Effect Of Modulation Research Articles

The host-guest effect of D-xylose constructs the weak-synergistic sheath structure of Zn2+ to achieve high performance of aqueous zinc ion batteries at the low temperature

Aqueous zinc ion batteries (AZIBs) have been widely concerned because of their low cost and high safety. However, zinc anodes are affected by active H2O, which promotes side reactions, and performs poorly at low temperatures. Herein, a weak-synergistic solvated sheath structure of Zn2+ is implemented by constructing a host–guest solvation modulation effect with the addition of D-xylose. As the host, D-xylose can replace the guest H2O in the solvated shell of Zn2+, weaken the interaction of Zn2+ with the guest H2O and SO42−, and destroy the original hydrogen bond network of the guest H2O-H2O. This electrolyte can greatly reduce side reactions induced by reactive H2O and lower the freezing point. Consequently, the electrolyte containing D-xylose has a high ionic conductivity of 21.2 mS cm−1 at −10 °C. The Zn||Zn battery can run stably for more than 2000 h at 25 °C (1 mA cm−2) and −10 °C (0.5 mA cm−2). Furthermore, the Zn||PANI battery displays promising capacity and sustained stability over 1000 cycles at −10 °C with an average CE of up to 100 %. This study highlights a new electrochemical perspective to achieve a weak-synergistic structure around Zn2+, providing new insights into the application of AZIBs at low temperatures.

Bidirectional all-PM Er-doped fiber laser based on a self-stabilized interferometer mode-locker

We demonstrate a bidirectional all polarization-maintaining (PM) Er-doped fiber laser based on a self-stabilized interferometer mode-locker. By utilizing mechanical sharing and multiplexing propagation directions, the laser has balanced bidirectional outputs and passively suppresses common-mode noise. We also investigate the intra-cavity pulse dynamics via numerical simulations, which coincides well with experimental observations. The self-stabilized interferometer compensates for the group delay difference between the polarization components induced by linear birefringence. The cross-phase modulation effect in the self-stabilized interferometer leads to asymmetric spectra. In addition, from 10 kHz to 1 MHz frequency range, the integrated RMS phase noise in clockwise (CW) and counter-clockwise (CCW) directions are 0.124 mrad and 0.14 mrad, respectively. The integrated RMS RIN in CW and CCW directions are 439 ppm and 464 ppm. Due to passive common-mode noise cancellation, the repetition frequency difference can be stabilized near 19 Hz in 2500 s gate time. The stability of the repetition frequency difference can reach a minimum value of 4.167 × 10−4 at a gate time of 100 s. This novel bidirectional all-PM Er-doped fiber laser based on a self-stabilized interferometer mode-locker can provide a new scheme for the construction of an all-PM dual-comb system.

Numerical investigation of vibratory response of planetary gear sets and modulation effects induced by carrier rotation

In geared system, the main source of excitation is generated by the mesh process itself. Depending on the dynamic conditions involved, the system may present a variety of problems, ranging from acoustic nuisance to system failure. Predicting and controlling the mesh process at an early design stage is a key point to avoid such issues. The problem is complex, mainly due to its multi-scale nature. Indeed, the vibroacoustic behavior of geared systems (on the scale of a meter) depend on the local micro-geometry of the teeth (of the scale of a micron), associated with the transmission error. Moreover, the problem is parametric in nature, due to the periodic fluctuation of the mesh stiffness. These parametric internal excitations generate dynamic mesh forces which are transmitted to the housing through wheel bodies, shafts and bearings. In the case of planetary gear sets, the numerical prediction presents a complementary challenge as, in many application, the carrier rotation modulates the housing vibration response, at its rotational frequency. This paper present an original simulation process to deal with modulation effects in planetary gear systems.

Timing and Graded BMP Signalling Determines Fate of Neural Crest and Ectodermal Placode Derivatives from Pluripotent Stem Cells.

