Abstract This work introduces Version 2.0 of the Hamburg ANatomical NEurointerventional Simulator (HANNES): a novel modular neurointerventional simulator designed to provide a realistic platform for simulating various neurovascular pathologies and their endovascular therapies. Collaboratively developed by physicians and engineers, the neurointerventional simulator is designed with a modular product architecture combining standardised and variant modules to represent different training scenarios. The additively manufactured patient-based and patient-specific blood vessel tree consists of up to 13 individual components, including standardised features and interfaces for ease of connection. Patient-specific vessel models derived from medical imaging data allow customisation and complexity adjustment. HANNES supports diverse neurointerventional training scenarios, including various modalities of aneurysm embolisation, internal carotid artery stenosis, and thrombotic vessel occlusions, which can be treated through a transradial or transfemoral approach. The use and benefits of the model were evaluated with a group of trainees, who provided positive feedback, confirming the model's practicality and effectiveness in enhancing neurointerventional technical skills. In conclusion, HANNES represents a significant advancement in neurointerventional training, addressing the limitations of traditional training methods by simulating diverse disease patterns, enhancing medical staff's skills, and facilitating product testing.