Modern Surgery Research Articles

The Evolution of Skull Base Surgery: A Bibliometric Analysis Spanning Nearly 125 Years

Abstract Introduction Skull base surgery has evolved from fundamental elements into a distinct multidisciplinary specialty. Using bibliometrics, we appraised the literature pertaining to skull base surgery since 1900 and studied the emergence of the specialty as a scholarly field. Methods We queried Web of Science for all content from past presidents of the North American Skull Base Society (N = 31) and their self-identified forebears, influences, contemporaries, and trainees (N = 115). Statistical and bibliometric analyses were performed using various Python packages on article metadata. Results Our query returned 28,167 articles. The most pertinent works (N = 15,529), identified algorithmically through an analysis of terms in titles, were published between 1900 and 2024 by 15,286 authors. The field exploded in the latter half of the 20th century, concurrently with increased interdisciplinary and international collaboration, and contemporaneously with the formation of centers of excellence and influential societies. Since 1950, prolific contributors to the field from neurosurgery, otolaryngology, radiology/radiation oncology, plastic surgery, and ophthalmology have increasingly subspecialized in skull base topics. The proportion of female authors in the corpus has grown from <1% in 1980 to 17% in 2023. We identify the articles that comprise the historical roots of modern skull base surgery, map the emergence of fundamental terminology within the corpus, and identify the authors who stand as key nodes of collaboration and influence. Conclusion The field of skull base surgery was born from pioneering individuals with training in varied disciplines. The coalescence of skull base surgery into a distinct and diversified subspecialty has been powered by dedicated collaborative efforts on a global scale.

Photo-crosslinking modified gelatin-silk fibroin hydrogel for accelerating wound repair of open abdomen

Open abdomen (OA), a major advance in modern trauma surgery, enables the treatment of severe abdominal trauma, infections, and hypertension by temporarily closing the abdominal cavity without suturing. Although OA can reduce mortality rates, it also presents challenges such as disruption of the abdominal environment, intestinal exposure, and impaired wound healing. Current temporary abdominal closure (TAC) techniques using polypropylene (PP) mesh are susceptible to abrasion and rupture of the intestine, leading to adhesions and serious complications such as intestinal fistulas and chronic wounds. These complications seriously impact outcomes due to mesh rigidity and its incompatibility with surrounding tissues. In this study, we designed a multifunctional hydrogel composed of GelMA (Gelatin Methacryloyl) and SilMA (Silk Fibroin Methacryloyl) as a promising solution for open abdominal wound repair. In vitro experiments confirmed the biocompatibility, self-healing properties, pro-angiogenic effects, and promotion of macrophage polarization. In vivo studies revealed that the GelMA-SilMA hydrogel could enhance abdominal wall tissue thickness and integrity via isolating the peritoneal cavity, protecting the intestinal tract, polarizing macrophages, promoting collagen formation, inducing neovascularization, inhibiting oxidative stress, and suppressing inflammation. Furthermore, immunofluorescence, immunohistochemistry, and RNA sequencing were employed to evaluate the wound healing mechanisms of GelMA-SilMA hydrogels. The results demonstrated that the hydrogels can promote angiogenesis, inhibit inflammation and immune responses, and enhance wound healing by activating the HIF-a-VEGF signaling pathway, RAP1 signaling pathway, and PI3K-AKT signaling pathway. Hence, the multifunctional GelMA-SilMA hydrogel has tremendous potential for clinical use in open abdominal wound repair.

Surgical Profile of Osteosarcoma Patients in a Tertiary Referral Hospital in Surabaya, Indonesia

Osteosarcoma is a rare malignant bone disease with unclear etiology. It is primarily a disease of childhood with rapid bone growth in periods of rapid bone proliferation [such as in puberty]. Before the 1970s, prognosis for this malignancy is very grim with the only available form of treatment are limb ablation [amputation]. The advent of modern chemotherapy, in addition to the development of modern limb salvage surgery [LSS] techniques, mortality has decreased and quality of life of surviors have increased. Indonesia is a developing country with unequal distribution of adequate health facilities. Studies have shown that unlike western countries, most osteosarcoma patients in Indonesia are still treated with limb ablation procedures. A retrospective descriptive study is done on Dr. Soetomo General Hospital to discover the surgical profile of patients undergoing chemotherapy during the period of 2014-2020. Results have shown that the majority [26] underwent amputation, 17 underwent no surgical treatment, and the rest [9] LSS. The results of this research shows that the clinical reality of developing nations like Indonesia is still far from the ideal clinical situation in developed western nations where these studies originate.