Pluripotent stem cells (PSCs) offer many potential research and clinical benefits due to their ability to differentiate into nearly every cell type in the body. They are often used as model systems to study early stages of ontogenesis to better understand key developmental pathways, as well as for drug screening. However, in order to fully realise the potential of PSCs and their translational applications, a deeper understanding of developmental pathways, especially in humans, is required. Several signalling molecules play important roles during development and are required for proper differentiation of PSCs. The concentration and timing of signal activation are important, with perturbations resulting in improper development and/or pathology. Bone morphogenetic proteins (BMPs) are one such key group of signalling molecules involved in the specification and differentiation of various cell types and tissues in the human body, including those related to tooth and otic development. In this review, we describe the role of BMP signalling and its regulation, the consequences of BMP dysregulation in disease and differentiation, and how PSCs can be used to investigate the effects of BMP modulation during development, mainly focusing on otic development. Finally, we emphasise the unique role of BMP4 in otic specification and how refined understanding of controlling its regulation could lead to the generation of more robust and reproducible human PSC-derived otic organoids for research and translational applications.

Do stress hormones influence choice? A systematic review of pharmacological interventions on the HPA axis and/or SAM system.

The hypothalamus-pituitary-adrenal axis (HPA axis) and the sympathetic-adrenal-medullary system (SAM system), two neuroendocrine systems associated with the stress response, have often been implicated to modulate decision-making in various domains. This systematic review summarizes the scientific evidence on the effects of pharmacological HPA axis and SAM system modulation on decision-making. We found 6375 references, of which 17 studies fulfilled our inclusion criteria. We quantified the risk of bias in our results with respect to missing outcome data, measurements, and selection of the reported results. The included studies administered hydrocortisone, fludrocortisone (HPA axis stimulants), yohimbine, reboxetine (SAM system stimulants), and/or propranolol (SAM system inhibitor). Integrating the evidence, we found that SAM system stimulation had no impact on risk aversion, loss aversion or intertemporal choice, while SAM system inhibition showed a tentative reduction in sensitivity to losses. HPA axis stimulation had no effect on loss aversion or reward anticipation but likely a time-dependent effect on decision under risk. Lastly, combined stimulation of both systems exhibited inconsistent results that could be explained by dose differences (loss aversion) and sex differences (risk aversion). Future research should address time-, dose-, and sex-dependencies of pharmacological effects on decision-making.

Aeroacoustic analysis of fixed- and variable-pitch controlled multirotors and noise reduction via rotor phase control

This research conducts a comparative analysis of the aerodynamic and aeroacoustic characteristics of fixed-pitch and variable-pitch controlled multirotors (i.e., revolution per minute and collective pitch control). The study encompasses hovering and forward flight conditions, considering wind gust effects. Specifically, high-resolution time-frequency analysis is conducted to investigate the interference and modulation effects of multirotor noise. The analysis reveals significant variations in spectral characteristics depending on the control method. Notably, the frequencies of tonal noise from variable-pitch controlled multirotor do not exhibit short-periodic modulation, in contrast to those of fixed-pitch controlled multirotor. Considering the distinctive spectral characteristics of variable-pitch controlled multirotor, this study explores the effectiveness of noise reduction in variable-pitch controlled multirotor by implementing rotor phase control methods. To validate the noise reduction in time series simulations, a deep learning model is employed to determine the dynamically optimized rotor phases. A multilayer perceptron neural network was trained to derive the optimal rotor phase angles over time, considering the target observer points and flight conditions. The results demonstrate a substantial reduction in noise at the target observer points.

Self-Adaptive Intelligent Metasurface Cloak System with Integrated Sensing Units.

Metasurfaces, which are ultrathin planar metamaterials arranged in certain global sequences, interact uniquely with the surrounding light field and exhibit unusual effects of light modulation. Many interesting applications have been discovered based on metasurfaces, particularly in invisibility cloaks. However, most invisibility cloaks are limited to working in specific directions. Achieving effectiveness in multiple directions requires the metasurface to be designed with both perception and modulation capabilities. Current multi-directional metasurface cloak systems are implemented with discrete components rather than an integrated sensing component. Here, we propose an intelligent metasurface cloak system that integrates sensing units, resulting in the cloaking effect with the help of a real-time direction sensor and an adaptive feedback control system. A reconfigurable reflective meta-atom based on phase modulation is presented. Sensing units replace parts of the meta-atoms in the designed tunable metasurface, integrating with an FPGA responsible for measuring the direction and frequency of the incident wave, constituting a closed-loop system together with the feedback parts. Experimental results demonstrate that the metasurface cloak system can recognize the different directions of the incoming wave, and can adaptively manipulate the reflected phase of EM waves to conceal objects without any human participation.

