Modification Of Porphyrins Research Articles

Synthetic transformations of porphyrins – Advances 2002-2004

Contemporary methods for the modification of porphyrins are presented. In association with the Third International Conference on Porphyrins and Phthalocyanines (ICPP-3) a survey of current method developments and reactivity studies is made. The review focuses on synthetic transformations of porphyrins currently in use for various applications and on functional group transformations. A brief survey of important developments covers selectively the literature from late 2001 to early 2004.

ChemInform Abstract: Porphyrins. Part 38. Reaction of Porphyrins Containing Hydroxy(alkoxy)ethyl or Alkoxymethyl Substituents with Nucleophiles in the Presence of Zinc Acetate. A Novel, Promising Method for the Modification of Porphyrins on the Periphery of the Macrocycle.

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Porphyrins. 38. Reaction of Porphyrins Containing Hydroxy(alkoxy)ethyl or Alkoxymethyl Substituents with Nucleophiles in the Presence of Zinc Acetate. A Novel, Promising Method for the Modification of Porphyrins on the Periphery of the Macrocycle

Porphyrins which contain 1-hydroxy(alkoxy)ethyl or alkoxymethyl substituents on the periphery of the macrocycle (i.e. formally able to yield “benzyl type” carbocations) react with nucleophiles (4-tert-butylphenol or the β-diketones acetylacetone, benzoylacetone, dibenzoylmethane, or 4,4,4-trifluoro-1-(2-thienyl)-1,3-butanedione) in the presence of excess zinc acetate. They give high yields of the corresponding addition products, which are the zinc complexes of porphyrins with a 1-(4-tert-butylphenoxy)ethyl substituent or with substituents containing β-diketone residues.

Synthesis of Mono- and Di(oxopyri)porphyrins: A New Approach through Ring Enlargement with Diazomethane

A novel approach for porphyrin modification is provided by ring-enlargement reactions. Treatment of dioxochlorins (see scheme) and tetraoxobacteriochlorins with diazomethane results in formation of the corresponding mono- and di(oxopyri)porphyrins.

47] Hemoglobin porphyrin modification

This chapter provides information on hemoglobin porphyrin modification. Generally, hemoglobin porphyrin modifications are performed in four steps, which are (1) preparation of globin, (2) chemical modification of hemes and porphyrins, (3) recombination of globin with modified hemes, and (4) purification of the reconstituted hemoglobin. Hemoglobin in red blood cells and myoglobin in muscle are important oxygen-carrying hemoproteins consisting of an oxygen-binding group, heme, and globin. Neither heme nor globin combines with oxygen reversibly; therefore, this function of hemoglobin and myoglobin must be related to the interaction between heme and globin. An excellent technique for the study of this interaction is the chemical modification of the heme in hemoglobin. Combination of globin with hemin is a physiological process in vivo because these two components are known to be synthesized separately in the cells. In addition, it is possible to investigate the effect of electron distribution of the heme on the ligand affinity and optical property of hemoglobin by using various reconstituted hemoglobins.