An excessive sense of responsibility has been attributed a key role in recent models of obsessive-compulsive disorder (OCD). This study presents the development and initial validation of the Responsibility Questionnaire. Three hundred ninety-seven volunteer adults participated in the study. The Responsibility Questionnaire demonstrated adequate stability over a 6-week interval. Correlation analysis showed that responsibility was significantly related to obsessive-compulsive symptoms, thought suppression, irrational beliefs, and obsessional thoughts. Results are discussed in terms of current models of OCD and the implications for future research.