“Classroom revolution” is a comprehensive reform of the traditional classroom from the aspects of teaching methods, teaching contents, teaching means and teaching evaluation. It is the internal requirement of establishing a modern classroom teaching model and the inevitable trend of the development of modern educational technology. In practice, the implementation of the “classroom revolution” confronts difficulties and dilemmas in Applied Undergraduate Colleges and Universities. Starting from the exploration of the implementation background and practical significance of the “classroom revolution”, this study deeply analyzes the necessity of the “classroom revolution” in Colleges and universities, puts forward some methods and paths to break through the difficulties from the aspects of top-level design, teachers’ ability and consciousness, work incentive mechanism in view of the practical problems existing, and gives the specific methods of reform practice according to the practical requirement. Through this path, the goal of improving classroom value has been guaranteed.