Linear Regression Analysis Model Research Articles

Effects of Hepatorenal Function on Urinary Alzheimer-Associated Neuronal Thread Protein: A Laboratory-Based Cross-Sectional Study Among the Older Chinese Population.

Urinary Alzheimer-associated neuronal thread protein (AD7c-NTP) is a biomarker for the early diagnosis of Alzheimer's disease (AD). It remains unclear whether hepatorenal function affects the urinary AD7c-NTP level. To evaluate the effects of hepatorenal function on urinary AD7c-NTP level. We enrolled 453 participants aged 60-100 years. An automated chemistry analyzer was used to determine the indicators of serum hepatorenal function. Enzyme-linked immunosorbent assay was used to measure the urinary AD7c-NTP level. Spearman's correlation analysis showed a negative correlation between urinary AD7c-NTP levels and indicators of hepatorenal function, including albumin (r = -0.181, p < 0.001), albumin/globulin ratio (r = -0.224, p < 0.001), cholinesterase (r = -0.094, p = 0.046), total carbon dioxide (r = -0.102, p = 0.030), and glomerular filtration rate (r = -0.260, p < 0.001), as well as a positive correlation with globulin (r = 0.141, p = 0.003), aspartate transaminase (r = 0.186, p < 0.001), blood urine nitrogen (r = 0.210, p < 0.001), creatinine (r = 0.202, p < 0.001), uric acid (r = 0.229, p < 0.001), and cystatin C (r = 0.265, p < 0.001). The least absolute shrinkage and selection operator (LASSO) regression analysis and multiple linear regression model analyses showed that the statistically significant hepatorenal indicators for predicting AD7c-NTP were A/G (p = 0.007), AST (p = 0.002), BUN (p = 0.019), and UA (p = 0.003). The effects of hepatorenal indicators should be considered when using urinary AD7c-NTP levels in clinical settings.

The Effect of Supervisory Performance on The Quality of Mathematics Education In Grade II Students of EBC Turiscai

Improving the performance of supervisors and the quality of student education has a positive relationship because a maximum and good learning style will provide good quality education. The hypothesis of the supervisor performance variable (X) on the quality of education (Y) of students in Ensino Basico 3o Ciclo Turiscai shows that there is a positive and significant influence individually because the ttable &gt; is 7,937&gt; 2,000 then Ha is accepted. This means that better supervisor performance (X) will provide higher quality education for students at Ensino Basico 3o Ciclo Turiscai. From the results of the calculation of a simple regression correlation analysis, it shows that the coefficient (r) of 0.722 or 72.2% means that the supervisory performance variable (X) has a fairly close relationship or has a strong enough correlation with the variable Education quality (Y) in Ensino Basico 3o Ciclo Turiscai and the coefficient of determination (r2) of 0.521 or 52.1% means that the contribution or contribution of supervisor performance (X) is given to the variable Education quality (Y) of 0.521 or 52.1% while The remaining 47.9% was influenced by other factors. Based on the calculation results with a simple linear regression analysis model, the value is obtained that the supervisory performance variable (X) shows a unidirectional or positive regression coefficient value of 0.628 against the education quality variable (Y). This can be interpreted that the performance of supervisors (X) affects the quality of education (Y) by 0.628 or 62.8% in Ensino Basico 3o Ciclo Turiscai.

Baseline Association between Healthy Eating Index-2015 and Health-Related Quality of Life in Breast Cancer Patients Enrolled in a Randomized Trial.

Health-related quality of life (HRQoL) represents one of the most concerning aspects for cancer patients. The Healthy Eating Index (HEI) is an a priori diet quality index directly associated with health outcomes and HRQoL in cancer survivors in North American populations. We evaluated, in a Mediterranean population, the baseline associations between HEI-2015 and HRQoL in 492 women with breast cancer recruited in a DEDiCa lifestyle trial. Dietary data were obtained from 7-day food records; HRQoL was assessed through the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ C30) and the C30 Summary Score (SumSc). Analysis of variance and multivariable linear and log-gamma regression models were performed. Mean and standard deviation for HEI-2015 score was 68.8 ± 11.2; SumSc was 81.5 ± 12.9. Women with lower HEI-2015 score had higher BMI, were more frequently exposed to tobacco smoke and had fewer years of education. Patients with a HEI-2015 score greater than 68.7 (median value) showed a significant increase in SumSc of 4% (p = 0.02). HEI-2015 components also associated with SumSc were beans and greens (β = 1.04; p = 0.02). Weak associations were found for total vegetables and saturated fats. Higher diet quality in breast cancer survivors was associated with higher overall HRQoL in this cross-sectional analysis.

