Modernization Of Chinese Medicine Research Articles

Chinese Herbal Medicines for Rheumatoid Arthritis: Text-Mining the Classical Literature for Potentially Effective Natural Products.

Background Rheumatoid arthritis (RA) is an autoimmune disease characterized by multijoint swelling, pain, and destruction of the synovial joints. Treatments are available but new therapies are still required. One source of new therapies is natural products, including herbs used in traditional medicines. In China and neighbouring countries, natural products have been used throughout recorded history and are still in use for RA and its symptoms. This study used text-mining of a database of classical Chinese medical books to identify candidates for future clinical and experimental investigations of therapeutics for RA. Methods The database Encyclopaedia of Traditional Chinese Medicine (Zhong Hua Yi Dian) includes the full texts of over 1,150 classical books. Eight traditional terms were searched. All citations were assessed for relevance to RA. Results and Conclusions. After removal of duplications, 3,174 citations were considered. After applying the exclusion and inclusion criteria, 548 citations of traditional formulas were included. These derived from 138 books written from 206 CE to 1948. These formulas included 5,018 ingredients (mean, 9 ingredients/formula) comprising 243 different natural products. When these text-mining results were compared to the 18 formulas recommended in a modern Chinese Medicine clinical practice guideline, 44% of the herbal formulas were the same. This suggests considerable continuity in the clinical application of these herbs between classical and modern Chinese medicine practice. Of the 15 herbs most frequently used as ingredients of the classical formulas, all have received research attention, and all have been reported to have anti-inflammatory effects. Two of these 15 herbs have already been developed into new anti-RA therapeutics—sinomenine from Sinomenium acutum (Thunb.) Rehd. & Wils and total glucosides of peony from Paeonia lactiflora Pall. Nevertheless, there remains considerable scope for further research. This text-mining approach was effective in identifying multiple natural product candidates for future research.

China as a health donor for african countries

The article devoted to China-Africa cooperation in healthcare, which is 57 years old. Beijing provides medical assistance to all African countries, which have diplomatic relations with China. Chinese doctors use the achievements of modern and traditional Chinese medicine in their practice. Medical specialists are fighting malaria, operating eye diseases within the framework of the «Go to the light» program, and implementing a program of cooperation in the treatment of HIV infection.

Discriminant Analysis of Traditional Chinese Medicinal Properties Based on Holistic Chemical Profiling by 1H-NMR Spectrometry.

Medicinal property, which is closely related to drug chemical profiling, is the essence of traditional Chinese medicine (TCM) theory and has always been the focus of modern Chinese medicine. Based on dozens of classic and commonly used TCM herbs with recognized medicinal properties, the present study just aimed to investigate the feasibility and reliability of medicinal property discriminant by using 1H-NMR spectrometry, which provided a mass of spectral data showing holistic chemical profile for multivariate analysis and data mining, including principal component analysis (PCA), Fisher linear discriminant analysis (FLDA), and canonical discriminant analysis (CDA). By using FLDA for two-class recognition, a large majority of test herbs (59/61) were properly discriminated as cold or hot group, and the only two exceptions were Chuanbeimu (Fritillariae Cirrhosae Bulbus) and Rougui (Cinnamomi Cortex), suggesting that medicinal properties interrelate with flavor and body tropism, and all these factors together bring up medicinal property and efficacy. While by performing CDA, 98.4% of the original grouped herbs and 77.0% of the leave-one-out cross-validated grouped cases were correctly classified. The findings demonstrated that discriminant analysis based on holistic chemical profiling data by 1H-NMR spectrometry may provide a powerful alternative to have a deeper understanding of TCM medicinal property.

