Modified Radical Operation Research Articles

The Effect of Arita in Postoperative Drainage of Patients with Breast Cancer Modified Radical Surgery

Purpose: To study the application of Arista in breast cancer modified radical surgery, whether there is any effect on postoperative drainage. Methods: To collect the data of patients who have undergone breast cancer modified radical surgery in our hospital within two years; It was divided into control group, single dose group, double dose group and multi-dose group, and compared with those in the four groups. Results the flow rate of the single dose group was faster than that of the control group, and the double-dose group was better than that of the single dose group, and there was no significant difference between the two groups. Conclusion in the treatment of breast cancer modified radical operation, it can significantly reduce the tissue exudation and reduce the induced flow, and the overuse does not have a better effect.

Clinicopathological features and treatment of bilateral asynchronous breast cancer: report of 13 cases

Objective To analyze the clinicaopathological features and treatment of bilateral asynchronous breast cancer. Methods The clinical and pathological data of 13 patients with bilateral asynchronous breast cancer admitted in our hospital from 2010 to 2016 were retrospectively reviewed. Results The bilateral asynchronous breast cancer accounted for 1.7% of all breast cancer patients admitted in the same period (13/782). The median age of patients at first onset was 47. The modified radical operation was the main surgical modality (12/13 for the first cancer; 8/13 for the second cancer). The clinical stage Ⅱ was predominant in all patients (10/13 of the first cancer; 9/13 of the second cancer). Invasive ductal cancer was the most common pathologic type (in 11/13 of the first cancer; 11/13 of the second cancer). Hormone receptors were highly expressed in most of the cases (9/13 of the first cancer; 7/13 of the second cancer). The disease-free interval was more than 10 years in most cases (8/13). Among 13 cases local recurrence was detected in 1 case, distant metastases in 2 cases, and 1 case died from distant metastasis. Conclusion The bilateral asynchronous breast cancer has a low incidence; however, a close follow up is necessary for early detection and treatment of the second carcinoma. Key words: Breast neoplasms; Neoplasms, multiple primary; Pathology conditions, signs and symptoms; Treatment outcome

Expression of ERβ gene in breast carcinoma and the relevance in neoadjuvant therapy

In the present study, we examined the expression of the estrogen receptor β (ERβ) gene in breast cancer and its relevance in neoadjuvant therapy. In total, 120 breast cancer patients who were hospitalized in the Departments of Breast Disease and Medical Oncology served as the subjects of this study. The subjects were diagnosed with breast cancer phase II to phase IIIA, as confirmed by aspiration biopsy and iconography. The patients were divided into two groups in a randomized control manner, with 60 patients in each group. The experimental group was administered the taxotere + epirubicin + cyclophosphamide (TEC) plan for 3–4 cycles of chemotherapy before the modified radical operation of breast cancer. In the control group, no TEC chemotherapy was carried out prior to operation. Instead, the breast lesion was removed directly by operation. After the operation, the IHC method was used to stain the ERβ protein in the lesion tissue. The patients were classified according to whether the basement membrane was broken through; 5 cases had non-infiltrative carcinoma and 115 cases had infiltrative carcinoma. According to the pathology of the lesion, 114 cases had breast ductal carcinoma, 2 cases had mucinous breast carcinoma (of which there were 2 cases combined with ductal carcinoma), and 4 cases had breast lobular carcinoma. The ERβ gene was found to be expressed in normal and breast cancer tissues. When ERβ gene expression was compared before and after the chemotherapy, its expression was significantly increased in breast cancer tissues, which shows a significant statistical difference (P<0.05). In the experimental group, the expression of ERβ gene in carcinoma tissue was significantly lower than that in the control group, and differences were statistically significant (P<0.05). Therefore, expression of the ERβ gene in breast carcinoma tissues was high. The application of adjuvant chemotherapy before the modified radical operation for breast carcinoma can significantly lower the level of ERβ expression. The expression levels of ERβ gene in the carcinoma tissue of the patients can be treated as the evaluation index for neoadjuvant chemotherapy. Regarding targeted therapy and corresponding drug development for breast carcinoma, ERβ can act as one of the specific drug targets.