Uncertain statistics models for characterizing annual total energy production

In the field of annual total energy production, it is hard to determine whether the experimental data is linear or nonlinear growth characteristics. Therefore, different regression models are used to test the properties of the observed data. This article uses actual data to perform parameter estimation and residual analysis of linear and nonlinear regression models. In addition, uncertain nonlinear time series model is used to fit the experimental data in order to find a more suitable statistics model after obtaining the growth properties of the observed data. A test is introduced to prove that the disturbance terms presented in the regression and time series models are actually uncertain variables, not random variables. Moreover, the uncertain hypothesis tests show that the uncertain time series model is in better agreement with the real data of the annual total energy production.

PENGARUH PERSONAL SELLING TERHADAP KEPUTUSAN PEMBELIAN PRODUK KUE

In a market that is increasingly competitive and influenced by ongoing technological developments, companies are required to develop effective marketing strategies to achieve their goals, including creating value and satisfying customer needs. One of the pioneers in the dessert box industry in Indonesia is Bittersweet by Najla, renowned for its innovation in presenting sweet treats in box form. This study aims to investigate the influence of personal selling on purchasing decisions of products from Bittersweet By Najla. The study employs a quantitative method by collecting information from primary and secondary sources through questionnaires and literature studies. This research uses a multiple linear regression analysis model as the research method. The population studied consists of residents in the vicinity who have made purchases at Bittersweet By Najla, with a sample of 50 respondents selected incidentally through a Likert scale-based questionnaire. Partial analysis results indicate that personal selling has a positive and significant impact on purchase decisions, supported by a significant t-value (4.012 &gt; 1.677) and low statistical significance (0.000 &lt; 0.05). These findings provide valuable insights for companies in designing more efficient marketing strategies, emphasizing the development of personal selling skills to enhance product appeal, build consumer trust, and achieve desired marketing objectives.

The Effect of Intellectual Capital on Stock Return Through Financial Performance

In the era of globalization and increasingly fierce competition, companies are required to increase their competitiveness by optimally utilizing the assets they own, one of the assets that is increasingly important for companies is intellectual capital. The purpose of this study is to examine whether intellectual capital affects stock returns through financial performance, which has the aim of knowing the influence of intellectual capital on financial performance, the influence of intellectual capital on stock returns, the effect of stock returns on financial performance, and whether or not financial performance mediates the relationship between intellectual capital and stock returns. A multiple linear regression analysis model with path analysis is an analysis method used in this study that aims to test whether there is a direct or indirect influence between independent, dependent, and intervening variables. Data testing tool using SPPS24 software. The population object in this study is companies listed on the IDX Indexes LQ45 for the 2018-2022 period; with the purposive sampling method, the samples collected are 33 companies with a total of 45 companies' observation data. The results showed that intellectual capital affects financial performance. These results show that the effect of financial performance on stock returns is statistically significant. The indirect influence of the statistical analysis results is greater than the direct influence of intellectual capital on stock returns. Thus, financial performance mediates the influence of intellectual capital on stock returns. This result explains that the company must utilize and maintain intellectual capital, and sound financial performance affects the stock returns received by investors, which later show good company value. Companies must utilize and maintain their intellectual capital because good financial performance, which results from the utilization of intellectual capital, will increase stock returns and reflect good company value in the eyes of investors.

