1.1. Seven cases of pituitrin shock occurring under anesthesia are reported, two in detail. A brief review of the pertinent literature is presented.2.2. Pituitrin shock may be a manifestation of (a) anaphylaxis, frequently due to previous sensitization with a posterior pituitary preparation, or (b) coronary artery constriction with resulting myocardial anoxia, cardiac dilatation, and decreased cardiac output.3.3. Therapy in the unanesthetized patient, whether due to anaphylaxis or coronary constriction, should consist of adrenalin (or ephedrine), intravenous fluid, and oxygen. In the patient anesthetized with ether or cyclopropane, adrenalin (or ephedrine) might prove deleterious to the patient, and therapy should be confined to the use of intravenous fluid and oxygen.4.4. Modes of usage of pituitrin are discussed with a view toward elimination of shock reaction.