitis media (COM) is still highly prevalent in developing countries and often become main cause of deafness and morbid complication. Appropriate management may decrease the morbidity and mortality rate. The aim of the study are to evaluate preoperative and intraoperative finding among COM patients. A descriptive study was conducted at Mohammad Hoesin Hospital Palembang from April 2015 to April 2018. A secondary data was taken from medical records. A total of 252 patients were included in this study with the highest incidence was at 21-30 years old group (29,36 %) with male predominance. The most frequent preoperative assessment were total perforation of tympanic membrane in 104 patients (41.26 %), moderately severe mixed hearing loss in 61 patients (24,2%), and mastoiditis with cholesteatoma in computed tomography (CT) finding in 158 patients (62,69 %). In intraoperative finding, there were 202 patients (80,15%) with cholesteatoma whereas 103 patients (40,87 %) with granulation tissue. Ossicular chain destruction were found in 141 patients (55,95 %). Canal Wall Down Mastoidectomy (CWD) were performed in 190 patients (75,39 %). The prevalence of COM with cholesteatoma at Mohammad Hoesin hospital is still high. Operative management using CWD technique is preferred in cases of COM with cholesteatoma.

EEG changes in patients with intracranial tumors and seizures symptom at Mohammad Hoesin Hospital Palembang

This study was conducted to determine the EEG changes in intracranial tumor patients with symptoms of seizures and the correspondence between the location of tumor by the location of the EEG abnormality. This is a cross-sectional descriptive study using primary and secondary data. Samples were collected consecutively over a period of 1 year. Of the 35 samples, abnormal EEG in patients with primary intracranial tumors obtained 68,2%, whereas in metastatic intracranial tumors obtained in 84,6%. From the abnormal EEG, in primary intracranial tumors description focal slowing in 60.0%, epileptic activity 20.0%, accompanied focal epileptic activity and focal slowing in 13.3%. Whereas in patients with intracranial tumor metastasis overview the form of a focal slowing in 36.4%,epileptic activity in 18.2%, and deceleration focal epileptiform activity accompanied by 45.5%. Presence of the EEG abnormality locations in tumor area 23.1%, non-tumor area by 38.5%, tumor and non-tumor area area by 38.5%. In this study, most patients have an abnormal EEG which more common in the form of a focal slowing compared epileptic activity, and some abnormalities are located in non-tumor areas. This indicates that the seizures that occur may be more due to irritation lesions than for the formation of epileptic focus.

The correlation between uric acid and stages of malignancy among gastric cancer patient in Palembang, Indonesia

Gastric cancer is a malignant gastric mucosal cancer that often began on the side where the gastric layer is inflamed. Previous research has shown that high uric acid levels are associated independently with an increased risk of gastric cancer and it is suspected that there is a correlation between gastric cancer and elevated levels of uric acid levels but is still poorly known in detail. The aim of this study was to analyse the correlation between uric acid levels and stage of malignancy of gastric cancer patients in the oncology department of Mohammad Hoesin Hospital Palembang. This research was an analytic observational study by using a cross-sectional design to test the correlation between uric acid levels and stages of malignancy in gastric cancer. The results obtained was analyzed using Goodman and Kruskal’s Gamma correlation test. The Goodman and Kruskal’s gamma test results showed a strong correlation (p=0,033; r=0,746) between uric acid levels and which shows a significant correlation with 95% of confidence levels. Every increment in uric acid levels would be followed by an increase in stages of malignancy in gastric cancer.

The first investigation of AAC(6’)-Ib enzyme in carbapenem-resistant enterobacteriaceae isolated from Indonesian patients

