Model Of Human Lung Cancer Research Articles

Development of three human small cell lung cancer models in nude mice.

The transplantation of seven human small cell lung cancers (SCLC) into athymic nude mice resulted in the development of three tumor lines that are suitable for study of biology and for tests of new drugs and combinations. They were characterized and the response to known drugs was determined. An identical tumor response was observed in the nude mouse system and in the patient in all four comparisons available.

Atypical cilia in rabbit bronchial epithelial cells induced by elastase: an ultrastructural study.

Ultrastructural study of the bronchial epithelium of elastase-treated rabbits revealed the presence of luminal atypical cilia resembling the pathological cilia seen in the tracheobronchial epithelium in animal models of human lung cancer. It is suggested that the results may contribute to knowledge of the mechanisms whereby compound cilia are produced.

Dose-response studies in experimentally induced lung tumours

The results of some experimental investigations by the author and his collaborators during recent years are presented in this paper. The number of mouse lung adenomas induced by urethane is dose-dependent. This is true both for newborn mice and adult mice and also under conditions of transplacental transmission. The existence of a dose-response effect has also been shown for adenomas induced in embryonic lung tissue organ cultures by the injection of urethane into pregnant mice. The establishment in this laboratory of an experimental model of human lung cancer by intratracheal instillation of carcinogenic compounds into rats made possible a systematic study of dose-response effects in the induction of experimental bronchogenic carcinomas and precancerous lesions using benzo[a]pyrene, 1,2,5,6-dibenzanthracene, and 7,12-dimethyl-benz[a]anthracene. A decrease in the amount of carcinogen always resulted in a decrease in the induction rate of malignant tumours and precancerous lesions. Repeated injections stimulated the blastomogenic effect. “Borderline” doses did not induce cancer but precancerous lesions were found. “Noncarcinogenic” doses can be determined for each experiment and each carcinogen. The problem of maximum permissible dose or concentration of carcinogenic substances has been discussed but there is some difference of opinion on this question. Nevertheless, the regular experimental finding of a dose-response effect can serve as a basis for cancer prevention.