Insula-Medial Prefrontal Cortex Functional Connectivity Modulated by Transcutaneous Auricular Vagus Nerve Stimulation: An fMRI Study.

Transcutaneous auricular vagus nerve stimulation (taVNS) is an emerging neuromodulation technology that has been reported to be beneficial in the treatment of diseases by several studies, but its exact mechanism of action is still unclear. It has been demonstrated that taVNS can influence interoceptive signals. Notably, the processing of interoceptive signals is directly related to many diseases, such as depression, anxiety, and insomnia. The insula and the medial prefrontal cortex (MPFC) communicate during the bottom-up transmission of taVNS-induced signals, and both play a role in interoceptive signal processing. By focusing on the insula and MPFC, our research pioneers detail the potential interactions between interoceptive signal processing and the neuromodulation effects of taVNS, providing novel insights into the neurobiological mechanisms of taVNS. Two functional connectivity (FC) analyses (region of interest-based and seed-based) were used in this study. We observed that negative connectivity between the insula and the MPFC was significantly weakened following taVNS, while there were no statistical changes in the sham group. Our findings elucidate potential mechanisms linking vagal activity with intrinsic FC among specific brain regions and networks. Specifically, our results indicate that taVNS may enhance the ability to flexibly balance interoceptive awareness and cognitive experiences by modulating the FC between the insula and MPFC. The modulation effects may impact body-brain interactions, suggesting the mechanism of taVNS in therapeutic applications.

TRESK channel activation ameliorates migraine-like pain via modulation of CGRP release from the trigeminovascular system and meningeal mast cells in experimental migraine models

AimsAccumulating evidence indicates the involvement of TRESK potassium channels in migraine, however, effects of TRESK activation on migraine-related mechanisms remain unclear. We explored effects of TRESK channel modulation on migraine-related behavioral and molecular markers in in-vivo and ex-vivo rat models of migraine. Main methodsThe selective TRESK activator cloxyquin at different doses, the TRESK inhibitor A2764, and the migraine drug sumatriptan were tested alone or in different combinations in nitroglycerin (NTG)-induced in-vivo model, and in ex-vivo meningeal, trigeminal ganglion and brainstem preparations in which CGRP release was induced by capsaicin. Mechanical allodynia, CGRP and c-fos levels in trigeminovascular structures and meningeal mast cells were evaluated. Key findingsCloxyquin attenuated NTG-induced mechanical allodynia, brainstem c-fos and CGRP levels, trigeminal ganglion CGRP levels and meningeal mast cell degranulation and number, in-vivo. It also diminished capsaicin-induced CGRP release from ex-vivo meningeal, trigeminal ganglion and brainstem preparations. Specific TRESK inhibitor A2764 abolished all effects of cloxyquin in in-vivo and ex-vivo. Combining cloxyquin and sumatriptan exerted a synergistic effect ex-vivo, but not in-vivo. SignificanceOur findings provide the experimental evidence for the anti-migraine effect of TRESK activation in migraine-like conditions. The modulation of TRESK channels may therefore be an attractive alternative strategy to relieve migraine pain.

Effects of serotonergic manipulation in the brainstem and hypothalamus of overnourished rats during lactation

Previous studies suggest that being overweight and obese is capable of altering brain function during critical periods due to the higher plasticity of the brain during development. However, more literature still needs to be on the immediate effect of overnutrition and serotonin modulation in brain areas. In this study, we aimed to evaluate the effects of serotoninergic manipulation on oxidative stress and pro-inflammatory markers in the brainstem and hypothalamus of overnourished rats. The fluoxetine treatment was performed from postnatal day 3 (PND3) to postnatal day 21 (PND21) to evaluate mitochondrial function, oxidative balance, and the mRNA levels of monoaminergic molecules such as serotonin and dopamine, pro-inflammatory cytokines, and BDNF. Neonatal overnutrition induces molecular and biochemical changes in the brainstem and hypothalamus. These nutritional disturbances during lactation dysregulate energy balance and cellular redox, inducing oxidative stress. Conversely, modulation of the serotoninergic system through pharmacological use of fluoxetine was able to reverse the deleterious effects of overnutrition during lactation, enabling better brain development and delaying the development of pathologies and oxidative stress.

