Moderate Aerobic Exercise Research Articles

Usefulness of Aerobic Exercise for Home Blood Pressure Control in Patients with Diabetes: Randomized Crossover Trial.

Hypertension usually coexists with diabetes mellitus and significantly increases the risk of macrovascular complications. Blood pressure measured at home, especially nocturnal blood pressure, is particularly important because it is more strongly associated with target organ damage than clinical blood pressure measurements. Regular moderate aerobic exercise has been shown to have anti-hypertensive effects. This study aimed to investigate the effects of aerobic exercise on home blood pressure in patients with diabetes. This randomized crossover trial was based on outpatient treatment at a university hospital. In this randomized crossover trial, 124 patients with type 2 diabetes were randomly assigned to two groups over 56 days: an exercise preceding group (exercise intervention for 28 days and then no exercise intervention for the following 28 days) and an exercise lagging group (no exercise intervention for 28 days and then exercise intervention for the following 28 days). The associations between the nocturnal blood pressure and exercise intervention were assessed accordingly. A decrease in blood pressure was observed in the morning and evening, at 2 a.m. and 3 a.m. after exercise intervention; however, there was no significant difference between groups. Moderate exercise was not effective in lowering nocturnal blood pressure in this study.

Protection against Osteoarthritis Symptoms by Aerobic Exercise with a High-Protein Diet by Reducing Inflammation in a Testosterone-Deficient Animal Model

A testosterone deficiency potentially increases osteoarthritis (OA) symptoms, and dietary protein and exercise affect them. However, their efficacy and their interactions are still unclear. We hypothesized that a high-protein diet (HPD) and regular exercise modulated OA symptoms in testosterone-deficient rats, and it was examined in bilateral orchidectomized (ORX) and monoiodoacetate (MIA)-injected rats. The ORX rats were given a 30 energy percent (En%) protein (HPD) or 17.5 En% protein (CD). Both groups had 39 En% fat in the diet. Non-ORX-CD rats (sham-operation of ORX) were given the CD and no exercise (normal control). After an eight-week intervention, all rats had an injection of MIA into the left knee, and the treatments were continued for an additional four weeks. The non-ORX-CD rats showed a significant increase in body weight compared to the ORX rats, but the ORX rats had elevated fat mass. ORX exacerbated the glucose tolerance by lowering the serum insulin concentrations and increasing insulin resistance. ORX exacerbated the OA symptoms more than the non-ORX-CD. The HPD and exercise improved bone mineral density and glucose metabolism without changing serum testosterone concentrations, while only exercise increased the lean body mass and decreased fat mass, lipid peroxide, and inflammation. Exercise, but not HPD, reduced the OA symptoms, the weight distribution in the left leg, and running velocity and provided better relief than the non-ORX-CD rats. Exercise with HPD improved the histology of the knee joint in the left leg. Exercise reduced lipid peroxide contents and TNF-α and IL-1β mRNA expression in the articular cartilage, while exercise with HPD decreased MMP-3 and MMP-13 mRNA expression as much as in the non-ORX-CD group. In conclusion, moderate aerobic exercise with HPD alleviated OA symptoms and articular cartilage degradation in a similar way in the non-ORX rats with OA by alleviating inflammation and oxidative stress.

The Effect of an Aerobic Exercise Period on Levels of Depression and Interleukin- 6 Cytokine During Pregnancy and Postpartum in NMRI Mice

Background and Objectives Depression during pregnancy is a common mental disorder that has many side effects, including a disorder of the immune system. Recently, the available evidence supports the use of aerobic exercise interventions in reducing depressive symptoms in mothers. The aim of this study was to investigate the effect of an aerobic exercise period on levels of depression and Interleukin-6 (IL-6) concentration during pregnancy and postpartum in NMRI female mice. Methods In this experimental and baseline study, 40 female NMRI mice with an approximate age of 80- 90 days and a weight of 22-25 g were divided into four groups: Non Exercise in Pregnancy, Non Exercise in Postpartum, Exercise in Pregnancy, Exercise in Postpartum. After seeing the vaginal plaque and confirming the day of pregnancy of the animals, two running wheels were placed inside the cage of each pregnant animal for aerobic activity. In order to induce depression during pregnancy and postpartum, pregnant mice from day 5 to 19 of pregnancy were exposed to stress for three sessions a day, and to assess depression levels, the rate of delay in access to food after 24 hours of food deprivation was measured in seconds. At the end of the protocol, blood samples were taken from the heart to assess IL-6 and the data were analyzed using one-way Analysis of variance (ANOVA) . Results According to the findings of this study, moderate and low intensity aerobic exercise during pregnancy as well as in the postpartum period led to a significant decrease in levels of depression (P<0.05) and concentration of IL-6 as an inflammatory cytokine in trained mice compared to sedentary mice (P<0.05). Conclusion This results of the present study showed, the aerobic activity used was able to reduce the levels of depression and the concentration of inflammatory factor IL-6 during pregnancy and postpartum. Therefore, low-intensity aerobic activity can probably be used as a non-pharmacological intervention during this period to reduce depressive symptoms and improve immune function.