ACUTE PANCREATITIS: IS THERE ANY RELATIONSHIP BETWEEN HEMATOCRIT AND SEVERITY OF THE DISEASE?

Introduction. Acute pancreatitis (AP) is one of the unsolved clinical problems in the practice of modern gastroenterology, surgery, and emergency medicine, which does not lose its relevance even with the advent of modern and high-tech diagnostic and therapeutic solutions. The failure of modern methods to diagnose and stratify the severity of the disease in the early stages after hospitalization of patients lead to the loss of precious time at the beginning of resuscitation measures in severe forms of AP. The aim. To assess the presence and strength of the correlation between hematocrit count and the severity of AP on the first day of the disease. Materials and methods. Polychoric analysis and receiver operating characteristic (ROC) analysis were used to assess the association and predictive value of hematocrit with the severity of AP. Only patients who arrived at the hospital within 24 hours of the onset of the disease were included in the study. Results. The correlation coefficient φ2 between hematocrit (at the reference value of 45%) and severity of AP is 0.34. The coefficient of mutual conjugation of K. Pearson (C) is equal to 0.5 which indicates the presence of a relationship between the hematocrit count and the severity of AP. After conducting the ROC analysis, it was determined that with the isolated use of hematocrit indicator provided its value of > 44.4%, almost 70% of patients were diagnosed with severe AP; almost 90% of patients with a hematocrit level of £ 44.4% did not have severe AP. Also, due to the rather high values of the indicators of the prognostic capacity of the ROC analysis, it is possible to state about the presence of prognostic significance of hematocrit indicator for severe AP within the first day from the onset of the disease. Conclusions. Thus, the hematocrit number has a significant relationship with the severity of AP when calculated during the first day from the onset of the disease, which makes it promising for building systems of stratification of the severity of AP earlier than suggested by revised Atlanta criteria.

Obesity treatment in adolescents and adults in the era of personalized medicine.

In this multi-professional review, we will provide the in-depth knowledge required to work in the expanding field of obesity treatment. The prevalence of obesity has doubled in adults and quadrupled in children over the last three decades. The most common treatment offered has been lifestyle treatment, which has a modest or little long-term effect. Recently, several new treatment options-leading to improved weight loss-have become available. However, long-term care is not only about weight loss but also aims to improve health and wellbeing overall. In the era of personalized medicine, we have an obligation to tailor the treatment in close dialogue with our patients. The main focus of this review is new pharmacological treatments and modern metabolic surgery, with practical guidance on what to consider when selecting and guiding the patients and what to include in the follow-up care. Furthermore, we discuss common clinical challenges, such as patients with concurrent eating disorder or mental health problems, and treatment in the older adults. We also provide recommendations on how to deal with obesity in a non-stigmatizing way to diminish weight stigma during treatment. Finally, we present six microcases-obesity treatment for persons with neuropsychiatric disorders and/or intellectual disability; obesity treatment in the nonresponsive patient who has "tried everything"; and hypoglycemia, abdominal pain, and weight regain after metabolic surgery-to highlight common problems in weight-loss treatment and provide personalized treatment suggestions.

Revolutionizing thoracic surgery education: a bibliometric analysis of the past decade’s literature

ObjectivesThoracic surgery is a complex field requiring advanced technical skills and critical decision-making. Surgical education must evolve to equip trainees with proficiency in new techniques and technologies.MethodsThis bibliometric analysis systematically reviewed 113 articles on thoracic surgery skills training published over the past decade, retrieved from databases including Web of Science. Publication trends, citation analysis, author and journal productivity, and keyword frequencies were evaluated.ResultsThe United States contributed the most publications, led by pioneering institutions. Simulation training progressed from basic to sophisticated modalities and virtual reality emerged with transformative potential. Minimally invasive techniques posed unique learning challenges requiring integrated curricula.ConclusionOngoing investments in educational research and curriculum innovations are imperative to advance thoracic surgery training through multidisciplinary strategies. This study provides an evidentiary foundation to optimize training and address the complexities of modern thoracic surgery.