Autonomic Nervous System: A Therapeutic Target for Cardiac End-Organ Damage in Hypertension.

More than 1.5 billion people worldwide have arterial hypertension. Hypertension increases the risks of death and cardiovascular disease, such as atrial fibrillation and heart failure. The autonomic nervous system plays an essential role in hypertension development and disease progression. While lifestyle factors, such as obesity and obstructive sleep apnea, predispose to hypertension by increasing sympathetic activity, hypertension itself maintains the autonomic nervous imbalance, providing the substrate for atrial fibrillation and heart failure. Therefore, autonomic nervous system modulation either by direct targeting or indirect treatment of comorbidities has the potential to treat both hypertension and related atrial and ventricular end-organ damage. We discuss interventions for the modulation of the autonomic nervous system for hypertension and related cardiac end-organ damage, including pharmacological adrenergic beta-receptor blockade, renal denervation, carotid baroreceptor stimulation, low-level vagal stimulation, and ablation of ganglionated plexuses. In summary, the literature suggests that targeting the autonomic nervous system potentially represents a therapeutic approach to prevent atrial and ventricular end-organ damage in patients with hypertension. However, clinical trials specifically designed to test the effect of autonomic modulation on hypertension-mediated cardiac end-organ damage are scarce.

Lack of effect of cAMP modulation during pre-maturation in vitro on development to the blastocyst stage and expression of specific genes associated with lineage commitment

Pharmacological elevation of cAMP of cultured cumulus-oocyte complexes (COC) before or coincident with initiation of maturation has been reported to improve outcomes for various systems for in vitro production of embryos. Here it was hypothesized that artificial elevation of cAMP in the oocyte for a 2-h period of pre-maturation would improve developmental competence of matured oocytes and result in increased blastocyst yield and alter expression of genes important for embryonic differentiation. Treated COC were cultured for 2 h with dibutyryl cAMP (dbcAMP), a membrane-permeable form of cAMP, and 3-isobutyl-1-methylxanthine (IBMX), which inhibits phosphodiesterases that convert cAMP to ATP. Subsequently, oocytes were matured and fertilized and the resultant embryos cultured for 7.5 d. There was no effect of treatment on the percent of oocytes or cleaved embryos becoming blastocysts or on transcript abundance of EOMES, GATA4, NANOG, SOX2, or SOX17 in the blastocyst. Results do not support the use of pharmacological enhancers of cAMP concentrations in the oocyte for improving the blastocyst yield following in vitro oocyte maturation, fertilization, and embryo culture.

Review on Therapeutic Diversity of Oxazole Scaffold: An Update

AbstractOxazole, a five‐membered cyclic ring containing oxygen and nitrogen, displays diverse interactions and structural variations, enhancing its potential applications across various domains. Oxazole derivatives exhibit diverse pharmacological activities, including antidiabetic, anticonvulsant, anticancer, phosphodiesterase inhibition, antiprotozoal, and antibacterial effects, making them appealing to medicinal chemists. Their presence in naturally occurring pharmacologically active substances as well as synthetic medicines underscores their therapeutic potential. This review encompasses recent advancements in the biological activities of oxazole derivatives during the period of 2018–2023. The discussed activities include antitumor, central nervous system (CNS) modulation, antidiabetic, anti‐Alzheimer, antibacterial, and enzyme inhibitory effects. The review highlights the mechanisms of action of these compounds in various diseases, the most potent compounds along with their respective IC50/MIC (inhibitory concentration/minimum inhibitory concentration) values, and discusses the models utilized for quantifying their activity. Currently, there are eight FDA‐approved drugs bearing oxazole scaffolds available in the market. Analysis of the literature reveals that the antitumor activity of oxazole derivatives is particularly noteworthy among their various activities. The incorporation of phenyl, methoxyphenyl, or halogen‐substituted phenyl moieties significantly enhances therapeutic activities compared to reference drugs. The substitution flexibility at three positions of oxazole derivatives contributes to their spectrum of pharmacological activities.