Influence of a 12-month supervised, intensive resistance, aerobic and impact exercise intervention on muscle strength in prostate cancer patients undergoing anti-hormone therapy: Study protocol for the randomized, controlled Burgdorf study

IntroductionReduced testosterone levels due to androgen deprivation therapy (ADT) in prostate cancer patients cause common side effects, such as reduced muscle strength and bone density, increased fat mass, sexual dysfunction and fatigue. Short-term exercise during ADT has proven to be safe and effective in exhibiting a positive impact on body composition, sexual dysfunction and fatigue. However, there are only three randomized controlled trials that investigate one-year supervised impact exercise interventions, none of which examined follow-up effects after the intervention. Therefore, this study will conduct a one-year impact exercise intervention and assess follow-up effects up to one year later. Material and methodsThe aim of the randomized, controlled Burgdorf study is to assess the effects of a supervised 12-month intensive multimodal exercise intervention in comparison to a moderate aerobic exercise intervention, on muscle strength in prostate cancer patients receiving ADT. Additionally, quality of life, fatigue, body composition, erectile dysfunction, bone pain, physical activity level, endurance capacity, body-mass-index, waist and hip circumference and prostate-specific antigen- and testosterone levels will be assessed up to one year later. DiscussionThe Burgdorf study is the first study to conduct two different one-year supervised exercise interventions, and follow-up with patients for up to one year after the intervention. Results could provide important insights into the long-term effects of interventions on those parameters negatively affected by ADT, which could specify or newly establish care structures. Trial registrationGerman Clinical Trials Register, DRKS00009975. Registered 2016-02-09, https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00009975

Comparative effects of 6-weeks progressive resistance exercise and moderate intensity aerobic exercise on CD4 count and weights of people living with HIV/AIDS in Alex-Ekwueme Federal University Teaching Hospital Ebonyi State.

Introduction:The most significant clinical challenges in people living with HIV/AIDS (PLWHA) are decline in CD4+ T helper cells and abnormal weight reduction. Consequently, PLWHA who are on Anti-Retroviral Therapy (ART) or Highly Active Anti-Retroviral Therapy (HAART) are usually predisposed to coronary artery diseases due to abnormal weight gain (lipohypertrophy), though with improved and unstable Cluster of Differentiation 4 (CD4) counts.The main aim of this study was to compare the effects of 6 weeks progressive resistance exercise (PRE) and moderate intensity aerobic exercise (MIAE) on CD4 count, and weight of PLWHA in Alex-Ekwueme Federal University Teaching Hospital Ebonyi State.Method:The study adopted quasi experimental research design. The population of the study was 60 Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome patients that attended HIV clinics at Alex-Ekwueme Federal University Teaching Hospital Abakaliki (AE-FUTHA) which formed 58 sample sizes for this study.Simple random sampling technique was adopted for the study and flow cytometry, Heel Densitometer (X-rite 331C), and Omron BF 400 were the instrument used for data collection of CD4 counts and weight respectively; and they are standardized hence not validated. Mean, standard deviation and Analysis of Co-variance (ANCOVA) were used to analyze the data obtained. The reliability coefficient obtained from the pilot study was 0.848 and 0.994 for CD4 and WEIGHT respectively.Results:The major findings revealed a significant difference after 6 weeks’ PRE and MIAE on CD4 and Weight of PLWHA.Conclusion:Health promotion policy maker's arm of the government and Healthcare givers should integrate and enforce the use of exercises either as a single regimen or combined exercises into the management plan of PLWHA for greater boost in absolute CD4 count bearing in mind that both have positive effects. Physiotherapist should be integrated in the managements of PLWHA for appropriate prescription and education of therapeutic exercises for body weight.