Autologous Tissue Repair and Total Face Restoration

Total face restoration remains a challenge in modern reconstructive surgery. After 17 years of experiments and preliminary clinical studies, a new concept of face prefabrication was developed for face restoration with autologous tissue. To evaluate the long-term results of face restoration with autologous tissue and report a finalized and standardized approach of face prefabrication. In this single-center long-term retrospective study, 32 patients who underwent total face restoration between 2005 and 2022 were reviewed. These patients underwent total facial reconstruction, which included flap prefabrication, 3-dimensional printing, tissue expansion, and flap transfer with aid of indocyanine green angiography (IGA). The flap first undergoes prefabrication by transferring vascularized fascia under the skin of the selected chest. A tissue expander is then placed under the fascia to create a large, thin, reliable skin flap after expansion. Once completed, the flap is transferred to the face during the second stage of the reconstruction. Intraoperative IGA is performed to guide the design of subsequent openings for facial fissures. Data were analyzed from July to September 2023. Flap healing, reconstructive outcome, and patient recovery were assessed during follow-up. Three questionnaires, including the 36-Item Short Form Health Survey (SF-36), Aesthetic and Functional Status Score of Facial Soft-Tissue Deformities/Defects, and the EuroQoL Health-Related Quality of Life (EQ-5D-5L), were used to evaluate the quality of life and satisfaction with facial aesthetic and functional status. Of 24 included patients, 14 (58%) were male, and the mean (range) age was 32.9 (8-62) years. The mean (range) follow-up was 5.6 (2-12) years. All patients reported a significant improvement in quality of life (SF-36), especially in mean (SD) social functioning (preoperative score, 53.65 [34.51]; postoperative score, 80.73 [19.10]) and emotional stability (preoperative score, 56.67 [25.55]; postoperative score, 71.17 [18.51]). A total of 22 patients (92%) went back to work. Mean (SD) facial aesthetic status (preoperative score, 4.96 [3.26]; postoperative score, 11.52 [3.49]; P < .001) and functional status (preoperative score, 11.09 [3.51]; postoperative score, 15.78 [3.26]; P < .001) also improved. In addition, there was a significant increase in overall satisfaction and self-reported health status (preoperative score, 8.13 [1.52]; postoperative score, 3.58 [2.31]). In this study, 5-year follow-up results suggested that this innovative approach to total face restoration offered a safe and valid option for indicated patients, with acceptable reconstructive and cosmetic outcomes.

Introduction. The technical landscape of modern epilepsy surgery

Introduction. The technical landscape of modern epilepsy surgery

КЛИНИКО-ЭКОНОМИЧЕСКАЯ ЭФФЕКТИВНОСТЬ ПРИМЕНЕНИЯ ФОТОДИНАМИЧЕСКОЙ ТЕРАПИИ В ЛЕЧЕНИИ ПАЦИЕНТОВ С ФЛЕГМОНАМИ ЧЕЛЮСТНО-ЛИЦЕВОЙ ОБЛАСТИ И ШЕИ

Background. Treatment of patients with phlegmon of the maxillofacial area is an urgent problem in modern maxillofacial surgery. Objective. To conduct a clinical and economic evaluation of the local photodynamic therapy (PDT) effectiveness during the postoperative period in comparison with traditional treatment in patients with phlegmon of the maxillofacial area and neck. Material and methods. Clinical and economic features of treatment of patients with a confirmed diagnosis of “Phlegmon of the maxillofacial area and neck” (ICD-10: L03.2) with local use of PDT were studied and analyzed. Economic efficiency was evaluated based on the cost-effectiveness analysis. The economic effect of preventing direct damage (for inpatient treatment, payment of temporary disability benefits) as well as indirect damage (loss of gross domestic product) because of reduced hospital length of stay has been determined. Results. The advantage of a local application of PDT both from a clinical point of view (reducing the time for cleansing a wound from purulent-necrotic masses, relieving edema, resolving infiltrate, the appearance of granulations, reduced length of inpatient treatment) and from an economic point of view (the overall economic effect for the period of inpatient treatment of 1 patient with PDT was 3092.67 BYN) has been shown. Conclusion. The results demonstrate the clinical and economic feasibility of wider local use of PDT in the complex treatment of patients with phlegmon of the maxillofacial area and neck.

