Moderate Association Research Articles

Exploring the association between early-life air pollution exposure and autism spectrum disorders in children: A systematic review and meta-analysis

The objective of this meta-analysis is to investigate the association between air pollution and the vulnerability of children to autism spectrum disorders (ASD). A thorough examination and analysis of data obtained from a compilation of 14 studies was undertaken, with a particular emphasis on investigating the effects of nitrogen dioxide (NO2), oxide of nitrogen (NOx), ozone (O3), and particulate matter (PM10 and PM2.5) on individuals diagnosed with ASD. The findings demonstrate a moderate association between exposure to nitrogen dioxide (NO2) and ASD, as indicated by a combined odds ratio (OR) of 1.13 and a 95% confidence interval (CI) spanning from 0.77 to 1.549. O3 shows a combined odds ratio (OR) of 0.82, along with a 95% confidence interval (CI) ranging from 0.49 to 1.14. NOx shows a moderate level of heterogeneity (I² = 75.9%, p = 0.002), suggesting that the impact of NOx on the risk of ASD. There is a statistically significant relationship between exposure to O3 and ASD, although the strength of this relationship is diminished. The findings demonstrated a noteworthy correlation between exposure to PM10 and PM2.5 and the occurrence of ASD. The study found a significant correlation, in relation to PM2.5, with a combined odds ratio (OR) of 1.22 and a 95% confidence interval (CI) ranging from 1.11 to 1.34. The findings have significant implications for the formulation of programs aimed at reducing exposure to harmful chemicals, especially among vulnerable groups such as children.

Developmental cascades from maternal preconception stress to child behavior problems: Testing multilevel preconception, prenatal, and postnatal influences.

Although maternal stress during pregnancy and even before conception shapes offspring risk for mental health problems, relatively little is known about the mechanisms through which these associations operate. In theory, preconception and prenatal stress may affect offspring mental health by influencing child responses to postnatal caregiving. To address this knowledge gap, this study had two aims. First, we examined associations between preconception and prenatal stress with child temperament profiles at age four using multilevel assessment of maternal perceived stress and stress physiology. Second, we tested child temperament profiles as moderators of associations between observed parenting behaviors during a parent-child free-play interaction when children were 4 years old and child behavior problems 1 year later. Latent profile analyses yielded four distinct child temperament profiles: inhibited, exuberant, regulated low reactive, and regulated high reactive. Consistent with hypotheses, preconception, and prenatal stress each independently predicted the likelihood of children having temperament profiles characterized by higher negative emotionality and lower regulation. Specifically, preconception perceived stress and prenatal cortisol predicted likelihood of children having an exuberant temperament, whereas prenatal perceived stress predicted likelihood of children having an inhibited temperament. Contrary to hypotheses, temperament profiles did not moderate predictions of child behavior problems from observed parenting behaviors; however, responsive parenting behaviors inversely predicted child behavior problems independently of child temperament. These findings add to growing evidence regarding effects of preconception factors on child outcomes and underscore a central role for responsive parenting behaviors in predicting more favorable child mental health independent of child temperament. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Childhood trauma and psychopathy: The moderating role of resilience.

Despite accumulating evidence of significant albeit moderate associations between childhood trauma and psychopathy, little is known about the potential moderators of these associations. To advance knowledge in this area, the present study investigated the moderating role of resilience in the childhood trauma-psychopathy link. A community sample of 521 adult participants from the Netherlands (40.1% men; Mage = 35.27 years, SD = 15.99) completed two self-report questionnaires measuring psychopathic personality traits: a self-report measure of resilience and a retrospective measure of childhood traumatic experiences. Correlation analyses were employed to investigate bivariate associations among study variables. Moderated multiple regression analyses with bootstrapping followed by simple slope analyses were employed to examine Childhood Trauma × Resilience interactions in predicting scores of psychopathy subscales. Childhood trauma had small positive associations with psychopathic traits across the board, with the exception of a small negative association with boldness traits, as well as a small negative association with resilience. Resilience was strongly and positively related to boldness, and negatively related to affective (callousness, meanness) and behavioral (antisocial, disinhibition) traits of psychopathy. Resilience moderated six out of seven associations between childhood trauma and psychopathic traits. Resilience appeared to represent a significant buffer in the associations between childhood traumatic experiences and psychopathic traits, such that these associations became weaker and nonsignificant (and even negative for boldness) at higher levels compared to lower levels of resilience. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

