Model Of Regeneration Research Articles

Academic Regeneration Modelling: Factors Influencing the Attractiveness of Young Academic Talent

This research is crucial because universities need to compete to draw and keep the greatest talent for the improvement of society's growth and education. The purpose of this study is to examine how organizational culture, information technology infrastructure, and sustainability values influence the attraction of young academic talent. Young academics at Satya Terra Bhinneka University serve as the research objectives. This study employed partial least squares (PLS) analysis using the SmartPLS program. Validity and reliability of the study variables are tested initially using the outer model. Then inner model test to evaluate the impact of various study factors. The findings of this study show that organizational culture, information technology infrastructure, and sustainability values have positive and significant effect on the attraction of young academic talent.

Cross-linking of mesoporous bioactive glass nanoparticle incorporated gelatin hydrogels by tannic acid with enhanced mechanical performance and stability

Gelatin-based hydrogels are used in diverse biomedical applications, such as wound dressings, tissue regeneration, and cell culture models. However, gelatin requires additional cross-linking to form a stable hydrogel. Tannic acid (TA), a polyphenolic compound, can undergo the Michael addition reaction and Schiff's base reaction with primary amine groups in neutral aqueous solutions. In this work, TA was selected as a cross-linker of gelatin to fabricate hydrogels reacting with primary amine groups in the gelatin molecular chain. Primary amine-modified mesoporous bioactive glass nanoparticles (AMBGNs) were added to further enhance the cross-linking of the system. The swelling ratios and weight losses showed that the most stable hydrogels retain approximately 53 % of their mass after 28 days of immersion in PBS solution. Young's modulus increased significantly with the increase in the content of TA and AMBGNs. The addition of TA and AMBGNs also resulted in a substantial reduction of gelation time. The prepared hydrogels possessed adequate stability and mechanical properties and showed potential for customized application in a variety of clinical service settings, such as wound healing, bone regeneration, and soft tissue regeneration.

Some Numerical Results on Chemotactic Phenomena in Stem Cell Therapy for Cardiac Regeneration

Biological models for cardiac regeneration and remodeling, along with the effects of cytokines or chemokines during the therapy with mesenchymal stem cells after a myocardial infarction, are of crucial importance for understanding the complex underlying mechanisms. This paper presents a mathematical model composed of three coupled partial differential equations that describes the dynamics of stem cells, nutrients and chemokines, highlighting the fundamental role of the chemokines during the myocardial tissue regeneration process. The system is solved numerically using mimetic difference operators and the MOLE library for MATLAB. The results show the tissue regeneration process in the necrotic part closest to the cell implantation area.

Concept of Normativity in Multi-Omics Analysis of Axon Regeneration.

Transcriptomes and proteomes can be normalized with a handful of RNAs or proteins (or their peptides), such as GAPDH, β-actin, RPBMS, and/or GAP43. Even with hundreds of standards, normalization cannot be achieved across different molecular mass ranges for small molecules, such as lipids and metabolites, due to the non-linearity of mass by charge ratio for even the smallest part of the spectrum. We define the amount (or range of amounts) of metabolites and/or lipids per a defined amount of a protein, consistently identified in all samples of a multiple-model organism comparison, as the normative level of that metabolite or lipid. The defined protein amount (or range) is a normalized value for one cohort of complete samples for which intrasample relative protein quantification is available. For example, the amount of citrate (a metabolite) per µg of aconitate hydratase (normalized protein amount) identified in the proteome is the normative level of citrate with aconitase. We define normativity as the amount of metabolites (or amount range) detected when compared to normalized protein levels. We use axon regeneration as an example to illustrate the need for advanced approaches to the normalization of proteins. Comparison across different pharmacologically induced axon regeneration mouse models entails the comparison of axon regeneration, studied at different time points in several models designed using different agents. For the normalization of the proteins across different pharmacologically induced models, we perform peptide doping (fixed amounts of known peptides) in each sample to normalize the proteome across the samples. We develop Regen V peptides, divided into Regen III (SEB, LLO, CFP) and II (HH4B, A1315), for pre- and post-extraction comparisons, performed with the addition of defined, digested peptides (bovine serum albumin tryptic digest) for protein abundance normalization beyond commercial labeled relative quantification (for example, 18-plex tandem mass tags). We also illustrate the concept of normativity by using this normalization technique on regenerative metabolome/lipidome profiles. As normalized protein amounts are different in different biological states (control versus axon regeneration), normative metabolite or lipid amounts are expected to be different for specific biological states. These concepts and standardization approaches are important for the integration of different datasets across different models of axon regeneration.