Clinical and prognostic analysis of 21 cases of primary breast lymphoma

目的探讨原发性乳腺淋巴瘤（PBL）患者临床特征及治疗方法对预后的影响。方法对2003年至2013年所收治的21例PBL患者的临床资料进行回顾性分析。根据治疗方案的不同对患者进行分层分析，比较手术、预防性腰穿鞘注、利妥昔单抗应用对患者疗效和预后的影响。结果21例患者中6例行乳腺肿块穿刺活检术，2例行乳腺癌改良根治术，其余均行单纯乳腺肿块切除术后经病理学检查明确诊断。其中弥漫大B细胞淋巴瘤（DLBCL) 17例，黏膜相关淋巴组织结外边缘区B细胞淋巴瘤（MALT淋巴瘤）、滤泡性淋巴瘤、Burkitt淋巴瘤、皮下脂膜炎样T细胞淋巴瘤各1例。所有患者中仅1例肿块直径>7 cm (MALT淋巴瘤患者），其余均<5 cm。治疗后完全缓解（CR)19例，部分缓解和疾病进展各1例。中位随访14(6~75)个月，21例患者中1例死亡，3年总生存（OS)率为92.3%。化疗+手术组(15例）患者的无进展生存（PFS)时间较单纯化疗组（6例）延长，差异有统计学意义（60个月对22个月，P=0.015），但两组患者的CR率和OS时间差异无统计学意义（P值均>0.05）。20例CD20阳性患者中接受利妥昔单抗治疗者17例，与未接受的3例比较，CR率和PFS、OS时间差异均无统计学意义（P值均>0.05）。8例患者接受预防性腰穿鞘注治疗，与13例未接受者比较，中枢神经系统浸润发生率差异无统计学意义(P=0.381)。结论PBL以DLBCL多见，治疗效果较好，手术治疗仅为明确诊断，并不延长患者OS时间。PBL患者行预防性腰穿鞘注治疗不降低中枢神经系统浸润发生率。

Perioperative nursing of 20 cases with endoscope-assisted modified radical opera-tion for preserving nipple-areola and I-stage breast prosthesis reconstruction

Objective To explore perioperative major nursing in the treatment of patients with endoscope -assisted modified radi-cal operation for preserving nipple -areola andⅠ-stage breast prosthesis reconstruction.Methods A total of 20 cases of medical records were reviewed and nursing plan and methods were analyzed , nursing experiences were summarized.Results The 20 patients’reconstructed breasts were symmetrical with beautiful contour , the cases made a excellent functional recovery of the ipsilateral upper extremity.The pa-tients were followed up from five months to 29 months with an average of 15 months.There was no operative complication in these cases such as recurrence and metastasis.Conclusions The endoscope-assisted modified radical operation for preserving nipple -areola and I-stage breast prosthesis reconstruction has the advantages including less surgery trauma , rapid recovery and good cosmetic results.Given strength-ened perioperative nursing can decrease the occurrence of postoperative complications , improve the patient’s life quality and recovering. Key words: Breast cancer; Endoscope; Prosthesis replacement; Breast reconstruction; Nursing

Application of mastoscopic in modified radical operation for preserving nipple-areolar complex

Objective To probe the effect of mastoscopic in modified radical mastectomy operation for preserving nippleareolar complex in the treatment of breast cancer.

Microvasculature, blood flow, and vasoreactivity in rabbit sinus mucosa after surgery.

To study the circulatory integrity of the sinus mucosa following surgery, the vascular anatomy, blood flow, and vasoconstrictor response of the regenerated microcirculatory network were analyzed. Forty-six New Zealand White rabbits were operated on unilaterally with either a modified radical operation (MRO) or middle meatal antrostomy (MMA), using the nonoperated sinus for control purposes. After surgery, the animals were left to heal for 1 month. Vascular casts were prepared with a low-viscosity methyl methacrylate resin and studied by scanning electron microscopy. Blood flow was measured by means of radiolabeled microspheres (tin 113 [113Sn]). The vasoconstrictor response to oxymetazoline at increasing concentrations was measured with laser Doppler flowmetry. The number of vessels increased significantly in the regenerated mucosa. The vascular casts displayed a rich microcirculation with local signs of angiogenesis. However, there was no difference in blood flow between the operated cavities and their control sides. Following MRO the regenerated mucosa was more sensitive to the vasoconstrictor effect of oxymetazoline, compared with the control side. This difference was not evident in the MMA-operated sinuses. In this model, surgery does not seriously interfere with the sinus blood flow, although the regenerated mucosa did display an altered vasoreactivity. These findings should be considered in relation to the effects of surgery intended to limit local inflammation and to ensure the ventilation of the sinuses.

Effects of surgery on mucosal pathologic changes following experimental sinusitis in rabbit.

In the present investigation, the regenerative capacity of the infected maxillary sinus mucosa following surgical procedures was studied in a rabbit model. Sinusitis was induced by occluding the ostium with and without the addition of Staphylococcus aureus or Bacteroides fragilis, or by provoking a prolonged bacterial infection with both pathogens. The surgical procedures performed were 1) widening of the natural sinus ostium (middle meatal antrostomy; MMA) and 2) removal of sinus mucosa without ostial interference (modified radical operation; MRO). The histologic features of the entire nose-sinus complex were studied, graded semiquantitatively, and compared with findings in untreated sinusitis, or after surgery only. Whereas MMA and MRO both led to a decrease of the inflammatory features of the sinus mucosa in induced sinusitis, persistent local histopathology was observed in the ostial region following MMA surgery. This indicates the importance of local pathologic changes resulting from interactions of bacterial colonization, inflammation, and surgery in chronic sinusitis.