(O-31) ASSOCIATION BETWEEN SEXUAL AGENCY AND SEXUAL SATISFACTION IN BRAZILIAN AND PORTUGUESE UNIVERSITY STUDENTS

Abstract Aim This study aimed to verify the association between sexual agency and sexual satisfaction in Portuguese and Brazilian university students. Method 322 university students, 161 Brazilian and 161 Portuguese, aged between 18 and 29, took part in this cross-sectional study by answering an online questionnaire. The measures used were a sociodemographic questionnaire, the Sexual Attitudes Scale, the New Sexual Satisfaction Scale and the Sexual Assertiveness Scale. The data was analyzed using descriptive statistics and Spearman correlation. Ethical procedures were met. Results The measures of individual sexual satisfaction (BR 0.446/PT 0.499), relational sexual satisfaction and in sexual satisfaction of sexual activity (BR 0.375/PT 0.363), and total sexual satisfaction (BR 0.454/PT 0.458), showed significant (p<0.01) moderate positive associations with the dimension of sexual assertiveness initiation, related to sexual agency to initiate sexual relations and communicate desires to the partner in both groups. This is a finding that contradicts the rules associated with traditional sexual scripts, which advocate that women tend to behave passively in relation to their partner's desires. Conclusion The association between initiative and sexual satisfaction demonstrates the need to go against traditional sexual scripts, encouraging women to recognize and communicate their desires, and to validate the right to pleasure and sexual satisfaction. Expanding communication and listening to desires, opening up to different ways of giving and receiving physical pleasure, can increase the feeling of desire and the possibility of feeling desired, favoring the possibility of individual and shared pleasure and satisfaction. Financing No conflict.

The Silhouettes Fatigue Scale: further validation in Spanish-speaking university students and adults with chronic pain

Purpose The aim of this study was to evaluate the psychometric properties of the Silhouettes Fatigue Scale (SFS) when used to assess fatigue in undergraduates and middle-aged adults with chronic pain. Materials and methods A total of 426 undergraduates and 207 middle-aged individuals with chronic pain participated in this study. Participants were asked to respond to a survey including the SFS as well as another validated measure of fatigue, questionnaires about pain catastrophizing and pain interference, and questions about pain (i.e., location, duration, and intensity). Convergent, discriminant, criterion and known-groups validity were evaluated. Results Convergent validity was supported by a strong association between the two scales measuring fatigue. Discriminant validity was supported by stronger associations between the two fatigue scales scores compared to those between the SFS and pain catastrophizing scores. Criterion validity was supported by moderate associations between the SFS and measures of pain intensity and pain interference. Finally, known-groups validity was supported by significant differences in the SFS scores between students without chronic pain, students with chronic pain, and middle-aged individuals with chronic pain. Conclusions The findings support the validity of the SFS scores when used to assess fatigue in undergraduates and middle-aged adults with chronic pain.

Abstract 5169: Circulating levels of ANGPTL3, PCSK9, apoCIII and lipoprotein (a) in high-grade serous ovarian cancer