Decellularized extracellular matrix-decorated 3D nanofiber scaffolds enhance cellular responses and tissue regeneration

The use of decellularized extracellular matrix products in tissue regeneration is quite alluring yet practically challenging due to the limitations of its availability, harsh processing techniques, and host rejection. Scaffolds obtained by either incorporating extracellular matrix (ECM) material or coating the surface can resolve these challenges to some extent. However, these scaffolds lack the complex 3D network formed by proteins and growth factors observed in natural ECM. This study introduces an approach utilizing 3D nanofiber scaffolds decorated with dECM to enhance cellular responses and promote tissue regeneration. Notably, the dECM can be customized according to specific cellular requirements, offering a tailored environment for enhanced therapeutic outcomes. Two types of 3D expanded scaffolds, namely radially aligned scaffolds (RAS) and laterally expanded scaffolds (LES) fabricated by the gas-foaming expansion were utilized. To demonstrate the proof-of-concept, human dermal fibroblasts (HDFs) seeded on these scaffolds for up to 8 weeks, resulted in uniform and highly aligned cells which deposited ECM on the scaffolds. These cellular components were then removed from the scaffolds through decellularization (e.g., SDS treatment and freeze-thaw cycles). The dECM-decorated 3D expanded nanofiber scaffolds can direct and support cell alignment and proliferation along the underlying fibers upon recellularization. An in vitro inflammation assay indicates that dECM-decorated LES induces a lower immune response than dECM-decorated RAS. Further, subcutaneous implantation of dECM-decorated RAS and LES shows higher cell infiltration and angiogenesis within 7 and 14 days than RAS and LES without dECM decoration. Taken together, dECM-decorated 3D expanded nanofiber scaffolds hold great potential in tissue regeneration and tissue modeling. Statement of significanceDecellularized ECM scaffolds have attained widespread attention in biomedical applications due to their intricate 3D framework of proteins and growth factors. Mimicking such a complicated architecture is a clinical challenge. In this study, we developed natural ECM-decorated 3D electrospun nanofiber scaffolds with controlled alignments to mimic human tissue. Fibroblasts were cultured on these scaffolds for 8 weeks to deposit natural ECM and decellularized by either freeze-thawing or detergent to obtain decellularized ECM scaffolds. These scaffolds were tested in both in-vitro and in-vivo conditions. They displayed higher cellular attributes with lower immune response making them a good grafting tool in tissue regeneration.

A hybrid solar-driven membrane distillation-assisted liquid desiccant air conditioning system: Mathematical modeling and feasibility analysis

Membrane distillation (MD) is a promising method for liquid desiccant (LD) regeneration as it can mitigate LD carryover and produce freshwater as a by-product. Previous research on MD regeneration was mainly focused on performance evaluation and optimization of the regenerator itself. This paper proposed a hybrid solar-driven direct contact MD (DCMD) regeneration-assisted liquid desiccant air conditioning (LDAC) system for air dehumidification, cooling, and freshwater production. A mathematical model for the DCMD regenerator was first developed by considering both temperature and concentration polarizations. This model was validated against the experimental data in terms of the outlet channel temperature and LD solution concentration in the feed tank with relative deviations of ± 9.8 % and ± 0.5 %, respectively. The DCMD model was further integrated into an LDAC system with a batch-wise operation. To investigate the technical feasibility of the proposed system, a one-week simulation was conducted in a residential house during summer in a tropical climate area of Australia. The results showed that the latent heat load was effectively removed from the process air and the regenerated liquid desiccant solution can meet the dehumidification requirement with a concentration over 30.0 wt%. The dehumidification rate and regeneration rate were at 0.49–1.25 kg/h and 0.95–4.25 kg/h, respectively. Solar energy contributed to 52 %-78 % of the total system thermal energy consumption. Furthermore, this system can produce 11.0–12.8 kg of water daily.

Il34 rescues metronidazole-induced impairment of spinal cord regeneration in zebrafish central nervous system.