Effects of Caffeine Intake on Cardiopulmonary Variables and QT Interval after a Moderate-Intensity Aerobic Exercise in Healthy Adults: A Randomized Controlled Trial.

Caffeine is considered a widely consumed natural and legal psychoactive stimulant with several effects on the body. The present study attempted to investigate the effects of caffeine consumed before and after a physical exercise on cardiovascular and cardiorespiratory functions in healthy adults. 36 healthy adult males were recruited and randomly allocated to one of the three (3) groups: group I (exercise without caffeine consumption), group II (caffeine beverage intake before exercise), and group III (caffeine beverage intake immediately after exercise). The heart rate (HR), QTc interval, blood pressure (BP), respiratory rate (RR), oxygen consumption (VO₂), and carbon dioxide emission (VCO₂) were measured at 0, 5, 10, and 15 min after the exercise. We observed a significant difference in all measured outcomes during the different recovery times in all the groups (p < 0.05). HR, RR, SBP, VO2, and VCO2 gradually decreased with time, DBP contrarily increased with time, and the QTc showed an irregular pattern. We can affirm that ingestion of caffeine before and after moderate aerobic exercise slows down the parasympathetic stimulation, heart rate recovery, and the recovery of HR and QTc with no major effects on BP, RR, VO₂, and VCO₂ in healthy adult men.

Effect of Moderate Intensity Aerobic Exercise on Fertility Hormones in Male Obese Individual in Nnewi, Nigeria

Effect of Moderate Intensity Aerobic Exercise on Fertility Hormones in Male Obese Individual in Nnewi, Nigeria

Effect of aerobic exercise on cognition in elderly persons with mild cognitive impairment

Objective: To determine the effect of aerobic exercise on cognition in elderly persons with mild cognitive impairment. Methodology: This randomized controlled trial was conducted at Physiotherapy Rehabilitation center of NCS University, Swabi Campus. The inclusion criteria were age group between 60 to 70 years, MMSE 18-23 and able to walk independently without use of assistive device. Those with musculoskeletal disorders, current medical condition for which exercise was contraindicated, had cardiac and respiratory disorders were excluded from the study. A sample of 60 patients were randomly divided into experimental and control group using sealed envelope technique. Treatment for the experimental group was moderate intensity aerobic exercise program i.e., walking and control group received active range of motion exercises and stretching 5days/week for 6 weeks. Control group performed gentle active range of motion exercises and stretching exercises to large muscle groups of lower limb and trunk muscles for 5-7 cycles of 10 repetitions for 20 mins for 5 days/week and training was continued for 6 weeks. MMSE, MoCA, Trail making Test A and B were done at baseline and after 6 weeks of intervention. Results: Of the 75 patients assessed, 60 were included; of them there were 30 in each group. Mean age was 62.49±1.82years. There were 35(56.5%) males and 24 (38.7%) females. Intra-group analysis showed significant improvement in outcomes measures MMSE, MoCA, TMT-A and B after six weeks of intervention in aerobic training group (p&lt;0.05). Inter-group analysis showed significant differences in scores of neurocognitive measures (p&lt;0.05) after six weeks of training. Conclusion: Aerobic exercise showed improvement in neurocognitive domains of elderly persons with mild cognitive impairment after 6 weeks of intervention.

Acute aerobic exercise and attentional focus influence the self-positivity bias in emotional evaluation. Evidence from an experimental study

Abstract The influence of aerobic exercise, as a possibly mood-enhancing experience, was investigated for its effect on emotional evaluation of self- vs. other-related emotional (e.g., my/his joy) or neutral (e.g., my/his notes) stimuli. N=30 participants (healthy, female novices, i.e., with no regular, dedicated training schedule) performed four separate sessions of moderate aerobic exercise (22 min of cycling at 60-70% HRmax). Attentional focus was manipulated across exercise bouts (internal focus vs. external focus vs. no instructed attention focus vs. control condition consisting of no exercise and no instructed attention focus). Emotional evaluation of verbal stimuli was assessed 10 minutes after each exercise bout. Exercise increased self-reported positive affect compared to the inactive control condition regardless of attentional focus. Exercising without instructed attentional focus led to faster reaction times in the emotional evaluation task compared to the inactive control condition. Instructed internal or external attentional focus did not affect evaluations (number of valence-congruent responses) or reaction times compared to the no-exercise control condition. Self-reported internal attentional focus during cycling was associated with a subsequently stronger, and in the case of an external focus with a subsequently rather reduced self-positivity bias in the evaluation of self-related, positive vs. other-related positive words.