The Politics within the Changing of Status of Traditional Chinese Medicine and the Development of Traditional Chinese Medicine in Modern China

근대 동아시아 전통의학의 지위 부침과 변화는 메이지시대 한방의학을 제도적으로 폐지하였던 일본의 역사적 경험이 끼친 영향이 컸다. 이는 식민지 조선, 대만뿐만 아니라 주권국가로서 면모를 유지하였던 중국 역시 예외가 아니었다. 중국은 근대로 접어들면서 전통문화를 부정하고 서양문명을 급급하게 추구하는 근대주의 사조가 팽배하였다. 그 가운데 중의부정론과 중의폐지론이 제기되었다. 그리고 일본에 갔다 온 의학유학생과 정계인사에 의해 법적, 제도적으로 중의학을 배제하려는 중의폐지안도 등장하였다. 이로써 근대 중의학은 식민지 조선의 한의학과 마찬가지로 불안정한 지위에 처하게 되었다. 하지만 식민지 조선과 달리 끝까지 주권국가였던 중국에서는 중의폐지론자도 있었지만, 국수주의, 민족주의, 민생주의 등 이념으로 무장한 중의옹호론자 역시 엄연히 존재하였다. 중의폐지론자와 중의옹호론자는 치열한 각 축전을 전개하였다. 양쪽의 대립은 비록 중·서의계 각각의 집단 이익과 무관하지 않았지만, 한편으로는 동서의학의 관계 설정 및 중국 의료근대화 방식 등의 문제에 대한 논의와 고민을 심화시키는 데 기여하였다. 한편, 조선인 한의계와 마찬가지로 근대 중의계는 서양의학을 배척할 대상으로 보지 않고, 일찍부터 동서의학의 대화를 모색하기 시작하였다. 중서의회통, 중의과학화, 이후 중서의결합까지 근대 중의학은 서양의학을 수용하여 중의학 스스로 개량과 혁신을 시도하며 새로운 형태로 변화하였다. 하지만 서양의학을 수용하는 것과 동서의학의 근본적 차이를 무시한 채 동아시아의학의 서양의학화를 지향하는 것은 별개의 문제였다. 일원적인 근대 과학 인식을 거부하고 서양의학을 상대한 동아시아 전통의학의 독특한 가치를 주장하는 인식은 근대 한중양국에서 공유되고 있었다. 그리고 그 시대에 공통적으로 미해결된 문제로 남겨진 동아시아 전통의학의 과학화와 동서의학 절충의 과제는 오늘날 중국의 중서의결합, 한국의 동서의학 통합(혹은 협진) 같은 형식으로 계속 추진되고 있다.In the Meiji Period, Japan abolished Kampo Medicine systematically; the historical experience impacted the status’ changing of traditional medicine in modern East Asia. The situation was not only in Korea and Taiwan that are colonies, while China, who could maintain the form of a sovereign country, was not exceptional. In modern times, the trend of thought that blindly denied traditional culture and pursued westernizing was very active, and the theory of denying or abolishing traditional Chinese medicine came on stage under the background. Some oversea medical students who had come back from Japan and some politicians launched the campaign of“abolishing traditional Chinese medicine”, which wanted to abolish Chinese traditional medicine systematically and legitimately. Since then the traditional Chinese medicine’s status, which is the same as traditional Korean medicine, was greatly shaken. Nonetheless, it is different from colonial Korea that China has maintained the status of a sovereign state all along. Although there was a group who tried to abolish traditional Chinese medicine, meanwhile there was a group who embraced nationalism and people’s livelihood, and the group was headed by traditional Chinese medical circles. The two groups competed fiercely. Although the antagonism between the two groups was closely related with the respective advantages of Chinese and western medical circles, their argument made contribution to the deep thinking and discussion about the relationship between eastern and western medicine and the modernization of Chinese medicine. On the other hand, traditional Chinese medical circles in modern times, who were the same as traditional Korean medical circles, didn’t regard western medicine as something that should be repelled, on the contrary, they tried to communicate with western medicine in very early times. From confluence of Chinese and western medicine, scientization of traditional Chinese Medicine, to combination of traditional Chinese and western medicine in later times, modern traditional Chinese medicine absorbed western medicine constantly, tried to promote the reformation and improvement by itself, and accomplished new development. Absorbing western medicine, however, is different from pursuing westernization of east medicine blindly without the awareness of the difference between them. Some of the men of insight in the two countries had the consensus that they would refuse unitary learning of modern science, and emphasize the unique value of traditional East Asia in comparison with western medicine. The tasks of scientific systemizing traditional East Asia medicine and harmonizing eastern and western medicine were not solved at that time by the two countries; nowadays the combination of Chinese traditional and Western medicine in China and medical integration of eastern traditional and Western medicine in Korea are trying to figure out the solutions.