Metronidazole (MTZ), a commonly used anti-infective drug in clinical practice, has also been employed as a prodrug in cell-targeted ablation systems in scientific research, exhibiting significant application value. However, it has been demonstrated that MTZ can induce neurotoxic symptoms to some extent during its use, and there is currently a lack of effective means to circumvent its toxicity in both clinical and research settings, which limits its application. Therefore, exploring the specific mechanisms underlying MTZ-induced neurotoxic symptoms and elucidating countermeasures will enhance the practical value of MTZ. In this study, using a zebrafish spinal cord injury regeneration model, we confirmed that MTZ neurotoxicity leads to impaired axon regeneration in the central nervous system. By overexpressing il34 in the central nervous system of zebrafish, we eliminated the inhibitory effect of MTZ on axonal regeneration and demonstrated that the pro-regenerative effect against MTZ neurotoxicity is not caused by excessive macrophages/microglia chemoattracted by interleukin 34(Il34). Transcriptome sequencing analysis and GO enrichment analysis of differentially expressed genes between groups revealed that Il34 may counteract MTZ neurotoxicity and promote spinal cord injury repair through biological processes that enhance cellular adhesion and cell location. In summary, our work uncovers a possible cause of MTZ neurotoxicity and provides a new perspective for eliminating MTZ toxicity.

Induced pluripotent stem cells: A game-changer in dentistry’s regenerative landscape

In recent years, induced pluripotent stem cells (iPSCs) have emerged as a transformative force in regenerative medicine, offering unprecedented opportunities for advancements in various fields. This review explores the revolutionary impact of iPSCs specifically within the realm of dentistry, where regenerative strategies are increasingly sought to address oral and craniofacial tissue defects. iPSCs, derived from somatic cells through reprogramming, exhibit pluripotency and can differentiate into various cell types, including dental-specific lineages such as odontoblasts, ameloblasts, and osteoblasts. The application of iPSCs in dentistry holds immense promise for tissue repair, regeneration, and disease modelling. This review delves into the key aspects of iPSC-based approaches in dental research, covering topics such as tooth regeneration, periodontal tissue engineering, and craniofacial defect repair. We discuss the challenges and advancements in iPSC technology, emphasizing the potential for personalized regenerative therapies tailored to individual patients.

Tumor necrosis factor α receptor 1A transduces the inhibitory effect on axon regeneration triggered by IgG anti-ganglioside GD1a antibodies

Anti-ganglioside antibodies (anti-Gg Abs) have been linked to delayed/poor clinical recovery in both axonal and demyelinating forms of Guillain-Barrè Syndrome (GBS). In many instances, the incomplete recovery is attributed to the peripheral nervous system's failure to regenerate. The cross-linking of cell surface gangliosides by anti-Gg Abs triggers inhibition of nerve repair in both in vitro and in vivo axon regeneration paradigms. This mechanism involves the activation of the small GTPase RhoA, which negatively modulates the growth cone cytoskeleton. At present, the identity/es of the receptor/s responsible for transducing the signal that ultimately leads to RhoA activation remains poorly understood. The aim of this work was to identify the transducer molecule responsible for the inhibitory effect of anti-Gg Abs on nerve repair. Putative candidate molecules were identified through proteomic mass spectrometry of ganglioside affinity-captured proteins from rat cerebellar granule neurons (Prendergast et al., 2014). These candidates were evaluated using an in vitro model of neurite outgrowth with primary cultured dorsal root ganglion neurons (DRGn) and an in vivo model of axon regeneration. Using an shRNA-strategy to silence putative candidates on DRGn, we identified tumor necrosis factor receptor 1A protein (TNFR1A) as a transducer molecule for the inhibitory effect on neurite outgrowth from rat/mouse DRGn cultures of a well characterized mAb targeting the related gangliosides GD1a and GT1b. Interestingly, lack of TNFr1A expression on DRGn abolished the inhibitory effect on neurite outgrowth caused by anti-GD1a but not anti-GT1b specific mAbs, suggesting specificity of GD1a/transducer signaling. Similar results were obtained using primary DRGn cultures from TNFR1a-null mice, which did not activate RhoA after exposure to anti-GD1a mAbs. Generation of single point mutants at the stalk region of TNFR1A identified a critical amino acid for transducing GD1a signaling, suggesting a direct interaction. Finally, passive immunization with an anti-GD1a/GT1b mAb in an in vivo model of axon regeneration exhibited reduced inhibitory activity in TNFR1a-null mice compared to wild type mice. In conclusion, these findings identify TNFR1A as a novel transducer receptor for the inhibitory effect exerted by anti-GD1a Abs on nerve repair, representing a significant step forward toward understanding the factors contributing to poor clinical recovery in GBS associated with anti-Gg Abs.

