In spite of the presence of modern healthcare facilities such as hospitals, clinics, and health centers, coupled with well advanced modern medical technology, many people in Ghana continue to patronize traditional medicine. Using the qualitative approach, this study investigates the state and practice of traditional medicine among the Ewe of Ghana in contemporary times. In the first place, the study reviews literature on traditional medicine and African healing systems. Secondly, the study discusses the methodological framework. In addition, the study explores the state and practice of traditional medicine among the Ewe of Ghana, focusing on the ethnography of diseases, the topography of traditional medicine practitioners, and the prospects and challenges of the practice of traditional medicine in contemporary times. Data collection instruments such as interviews and observations were used to collect primary data. The study finds that traditional medicine contributes to alternative medicine, saves people from disabilities, and ensures the affordability of healthcare. However, it has been bedeviled with challenges such as the problem of licensing, lack of association, destruction of medicinal herbs, and infrastructural problems. The study concludes that traditional medicine continues to play a major role in healthcare delivery among the Ewe of Ghana in spite of the presence of modern healthcare systems. More significant is the fact that the study contributes to knowledge in the field of medical anthropology and Ewe ethno-medical history. Keywords: African Traditional Medicine, African Healing Systems, State and Practice, Ewe, Challenges and Prospects