Results of total middle ear reconstruction surgery for postoperative modified radical operation cases

Results of total middle ear reconstruction surgery for postoperative modified radical operation cases

The macroscopic diagnosis of lymph node metastasis from early gastric cancer

As the proportion of early gastric cancers (EGC) has been steadily increasing, modifications of the "radical lymphadenectomy" approach to stomach cancer have been attracting considerable attention; however, accurate pre- and intraoperative evaluations of tumor extent are essential for the successful application of this method. We examined the reliability of macroscopically diagnosing node involvement by reviewing the operative and pathological records of 522 patients with EGC. Of 59 patients histologically diagnosed as node-positive (n+), only 19 (32%) had been macroscopically diagnosed as node-positive (N+). In contrast, of 61 N+ patients, 42 (69%) were in fact n-. Metastases from histologically diffuse type carcinomas were less accurately diagnosed than those from intestinal type tumors. In 44% of the false-positive (N+/n-) patients, the tumor had been preoperatively diagnosed as advanced, which seemed to have lead to intraoperative overdiagnosis. These results suggest that lymph node metastases from EGC cannot be reliably diagnosed during surgery. The indications for a modified radical operation should thus be decided according to preoperative tumor evaluation based on the depth of invasion.

Surgical hearing rehabilitation of the chronic suppurating middle ear.

Since 1946, when I initiated my practice in otosclerosis surgery, I have felt confident that the new technique brought about by fenestration would substantially improve functional prognosis in the surgery of chronic middle ear infections. In February, 1950, I published my first work 1 in this field, on a type of operation which I called semiconservative, an improvement of Ramadier's antroattical emptying procedure and similar to the modified radical operation. In semiconservative operation middle ear structures are much more respected and preserved than in radical procedure. In a consecutive series of operations an average postoperative hearing level of 43.9 db. was obtained (Fig. 1). However, the attainment of complete social level was not possible in most cases, owing to the fact that the physical features of a middle ear treated by this procedure were not favorable for a correct transmission and transformation of Submitted for publication May 6, 1958. Public

Chronic Suppurative Otitis Media. Modified Radical Operation

Chronic Suppurative Otitis Media. Modified Radical Operation

Bilateral Chronic Suppurative Otitis Media. Acute Serous Labyrinthitis of Right Ear. Radical Mastoid Operation in Quiescent Stage. Modified Radical Operation Left Ear

Bilateral Chronic Suppurative Otitis Media. Acute Serous Labyrinthitis of Right Ear. Radical Mastoid Operation in Quiescent Stage. Modified Radical Operation Left Ear

THE MODIFIED RADICAL OPERATION ON THE MASTOID

A modified radical operation on the mastoid was devised with the idea of removing the diseased bone in selected cases of chronic suppurative otitis media and conserving or improving the hearing by leaving undisturbed the membrana tympani and the ossicles. Early in the nineties, soon after the introduction of the radical operation, Panse, Scheibe and Jansen were the first who made any attempt to preserve the ossicles. In 1897, Stacke recommended their preservation, and later Siebenmann several times made the same recommendation. Stacke's first case was reported in 1895, and the observations were published in 1897; in 1911, he¹wrote of his method of operation, giving the indications and technic. In 1909, Bondy²reported having performed the operation on a number of patients and enumerated his ideas of the indications and his operative steps. In 1912, Bárány³published a report on "Conservative Radical Operation

A modified radical operation for chronic suppurative otitis media. Presentation of patients showing results

The LaryngoscopeVolume 34, Issue 3 p. 210-213 Article A modified radical operation for chronic suppurative otitis media. Presentation of patients showing results† Dr. Hugh B. Blackwell, Dr. Hugh B. Blackwell New YorkSearch for more papers by this author Dr. Hugh B. Blackwell, Dr. Hugh B. Blackwell New YorkSearch for more papers by this author First published: March 1924 https://doi.org/10.1288/00005537-192403000-00008 † Read before the Section on Otology, New York Academy of Medicine November 9, 1923. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Volume34, Issue3March 1924Pages 210-213 RelatedInformation

X. Results in Four Cases of a Modified Radical Operation for Chronic Purulent Otitis Media

X. Results in Four Cases of a Modified Radical Operation for Chronic Purulent Otitis Media

LIV. A Modified Radical Operation for Chronic Suppurative Otitis Media

LIV. A Modified Radical Operation for Chronic Suppurative Otitis Media