Randomized Clinical Trial: Bone Bioactive Liquid Improves Implant Stability and Osseointegration.

Implant stability can be compromised by factors such as inadequate bone quality and infection, leading to potential implant failure. Ensuring implant stability and longevity is crucial for patient satisfaction and quality of life. In this multicenter, randomized, double-blind clinical trial, we assessed the impact of a bone bioactive liquid (BBL) on the Galaxy TS implant's performance, stability, and osseointegration. We evaluated the impact stability, osseointegration, and pain levels using initial stability quotient (ISQ) measurements, CBCT scans, and pain assessment post-surgery. Surface analysis was performed using scanning electron microscopy (SEM) and atomic force microscopy (AFM). In vitro studies examined the BBL's effects on dental pulp pluripotent stem cells' (DPPSCs') osteogenesis and inflammation modulation in human macrophages. All implants successfully osseointegrated, as demonstrated by the results of our clinical and histological studies. The BBL-treated implants showed significantly lower pain scores by day 7 (p < 0.00001) and improved stability by day 30 (ISQ > 62.00 ± 0.59, p < 8 × 10-7). By day 60, CBCT scans revealed an increased bone area ratio in BBL-treated implants. AFM images demonstrated the BBL's softening and wettability effect on implant surfaces. Furthermore, the BBL promoted DPPSCs' osteogenesis and modulated inflammatory markers in human primary macrophages. This study presents compelling clinical and biological evidence that BBL treatment improves Galaxy TS implant stability, reduces pain, and enhances bone formation, possibly through surface tension modulation and immunomodulatory effects. This advancement holds promise for enhancing patient outcomes and implant longevity.

Platelet-derived extracellular vesicles in cardiovascular disease and treatment - from maintaining homeostasis to targeted drug delivery.

Cardiovascular disease (CVD) remains a major global health burden. Rising incidences necessitate improved understanding of the pathophysiological processes underlying disease progression to foster the development of novel therapeutic strategies. Besides their well recognized role in CVD, platelet-derived extracellular vesicles (PEVs) mediate inter-organ cross talk and contribute to various inflammatory diseases. PEVs are readily accessible diagnostic biomarkers that mirror pathophysiological disease progression but also may confer cardioprotective properties. Monitoring the effects of modulation of PEV signatures through pharmacotherapies has also provided novel insights into treatment efficacy. Furthermore, exploiting their inherent ability to infiltrate thrombi, atherosclerotic plaques and solid tumours, PEVs as well as platelet-membrane coated nanoparticles are emerging as novel effective and targeted treatment options for CVD and cancer. Collectively, in-depth characterization of PEVs in various diseases ultimately enhances their use as diagnostic or prognostic biomarkers and potential therapeutic targets, making them clinically relevant candidates to positively impact patient outcomes.

Modulation effects of repetitive transcranial magnetic stimulation on target and indirect target nodes in patients with major depressive disorder

Clinical studies intensively highlight two critical brain regions, i,e, dorsal lateral prefrontal cortex (DLPFC) (target node) and subgenual anterior cingulate cortex (sgACC) (indirect target node) for the treatment of neuroimaging-guided repetitive transcranial magnetic stimulation (rTMS) in major depressive disorder (MDD). However, it remains unclear whether the clinical rTMS treatment could modulate the activity of the target and indirect target nodes in MDD patients. We aim to identify the rTMS-induced alteration of brain local and functional connectivity (FC) activities in the target and indirect target nodes. 38 patients with MDD were recruited for taking part in the 2-week rTMS treatment. We identified left DLPFC and right sgACC as the target and indirect target nodes for each participant, using the neuroimaging guided method, and further explored the rTMS-induced modulation on the brain functional activity of the two nodes. Ultimately, 28 patients were included in the analysis. We found that subjects had significant improvement in depressive symptoms, and their brain functional activities were reorganized. rTMS reduced the FC activity between the target and indirect target nodes, while the brain local activity in these nodes did not show rTMS-induced changes. The FC reduction was not associated with improvement in depressive symptoms. These results confirmed the clinical significance of the target node (DLPFC) and indirect target node (sgACC) in the rTMS treatment of MDD, and further shed light on the brain functional reorganization underpinning clinical practice of rTMS.