Two-dimensional modeling and simulation of a conceptual barocaloric regenerator with polydimethylsiloxane rubber in a tube bank matrix design

Two-dimensional modeling and simulation of a conceptual barocaloric regenerator with polydimethylsiloxane rubber in a tube bank matrix design

Theoretical and numerical study of a skeletal muscle regeneration model with inflammatory response

A mathematical model of skeletal muscle regeneration for immune-muscular cell interactions with a pro-inflammatory mediator is introduced and analyzed. The model is a multi-scale problem with discontinuities and numerically stiff. Thus, a nonstandard parametric stability analysis of the equilibria is carried out in order to investigate the potential muscular regeneration and the inflammation resolution.

Keratin 5 basal cells are temporally regulated developmental and tissue repair progenitors in bladder urothelium.

Urothelium forms a distensible yet impermeable barrier, senses and transduces stimuli, and defends the urinary tract from mechanical, chemical, and bacterial injuries. Biochemical and genetic labeling studies support the existence of one or more progenitor populations with the capacity to rapidly regenerate the urothelium following injury, but slow turnover, a low mitotic index, and inconsistent methodologies obscure progenitor identity. The progenitor properties of basal keratin 5 urothelial cells (K5-UCs) have been previously investigated, but those studies focused on embryonic or adult bladder urothelium. Urothelium undergoes desquamation and apoptosis after birth, which requires postnatal proliferation and restoration. Therefore, we mapped the fate of bladder K5-UCs across postnatal development/maturation and following administration of cyclophosphamide to measure homeostatic and reparative progenitor capacities, respectively. In vivo studies demonstrate that basal K5-UCs are age-restricted progenitors in neonates and juveniles, but not in adult mice. Neonatal K5-UCs retain a superior progenitor capacity in vitro, forming larger and more differentiated urothelial organoids than adult K5-UCs. Accordingly, K5-UC transcriptomes are temporally distinct, with enrichment of transcripts associated with cell proliferation and differentiation in neonates. Induction of urothelial proliferation is sufficient to restore adult K5-UC progenitor capacity. Our findings advance the understanding of urothelial progenitors and support a linear model of urothelial formation and regeneration, which may have significant impact on therapeutic development or tissue engineering strategies.NEW & NOTEWORTHY Fate mapping reveals an important linear relationship, whereby bladder basal urothelial cells give rise to intermediate and superficial cells in an age-restricted manner and contribute to tissue repair. Neonatal basal cells reprise their role as superior progenitors in vitro and display distinct transcriptional signatures, which suggest progenitor function is at least partially cell intrinsic. However, the urothelium progenitor niche cannot be overlooked, since FGF7 rescues adult basal cell progenitor function.

Biological attributes required for epidermal regeneration: Evaluation of the next-generation autologous cell harvesting device.

Early wound intervention and closure is critical for reducing infection and improving aesthetic and functional outcomes for patients with acute burn wounds and nonthermal full-thickness skin defects. Treatment of partial-thickness burns or full-thickness injuries with autologous skin cell suspension (ASCS) achieves robust wound closure while limiting the amount of donor skin compared with standard autografting. A Next Generation Autologous Cell Harvesting Device (NG-ACHD) was developed to standardize the preparation process for ASCS to ensure biological attributes are obtained known to correlate with well-established safety and performance data. This study compared ASCS prepared using the NG-ACHD and ACHD following the manufacturer's guidance, evaluating cellular yields, viability, apoptotic activity, aggregates, phenotypes and functional capacity. Non-inferiority was established for all biological attributes tested and comparable healing trajectories were demonstrated using an in vitro skin regeneration model. In addition to standardization, the NG-ACHD also provides workflow efficiencies with the potential to decrease training requirements and increase the ease of incorporation and utilization of ASCS in clinical practice.

Exploring Importance and Regulation of Autophagy in Cancer Stem Cells and Stem Cell-Based Therapies.

