Boron nitride (α-crystal modification) with significant surface non-uniformity was treated in a high-frequency, low-temperature plasma. The properties of the starting and modified samples were analysed by gas chromatography. Retention values and heats of adsorption for close-to-zero coverage of the surface for several compounds were determined. The chromatographic properties of α-boron nitride samples treated in plasma are improved. The retention time decreases and the symmetry of chromatographic peaks of oxygen-containing compounds is improved. This allows the modified boron nitride to be used for the separation of different mixtures.