Mineral Resources estimation plays a crucial role in the profitability of the future of mining operations. The conventional geostatistical methods used for grade estimation require expertise, understanding and knowledge of the spatial statistics, resource modelling, geology, mining engineering as well as clean validated data to build accurate block models. However, the geostatistical models are sensitive to changes in data and would have to be rebuilt on newly acquired data with different characteristics, which has proved to be a time-consuming process. Machine learning methods have in recent years been proposed as an alternative to the geostatistical methods to alleviate the problems these might suffer from in Mineral Resource estimation. In this paper, a systematic literature review of machine learning methods used in Mineral Resource estimation is presented. This has been conducted on such studies published during the period 1990 to 2019. The types, performances, and capabilities, of several machine learning methods have been evaluated and compared against each other, and against the conventional geostatistical methods. The results, based on 31 research studies, show that the machine learning-based methods have outperformed the conventional grade estimation modelling methods. The review also shows there is active research on applying machine learning to grade estimation from exploration through to exploitation. Further improvements can be expected if advanced machine learning techniques are to be used.