Infiltration is one of the key components of rainfall-runoff processes at small catchment scale and is therefore a vital component of hydrological models. However, small catchments typically lack direct infiltration measurements and associated soil hydraulic characteristics, which are being substituted with soil databases and pedotransfer functions built upon these databases. We utilized two sets of pedotransfer functions Rosetta 3 and EUPTFv2 derived from two well known soil databases: UNSODA, based on US and global soil data, and EU-HYDI, based on EU soil data. Our study evaluates the impact of choosing one of these pedotransfer functions on modeled infiltration in relation to variable initial moisture content- It investigates the behavior of the simplified infiltration models of Green-Ampt and Philip under different initial conditions, in comparison with Richards’ complex solution, which is used as a benchmark. Our evaluation was conducted using soil property data available in the Czech Republic, covering ten USDA soil textures that are prevalent within the European Union. The applied initial moisture conditions were derived for specific suction pressure values that correspond to hydrological initial conditions ranging from near saturation to near the permanent wilting point. Variation in the derived parameters for the Green-Ampt and Philip models across the pedotransfer function sources results in considerable variation in the modeled infiltration. Our results imply different sensitivities of the simplified infiltration models to the initial moisture for different pedotransfer functions. The Green-Ampt and Philip infiltration models demonstrate better alignment with Richards’ complex solution with a low and consistent RMSE when using the Rosetta 3 pedotransfer function. By contrast, the EUPTFv2 model scenarios, show a clear trend of increasing RMSE towards dry initial conditions. As the European soil database is not an open data source, we only hypothesize that the distributions of soil characteristics in the European soil database differ systematically from those in UNSODA, and that this would cause different results of pedotransfer functions for different initial moisture conditions. The findings of this study are important for selecting appropriate infiltration models and, appropriate pedotransfer functions for estimating model parameters, and for assessing uncertainties connected with varying initial conditions.