Abstract Background: Ovarian cancers require abundant amounts of lipids for their growth. Recent years have highlighted the role of ANGPTL3, PCSK9, ApoCIII and Lp(a) as key players in lipid metabolism. But circulating levels of these factors in ovarian cancers have not been thoroughly investigated to date. Objective: We assessed the profiles of plasma ANGPTL3, PCSK9, ApoCIII and Lp(a) in ovarian high-grade serous carcinoma (HGSC). Methods: Plasma samples collected from women diagnosed with an HGSC (n=31) or a benign ovarian lesion (BOL, n=40) were analyzed for plasma lipid profile (ApoB, total cholesterol, HDL, triglycerides, Lp(a) levels) on a clinical modular platform (Roche). ApoCIII, ANGPTL3 and PCSK9 levels were measured with commercially-available ELISA kits. Differences between HGSC and BOL were assessed by two-group comparisons. Pairwise correlation strength between variables was evaluated with Spearman’s rank order tests. Logistic regression modelling was used to further examine the associations between selected variables and HGSC diagnoses. Results: ANGPTL3 levels increased in HGSC (84.1 ng/ml, SD=29.2ng/ml, n=31) compared to BOL (66.9ng/ml, SD=30.7 ng/ml, n=40; HGSC vs BOL p=0.02). Receiver operating characteristic (ROC) curve suggested that plasma ANGPTL3 levels were moderately associated with HGSC (AUC=67.7%, p=0.005 1) and did not increase predictive performance of ovarian tumor biomarkers CA125 and HE4 in multivariable model. Associations between ANGPTL3 levels and cholesterol (HDL, non-HDL, LDL and total) could be observed in the control group but not in the HGSC group. The same dissociation was observed for the inverse correlation between HDL and triglycerides in HGSC. Furthermore, moderate associations were observed between PCSK9 & CA19-9 in the entire cohort (rho=0.34, n=53, p=0.013) and Lp(a) & CA125 in HGSC cases (rho=0.51, p= 0.017). Conclusion: In this cohort of 71 women, we report increased levels of ANGPTL3 in HGSC with an effect size (Cohen’s D) of 0.57. Confirmation of this result in larger cohort studies (minimal n>50 in each group) would warrant further investigation into the roles of circulating ANGPTL3. Its inhibition may allow to tackle deregulated lipid metabolic pathways contributing to ovarian cancer progression. Citation Format: Emilie Wong Chong, France-Hélène Joncas, Pierre Douville, Dimcho Bachvarov, Frédéric Calon, Nabil Seidah, Caroline Diorio, Anne Gangloff. Circulating levels of ANGPTL3, PCSK9, apoCIII and lipoprotein (a) in high-grade serous ovarian cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 5169.

Bone density measured on sagittal reconstructed CT is highly correlated with axial CT but both measurements are only moderately correlated with DEXA T-scores

BackgroundDuring the preoperative evaluation of a patient being considered for spinal surgery, Dual-energy x-ray absorptiometry (DEXA) has been traditionally used to diagnose poor bone mineral density (BMD) as a risk factor. As ordering a DEXA can add cost and delay diagnosis, spine surgeons have more recently began to use Hounsfield Units (HU) measured on computed tomography scans (CT) as a measure of BMD. The aim of our study was to evaluate associations between DEXA and HU on lumbar spine CT scans. MethodsForty-two patients (32 female, 10 male, mean age = 67.7 years) with DEXA and lumbar spine CT scans performed within one year of each other were identified. DEXA T-scores were collected from the hip, forearm and L1-L4. HU was determined using the maximum region of interest within the cancellous area in the mid-vertebral body from L1-L4 in the sagittal and axial planes. ResultsUsing the lowest T-score, 8 (19 %) cases were osteoporotic and 25 (60 %) were osteopenic. Statistically significant differences in HU were seen in osteoporotic cases (Axial HU = 59.2, Sagittal HU = 61.1, p = 0.006) compared to osteopenic (Axial HU = 119.8, Sagittal HU = 122.9) and normal cases (Axial HU = 141.2, Sagittal HU = 142.3). There were moderate associations between the spine T-scores and CT HUs (Axial HU:r2 = 0.50, Sagittal HU:r2 = 0.49, p < 0.001), weak associations between the Axial HU (r2 = 0.48, p < 0.000) and Sagittal HU (r2 = 0.48, p < 0.000) with hip T-scores, and no correlations with forearm T-scores. There were strong associations between Axial HU and Sagittal HU (r2 = 0.98, p < 0.001). Clinical relevanceThe results of the current study show a strong association between the sagittal and axial vertebral HU measurements, which supports the clinical use of either measurement technique. The weak correlation between T-scores and HU is consistent with prior studies and warrants future studies to determine which modality will better predict postoperative mechanical failures in patients undergoing spinal surgery. Level of EvidenceIII.

Time-savoring moderates associations of solitude with depressive mood, loneliness, and somatic symptoms in older adults' daily life.