Peran Kepemilikan Manajerial Memoderasi Tingkat Hutang, Ukuran Perusahaan, Arus Kas Operasi Terhadap Persistensi Laba

This study uses management ownership as a moderating variable to examine the effects of debt levels, firm size, and operating cash flow on earnings persistence. Quantitative approaches are employed in this study. Up to 80 samples were selected via purposive selection, with the population of this study consisting of industrials sector companies listed on the Indonesia Stock Exchange in 2019–2022. Multiple linear regression analysis models and moderated regression analysis (MRA) were used for the hypothesis testing, with the moderator variables being tested. The results of this research based on partial testing (t test) probability value of the debt level variable is 0.008. The firm size variable is 0.032. The operating cash flow variable is 0.160. The managerial ownership variable is 0.014. The degree of debt and management ownership have an interaction variable of 0.016. The interaction variable between firm size and managerial ownership is 0.010. Additionally, managerial ownership and operating cash flow interact with a coefficient of 0.132. Known that debt levels and firm size have positive effect on profit persistence, while operating cash flow has no effect on profit persistence. The moderating effect of managerial ownership can amplify the favorable impact of debt levels on earnings persistence. However, the favorable impact of company size and operating cash flow on earnings persistence cannot be amplified by managerial ownership

Export Instability, Investment, Export Growth and Economic Growth in India

The “Export-led Growth Hypothesis,” as it is known in the literature, is still a popular issue in both theoretical and empirical research. According to the export-led growth hypothesis (ELGH), a key factor in determining growth is the expansion of exports. It asserts that growing capital and labour inputs into the economy as well as exports can contribute to a country’s overall growth. The association between economic development, export growth, export fluctuation, and real effective exchange rate (REER) in India from 2001 to 2021 is examined in this paper using a multiple linear regression analysis model. Additionally, the impacts of foreign exchange, export fluctuation on investment, and import of capital goods have also been studied. The autocorrelation is also tested using the Durbin-Watson (D-W) test. Investigation of the association between income growth and exports in the context of India reveals that the country’s exports haven’t increased significantly enough to prove the theory of export-led growth. For instance, ceteris paribus, one per cent change in exports over time is expected to result in a 0.007 per cent increase in GDP. Weaker global demand, inflation, dropping exports, and growing global trade conflict all contribute to a weaker-than-expected positive link between GDP and exports. However, the findings have also shown that one per cent rise in instability increases GDP by 5.04 per cent. Furthermore, research has indicated that export instability does contribute to import for capital goods and demonstrates the relationship between investment and export instability is positive but not statistically significant. The result for policy is that, in order to decrease the negative impacts of export fluctuations, India should concentrate on those goods in which it has a competitive edge. The primary factors of the excessive volatility and restricted growth must be fully investigated in order to mitigate instability, and inherent flaws must be addressed.

The influence of technical and fundamental factors on stock prices in banking companies listed on the Indonesia stock exchange in 2018-2022

This study was conducted to analyze and find out how Trading Volume, Earning Per Share (EPS), Return On Asset (ROA), Return On Equity (ROE), and Debt to Equity Ratio (DER) affect Stock Prices in Banking Companies Listed on the Indonesia Stock Exchange in 2018-2022. The data in this study were taken from idx.co.id and yahoofinancial.com sources. The population in this study is 49 companies and the sample used in this study is 29 companies. This study uses quantitative data processed by the SPSS.27 software application with a multiple linear regression analysis model. The results of the study conclude that simultaneously Trading Volume, Earning Per Share, Return On Asset, Return On Equity, and Debt to Equity Ratio have a positive effect on stock prices. Trading Volume and Debt to Equity Ratio partially have a negative effect on stock prices. Meanwhile, Earning Per Share, Return On Asset, and Return On Equity, partially have a positive effect on stock prices.

On the QSPR Models of some Anti-Malaria Drugs using some Reversed Degree-Based Topological Indices

A topological index is a real number obtained from the chemical structure of a molecular graph that can be used to predict the physiochemical and biological properties of chemical compounds like drugs and benzene structures. This study aimed at proposing a quantitative structure-property relationship (QSPR) model for some physiological and biological properties of some anti-malaria drugs. Some reversed-degree-based topological indices of the molecular graphs of these drugs were computed; hence, a linear regression model analysis of these indices with the empirical values of the said properties of these drugs was carried out and presented. It was found that the topological indices computed for the said drugs have a good correlation with these physicochemical properties.