Analysis of Application Effect of Conventional Drugs Combined with Aerobic Exercise in the Treatment of Patients with Heart Failure

To retrospectively analyze the efficacy of polypharmacy conventional drugs and aerobic exercise diagnosed in the treatment of chronic heart failure is the objective of the study. From January 2021 to June 2022, 106 patients with chronic heart failure were hospitalized in cardiovascular department of Zhejiang hospital. The control group was taken conventional anti-heart failure drug treatment. On the basis of the control group, the research group implemented 12 w of scientific aerobic exercise and monitored the patient’s exercise status and treatment effect on the mobile phone exercise applications. After receiving medication and 12 w of aerobic exercise training, left ventricular systolic dysfunction and left ventricular diastolic dysfunction in the study were lower than those in the control group and the left ventricular ejection fraction increased significantly compared to the study group and differences between the two groups was statistically significant (p<0.05). The red blood cell distribution width and the opposite association were seen in the subjects studied using New York heart association grade and left ventricular ejection fraction in cardiac function was determined. Manifestations of red blood cells were negatively associated with the maximal oxygen consumption in exercise capacity. Maximum power and time of exhaustion were negatively correlated. The two different groups have marked differences in the left ventricular ejection fraction and New York heart association classification, improvement of maximal oxygen consumption and time of exhaustion (p<0.05). Failure in the application of anti-heart failure drug therapy combined with moderate aerobic exercise application in long-term heart failure patients can effectively reduce the red blood cell distribution width and improve the patient’s health. Cardiac function and exercise capacity, and aerobic exercise can effectively reduce the degree of myocardial damage, improve exercise tolerance, and promote medical recovery of heart failure patients.

Role of Exercise Intensity on Th1/Th2 Immune Modulations During the COVID-19 Pandemic.

The COVID-19 pandemic has led to several pioneering scientific discoveries resulting in no effective solutions with the exception of vaccination. Moderate exercise is a significant non-pharmacological strategy, to reduce the infection-related burden of COVID-19, especially in patients who are obese, elderly, and with additional comorbidities. The imbalance of T helper type 1 (Th1) or T helper type 2 (Th2) cells has been well documented among populations who have suffered as a result of the COVID-19 pandemic, and who are at maximum risk of infection and mortality. Moderate and low intensity exercise can benefit persons at risk from the disease and survivors by favorable modulation in Th1/Th2 ratios. Moreover, in COVID-19 patients, mild to moderate intensity aerobic exercise also increases immune system function but high intensity aerobic exercise may have adverse effects on immune responses. In addition, sustained hypoxia in COVID-19 patients has been reported to cause organ failure and cell death. Hypoxic conditions have also been highlighted to be triggered in COVID-19-susceptible individuals and COVID-19 survivors. This suggests that hypoxia inducible factor (HIF 1α) might be an important focus for researchers investigating effective strategies to minimize the effects of the pandemic. Intermittent hypoxic preconditioning (IHP) is a method of exposing subjects to short bouts of moderate hypoxia interspersed with brief periods of normal oxygen concentrations (recovery). This methodology inhibits the production of pro-inflammatory factors, activates HIF-1α to activate target genes, and subsequently leads to a higher production of red blood cells and hemoglobin. This increases angiogenesis and increases oxygen transport capacity. These factors can help alleviate virus induced cardiopulmonary hemodynamic disorders and endothelial dysfunction. Therefore, during the COVID-19 pandemic we propose that populations should engage in low to moderate exercise individually designed, prescribed and specific, that utilizes IHP including pranayama (yoga), swimming and high-altitude hiking exercise. This would be beneficial in affecting HIF-1α to combat the disease and its severity. Therefore, the promotion of certain exercises should be considered by all sections of the population. However, exercise recommendations and prescription for COVID-19 patients should be structured to match individual levels of capability and adaptability.