Episodes of solitude (being alone and without social interaction) are common in older age and can relate to decreased well-being. Identifying everyday resources that help maintain older adults' well-being in states of solitude is thus important. We investigated associations of daily solitude with subjective and physical well-being under consideration of time-savoring (i.e., attending to positive experiences and upregulating positive emotions). 108 older adults aged 65-92 years (M = 73.11, SD = 5.93; 58% women; 85% born in Switzerland) took part in an app-based daily diary study in 2022. Over 14 consecutive days, participants reported daily solitude, time-savoring, depressive mood, loneliness, and somatic symptoms in an end-of-day diary. Multilevel models revealed that participants reported higher depressive mood and loneliness, but not higher somatic symptoms on days on which they spent more time in solitude than usual. Higher-than-usual daily time-savoring was associated with lower depressive mood, loneliness, and somatic symptoms. Associations of solitude with depressive mood, loneliness, and somatic symptoms were weaker on days on which higher time-savoring than usual was reported. Findings highlight the potential of everyday time-savoring as a resource in older adults in the context of increased solitude.

Social media: A double-edged sword for LGBTQ+ youth

Social media has been described as both a safe and toxic space for LGBTQ+ youth. This mixed-methods online study examined whether differences in youth's open-ended narratives moderate associations between quantitative measures of online discrimination and mental health and substance use. Three thematic groups emerged from open-ended responses of 406 LGBTQ+ 14–18-year-old participants: social media as a source of connection, refuge, or rejection. Moderation analyses indicated that at higher levels of discrimination, youth in the connection narrative group experienced elevated associations between measures of discrimination and depression, anxiety, and substance use compared to the rejection group. The results highlight the significance of a mixed-methods approach, as narratives from LGBTQ+ youth about their social media experiences illuminated the quantitative findings. Findings also call for practices that acknowledge the dual-faceted nature of social media and promote connections within LGBTQ+ communities to increase LGBTQ+ youth's mental health resilience against online discrimination.

Community Awareness Model Based on Integrity, Attitude, Knowledge and Perception Towards Solid Waste Management and Environmental Care

Globally, the solid waste management (SWM) and environmental care (EC) are critical issues that require significant attention. Increasing community Awareness is one solution to address these challenges. Community awareness on SWM and EC refers to a community's knowledge and understanding of the importance of proper waste management and environmental care. The objectives in this study are: i) to identify the strength of relationships between variables and ii) to develop a multiple linear regression model for community Awareness, Integrity, Attitude, Knowledge, and Perception. A total of 254 respondents from UiTM Perak Branch, Tapah Campus participated by completing an online questionnaire, with 70.87% female and 29.13% male respondents. The study used a simple random sampling technique and applied correlation analysis and multiple linear regression. The results showed moderate associations (0.4 &lt; r &lt; 0.7) between community Awareness and Integrity, Attitude, Knowledge, and Perception regarding SWM and EC. The multiple linear regression model was found to be significant with a p-value of less than 0.05 where all variables were significantly contributed on community Awareness.

Associations between muscular strength and mental health in cognitively normal older adults: a cross-sectional study from the AGUEDA trial

ObjectiveTo examine the associations between muscular strength and mental health. DesignWe used baseline data of 91 cognitively healthy older adults (71.69 ± 3.91 years old, 57 % women) participating in the AGUEDA randomized controlled trial. MethodsMuscular strength was assessed using both objective (i.e., handgrip strength, biceps curl, squats, and isokinetic test) and perceived (i.e., International Fitness Scale) indicators. Psychological ill-being indicators: anxiety, depression, stress, and loneliness; and psychological well-being indicators: satisfaction with life, self-esteem, and emotional well-being) were assessed using a set of valid and reliable self-reported questionnaires. Linear regression analyses were performed adjusting for sex, age, years of education, body mass index , alcohol, diet, and smoking (model 1), and additionally by cardiorespiratory fitness (model 2). ResultsElbow extension was positively associated with stress in model 1 (β = 0.252, 95 % Confidence Interval [95 % CI] = 0.007 to 0.497, p = 0.044), and even after further adjustment for cardiorespiratory fitness (β = 0.282, 95 % CI = 0.032 to 0.532, p = 0.028). Perceived strength was negatively associated with depressive symptoms in model 1 (β = -0.271, 95 % CI = -0.491 to -0.049, p = 0.017) and model 2 reported associations tending towards significant (β = -0.220, 95 % CI = -0.445 to 0.005, p = 0.055). Handgrip strength was positively associated with self-esteem in model 1 (β = 0.558, 95 % CI = 0.168 to 0.949, p = 0.006) and model 2 (β = 0.546, 95 % CI = 0.135 to 0.956, p = 0.010). No further associations were found among other muscular strength and mental health variables. ConclusionHandgrip had a moderate association with self-esteem and there was a small association between perceived strength with depressive symptoms and elbow extension with stress. No other associations were observed between muscular strength and mental health outcomes in cognitively normal older adults.