Layperson-Delivered Telephone-Based Behavioral Activation Among Low-Income Older Adults During the COVID-19 Pandemic

Older adults are particularly vulnerable to loneliness and its physical and psychosocial sequelae, but scalable interventions are lacking, especially during disasters such as pandemics. To compare the effects of layperson-delivered, telephone-based behavioral activation and mindfulness interventions vs telephone-based befriending on loneliness among at-risk older adults. This assessor-blinded, 3-arm randomized clinical trial screened Chinese older adults through household visits and community referrals from April 1, 2021, to April 30, 2023, in Hong Kong. Eligible participants (≥65 years of age) who were lonely, digitally excluded, living alone, and living below the poverty line and provided consent to participate were randomized into behavioral activation, mindfulness, and befriending groups. Assessments were conducted at baseline, 1 month, and 3 months. As part of the Helping Alleviate Loneliness in Hong Kong Older Adults (HEAL-HOA) dual randomized clinical trial, 148 older laypersons were trained to deliver a twice-weekly 30-minute intervention via telephone for 4 weeks. The primary outcome was loneliness measured by the UCLA Loneliness Scale (range, 20-80) and the De Jong Gierveld Loneliness Scale (range, 0-6), with higher scores on both scales indicating greater loneliness. Secondary outcomes were depression, perceived stress, life satisfaction, psychological well-being, sleep quality, perceived social support, and social network. A total of 1151 participants (mean [SD] age, 76.6 [7.8] years; 843 [73.2%] female) were randomized to the behavioral activation (n = 335), mindfulness (n = 460) or befriending (n = 356) group. Most were widowed or divorced (932 [81.0%]), had primary education or below (782 [67.9%]), and had 3 or more chronic diseases (505 [43.9%]). Following intention-to-treat principles, linear mixed-effects regression model analyses showed that loneliness measured by the UCLA Loneliness Scale was significantly reduced in the behavioral activation group (mean difference [MD], -1.96 [95% CI, -3.16 to -0.77] points; P < .001]) and in the mindfulness group (MD, -1.49 [95% CI, -2.60 to -0.37] points; P = .004) at 3 months compared with befriending. Loneliness measured by the De Jong Gierveld Loneliness Scale was not significantly reduced at 3 months in the behavioral activation group (MD, -0.06 [95% CI, -0.26 to 0.13] points; P > .99]) but was in the mindfulness group (MD, 0.22 [95% CI, 0.03 to 0.40] points; P = .01) at 3 months compared with befriending. In the behavioral activation and mindfulness groups, sleep quality improved compared with befriending, but perceived stress increased. Psychological well-being and perceived social support improved in the behavioral activation group. No statistically significant between-group differences were observed in depression, life satisfaction, or social network. In this randomized clinical trial, scalable psychosocial interventions delivered remotely by older laypersons appeared promising in reducing later life loneliness and addressing the pressing mental health challenges faced by aging populations and professional geriatric mental health workforce shortages. Further research should explore ways to maximize the clinical relevance and cost-effectiveness of these interventions. Chinese Clinical Trial Registry Identifier: ChiCTR2300072909.

THE INFLUENCE OF LEARNING ORGANIZATIONS AND EMPLOYEE INNOVATION BEHAVIOR ON EMPLOYEE PERFORMANCE AT THE SURABAYA CITY CULTURE, YOUTH AND SPORTS AND TOURISM OFFICE WITH THE INTERVENING VARIABLE OF EMPLOYEE COMPETENCE

This study examines and demonstrates the impact of Learning Organizations and Employee Innovation Behavior on Employee Performance in the Department of Culture, Youth and Sports and Tourism of the City of Surabaya. The research design employed in this study is explanatory research, which aims to explain the causes and consequences of existing problems. Path Analysis, along with two multiple linear regression analysis models and SPSS ver 17.0, was utilized to analyze the data. Furthermore, this study is classified as associative research. The findings of this study confirm that learning organizations have a positive and significant influence on employee competence. Furthermore, employee innovation behavior also has a positive and significant impact on employee competence. Moreover, learning organizations positively and significantly affect employee performance, while employee innovation behavior also has a positive and significant influence on employee performance. Additionally, employee competence is found to have a positive and significant effect on employee performance. However, employee competence does not act as a mediating variable in the relationship between learning organizations and employee performance. On the other hand, employee competence does serve as a mediating variable in the relationship between employee innovation behavior and employee performance.