ИЗМЕНЕНИЯ БИОХИМИЧЕСКИХ ПОКАЗАТЕЛЕЙ КРОВИ У КРЫС ЛИНИИ WISTAR ПОСЛЕ ИМПЛАНТАЦИИ ФРАГМЕНТОВ СОСУДИСТЫХ ПРОТЕЗОВ

Background. This article deals with the use of biological vascular grafts made from bovine xenopericardium as a plastic material for reconstructive operations on the great vessels, which is one of the most important topics in modern vascular surgery. Aim. To compare changes in blood biochemical parameters in Wistar rats after implantation of fragments of biological and synthetic vascular grafts. Material and methods. The experimental study was performed on male laboratory Wistar rats (n = 50). The animals were divided into two groups: group 1 included 25 animals with implantation of a Dacron vascular graft; group 2 was composed of 25 animals with implantation of a vascular graft made from bovine xenopericardium. Blood samples from the laboratory rats were collected on days 3, 7, 14, 21 and 30 after the operation. Plasma urea, creatinine, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and lactate dehydrogenase levels were measured. Results. No clinically significant changes in concentrations of low molecular weight metabolites of nitrogen metabolism or liver enzymes activity, alkaline phosphatase and lactate dehydrogenase activity were observed after implantation of a biological vascular graft from bovine xenopericardium compared to the animals with implanted synthetic vascular graft. Conclusion. The use of a biological vascular graft made from bovine xenopericardium does not cause clinically significant changes in blood biochemical parameters in laboratory rats.

Mini-invasive video thoracoscopic interventions in patients with acute pleural empyema

The use of video thoracoscopic interventions in patients with acute pleural empyema is gaining momentum in modern thoracic surgery. The need of determining the optimal timing of their implementation depending on the duration of the disease and the nature of changes in the parietal and visceral pleura remains open. The nature of changes in the parietal and visceral pleura of 249 patients with acute pleural empyema treated with video thoracoscopic interventions was evaluated. Patients were divided into 5 groups depending on the duration of the disease. It was determined that fibrinous accumulations in acute pleural empyema are replaced by cavity fragmenting formations after 6 weeks from the onset of the disease. The cessation of purulent exudate accumulation and the duration of pleural drainage after thoracoscopy depends on the duration of the disease at the time of thoracoscopy, as evidenced by the duration of pleural drainage in the period up to one month – 8 days from the onset of the disease, up to two months – 15 days, and after 8 weeks of duration – reached 20 days. The main indications for open surgical intervention in this group of patients were the failure of fractional lavage of the empyema cavity due to drainage or the impossibility of adequate rehabilitation according to the presence of a bronchopleural fistula with a duration of its existence of no more than 1 month and no tendency to closure. Inflammatory changes in the pleura in the form of fibrin deposits and cavity fragmentation in pleural empyema increase rapidly enough, the possibility of its effective rehabilitation during thoracoscopy without open surgical interventions is limited to 6 weeks from the onset of the disease. Keywords: acute purulent diseases of the pleura, minimally invasive surgical treatment, sanitation of the pleural cavity, duration of the disease.

Особливості виникнення поширеного перитоніту та вплив поліморфізму гена 5,10-метилентетрагідрофолатредуктази

It is relevant in modern surgery to clarify the risk factors of widespread peritonitis and to improve the treatment and diagnostic algorithms for the management of such patients. Aim - to establish the features of the occurrence of widespread peritonitis and the influence of MTHFR gene polymorphisms on the risk of its occurrence. Materials and methods. The study included 100 patients who underwent surgical interventions for acute abdominal diseases complicated by peritonitis: acute appendicitis (48%), acute cholecystitis (32%), perforated ulcer of the stomach or duodenum (8%), tumor perforation (3%), injuries of the abdominal cavity (3%), pinched hernia (2%) and intestinal obstruction (4%). Genotypes of MTHFR gene polymorphisms rs1801131 and rs1801133 were determined by real-time polymerase chain reaction. Mathematical processing of the research results was carried out using the Statistica 10 program. Results. The risk of disseminated peritonitis was increased with perforated gastric or duodenal ulcer, tumor perforation, abdominal trauma, herniated hernia, or intestinal obstruction compared with acute appendicitis and cholecystitis. The risk of disseminated peritonitis was lower in II blood group carriers compared and was associated with temperature at hospitalization and pulse rate. Conclusions. The factors determining the risk of disseminated peritonitis in the multivariate regression model were the diagnosis, heart rate, and the rs1801131 genotype of the MTHFR gene. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.

Use of Vascular Shunt at the Time of Pancreatectomy with Venous Resection: A Systematic Review.