Background: Over the past decade, numbers of Carbapenemase Producing-Carbapenem Resistant Enterobacteriaceae (CP-CRE) has been increasing worldwide and it has been becoming a threat because of its resistance against carbapenem which is considered as the “last resort” antibiotic. Therapy options for its infection are still limited. Aminoglycoside serves as one of the most commonly used antibiotics, but the resistance against it has already been presented for a long time. Aminoglycoside Modifying Enzyme (AME) is the most important resistance mechanism against aminoglycoside. AAC(6’)-Ib enzyme is one of the most common AME produced by the gram-negative bacteria.&#x0D; Objectives: This study wished to identify the gene of this enzyme among CRE isolated from infected Indonesian patients in Dr. Mohammad Hoesin Hospital Palembang.&#x0D; Methods: Twenty-eight isolates collected from CRE-infected patients identified by Vitek 2 Compact (bioMerieux, USA) in dr. Mohammad Hoesin Hospital Palembang during September—November 2017. AAC(6’)-Ib gene was identified using PCR method, then visualize by electrophoresis. The result is then analyzed by comparing it with a susceptibility test. &#x0D; Results: Out of 28 samples, AAC(6’)-Ib is identified in 22 (78.57%) samples. Samples with AAC(6’)-Ib showed to be less resistant to various antibiotics, significantly to amikacin (p=0.023).&#x0D; Conclusion: AAC(6’)-Ib gene is found in most of samples implying its frequent occurrence in Indonesian patients.

Malignancy Risk Factors of Hydatidiform Mole

Abstract&#x0D; Objective: to determine risk factors inhydatidiform mole patients who will develop into Gestational Trophoblast Neoplasm (GTN) in Dr.Mohammad Hoesin Hospital Palembang&#x0D; Method: An observational analytical study with case control design was conducted in Department of Obstetrics and Gynecology in Dr. Mohammad Hoesin Hospital Palembang / Faculty of Medicine Sriwijaya University Palembang from January 2017 to August 2017. The frequency and distribution of data are described in tables. Bivariate analysis was done to determine correlation between independent variable and dependent variable using Chi Square/Fisher Exact test and multivariate analysis was used to know which independent variable has the biggest influence to the occurrence of Gestational TrophoblastNeoplasm (GTN) post evacuation of hydatidiform mole. Data analysis was done using SPSS version 21.0.&#x0D; Results: There were 45 patients who fulfilled inclusion criteria with control group and case group ratio 1 : 2 (15 cases and 30 controls). Statistical analysis showed a significant correlation between patient age, pre-evacuation β HCG level, parity, and histopathologic appearance with occurrence of Gestational Trophoblast Neoplasm (GTN) after evacuation of hydatidiform mole (p &lt;0,05). From multivariate analysis, it was found that pre-evacuation β HCG levels ≥ 134,182.5 mIU/ml was a risk factor of Gestational Trophoblast Neoplasm (OR = 77.008, p value = 0.004).&#x0D; Conclusion: Pre-evacuation β HCG levels ≥ 134,182.5 mIU / ml is a risk factor for the occurrence of Gestational Trophoblast Neoplasm (GTN).&#x0D; Keywords: Hydatidiform mole, GTN, age, pre-evacuation β HCG level, parity, uterine size, blood type, hysthopathology feature

Malignancy risk factors of hydatidiform mole

Objective: to determine risk factors in hydatidiform mole patients who will develop into Gestational Trophoblast Neoplasm (GTN) in Dr. Mohammad Hoesin Hospital Palembang Method:An observational analytical study with case control design was conducted in Department of Obstetrics and Gynecology in Dr. Mohammad HoesinHospital Palembang / Faculty of Medicine Sriwijaya University Palembang from January 2017 to August 2017. The frequency and distribution of data are described in tables.Bivariate analysis was done to determine correlation between independent variable and dependent variable using Chi Square/Fisher Exact test and multivariate analysis was used to know which independent variable has the biggest influence to the occurrence of Gestational TrophoblastNeoplasm (GTN) post evacuation of hydatidiform mole. Data analysis was done using SPSS version 21.0. Results: There were 45 patients who fulfilled inclusion criteria with control group and case group ratio 1 : 2 (15 cases and 30 controls). Statistical analysis showed a significant correlation between patient age, pre-evacuation β HCG level, parity, and histopathologic appearance with occurrence of Gestational Trophoblast Neoplasm (GTN) after evacuation of hydatidiform mole (p &lt;0,05). From multivariate analysis, it was found that pre-evacuation β HCG levels ≥ 134,182.5 mIU/ml was a risk factor of Gestational Trophoblast Neoplasm (OR = 77.008, p value = 0.004). Conclusion:Pre-evacuation β HCG levels ≥ 134,182.5 mIU / ml isa risk factor for the occurrence of Gestational TrophoblastNeoplasm (GTN).