Cytotoxicity of Cichorium intybus L. metabolites (Review).

Cichorium intybus L. (Chicory) is a widely distributed, edible, perennial, herbaceous member of the Asteraceae family. Besides its use in modern Chinese herbal medicine, its ethnomedicinal use is evident in the text from ancient Greece, Egypt and China. It is also used as a food and coffee substitute, which is mainly responsible for its extensive domestication. In recent decades, cytotoxic studies of C. intybus extracts have shown its antitumor potential. These studies also identified metabolite constituents including guaianolides, 6‑methoxyflavone, eudesmanolides, germacranolides, polyacetylene, sterol, anthocyanin, delphinidin, 3,4‑dihydroxyphenethyl and other novel compounds. Many of these phytometabolites have shown positive cytotoxic activities in vitro, and antitumor action in vivo and in clinical trials, demonstrating the potential of C. intybus metabolites as antitumor drugs. Structural activity relationship studies have further confirmed these bioactivities. In this review, we focused on the phytochemicals of C. intybus with reported cytotoxicity and potential antitumor properties. We also discuss their specificity towards tumor cells, structural activity relationship, the involved signaling pathways and molecular mechanism, with the expectation of the future development of efficient and targeted antitumor therapeutic strategies.

The Making of Modern Chinese Medicine, 1850–1960, written by Bridie Andrews

The Making of Modern Chinese Medicine, 1850–1960, written by Bridie Andrews

The Role of Periplaneta americana (Blattodea: Blattidae) in Modern Versus Traditional Chinese Medicine

The purpose of this review is to elaborate the role of Periplaneta (P.) americana L. in modern and traditional Chinese medicine (TCM) and compare the use of the species in these two forms of medical treatments. From searches on Google Scholar, PubMed, and Web of Science databases, studies were identified involving TCMs with P. americana, which have a history of use over several thousand years, and demonstrate how extracts from this insect play a role in the treatment of diseases through antibacterial, antiviral, antitumor activity, and enhancement of immune function. Extracts from P. americana have not been fully developed for clinical use because the active components have not been completely purified or their molecular mechanisms thoroughly understood. The development of extraction technology in modern Chinese medicine has revealed that many extracts from P. americana are able to play an important role in the control of diseases such as cancer. Drugs such as 'Kangfuxin Solution' and 'Xinmailong Injection' are now widely used for gastrointestinal ulcers and chronic heart failure, having achieved beneficial curative effects in clinical studies. Based on this, the information from studies of P. americana in TCM and modern medicine should be combined and their respective advantages applied. This review provides an overview of the role of P. americana in modern and TCM and thus contributes to identification of further applications and area requiring drug development.

