The article summarizes the results of their own research in the field of one of the original areas of reflexology – pharmacopuncture or, in other words, local stimulation. This term in our case refers to a method of irritating reflexology points with small doses of drugs considered as low-energy factors. Synonyms of the method, reflecting little significant differences, are aquapuncture, biopuncture, mesotherapy and some others. In the mechanisms of method, the significance of the prolongation of the reflex response due to changes in the volume of tissues in the region of points and the formation of multiple depots of the drug used are highlighted. However, the issues of more subtle links remain unclear, which determined the purpose of the study – to identify as such the targeted effect of drugs used through local stimulation. Dorsopathy at the lumbosacral level was chosen as a research model, which is to a certain extent associated with the formation of reflexology in the country, the methods of which were largely developed and refined using the model of neurological pain syndromes. Naturally, we took into account the medical, social and economic significance of the problem. In a series of completed dissertation studies of our employees, the therapeutic possibilities of local use of the drug Alflutop, indicated for the studied pathology, were analyzed. Evaluation of the effectiveness of this approach was based on taking into account the dynamics of clinical and additional characteristics and, in particular, the results of psychological and electrophysiological examination, including zonal thermography, vascular tests, etc. At the same time, the addition and even potentiation of the reflex and drug links of the method was noted, which determines a reliable superiority over the standard therapeutic effect or placebo control. Fundamentally significant in this regard was the positive structural and modifying effect in relation to the state of the intervertebral discs, confirmed by the data of ultrasonic video densitometry of these structures. Attention should also be paid to the fact of strengthening the effectiveness of pharmacopuncture through the parallel use of modern hardware technology – low-frequency electromagnetic stimulation. The presented materials are also reflected in monographs, a number of methodological manuals and protected patents for the invention.