The rising diffusion of vascular resections during complex pancreatectomy for malignancy, for both oncological and technical matters, brought with it the use of vascular shunts, either temporary or definitive, to prevent bowel congestion and liver ischemia. This study aimed to systematically review the literature on the technical feasibility of vascular shunts during advanced pancreatic surgery, analyzing intraoperative and postoperative outcomes. A systematic literature search was performed on PubMed, Scopus, Web of Science, and the Cochrane Library Central, according to PRISMA guidelines. Studies published before 2006 were excluded, considering the lack of a standardized definition of locally advanced pancreatic cancer. The main outcomes evaluated were the overall complication rate and shunt patency. Among 789 papers retrieved from the database search, only five fulfilled the inclusion criteria and were included in the review, amounting to a total of 145 patients undergoing a shunt creation at the time of pancreatectomy. Pancreatic adenocarcinoma (PDAC) was found to be the most common diagnosis and pancreaticoduodenectomy was the main surgical procedure, accounting for 88% and 83% of the overall cohort, respectively. The distal splenorenal shunt was the most performed. Overall, 44 out of 145 patients (30%) experienced postoperative complications; the long-term patency of definitive shunts was 83% (110 out of 120 patients). An increasing number of patients with borderline resectable or locally advanced PDAC are becoming amenable to resection and shunt creation may facilitate vascular resection with clear margins, becoming a valid tool of modern pancreatic surgery.

COMPLICATIONS OF CONSERVATIVE AND SURGICAL TREATMENT OF FRACTURES OF THE MANDIBULAR CONDYLAR PROCESS (LITERATURE REVIEW)

One of the most pressing problems in modern maxillofacial surgery is the treatment and rehabilitation of patients with fractures of the condylar process of the mandible. According to various statistical data, the incidence of fractures at this site is 19-37%, and these fractures are the most controversial in terms of diagnosis and treatment. In recent years, there has been an increase in severe forms of mandibular condyle fractures: bilateral, combined, intra-articular, leading to serious complications that affect the functioning of the temporomandibular joint. The data obtained indicated the need for a detailed study of this pathology in order to make a qualitative diagnosis and improve the available treatment methods. The aim of the study – to analyse and summarise current data from the scientific literature on possible complications in the treatment of the condylar process fractures of the mandible. Materials and methods. The bibliosemantic method was used to clarify the state of the problem, to study the analysis of the results of previous scientific research based on the literature sources and electronic resources. Results and discussion. The management of patients with mandibular condylar fractures is widely discussed in the literature due to their high prevalence, but there is still no consensus on the optimal management of patients with this pathology. To date, there are many studies that highlight certain complications of conservative and surgical treatment, but they are not generalised or systematised. Conclusions. Summarizing, we can conclude that complications occur during both conservative and surgical treatment of patients with mandibular condyle fractures. Complications are most often associated with incomplete diagnosis, incorrect choice of treatment method, and depend on the method of access and fixation in surgical treatment.

Phantom sensation in genital gender-affirming surgery: a narrative review.

To review findings related to phantom genital sensation, emphasizing phantom sensation in the transgender and gender diverse (TGD) population. We discuss prevalence, presentation and potential implications for sensory outcomes in genital gender-affirming surgery. There is a high prevalence of phantom genital sensations in the TGD population. The prevalence varies by body part, approaching 50% in the most frequently reported transgender phantom - the phantom penis. Unlike genital phantoms that occur after trauma or surgery which are often painful, transgender phantoms are typically neutral and often erogenous in experience. Phantom sensation in the TGD population can be an affirming experience and important part of sexual well being and embodiment. Recent studies have begun to characterize the prevalence and presentations of phantom genital sensations in TGD people, informing our evolving understanding of the sensory experiences of the transgender and gender diverse population. Targeting integration of these centrally-mediated phantom genital sensations with the peripherally generated sensation from genital stimulation may represent one potential avenue to improve sensation and embodiment following genital gender-affirming surgical procedures. Additionally, emerging techniques in modern peripheral nerve surgery targeting phantom pain may offer potential treatment options for painful phantom sensation seen after cases of genital surgery or trauma.