Perioperative acupuncture--a novel concept instead of acupuncture anesthesia

Despite anesthesia(AA) being one of the most significant achievements in modern Chinese medicine, it cannot provide complete anesthesia effect and is eliminated from clinical use. A large number of clinical practices has confirmed that applied to patients is far beyond the meaning and scope of traditional anesthesia and has special advantages. This article proposes a novel concept of acupuncture by summarizing the benefits of using before during and after surgical operation. Acupuncture can relieve anxiety and stress during the pre-operative stage. Furthermore, using during operation reduces the usage of narcotics, stress response, maintains the respiratory stability and homeostasis and provides protections to vital organs during surgery. After surgery, using during the postoperative stages enhances recovery and effectively alleviates postoperative pain, prevents common postoperative discomforts such as nausea and vomiting. It may also improve patients′ long-term prognoses. This article analyzes the beneficial effect of in perioperative period, and puts forward the new concept of acupuncture to replace AA. This review aims to improve the clinical efficacy of acupuncture, promote the application of in perioperative period, accelerate the recovery of patients, reduce the perioperative mortality and improve the prognosis. Key words: Acupuncture; Acupuncture anesthesia; Perioperative

Application of Herbal Medicines with Heat-Clearing Property to Anti-Microinflammation in the Treatment of Diabetic Kidney Disease.

Diabetic kidney disease (DKD) is a global pandemic, and microinflammation has been reported as an important pathogenic factor of DKD. Traditional Chinese Medicine (TCM) has been used in the treatment of DKD for thousands of years, and modern Chinese medicine studies have found that herbal medicines with heat-clearing property have a curative anti-inflammation effect in DKD. This article reviews the new clinical and experimental progress made in herbal medicines with heat-clearing property, in the treatment of DKD, as well as their safety aspects.

Accelerating the comprehensive and systematic evaluation of clinical evidence for Chinese medicine using a whole-evidence approach

Modern Chinese medicine is rooted in classical literature and the legacies provided by ancient doctors and their patients. It is also grounded in the practices of expert clinicians and increasingly informed by clinical and experimental research. Considering Chinese medicine's stage of international development, a whole-evidence approach is an appropriate method for compiling and synthesizing different types and levels of evidence for specific types of interventions. This approach can be used for the wide range of clinical conditions that Chinese medicine commonly treats.

Wulingsan (Oryeongsan/Goreisan) ameliorate lipid metabolism of obesity rats via regulation of the plasma metabolic profiling.

Wulingsan has been used to cure disease about disorders related to fluid balance for thousands of years. The clinical practice of modern Chinese medicine has found that Wulingsan has the effect on reducing weight and fat, but its mechanism is not clear. This study investigated its effects on obesity rats and explored the underlying mechanisms by analyzing the plasma metabolic profiling. The effects of Wulingsan on obesity were evaluated with obesity rats induced by high-fat diet. Ultra high performance liquid chromatography coupled with quadrupole time of flight mass spectrometry (UPLC-Q-TOF/MS) was performed to discover potential biomarkers and evaluate whether Wulingsan could regulate these biomarkers. The levels of triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL-C), and low-density lipoprotein (LDL-C) in serum were assessed by ELISA kits. Remarkably, TG, TC, HDL-C and LDL-C in obesity rats were ameliorated after oral administration of Wulingsan. Further investigation indicated that the plasma metabolic profiles were clearly improved. Twelve potential biomarkers were identified. After intervention, these biomarkers turned back to normal level at some extent. The results showed that Wulingsan extract groups were normalized. Additionally, this study also showed that the metabonomics method was a promising tool to unravel how traditional Chinese medicines worked and these data can provide scientific basis for clinical application of Wulingsan.

Chinese Medicine in the Battle Against Obesity and Metabolic Diseases.