Autophagy is a globally conserved cellular activity that plays a critical role in maintaining cellular homeostasis through the breakdown and recycling of cellular constituents. In recent years, there has been much emphasis given to its complex role in cancer stem cells (CSCs) and stem cell treatment. This study examines the molecular processes that support autophagy and how it is regulated in the context of CSCs and stem cell treatment. Although autophagy plays a dual role in the management of CSCs, affecting their removal as well as their maintenance, the intricate interaction between the several signaling channels that control cellular survival and death as part of the molecular mechanism of autophagy has not been well elucidated. Given that CSCs have a role in the development, progression, and resistance to treatment of tumors, it is imperative to comprehend their biological activities. CSCs are important for cancer biology because they also show a tissue regeneration model that helps with organoid regeneration. In other words, the manipulation of autophagy is a viable therapeutic approach in the treatment of cancer and stem cell therapy. Both synthetic and natural substances that target autophagy pathways have demonstrated promise in improving stem cell-based therapies and eliminating CSCs. Nevertheless, there are difficulties associated with the limitations of autophagy in CSC regulation, including resistance mechanisms and off-target effects. Thus, the regulation of autophagy offers a versatile strategy for focusing on CSCs and enhancing the results of stem cell therapy. Therefore, understanding the complex interactions between autophagy and CSC biology would be essential for creating therapeutic treatments that work in both regenerative medicine and cancer treatment.

Oxygen consumption rate of flatworms under the influence of wake- and sleep-promoting neurotransmitters.

Flatworms are among the best studied animal models for regeneration; however, they also represent an emerging opportunity to investigate other biological processes as well. For instance, flatworms are nocturnal and sleep during the day, a state that is regulated by sleep/wake history and the action of the sleep-promoting neurotransmitter gamma-aminobutyric acid (or GABA). Sleep is widespread across the animal kingdom, where it serves many nonexclusive functions. Notably, sleep saves energy by reducing metabolic rate and by not doing something more energetically taxing. Whether the conservation of energy is apparent in sleeping flatworms is unclear. We measured the oxygen consumption rate (OCR) of flatworms dosed with either (1) GABA (n = 29) which makes flatworms inactive or (2) dopamine (n = 20) which stimulates flatworms to move, or (3) day and night neurotransmitter-free controls (n = 28 and 27, respectively). While OCRdid not differ between the day and night, flatworms treated with GABA used less oxygen than those treated with dopamine, and less than the day-time control. Thus, GABA affected flatworm physiology, ostensibly by enforcing energy-conserving sleep. Evidence that dopamine increased metabolism was less strong. This work broadens our understanding of flatworm physiology and expands the phylogenetic applicability of energy conservation as a function of sleep.

Lipidomics and single-cell RNA sequencing reveal lipid and cell dynamics of porcine glycerol-injured skeletal muscle regeneration model

AimsIntramuscular fat (IMF) infiltration and extracellular matrix (ECM) deposition are characteristic features of muscle dysfunction, such as muscular dystrophy and severe muscle injuries. However, the underlying mechanisms of cellular origin, adipocyte formation and fibrosis in skeletal muscle are still unclear. Main methodsPigs were injected with 50 % glycerol (GLY) to induce skeletal muscle injury and regeneration. The acyl chain composition was analyzed by lipidomics, and the cell atlas and molecular signatures were revealed via single-cell RNA sequencing (scRNA-seq). Adipogenesis analysis was performed on fibroblast/fibro-adipogenic progenitors (FAPs) isolated from pigs. Key findingsThe porcine GLY-injured skeletal muscle regeneration model was characterized by IMF infiltration and ECM deposition. Skeletal muscle stem cells (MuSCs) and FAP clusters were analyzed to explore the potential mechanisms of adipogenesis and fibrosis, and it was found that the TGF-β signaling pathway might be a key switch that regulates differentiation. Consistently, activation of the TGF-β signaling pathway increased SMAD2/3 phosphorylation and inhibited adipogenesis in FAPs, while inhibition of the TGF-β signaling pathway increased the expression of PPARγ and promoted adipogenesis. SignificanceGLY-induced muscle injury and regeneration provides comprehensive insights for the development of therapies for human skeletal muscle dysfunction and fatty infiltration-related diseases in which the TGF-β/SMAD signaling pathway might play a primary regulatory role.

Mathematical Models of Wound Healing and Tissue Regeneration: Insights with Numerical Solution

Understanding and forecasting the dynamics of wound healing processes heavily relies on mathematical modeling. Researchers can understand the complicated connections between cells, tissues, and biochemical components involved in wound healing by using mathematical equations and computational simulations. One such mathematical model that has seeks the interest of researchers in exploring wound healing phenomenon is Fisher’s equation. In the present work, the equation is solved using differential quadrature method with trigonometric tension B-spline (TTBs) basis function. The obtained results are compared with the results obtained from earlier studies and the results are presented in form of tables and figures. The implementation of the particle swarm optimization algorithm has removes the dilemma of unknown parameter involvement in the TTBs and hence resulted in a novel technique to find the numerical results.