Factors Related to Caregivers' Intention to Vaccinate Their Elderly Family Members with Major Neurocognitive Disorders against COVID-19.

Vaccination helps reduce the risk of coronavirus disease 2019 (COVID-19) infection in elderly individuals with major neurocognitive disorders (MNDs). However, some caregivers are hesitant to have their elderly family members with MNDs vaccinated against COVID-19. This study explored the factors influencing caregivers' intentions to vaccinate elderly family members with MNDs against COVID-19. A total of 232 caregivers of elderly family members with MNDs participated in this study. In this survey, data regarding COVID-19 vaccination acceptance, fear, side effects, family members' attitudes toward vaccination, mental health status, neuropsychiatric symptoms, and cognitive impairments were collected from the elderly participants with MNDs. The associations between these variables and the caregivers' intention to vaccinate their elderly family members with MNDs against COVID-19 were examined using a multivariable linear regression analysis model. The results revealed that caregivers' perceived familial support for vaccination, the perceived value of vaccination, and autonomy to vaccinate elder family members were positively correlated with caregivers' intention to vaccinate elderly family members with MNDs, whereas elderly family members' age was negatively correlated with caregiver intentions. This study demonstrated that caregiver factors (perceived familial support, value of vaccination, and autonomy) and elderly family members' age were correlated with caregiver intention. These factors should be considered in developing interventions to enhance caregivers' intentions to vaccinate their elderly family members with MNDs against COVID-19.

Performance evaluation of different regression models: application in a breast cancer patient data

This paper provides a comprehensive analysis of linear regression models, focusing on addressing multicollinearity challenges in breast cancer patient data. Linear regression methodologies, including GAM, Beta, GAM Beta, Ridge, and Beta Ridge, are compared using two statistical criteria. The study, conducted with R software, showcases the Beta regression model’s exceptional performance, achieving a BIC of − 5520.416. Furthermore, the Ridge regression model demonstrates remarkable results with the best AIC at − 8002.647. The findings underscore the practical application of these models in real-world scenarios and emphasize the Beta regression model’s superior ability to handle multicollinearity challenges. The preference for AIC over BIC in Generalized Additive Models (GAMs) is rooted in the AIC’s calculation framework, highlighting its effectiveness in capturing the complexity and flexibility inherent in GAMs.

The role of solute polarizability and microenvironment in the spectroscopic behaviour of the local anesthetic drug - bupivacaine

The solvent dependent ground- and excited-state photophysical and photochemical properties of the local anesthetic drug – bupivacaine (BUP) – have been studied using a steady-state spectroscopic technique. The Kamlet-Taft solvent scale was used to describe the solvatochromism of BUP in terms of non-specific (dipole-dipole) and specific (hydrogen bonding) solute-solvent interactions. The performed analysis indicates that the major factor responsible for the shift of the absorption and fluorescence bands is solvent polarity, while the solvent acidity and basicity have a less significant effect. Finally, it has also been shown how the solvatochromic equations can be used, in principle, to obtain estimates for the ground- and excited-state (Franck-Condon and relaxed) dipole moments, the difference thereof and the polarizability of BUP from a simple analysis of spectral shift data (solvatochromic methods of Lippert and Mataga, McRae, Bakhshiev and Mataga and Kubota) and multiple linear regression analysis (model of solvatochromism developed by Bayliss, McRae and Ooshika). In addition, an innovative physical treatment was used, consisting of a non-linear fit of the absorption and emission spectral shift data using the theoretical model of solvatochromism developed by Bilot and Kawski and visualisation of the least squares coefficient (χ2) on a 3D map as a function of the solute polarizability and the gas phase absorption or fluorescence energies. Since the solute polarizability can affect both the electronic characteristics and the reactivity of the molecule, our investigations may have significant implications for the development of the pharmaceutical industry (understanding of the influence of the environment on intermolecular processes occurring in the drug-medium system).

Metabolomics of IgE-Mediated Food Allergy and Oral Immunotherapy Outcomes based on Metabolomic Profiling.