Obesity is a multi-factor chronic disease caused by the mixed influence of genetics, environments and an imbalance of energy intake and expenditure. Due to lifestyle changes, modern society sees a rapid increase in obesity occurrence along with an aggravated risk of metabolic syndromes in the general population, including diabetes, hepatic steatosis, cardiovascular diseases and certain types of cancer. Although obesity has become a serious worldwide public health hazard, effective and safe drugs treating obesity are still missing. Traditional Chinese medicine (TCM) has been implicated in practical use in China for thousands of years and has accumulated substantial front line experience in treating various diseases. Compared to western medicine that features defined composition and clear molecular mechanisms, TCM is consisted with complex ingredients from plants and animals and prescribed based on overall symptoms and collective experience. Because of their fundamental differences, TCM and western medicine were once considered irreconcilable. However, nowadays, sophisticated isolation technologies and deepened molecular understanding of the active ingredients of TCM are gradually bridging the gap between the two, enabling the identification of active TCM components for drug development under the western-style paradigms. Thus, studies on TCM open a new therapeutic avenue and show great potential in the combat against obesity, though challenges exist. In this review, we highlight six key candidate substances derived from TCM, including artemisinin, curcumin, celastrol, capsaicin, berberine and ginsenosides, to review their recent discoveries in the metabolic field, with special focus on their therapeutic efficacy and molecular mechanisms in treating obesity and metabolic diseases. In addition, we discuss the translational challenges and perspectives in implementing modern Chinese medicine into the western pharmaceutical industry.

Research progress on pharmacological effects of separation and combination methods based on traditional Chinese medicine property and flavor

The theory of medicinal properties of traditional Chinese medicine (TCM) is one of the core theories of TCM, which is an important basis for guiding the clinical application of TCM and the key supporting point for the modernization of TCM. How to study the modernization of TCM under the guidance of traditional Chinese medicine theory has become a great challenge for modern researchers. Currently, the researches in TCM mainly focus on chemical studies such as on active ingredients and effective components, lacking the guidance of traditional Chinese medicine theory, and losing the inherent characteristics of TCM. Therefore, the combination of the theory of TCM and the modernization of TCM and the establishment of research mode that is in line with the characteristics of modernization of traditional Chinese medicine under guidance by the theory of medicinal properties of TCM shall be the top priority in modern Chinese medicine research. The property and flavor of TCM are closely related to its chemical compositions, and also have certain regularity. The researches on the chemical components of TCM, systematic design of property and flavor, as well as the separation and combination of TCM property and flavor are beneficial to the overall analysis of the characteristics of TCM, showing great significance to inherit and carry forward TCM. The pharmacological effects about separation and combination methods based on TCM property and flavor were reviewed in this study, providing theoretical reference for the development of new drugs and the application of TCM.

Green Therapy of Cancer: A Promising Grope for Anticancer Strategy by Modern Chinese Medicine.

Green Therapy of Cancer: A Promising Grope for Anticancer Strategy by Modern Chinese Medicine.