Relationship of Quality of Life with Perceptions of Physical Fitness and Exercise Activity Level in the Elderly

Aim: The quality of life of any individual is influenced by various determinants. No study evaluated the relationship of quality of life with perceptions of physical fitness and exercise activity level in the elderly Indian population, so the present study aimed to find out the relationship of quality of life with perceptions of physical fitness and exercise activity level in the elderly. Methods: The study had a cross-sectional research design. Eighty- five participants with a mean age of 67 years participated in the study. SF-36 was used to evaluate the quality of life and the Physical Fitness and Exercise Activity of Older Adult’s scale was used to evaluate physical activity perceptions. Karl Pearson correlation coefficient was used to assess correlations and a t-test was used to see any gender differences. Results: Significant but weak to moderate associations were found between the perceived physical fitness, and exercise frequency with the physical functioning component of quality of life in the elderly. The Perceived motivators only mildly affect the social functioning aspect of an individual’s life. The Perceived barriers show moderate correlations with multiple components of the quality of life of an individual. Conclusion: Elderly people’s perception regarding physical fitness and exercise activity level significantly affects their quality of life, especially their physical functioning and exercise frequency. Keywords: Elderly population, Perceived physical fitness and exercise activity level, Physical activity, Quality of life, SF-36

A Network Analysis of Digital Clock Drawing for Command and Copy Conditions.

Graphomotor and time-based variables from the digital Clock Drawing Test (dCDT) characterize cognitive functions. However, no prior publications have quantified the strength of the associations between digital clock variables as they are produced. We hypothesized that analysis of the production of clock features and their interrelationships, as suggested, will differ between the command and copy test conditions. Older adults aged 65+ completed a digital clock drawing to command and copy conditions. Using a Bayesian hill-climbing algorithm and bootstrapping (10,000 samples), we derived directed acyclic graphs (DAGs) to examine network structure for command and copy dCDT variables. Although the command condition showed moderate associations between variables (= 0.34) relative to the copy condition ( = 0.25), the copy condition network had more connections (18/18 versus 15/18 command). Network connectivity across command and copy was most influenced by five of the 18 variables. The direction of dependencies followed the order of instructions better in the command condition network. Digitally acquired clock variables relate to one another but differ in network structure when derived from command or copy conditions. Continued analyses of clock drawing production should improve understanding of quintessential normal features to aid in early neurodegenerative disease detection.

Caught in the web: a meta-analysis of Internet addiction, excessive daytime sleepiness and depressive symptoms in adolescents

PurposeIn response to growing concerns over the negative consequences of Internet addiction on adolescents’ mental health, coupled with conflicting results in this literature stream, this meta-analysis sought to (1) examine the association between Internet addiction and depressive symptoms in adolescents, (2) examine the moderating role of Internet freedom across countries, and (3) examine the mediating role of excessive daytime sleepiness.Design/methodology/approachIn total, 52 studies were analyzed using robust variance estimation and meta-analytic structural equation modeling.FindingsThere was a significant and moderate association between Internet addiction and depressive symptoms. Furthermore, Internet freedom did not explain heterogeneity in this literature stream before and after controlling for study quality and the percentage of female participants. In support of the displacement hypothesis, this study found that Internet addiction contributes to depressive symptoms through excessive daytime sleepiness (proportion mediated = 17.48%). As the evidence suggests, excessive daytime sleepiness displaces a host of activities beneficial for maintaining mental health. The results were subjected to a battery of robustness checks and the conclusions remain unchanged.Practical implicationsThe results underscore the negative consequences of Internet addiction in adolescents. Addressing this issue would involve interventions that promote sleep hygiene and greater offline engagement with peers to alleviate depressive symptoms.Originality/valueThis study utilizes robust meta-analytic techniques to provide the most comprehensive examination of the association between Internet addiction and depressive symptoms in adolescents. The implications intersect with the shared interests of social scientists, health practitioners, and policy makers.