Nonlinear Crack-Wave Modulations in Shear Horizontal Wave Propagation for Fatigue Crack Detection

The nonlinear interaction of shear horizontal waves with fatigue cracks is investigated for structural damage detection. The focus is on the non-classical modulation effect in the presence of damage. The major principle of the method is explained theoretically and supported by a semi-analytical solution. The method is tested experimentally in aluminium beams with fatigue cracks. A combination of high-frequency ultrasonic and low-frequency vibration shear excitations are introduced to monitored beam components using low-profile piezoceramic shear actuators. Nonlinear vibro-acoustic responses are gathered using laser vibrometry. Vibration excitation frequencies are selected using experimental and numerical modal analysis. A series of vibro-acoustic experiments is performed for fatigue crack detection. The results show that the non-classical nonlinear vibro-acoustic effect – based on shear horizontal wave propagation – can be used for crack detection. In addition, the method also allows for damage localisation.

Mechanisms of Reappeared Period Shifts of Internal Solitary Waves Based on Mooring Array Observations in the Northern South China Sea

AbstractMooring observations have revealed that the daily reappeared time (DRt) of internal solitary waves (ISWs) in the northern South China Sea (SCS) manifests systematic shifts. This study aims to reveal the dynamic mechanisms behind this phenomenon using the theory of modulation of shear flow to the internal tide wave (IT) propagation. Approximate solutions for the frequency modulation function (FMF) and the amplitude modulation function (AMF) of ITs are derived and validated by the mooring array measurements on the northern SCS continental shelf in 2019 and 2020. Namely, the mechanisms of the ISW reappeared period shift (RPS derived from DRt) and amplitude variation are attributed to the modulation of low‐frequency flow with a period of about 7 days to ITs. The FMF is induced by the vorticity of the low‐frequency flow (FS1) and the Doppler shift (FS2). Thus, the sign of the FMF value may be positive (blue shift) and negative (red shift), depending on the algebraic summation of the two terms. The FS2 derived from mooring observed velocities confirms the modulation effects of mean current on the frequency shift and the amplitude variation of ITs and ISWs.

Superposition and Amplitude Modulation Effects in Separated Flow

Abstract This article adopts direct numerical simulation method to study concave cavity flow with high Reynolds number, and explores the influence of outer region structure on inner region turbulence of concave cavity flow, as well as the mechanism of coherent structure in the near wall region of concave cavity flow. This article finds that the superposition and amplitude modulation effects of separated flow are weaker than those in smooth wall turbulence. At different positions within the concave cavity, the superposition effect in the reattachment zone is the strongest, while the superposition effect in the separation zone is the weakest, indicating that flow separation prevents large-scale structures from outer region penetrating into the near wall region. The amplitude modulation effect of the reattachment point is the strongest, which is related to the strong adverse pressure gradient of the reattachment point.

Electrostatic Gating-Dependent Multiple Band Alignments in Ferroelectric α-In2Se3/α-Te van der Waals Heterostructures.

The two-dimensional ferroelectric van der Waals (vdW) heterojunction has been recognized as one of the most promising combinations for emerging ferroelectric memory materials due to its noncovalent bonding and flexible stacking of various materials. In this work, the first-principles calculations were performed to study the stable geometry and electronic structure of α-In2Se3/α-Te, incorporating the vdW correction via the DFT-D2 method. The reversal of the polarization direction in α-In2Se3 can induce a transition in the heterostructure from metallic to semiconductor, accompanied by a shift from type-III to type-I band alignment. These changes are attributed to variations in interfacial charge transfer. Analysis of the modulation effects of external electric fields reveals that the P↑ α-In2Se3/α-Te configuration maintains metallic, whereas the P↓ α-In2Se3/α-Te configuration exhibits a linear reduction in band gap. Furthermore, both heterostructural configurations will undergo transitions to type-II band alignment transitions at 0.2 V Å-1 and within a range from 0.2 to 0.3 V Å-1 under external electric fields. Our findings offer valuable insights for applications such as ferroelectric memory and static gate devices with multiband alignment.