Abstract. In order to design vortex generators for modern multi-megawatt wind turbines accurately, the 3D behaviour of the boundary layer has to be considered. Due to the rotation of the blade, the lift-enhancing rotational augmentation has a considerable impact, especially in the inner blade sections. To investigate the interaction of vortex generators and rotational augmentation, high-fidelity computational flow simulations by means of unsteady Reynolds-averaged Navier–Stokes methods are presented for a rotating blade of a generic 2 MW horizontal-axis wind turbine. The inner blade section is analysed with and without vortex generators for two different pitch settings, including one causing largely separated flow. Two ways of placing the vortex generators on the blade with different radial starting positions are investigated in order to find out if the coexistence of the two lift-enhancement methods (i.e. rotational augmentation and vortex generators) is beneficial. All simulations are performed with the flow solver FLOWer, and the vortex generators are modelled by the introduction of source terms into the computational domain through a so-called BAY (Bender–Anderson–Yagle)-type model. For the case without vortex generators, it is found that the strength of rotational augmentation largely depends on the effective angles of attack (i.e. the pitch setting). For the case with lower effective angles of attack, rotational augmentation is a cyclic phenomenon, whereas for the case with higher effective angles of attack, it generates large loads in the inner root section due to a constant centrifugal pumping mechanism in time. The results from the cases with vortex generators display a rather destructive interaction of vortex generators and rotational augmentation on the torque. For low effective angles of attack and thus attached flow conditions, vortex generators exhibit slight losses compared to the case without vortex generators, as they inhibit spanwise flow through rotational augmentation. For high effective angles of attack, the vortex generators placed over 30 % of the blade produce an increase of 3.28 % in torque compared to the case without vortex generators and high centrifugal pumping.