Biochemical responses in Pacific oysters Magallana gigas (Thunberg, 1793): Tools to evaluate the environmental quality of aquaculture areas

The discharge of sanitary sewage into the bays of the Florianópolis Metropolitan Area (Southern Brazil), has led to the contamination of oyster farms. Consequently, linear alkylbenzenes (LABs) were quantified in the sediment, and the biochemical responses in gills and digestive gland of oysters from six farms were assessed. Our findings revealed elevated levels of LABs in the sediment of the Imaruim and Serraria farms. Additionally, alterations were observed in the antioxidant enzymes: catalase, glutathione peroxidase and superoxide dismutase in both oyster tissue from the Serraria, Santo Antonio de Lisboa and Sambaqui farms. Furthermore, correlation analyses indicated strong and moderate associations between biochemical responses, organic contaminants, and certain physicochemical parameters. Consequently, our results demonstrated the activation of the antioxidant system in oysters, representing a protective response to the presence of sanitary sewage and other contaminants. Therefore, we propose the utilization of biochemical biomarkers for monitoring the environmental quality of farms.

Spillover Between Daily Marital Interactions and Parenting Practices: Sensory Processing Sensitivity as Moderators

The present study aimed to examine whether the spillover effects existed between daily marital interactions and daily parenting practices after disentangling the between- and within-family effects and whether parents’ sensory processing sensitivity (SPS) would moderate such associations. The current study included 127 parents (83.3% female and 16.7% male; M age = 34.18, SD = 4.15) who reported their marital interactions and parenting practices over 14 consecutive days. The results of two separate dynamic structural equation models showed that the spillover effects of marital interactions to parenting occurred in a transient and mood-congruent pattern, and SPS traits moderated the relations between marital conflict and negative parenting practices.

Carboxyhemoglobin in Cardiac Surgery Patients and Its Association with Risk Factors and Biomarkers of Hemolysis.

Cardiac surgery with cardiopulmonary bypass (CPB) is associated with hemolysis. Yet, there is no easily available and frequently measured marker to monitor this hemolysis. However, carboxyhemoglobin (CO-Hb), formed by the binding of carbon monoxide (a product of heme breakdown) to hemoglobin, may reflect such hemolysis. We hypothesized that CO-Hb might increase after cardiac surgery and show associations with operative risk factors and indirect markers for hemolysis. We conducted a retrospective descriptive cohort study of data from on-pump cardiac surgery patients. We analyzed temporal changes in CO-Hb levels and applied a generalized linear model to assess patient characteristics associated with peak CO-Hb levels. Additionally, we examined their relationship with red blood cell (RBC) transfusion and bilirubin levels. We studied 38,487 CO-Hb measurements in 1735 patients. CO-Hb levels increased significantly after cardiac surgery, reaching a peak CO-Hb level 2.1 times higher than baseline ( P < .001) at a median of 17 hours after the initiation of surgery. Several factors were independently associated with higher peak CO-Hb, including age ( P < .001), preoperative respiratory disease ( P = .001), New York Heart Association Class IV ( P = .019), the number of packed RBC transfused ( P < .001), and the duration of CPB ( P = .002). Peak CO-Hb levels also significantly correlated with postoperative total bilirubin levels (Rho = 0.27, P < .001). CO-Hb may represent a readily obtainable and frequently measured biomarker that has a moderate association with known biomarkers of and risk factors for hemolysis in on-pump cardiac surgery patients. These findings have potential clinical implications and warrant further investigation.

The relationship of neuropsychiatric symptoms with inflammatory markers in the hippocampus and cingulate cortex of bipolar disorder subjects: A post-mortem study