Microbiological challenges in the treatment of war injuries

The treatment of war injuries represents a continuing and recurrent challenge in modern reconstructive surgery. Previously, tumor resections and sepsis-related resections were mainly responsible for lengthy bone defects in Germany. In recent years another picture has increasingly emerged, particularly caused by the medical support of Ukraine. Aspects of military surgery are also becoming more important in civil hospitals, especially in the treatment of gunshot and explosion injuries. In Germany, war injuries are currently secondarily treated, as the distribution of patients is carried out according to the cloverleaf principle, weeks or months after the occurrence of the primary injury. In addition to complex bone and soft tissue defects of the extremities following such injuries, which often affect neural and vascular structures, reconstruction is often complicated by an increasing spectrum of multidrug-resistant pathogens. The definition of microbiological terms, such as contamination, colonization, critical colonization, local and systemic infections are important in the clinical routine in order to initiate a targeted treatment, especially in treatment with antibiotics. Wound swabs for determination of the spectrum of pathogens and the optimal testing of resistance are important for selecting the appropriate antibiotic agents. The concept of antibiotic stewardship (ABS) is established in many hospitals to improve the quality of antibiotic treatment and to minimize the formation of resistance. The selection of the method of reconstruction depends on the condition of the patient, the overall clinical constellation and the function to be expected after completion of treatment. The treatment of injuries due to violence and terrorism necessitates clear concepts and an interdisciplinary approach, especially with respect to microbiological challenges and increasing resistance situations.

Does 5-ALA Fluorescence Microscopy Improve Complete Resectability in Cerebral/Cerebellar Metastatic Surgery? A Retrospective Data Analysis from a Cranial Center.

(1) Background: In this study, the intraoperative fluorescence behavior of brain metastases after the administration of 5-aminolevulinic acid (5-ALA) was analyzed. The aim was to investigate whether the resection of brain metastases using 5-ALA fluorescence also leads to a more complete resections and thus to a prolongation of survival; (2) Methods: The following variables have been considered: age, sex, number of metastases, localization, involvement of eloquent area, correlation between fluorescence and primary tumor/subtype, resection, and survival time. The influence on the degree of resection was determined with a control MRI within the first three postoperative days; (3) Results: Brain metastases fluoresced in 57.5% of cases. The highest fluorescence rates of 73.3% were found in breast carcinoma metastases and the histologic subtype adenocarcinoma (68.1%). No correlation between fluorescence behavior and localization, primary tumor, or histological subtype was found. Complete resection was detected in 82.5%, of which 56.1% were fluorescence positive. There was a trend towards improved resectability (increase of 12.1%) and a significantly longer survival time (p = 0.009) in the fluorescence-positive group; (4) Conclusions: 5-ALA-assisted extirpation leads to a more complete resection and longer survival and can therefore represent a low-risk addition to modern surgery for brain metastases.

Advancements and Challenges in Modern Medicine and Surgery in Africa

Advancements and Challenges in Modern Medicine and Surgery in Africa

Modern thyroid surgery : Efficient and safe thyroidectomy technique

After decades of bilateral "subtotal" and later "total" thyroidectomy, the extent of resection is now determined individually depending on the dominant thyroid condition. The leading indication by far in the study, documentation and quality center (StuDoQ) register of the Surgical Working Group Endocrinology (CAEK) is currently the suspicion of malignancy, which is followed by benign symptomatic nodular goiter, functional disorders and confirmed malignancy. The decision for an intervention as well as the extent of resection must be rigorously established. Aids for intraoperative nerve monitoring, vessel-sealing and parathyroid autofluorescence increase the safety of thyroid resections but also the complexity. The surgical technique of lobectomy using modern devices for vessel sealing is an intricate process in which the positioning, access to the neck and amodified sequence of dissection steps are equally important. While the usefulness of neuromonitoring is nowadays no longer in doubt, this is not yet so clear for other technologies. Above all, however, modern thyroid surgery is characterized by the knowledge of one's own results and a clear positioning to follow-ups. The selection of any surgical aid should be based on this knowledge.

Role of Gold Nanoparticles for Diagnosis and Therapy of Malignancy

Abstract: Cancer is the second leading cause of global mortality. Modern medical technologies, including chemotherapy, radiation treatment, and surgery, are extending the lifespan of cancer patients. The potential of nano medicine opens up a new way to get over the restrictions of traditional cancer treatments. Due to their unique basic features, gold nanoparticles (AuNPs) have been extensively explored and used in the field of tumor diagnostics and therapy. Two perspectives are presented on the physical and chemical aspects of AuNPs' characteristics. Localized surface plasmon resonance (LSPR), radioactivity, and a high X-ray absorption coefficient are among the physical characteristics of AuNPs that are commonly employed in tumor diagnostics and therapy. AuNPs also have some advantages like customizable size and shape, as well as various physiochemical properties. Additionally, they can effectively encapsulate drugs to enable simultaneous therapy and incorporate supplementary imaging labels. Recent research has emphasized the use of multifunctional AuNPs in techniques that involve simultaneous diagnosis and therapy. This article explores the use of AuNPs in cancer diagnosis and treatment, detailing clinical trials and providing insights for researchers on their physiochemical properties.