Context: Agility is one of the adjustments organizations must make in a tumultuous environment. Organizational agility is a collection of concepts that aims to maximize both tangible and intangible resources while continuously improving the organization as a whole. It has a great impact on job engagement among nurses. Aim: To assess the relationship between organizational agility and job engagement among the staff nurses. Methods: A descriptive, correlational study approach was employed. Ain Shams University Hospital, one of the hospitals affiliated to Ain Sham University, served as the study's setting. Of the 303 staff nurses, 170 were chosen randomly for the study. The two instruments utilized were the Job Engagement Scale and the Organizational Agility Assessment Questionnaire. Results: The findings demonstrated that although 20% of the studied staff nurses exhibited a high perception level of organizational agility, the largest proportion (55%) demonstrated a moderate perception level. Additionally, 30% of the staff nurses reported moderate job engagement, and a larger percentage (60%) reported a high engagement level. Conclusion: A statistically significant positive relationship was observed between job engagement and organizational agility among staff nurses. The study recommends that hospital managers cultivate an agile atmosphere, enhance self-awareness, and ensure that organizational strategies promote resilience to effectively address daily challenges.