ABSTRACT It remains unclear how galactic environment affects star formation and stellar cluster properties. This is difficult to address in Milky Way-mass galaxy simulations because of limited resolution and less accurate feedback compared to cloud-scale models. We carry out zoom-in simulations to re-simulate 100–$300 \,\rm {pc}$ regions of a Milky Way-like galaxy using smoothed particle hydrodynamics, including finer resolution ($0.4 \,\rm {M_{\odot }{}}$ per particle), cluster-sink particles, ray-traced photoionization from O stars, H2/CO chemistry, and interstellar medium heating/cooling. We select ∼$10^{6} \,\rm {M_{\odot }{}}$ cloud complexes from a galactic bar, inner spiral arm, outer arm, and inter-arm region (in order of galactocentric radius), retaining the original galactic potentials. The surface densities of star formation rate and neutral gas follow $\Sigma _\mathrm{SFR}\propto \Sigma _\mathrm{gas}^{1.3}$, with the bar lying higher up the relation than the other regions. However, the inter-arm region forms stars two to three times less efficiently than the arm models at the same Σgas. The bar produces the most massive cluster, the inner arm the second, and the inter-arm the third. Almost all clusters in the bar and inner arm are small (radii <5 pc), while 30–50 per cent of clusters in the outer arm and inter-arm have larger radii more like associations. Bar and inner arm clusters rotate at least twice as fast, on average, than clusters in the outer arm and inter-arm regions. The degree of spatial clustering also decreases from bar to inter-arm. Our results indicate that young massive clusters, potentially progenitors of globular clusters, may preferentially form near the bar/inner arm compared to outer arm/inter-arm regions.