The Making of Modern Chinese Medicine, 1850–1960 by Bridie Andrews

Reviewed by: The Making of Modern Chinese Medicine, 1850–1960 by Bridie Andrews Xiaoping Fang Bridie Andrews. The Making of Modern Chinese Medicine, 1850–1960. Contemporary Chinese Studies Series. Vancouver: University of British Columbia Press, 2014. 294 pp. $99.00 (cloth). Repr. Honolulu: University of Hawai'i Press, 2015. 294 pp. $30.00 (paper). Western modernity as the single normative modernity has been the paradigm and criterion used to analyze and measure the rise of Chinese medicine in changing sociopolitical contexts. Within this narrative, the binary dichotomy between "Western" and "Chinese" medicine has been problematic. Bridie Andrews's The Making of Modern Chinese Medicine aims to break this dichotomy by examining the motives driving the active assimilation of Western medicine and the reasons for the rise of a new Chinese medicine. By analyzing the history of modern Chinese medicine, Andrews intends to shed light on the history of Western influences in non-Western societies and on the ways that science is perceived and performed as a marker of modernity. The book investigates the significant issues in modern Chinese medicine in chronological order. Chapters 2 and 3 mainly focus on medical practices up to the early twentieth century. The diverse spectrum of medical practice shows the coexistence of "modern" and "traditional" approaches to medicine and highlights the role of medical pluralism in the modernization process. From chapter 4 to chapter 8, the book analyzes how sociopolitical changes impacted Chinese medicine, facilitated responses to shifts in medical culture by early Chinese medical communities, the state, reformers, and medical professions, and contributed to the rise of modern Chinese medicine. The Japanese medical reform made a great impact on China's medical community and motivated the modern Chinese state to assume responsibility for public health care. Modern social and medical reformers integrated medicine into their struggles for sociopolitical change and the strengthening of Chinese medicine as an indigenous medicine. The rise of professional associations and the establishment of the National Quarantine Service became key events in the institutionalization of Western medicine in China, while the Chinese medical community underwent more significant institutionalization and professionalization. Western medicine also had a significant impact on modern Chinese medicine through the adoption of Western-style case histories and the relocation of acupuncture points in the new acupuncture. This book makes significant contributions to theoretical understandings of the history of Chinese medicine in modern China. Rather than upholding the dichotomy between Chinese and Western medicine, Andrews argues that the process was one of dynamic interactions and mutual impacts. She proposes a set of concepts to describe these effects: "translation" (or "appropriation") and "syncretism." The former involved "appropriat[ing] or translat[ing] elements of culture differently" and included missionary, European, and Japanese medical models for Chinese medicine. The latter implied a two-way exchange affecting both Western and Chinese medical practices, such as the West's curiosity regarding Chinese materia medica and Chinese practitioners' growing interest in Western medical practices and institutions [End Page E-17] (214). Andrews further suggests that "Chinese and Western medicines are two mirrors facing each other at a short distance. Each mirror holds the image not only of the other but also of the other's view of itself (216)." The book also greatly advances empirical understandings of three key issues in the history of medicine in China. First, it vividly reveals aspects of Western medical practice prior to its triumph and aggressiveness in the twentieth century that have been neglected up to this point. As the book shows, there were significant similarities between these and Chinese medicine, notably in the drug combinations used by both. Meanwhile, Western medical missionaries applied the strategy of "accommodation" to downplay the difference between their approach and that of Chinese medicine, such as looking for local substitutes for herbal medicines, comparing market prices, and adopting indigenous architectural styles for hospitals. Second, Andrews profoundly analyzes an important question about the rise of medical professionals with different training backgrounds and political inclinations and the emergence of different professional societies and associations. There were three medical associations by the establishment of the Nanjing Nationalist government in 1928: the China Medical Missionary Association (CMMA; also known as the China Medical Association...

A visual analysis of network pharmacology research trends

Objective: To understand the current situation of network pharmacology, and to analyze external and internal characteristics of literature, is of great significance for the development of network pharmacology in the future and its application in the modernization of Chinese medicine. Methods: Bibliometrics were adapted to perform visual analysis on the research status of network pharmacology with Citespace and SPSS for windows 22.0 version (IBM, Armonk, New York, USA). Knowledge map was used to analyze the knowledge system in the field, to identify the research hotspots and dynamic frontiers, and to elaborate the research status and development trend of domestic network pharmacology. Results: The research on network pharmacology in China is at the stage of the formation and construction of basic theories. At present, we focuses on the solution of actual disease problems and basic theoretical research, while the application in the research field of traditional Chinese medicine is a new hot spot and trend in the future development. Conclusions: It is important to pay attention to the connection and communication among the knowledge groups, so that a systematic knowledge system can be formed in the field of network pharmacology in domestic as soon as possible.

Protective effect of compound Danshen (Salvia miltiorrhiza) dripping pills alone and in combination with carbamazepine on kainic acid-induced temporal lobe epilepsy and cognitive impairment in rats