A Regeneration Model for Mitigation Against Attacks on HTTP Servers for Mobile Wireless Networks

The widespread expansion of the internet has fueled a global surge in the utilization of various online transactions, with a significant portion of such services operating on mobile web platforms. Simultaneously, the deployment of innovative Mobile Ad Hoc Network (MANET) technologies and mobile applications has grown as solutions for diverse tasks. Unfortunately, this progress has attracted the attention of hackers, who continually devise new strategies to exploit the vulnerabilities inherent in mobile networks. This study aims to address the escalating challenges posed by cyber threats in the era of widespread internet expansion, particularly focusing on securing mobile web platforms against sophisticated attacks such as Structured Query Language Injection (SQLi) for web-based database solutions and Denial of Service (DoS/DDoS) for various applications. In response to the identified vulnerabilities, this paper proposes an HTTP regeneration (HReg) model that not only detects various cyber-attacks but also ensures the uninterrupted provision of critical services during such incidents. The model introduces an innovative regeneration algorithm capable of scanning both the connection channel and web application to detect attacks, creating survivable connections within the underlying TCP engine to replace compromised ones during an ongoing attack. In simulated environments using OMNeT++, where the server is subjected to attacks, the experimental results demonstrate the efficacy of the model. The response and performance metrics, including throughput (73%), delivery ratio (68.8%), delay (3s), and network load, showcase the model's ability to detect and neutralize attacks. A comparison with state-of-the-art approaches highlights the superior performance of the regeneration model, attributed to its additional survivability layer. While the regeneration model proves robust in simulated environments, its real-world application may encounter limitations. Future research should explore these limitations to enhance the practical applicability of the proposed model. The proposed HReg model's resilient performance under attack conditions ensures the survivability of web-based applications. This innovative approach offers practical implications for securing mobile web platforms, providing continuous delivery of critical services even in the face of persistent and evolving cyber threats. This research addresses a significant gap in existing efforts by not only focusing on attack detection but also emphasizing the development of a survivable TCP connection for HTTP servers during attacks. The introduced regeneration model stands out for its unique ability to maintain service continuity, showcasing originality in the approach to cybersecurity in the context of web-based applications.

Numerical prediction of mean flow and acoustic field of a supersonic impinging jet

The three-dimensional turbulent mean flow and acoustic field of a supersonic jet impinging on a solid plate is studied computationally using the general purpose CFD code Ansys Fluent. A pressure-based coupled solver formulation with the second order weighted central-upwind spatial discretization is applied to compute transient solutions. Cold and hot jet thermal conditions are considered. Mean flow characteristics are investigated by a steady-state modeling approach. Acoustic radiation of impingement tones is simulated using a transient time-domain formulation. The effects of turbulence in steady-state are modeled by the SST k-ω turbulence model. The Wall-Modeled Large-Eddy Simulation (WMLES) model is applied to compute transient solutions. The near-wall mesh on the impingement plate is fine enough to resolve the viscosity-affected near-wall region all the way to the laminar sublayer. Nozzle-to-plate distance is parameterized in the model for automatic re-generation of the mesh and results. Steady-state predictions of hover lift loss and mean jet velocity distributions are compared with experimental data, and favorable agreement is reported. The transient solution reproduces the mechanism of impingement tone generation by the interaction of large scale vortical structures with the impingement plate. The acoustic near-field is directly resolved by Computational Aeroacoustics (CAA) to accurately propagate impingement tone waves to near-field microphone locations. Calculated impingement tone frequencies and sound pressure levels agree with experimental values.

Effect analysis on passive and active regeneration performance of catalytic diesel particulate filters at the equilibrium point in the presence of ash layer

AbstractCatalytic diesel particulate filters (CDPF) form the main post‐processing devices for the diesel engines. Particulates trapped by CDPF can be oxidized by nitrogen dioxide (NO2) and oxygen (O2). The CDPF passive and active regeneration model on platinum‐based catalyst in the presence of ash layer, including the mass, momentum, and enthalpy balances of the gas and the solid phase, the gas diffusion, and the kinetic of the soot oxidation reaction is performed and validated by the bench test. The effects of different temperatures on CDPF passive and active regeneration at the equilibrium point are analyzed. Further, the effective analysis of ash loading and ash layer distribution on the equilibrium state is conducted. The research on CDPF passive and active regeneration at the equilibrium point in the presence of ash layer provides a theoretical basis for CDPF application.