In the process of conical roller line processing, there will be problems such as low precision of processing parameters, long processing time, low utilization rate of machine tools, high rejection rate, and high processing cost, which will lead to low production efficiency. In order to solve this problem, it is necessary to iteratively optimize the size parameters, including inner diameter, ovality, and taper. By obtaining the optimal parameter combination, the size parameters in the production process are kept consistent, that is, the accuracy and performance of the workpiece during the processing are guaranteed so as to avoid the problem of quality difference, improve the production efficiency and reduce the processing cost. In view of the fact that there are often some constraints on the accuracy and efficiency in the machining process of tapered roller lines, how to optimize the parameters affecting the accuracy and the parameters affecting the efficiency to achieve balance between accuracy and efficiency in order to better meet the needs of customers for multi-objective optimization of the machining process has become the focus of research. Based on the existing research, this paper explores the multi-parameter optimization modeling and application in the machining process of tapered roller lines by constructing a satisfaction function, and then uses a genetic algorithm to iteratively search for the optimal solution by simulating natural selection and the genetic mechanism. Based on Python software v3.12, the production process of tapered roller bearings is simulated. The AHP analytic hierarchy process and CRITIC weight method are used to redistribute the parameter weights respectively. After eight iterations, it is concluded that the weight value assigned by the AHP analytic hierarchy process makes the satisfaction function value reach the best value of 0.99795 and tend to converge stably. The optimized parameter configuration significantly improves the machining accuracy and production efficiency of the tapered roller line. The optimal parameter combination is obtained: inner diameter: 9.9982 mm, ovality: 0.7 mm, taper: 0.5 degrees, production efficiency: 101.0.97 piece/h. In order to verify the optimization effect, the single value (X) and moving extreme difference (Rs) control charts in the measurement value control chart are used to analyze and verify the tolerance values of important parameters in the processing technology of the tapered roller line. The results show that the data points are all within the control limit, indicating that the processing process is in a statistical control state.