The development of data-driven heart sound classification models has been an active area of research in recent years. To develop such data-driven models in the first place, heart sound signals need to be captured using a signal acquisition device. However, it is almost impossible to capture noise-free heart sound signals due to the presence of internal and external noises in most situations. Such noises and degradations in heart sound signals can potentially reduce the accuracy of data-driven classification models. Although different techniques have been proposed in the literature to address the noise issue, how and to what extent different noise and degradations in heart sound signals impact the accuracy of data-driven classification models remains unexplored. To answer this question, we produced a synthetic heart sound dataset including normal and abnormal heart sounds contaminated with a variety of noise and degradations. We used this dataset to investigate the impact of noise and degradation in heart sound recordings on the performance of different classification models. The results show different noises and degradations affect the performance of heart sound classification models to a different extent; some are more problematic for classification models, and others are less destructive. Comparing the findings of this study with the results of a survey we previously carried out with a group of clinicians shows noise and degradations that are more detrimental to classification models are also more disruptive to accurate auscultation. The findings of this study can be leveraged to develop targeted heart sound quality enhancement approaches — which adapt the type and aggressiveness of quality enhancement based on the characteristics of noise and degradation in heart sound signals.