Total Transcriptome Responses to Low and Higher Intensity Aerobic Exercise Interventions in Older Adults

Glutathione is an intracellular antioxidant that neutralizes reactive oxygen species and prevents tissue damage. Dietary supplementation with the glutathione precursors glycine and n-acetylcysteine supports the maintenance of normal glutathione levels in several age-related diseases, but the optimal doses and their efficacy in healthy elderly are not established. We report results from a randomized controlled clinical trial in 114 healthy volunteers (mean age = 65 years) receiving glycine and n-acetylcysteine (GlyNAC) at three different doses for two weeks (1.2g/1.2, 2.4g/2.4g, 3.6g/.3.6g of each amino acid). Older subjects showed increased oxidative damage and a lower reduced-to-oxidized glutathione ratio (GSH:GSSG) compared to young subjects, but unchanged total glutathione levels. GlyNAC did not increase levels of circulating glutathione compared to placebo treatment, the primary study endpoint. However, stratification analyses suggest that subjects with high oxidative stress and low glutathione status responded with glutathione generation. We find that unrelated to glutathione status, healthy aging was associated with lower levels of fasting glycine that can be increased towards those observed in young subjects with supplementation. Using preclinical models, we find that tissue glycine depletion is a common feature of healthy aging. Supplementation of old mice with glycine efficiently improved age-related decline of mitochondrial respiratory function in skeletal muscle and prevented a gene program associated with protein catabolism observed in control-treated animals. In conclusion, GlyNAC is safe and well-tolerated and may selectively increase glutathione levels in older subjects with oxidative stress and glutathione demand. Our data further suggest that glycine may support mitochondrial function independently of NAC.

Exercise as a treatment for clinical depression in adults and progressing the physiotherapists role: A systematic review and meta-analysis

BACKGROUND: There has been extensive literature examining the efficacy of exercise interventions in the treatment of depression over the past few decades. However, there is ongoing debate regarding the optimal dosage, and the implications of utilising physiotherapists for the management of clinically depressed adults using exercise has not been examined. OBJECTIVES: This review aimed to examine the effectiveness of exercise as a treatment for depression (without comorbidities) and to determine the most effective dosage/mode to treat this population. This review strived to appraise the literature for a potential role for physiotherapists in depression management. METHODS: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol, a search for randomized controlled trials was conducted on the nine databases. All studies were appraised for quality using the Physiotherapy Evidence Database (PEDro) scale and Cochrane Risk of Bias Tool (RoB). Data was manually extracted, and pre- and post-intervention depression scores and program variables were analysed. RESULTS: Of the 5036 papers retrieved, 7 papers met this review’s inclusion criteria. The results of the meta-analysis reveal that exercise as a sole treatment and as an add-on is significantly effective in reducing depressive symptoms. The findings support the use of moderate intensity aerobic exercise for three sessions per week. CONCLUSIONS: Exercise was shown to significantly improve depressive symptoms in depressed adults. This review adds to the growing body of evidence regarding the important role of physiotherapists in the treatment of psychiatric disorders in the design and implementation of exercise interventions.

Hippocampal Oxidative Stress Induced by Radiofrequency Electromagnetic Radiation and the Neuroprotective Effects of Aerobic Exercise in Rats: A Randomized Control Trial.

The present study determined whether 4weeks of moderate aerobic exercise improves antioxidant capacity on the brain of rats against oxidative stress caused by radiofrequency electromagnetic radiation emitted from cell phones. Responses of malondialdehyde, catalase, glutathione peroxidase, and superoxide dismutase, as well as the number of hippocampal dead cells, were examined. Male Wistar rats (10-12wk old) were randomly assigned to 1 of 4 groups (N = 8): (1)moderate aerobic exercise (EXE) (2 × 15-30min at 1215m/min speed with 5 min of active recovery between sets), (2)exposure to 900/1800MHz radiofrequency electromagnetic waves 3hours per day (RAD), (3)EXE + RAD, and (4)exposure to an experimental phone without battery. Following the exposure, the number of the hippocampal dead cells was significantly higher in group RAD compared with groups EXE, EXE + RAD, and control group. Malondialdehyde concentration in group RAD was significantly higher than that of groups EXE, EXE + RAD, and control group. Also, the activity of catalase, glutathione peroxidase, and superoxide dismutase in groups EXE, EXE + RAD, and control group was significantly higher compared with those of the exposure group. This study demonstrated that moderate aerobic exercise enhances hippocampal antioxidant capacity against oxidative challenge in the form of radiofrequency electromagnetic waves.

Aerobic Exercise Mediated Increase in BDNF Expression Ameliorates Depression in Propylthiouracil-Induced Hypothyroidism in Adult Rats.