The immunometabolic mechanisms underlying variable responses to oral immunotherapy (OIT) in patients with IgE-mediated food allergy are unknown. To identify novel pathways associated with tolerance in food allergy, we used metabolomic profiling to find pathways important for food allergy in multi-ethnic cohorts and responses to OIT. Untargeted plasma metabolomics data were generated from the VDAART healthy infant cohort (N=384), a Costa Rican cohort of children with asthma (N=1040), and a peanut OIT trial (N=20) evaluating sustained unresponsiveness (SU, protection that lasts after therapy) versus transient desensitization (TD, protection that ends immediately afterwards). Generalized linear regression modeling and pathway enrichment analysis identified metabolites associated with food allergy and OIT outcomes. Compared with unaffected children, those with food allergy were more likely to have metabolomic profiles with altered histidines and increased bile acids. Eicosanoids (e.g., arachidonic acid derivatives) (q=2.4×10 -20 ) and linoleic acid derivatives (q=3.8×10 -5 ) pathways decreased over time on OIT. Comparing SU versus TD revealed differing concentrations of bile acids (q=4.1×10 -8 ), eicosanoids (q=7.9×10 -7 ), and histidine pathways (q=0.015). In particular, the bile acid lithocholate (4.97[1.93,16.14], p=0.0027), the eicosanoid leukotriene B4 (3.21[1.38,8.38], p=0.01), and the histidine metabolite urocanic acid (22.13[3.98,194.67], p=0.0015) were higher in SU. We observed distinct profiles of bile acids, histidines, and eicosanoids that vary among patients with food allergy, over time on OIT and between SU and TD. Participants with SU had higher levels of metabolites such as lithocholate and urocanic acid, which have immunomodulatory roles in key T-cell subsets, suggesting potential mechanisms of tolerance in immunotherapy. - Compared with unaffected controls, children with food allergy demonstrated higher levels of bile acids and distinct histidine/urocanic acid profiles, suggesting a potential role of these metabolites in food allergy. - In participants receiving oral immunotherapy for food allergy, those who were able to maintain tolerance-even after stopping therapyhad lower overall levels of bile acid and histidine metabolites, with the exception of lithocholic acid and urocanic acid, two metabolites that have roles in T cell differentiation that may increase the likelihood of remission in immunotherapy. This is the first study of plasma metabolomic profiles of responses to OIT in individuals with IgE-mediated food allergy. Identification of immunomodulatory metabolites in allergic tolerance may help identify mechanisms of tolerance and guide future therapeutic development.

Correlation between peripheral immature platelet level and coronary immature platelet levels in coronary artery disease: an observational study in cardiac referral centre in East Java, Indonesia.

To investigate the correlation between peripheral and coronary immature platelet, and factors that may predict coronary immature platelet levels. The cross-sectional, observational, analytical study was conducted at the Cardiovascular Diagnostic and Intervention Centre of Dr Soetomo General Academic Hospital, Surabaya, Indonesia, from November 2017 to January 2018, and comprised patients of either gender with coronary artery disease. Peripheral and coronary blood samples were retrieved during coronary catheterisation. Immature platelet fraction was acquired by examining whole blood samples analysed through automated flow cytometry. Relationship between peripheral and coronary immature platelet fractions and counts were analysed using parametric correlation test, followed by linear regression analysis model of variables that influenced coronary immature platelet fraction. The statistical analysis was carried out using SPSS Statistics for Windows, Version 25.0 (IBM Corp, Armonk, NY, USA). Of the 70 patients, 55(78.6%) were males and 15(21.4%) were females. The overall mean age was 57±5.32 years. There were 35(50%) patients with a history of smoking, and 34(48.6%) had hypertension and dyslipidaemia. Mean peripheral immature platelet fraction was 3.86±1.84% and mean coronary immature platelet fraction was 3.63±1.7%. There was a robust positive and significant correlation (r=0.882; p<0.001) between immature platelet levels in peripheral and coronary blood. Peripheral immature platelet and glycated haemoglobin >7.5 were independent predictors of coronary immature platelet (p=0.001). There was a strong correlation between immature platelet levels in peripheral and coronary blood.