Context: Temporal lobe epilepsy (TLE) is resistant to antiepileptic drugs (AEDs) and is associated with cognitive impairment. The modern Chinese medicine, compound Danshen dripping pills (CDDP), is clinically effective in treating epilepsy and improving cognitive impairment.Objective: This study evaluated the protective effects of CDDP alone and in combination with carbamazepine (CBZ) on kainic acid-induced TLE and cognitive impairment in rats.Materials and methods: Sprague–Dawley rats were randomly divided into five groups: control (sham operated), model, CDDP, CBZ and combined. A TLE model was then created via bilateral intrahippocampal injection of 0.35 μg kainic acid (KA). Rats received CDDP (85 mg/kg), CBZ (100 mg/kg) or combined (85 mg/kg CDDP +100 mg/kg CBZ) via intragastric administration for 90 d, respectively. Seizure intensity, apoptosis and glial cell line-derived neurotrophic factor (GDNF) were measured. Furthermore, the improvement in cognitive impairment and hippocampal neuronal damage was evaluated.Results: CDDP combined with CBZ significantly decreased seizure severity and frequency (p < 0.05) and ameliorated cognitive impairment (p < 0.05). The model group showed a significant reduction of neurons and Bcl-2/Bax expression in the hippocampus CA3 area (p < 0.01), the combined groups significantly reversed these change (p < 0.01). GDNF expression in the combined groups showed a clear increase over the model group (p < 0.05).Conclusion: These findings support the use of CDDP as an adjuvant drug for the treatment of TLE and cognitive deficit. Its mechanism might be related to an anti-apoptosis effect and up-regulation of GDNF.

A Brief Review on the Pathological Role of Decreased Blood Flow Affected in Retinitis Pigmentosa.

Retinitis pigmentosa (RP) represents a clinically and genetically heterogeneous disease characterized by progressive photoreceptor loss. In recent years, research has been rarely made in blood flow affected in RP. The specific mechanism of blood flow affected in RP is not completely clear. A number of studies indicated that the decreased blood flow was related to RP. According to clinical observation and treatment experience, Chinese medicine considered that blood stasis runs throughout the RP disease progression, and the blood stasis corresponding to Chinese herbal medicine has a positive effect on the clinical treatment of RP. Therefore, we proposed that the decreased blood flow may participate in the lesion. In this article, we will review the findings on the decreased blood flow affected in RP from the perspective of modern medicine and Chinese medicine.

GC-MS/MS method for the determination and pharmacokinetic analysis of borneol and muscone in rat after the intravenous administration of Xingnaojing injection.

A simple and sensitive gas chromatography with tandem mass spectrometry method was developed and validated for the simultaneous determination of borneol and muscone in rat plasma. The analytes and internal standard, naphthalene, were extracted using a convenient one-step liquid-liquid extraction method with ethyl acetate. The chromatographic separation was realized on a HP-5MS capillary column and detected in multiple reaction monitoring mode. Excellent linearity (R2 ≥0.996) was shown over 10.0-5000ng/mL for borneol and 2.5-250ng/mL for muscone. The lower limit of quantitation was 10 and 2.5ng/mL for borneol and muscone, respectively. The intra- and interday precisions were less than 7.52%, and the accuracy values were between -8.03 and 14.52%. The extraction recovery, matrix effect, and stability were sufficient to meet the Food and Drug Administration criteria. Meanwhile, the assay was successfully applied to the preclinical pharmacokinetic study of borneol and muscone following intravenous administration of Xingnaojing injection, a modern Chinese herbal medicine preparation.

Influence factors of hepatotoxicity of traditional Chinese medicine preparation products based on multidimensional structure dynamic process

Traditional Chinese medicine (TCM) products are the finished products by adopting certain preparation processes according to the profile of the herbs, with Chinese herbs or decoction pieces as the raw materials.Among their adverse reactions to the organs, hepatotoxicity can not be ignored. As a new stage of quality control in TCM, dynamic quality control system of the multidemensional structure process emphasized on the research of the effectiveness and safety, focused on the pretreatment, preparation process,dosage forms and drug delivery methods to control the quality of TCM preparation products and reduce the generation of hepatotoxicity.In this paper, we will start from these factors to discuss the causes of hepatotoxicity underlying drug products and hope to provide the reference for developing low toxicity and high quality modern Chinese medicine products.