• Hypothyroidism is associated with depressive symptoms. • Swimming exercise for 4 weeks alleviated depressive behavior in hypothyroid rats. • The enhanced irisin/BDNF axis activity following moderate aerobic exercise was positively correlated with climbing time in forced swimming test and with brain serotonergic system activity. • It is concluded that moderate aerobic exercise alleviated hypothyroidism-associated depression via increased BDNF expression. : The prevalence of depression with hypothyroidism is high. : To study the ability of aerobic exercise to improve hypothyroidism associated depression and to explore the underlying mechanisms. 21 adult male rats, allocated in three groups; Euthyroid, Hypothyroid (oral propyl-thiouracil for 45 days), Exercise-treated hypothyroid group (30 minutes, swimming, 4 weeks). Forced swim test and histopathological brain examination were performed. Serum free T3, T4, TSH, irisin, brain neurochemical, oxidant-antioxidant and apoptotic markers were measured . : Swimming exercise increased serum T3, T4, climbing and swimming times, brain serotonin, BDNF expression, glutathione peroxidase, antiapoptotic Bcl-2 and serum irisin levels and decreased TSH, immobility time, MDA, BAX/Bcl-2 ratio. Climbing time was positively correlated with BDNF, serotonin and T3. : Moderate aerobic exercise alleviated hypothyroidism-associated depression, via increased BDNF expression, which enhances hippocampal neurogenesis, serotonergic system activity and combat neuronal apoptosis.

Impact of the COVID-19 Pandemic on the Health Status and Behaviors of Adults in Korea: National Cross-sectional Web-Based Self-report Survey.

BackgroundThe COVID-19 pandemic has radically shifted living practices, thereby influencing changes in the health status and behaviors of every person.ObjectiveThe aim of this study was to investigate the impact of COVID-19 on the self-reported health status and health behaviors along with any associated factors in adults in the Republic of Korea wherein no stringent lockdown measures were implemented during the pandemic.MethodsWe conducted a web-based self-reported survey from November 2020 to December 2020. The study participants (N=2097) were identified through quota sampling by age, sex, and geographical regions among residents aged 19 years or older in Korea. The survey collected information on basic demographics, changes in self-reported health status, and health behaviors during the COVID-19 pandemic. Self-reported health status and health behaviors were categorized into 3 groups: unchanged, improved, or worsened. A chi-square test and logistic regression analyses were conducted.ResultsWith regard to changes in the self-reported health status, the majority (1478/2097, 70.5%) of the participants reported that their health was unchanged, while 20% (420/2097) of the participants reported having worser health after the COVID-19 outbreak. With regard to changes in health behaviors, the proportion of participants who increased tobacco consumption was similar to that of those who decreased tobacco consumption (110/545, 20.2% vs 106/545, 19.5%, respectively), while the proportion of those who decreased their drinking frequency was more than twice as many as those who increased their drinking frequency (578/1603, 36.1% vs 270/1603, 16.8%, respectively). Further, those who decreased their exercising frequency were more than those who increased their exercising frequency (333/823, 15.9% vs 211/823, 10%, respectively). The factor that had the greatest influence on lifestyle was age. In the subgroup analysis, the group aged 20-29 years had the highest number of individuals with both a worsened (100/377, 26.5%) and an improved (218/377, 15.7%) health status. Further, individuals aged 20-29 years had greater odds of increased smoking (6.44, 95% CI 2.15-19.32), increased alcohol use (4.64, 95% CI 2.60-8.28), and decreased moderate or higher intensity aerobic exercise (3.39, 95% CI 1.82-6.33) compared to individuals aged 60 years and older. Younger adults showed deteriorated health behaviors, while older adults showed improved health behaviors.ConclusionsThe health status and the behavior of the majority of the Koreans were not found to be heavily affected by the COVID-19 outbreak. However, in some cases, changes in health status or health behavior were identified. This study highlighted that some groups were overwhelmingly affected by COVID-19 compared to others. Certain groups reported experiencing both worsening and improving health, while other groups reported unchanged health status. Age was the most influential factor for behavior change; in particular, the younger generation’s negative health behaviors need more attention in terms of public health. As COVID-19 prolongs, public health interventions for vulnerable groups may be needed.

Moderate Intensity Aerobic Exercise Potential Favorable Effect Against COVID-19: The Role of Renin-Angiotensin System and Immunomodulatory Effects.