Increased levels of inflammation markers have been found in the peripheral tissue of individuals with bipolar disorder (BD), especially during mood episodes. Previous studies found distinctive inflammatory profiles across different brain regions, but potential associations with clinical symptoms are still lacking. This study aims to evaluate the association of neuropsychiatric symptoms with inflammatory markers in the hippocampus and cingulate of individuals with BD. Levels of IL-1β, IL-6, IL-17A, cortisol, and C-reactive protein (CRP) were measured in the hippocampus and anterior cingulate of 14 BD individuals and their non-psychiatric controls. Neuropsychiatric symptoms present in the three months before death were assessed using the Neuropsychiatric Inventory (NPI). In the BD group, greater NPI scores were associated with higher IL-6 in the hippocampus (p = 0.011) and cingulate (p = 0.038) and higher IL-1β (p = 0.039) in the hippocampus. After adjusting for age, sex and CDR, IL-1β and IL-6 were still associated with higher NPI in the hippocampus. In correlation analysis considering both BD and their controls, moderate positive associations were found between NPI and IL-6 and cortisol in the hippocampus (p < 0.001 and p = 0.006) and cingulate (p = 0.024 and p = 0.016), IL-1β (p < 0.001) and IL-17A in the hippocampus (p = 0.002). No difference in inflammatory markers was found according to type of psychotropic medication used. Hence, in individuals with BD, neuropsychiatric symptoms were differently associated with specific inflammatory cytokines and CRP in the hippocampus and cingulate. These results suggest that the neuroinflammatory changes occurring in BD may be more complex than previously expected and could be associated with clinical manifestations.

The influence of ambient environmental factors on breakthrough cancer pain: insights from remote health home monitoring and a proposed data analytic approach

BackgroundBreakthrough cancer pain (BTCP) is primarily managed at home and can stem from physical exertion and emotional distress triggers. Beyond these triggers, the impact of ambient environment on pain occurrence and intensity has not been investigated. This study explores the impact of environmental factors on the frequency and severity of breakthrough cancer pain (BTCP) in the home context from the perspective of patients with advanced cancer and their primary family caregiver.MethodsA health monitoring system was deployed in the homes of patient and family caregiver dyads to collect self-reported pain events and contextual environmental data (light, temperature, humidity, barometric pressure, ambient noise.) Correlation analysis examined the relationship between environmental factors with: 1) individually reported pain episodes and 2) overall pain trends in a 24-hour time window. Machine learning models were developed to explore how environmental factors may predict BTCP episodes.ResultsVariability in correlation strength between environmental variables and pain reports among dyads was found. Light and noise show moderate association (r = 0.50–0.70) in 66% of total deployments. The strongest correlation for individual pain events involved barometric pressure (r = 0.90); for pain trends over 24-hours the strongest correlations involved humidity (r = 0.84) and barometric pressure (r = 0.83). Machine learning achieved 70% BTCP prediction accuracy.ConclusionOur study provides insights into the role of ambient environmental factors in BTCP and offers novel opportunities to inform personalized pain management strategies, remotely support patients and their caregivers in self-symptom management. This research provides preliminary evidence of the impact of ambient environmental factors on BTCP in the home setting. We utilized real-world data and correlation analysis to provide an understanding of the relationship between environmental factors and cancer pain which may be helpful to others engaged in similar work.

Peer support as moderator of association between socioeconomic status and low-grade inflammation in adolescents.

Individuals who grow up in low-socioeconomic status (SES) families are at an increased risk of health problems across the lifespan. Although supportive social relationships are postulated to be a protective factor for the health of these individuals, the role of friend support in adolescence is not well understood. Given that low-grade inflammation is one key biological mechanism proposed to explain links between family SES and health outcomes, we examined whether adolescents' friend support buffers the association between family SES and low-grade inflammation among adolescents. 277 dyads of adolescents (63.5% female; 39.4% White, 38.3% Black, and 32.1% Hispanic; Mage = 13.92 years) and one of their parents participated in this longitudinal study (two waves approximately 2 years apart). Parents reported family objective SES (i.e., income, savings, and education) and family subjective SES (i.e., subjective social status). Adolescents reported perceived friend support. Fasting antecubital blood was drawn from adolescents at both visits. Low-grade inflammatory activity was represented by a composite of inflammatory biomarkers and numbers of classical monocytes. Adolescents' friend support moderated the associations of family subjective SES with both the inflammation composite and classical monocyte counts across cross-sectional, longitudinal, and prospective change (only significant for the inflammation composite) analyses. Specifically, lower family subjective SES was associated with higher levels of low-grade inflammation only among adolescents lower, but not higher, in friend support. No moderation was observed for objective SES. Supportive peer relationships buffer the link between family subjective, but not objective, SES and low-grade inflammation in adolescence. (PsycInfo Database Record (c) 2024 APA, all rights reserved).