Colonoscopy is one of the most common screening procedure to detect colorectal cancer. Sedation during colonoscopy decreases anxiety, discomfort, minimizes risks, and promotes the overall satisfaction of the patient. It’s a challenge for nurses to adopt a sedation regimen taking into consideration traditional and modern techniques and methods. Purpose: To compare moderate and deep sedation effects on satisfaction, length of stay, and overall experience of patients undergoing colonoscopy. Methods: A quasi-experimental research was conducted among 149 patients who responded to the Iowa Satisfaction with Anesthesia Scale after been consented pre-procedure. Results: Statistically significant differences were demonstrated for almost most items of Iowa satisfaction with the anesthesia scale, in addition to the clear difference between the post-procedure stay duration and time to have had their vitals baselined again. Conclusion: Deep sedation using Propofol was much more effective in enhancing patient satisfaction and reducing the length of stay and procedure duration substantially, thus contributing to a higher quality of care and improved performance of the endoscopy units.