The coronavirus disease (COVID-19) pandemic is caused by a novel coronavirus (CoV) named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). As the angiotensin converting enzyme 2 (ACE2) is the cellular receptor of SARS-CoV-2, it has a strong interaction with the renin angiotensin system (RAS). Experimental studies have shown that the higher levels of ACE2 or increasing ACE2/ACE1 ratio improve COVID-19 outcomes through lowering inflammation and death. Aerobic moderate intensity physical exercise fights off infections by two mechanisms, the inhibition of ACE/Ang II/AT1-R pathway and the stimulation of ACE2/Ang-(1–7)/MasR axis. Exercise can also activate the anti-inflammatory response so that it can be a potential therapeutic strategy against COVID-19. Here, we summarize and focus the relation among COVID-19, RAS, and immune system and describe the potential effect of aerobic moderate intensity physical exercise against CoV as a useful complementary tool for providing immune protection against SARS-CoV-2 virus infection, which is a novel intervention that requires further investigation.

Comparison of the effects of different aerobic exercise modes on myocardial hypertrophy, autonomic nerve function and exercise endurance in patients with essential hypertension.

article: Comparison of the effects of different aerobic exercise modes on myocardial hypertrophy, autonomic nerve function and exercise endurance in patients with essential hypertension - Minerva Surgery 2021 Nov 17 - Minerva Medica - Journals

Early Follicular Phase of the Menstrual Cycle May Be Associated With More Post-Exercise Hyperglycemia in Female Participants With Type 1 Diabetes

Despite substantial health benefits of exercise in people with type 1 diabetes (T1D), significant knowledge gaps exist around blood glucose (BG) responses to exercise in females with T1D, especially with regards to the menstrual cycle. We compared the impact of aerobic exercise on continuous glucose monitoring (CGM) glucose between the early follicular and late luteal phases of the menstrual cycle in 7 female participants with T1D (mean±SD: age 31±10 years, A1C 7.1±0.5%, VO2peak 33.2±4.3 mL/kg/min). Participants had regular menstrual cycles and were not using hormonal contraceptives. In each phase, participants performed moderate aerobic exercise (cycling at 50% of pre-determined VO2peak) for 45 minutes on an ergometer starting at 5 pm. Meal timing/composition and insulin dosage were kept as consistent as possible between sessions. Blood glucose was measured using CGM for 24 h before exercise and 24 h post exercise. There were no significant differences in mean CGM glucose between the two phases during the 24 h pre, 0-6 h post, overnight (midnight to 6 am) post, or 24 h post exercise. Mean CGM glucose was significantly higher 24 h post as compared to 24 h pre exercise (9.0±1.7 vs 7.3±1.6 mmol/L) in the follicular phase (p=0.0468). There were more post-exercise hyperglycemic episodes in the follicular phase compared with the luteal (2.9±1.7 vs 1.1±0.7, p=0.0453). Female T1D participants may be more prone to post-exercise hyperglycemia requiring insulin correction during the follicular phase of the menstrual cycle.

Combined exercise training improved exercise capacity and lung inflammation in rats with hepatopulmonary syndrome

AimPhysical exercise training attenuates pulmonary inflammation, but its effects on impaired respiratory function caused by hepatopulmonary syndrome (HPS) have not been evaluated. We determined if the combination of moderate intensity aerobic and resistance training during HPS development modifies exercise capacity, respiratory system mechanics, and lung inflammation responses. Main methodsWistar rats were randomly divided into sham, HPS, and HPS + combined exercise training groups. Fifteen days after HPS induction, a moderate intensity aerobic plus resistance exercise training protocol was performed five times a week for 5 weeks on alternate days. Exercise capacity, respiratory system mechanics, lung inflammation, pulmonary morphology, and immunohistochemistry were evaluated. Key findingsOverall, our findings indicated that combined exercise training efficiently increased the maximal running and resistance capacity of HPS animals. The training regimen reduced the expression of P2X7 in parenchymal leukocytes (P < 0.01), partially restored the expression of interleukin-10 in airway epithelium (P < 0.01), and increased the expression of TFPI in the airway epithelium (P < 0.01) as well as reduced its expression in parenchymal leukocytes (P < 0.01). However, exercise training did not attenuate HPS-induced respiratory mechanical derangements or lung tissue remodeling. SignificanceCombined exercise training can elicit adaptation with regard to both maximal running capacity and maximum strength and modify the expression of P2X7 and TFPI in parenchymal leukocytes and that of IL-10 in airway epithelium.