Effect of Healthcare Service Quality and Price on Patient Satisfaction

Healthcare services is a place that is needed by all levels of society. Good service will influence patient satisfaction. Patient satisfaction in health services is very important to pay attention to because it can describe the quality of service at the health service location. Knowing patient satisfaction is very useful for the relevant agencies in order to evaluate programs that are being implemented and to find which parts need improvement. This study aims to analyze the influence of service quality and price on patient satisfaction at Kartika Husada Jatiasih Hospital. This type of research is a survey. The analytical method used in this research uses linear and multiple regression analysis models. The research results show that service quality has a positive and significant effect on patient satisfaction at Kartika Husada Jatiasih Hospital. Price has a positive and significant effect on patient satisfaction at Kartika Husada Jatiasih Hospital. Service quality and price have a positive and significant effect on patient satisfaction at Kartika Husada Jatiasih Hospital. Managerial implications include holding regular training for all hospital staff and implementing an effective feedback system to get input from patients about the quality of service

Application of ultrasound-guided single femoral triangle and adductor canal block in arthroscopic knee surgery: a prospective, double-blind, randomized clinical study

PurposeTo compare the difference in analgesic effect between femoral triangle block (FTB) and adductor canal block (ACB) during arthroscopic knee surgery.MethodsPatients who underwent arthroscopic knee surgery were randomized preoperatively to FTB group or ACB group. For each group, 20 mL of 0.1% ropivacaine was injected. Primary outcomes: The numeric rating score (NRS) at 12 h after surgery at rest and during movement. Secondary outcome: (1) The NRS at post anesthesia care unit (PACU) and 2, 24 h after surgery at rest and during movement; (2) The quadriceps muscle strength at PACU and 2, 12, 24 h after surgery; (3) Consumption of Rescue analgesia; (4) Incidence of adverse reactions.ResultsThe NRS at 12 h after surgery at rest and during movement of ACB group were higher than FTB group. Among secondary outcomes, the NRS at PACU at rest and during movement, 2 h after surgery during movement of FTB group lower than ACB group; the quadriceps muscle strength at 2 h after surgery of FTB group stronger than ACB group. After multiple linear regression model analysis, the data showed additional statistically significant reduction NRS at 24 h after surgery at rest (0.757, p = 0.037) in FTB group. Other outcomes were similar between two groups.ConclusionsThe FTB appears to provide superior pain control after knee arthroscopy than ACB, the FTB is superior to the ACB in quadriceps muscle strength at 2 h after surgery.Trial registrationThe trial was registered in the Chinese Clinical Trial Registry (ChiCTR2300068765). Registration date: 28/02/2023.

The cooperative interaction of AOB and comammox clade A drives nitrification and N2O emissions in a long-term organic fertilized paddy soil

The newly discovered complete ammonia oxidizer (comammox Nitrospira) is able to single-step nitrification capability, and increased our understanding of soil nitrogen cycling. However, the response of comammox and ammonia-oxidizing bacteria (AOB) and archaea (AOA) to long-term fertilization and rhizosphere effects in paddy soils and their relative contribution to the nitrification-derived N2O emissions is still unclear. Here, we collected rhizosphere and bulk soils with thirty years of different fertilization strategies, i.e., non-fertilization (CK), chemical N, P, and K application (NPK), and NPK plus pig manure application (NPKM), respectively, to test changes in nitrification potential rate (PNR), N2O emission fluxes, abundance of ammonia oxidizers and their significant drivers. The result showed that NPKM significantly increased soil C and N levels, the proportion of soil middle-size particles (40.35–148.00 μm class), and soil PNR, but decreased soil N2O emissions, especially in the drying time of paddy (P < 0.05), compared to NPK fertilization. NPKM had the highest values of AOA, AOB, and comammox clade A amoA gene copy numbers (P < 0.05), but clade B was increased by the NPK in the rhizosphere soil. Furthermore, fertilization showed greater effects on ammonia oxidizers (except for clade B) than the rhizosphere effect. Mantel test showed that SOM, TP, pH, NH4+, and NO3− were main abiotic factors causing the niche separation among ammonia oxidizers. Linear regression analysis and structural equation model (SEM) showed that both PNR and N2O emission fluxes were significantly associated with the abundance of AOB and comammox clade A (P < 0.05). Therefore, our results underline the importance of AOB together with comammox clade A in nitrification and N2O production in long-term organic fertilized paddy fields, which could provide new ideas for the mitigation of N2O emission by adopting organic fertilization scenarios in Chinese paddy fields.