Objective: The effects of a health education model based on goal-setting theory on lifestyle, diet and nutrition, and psychological regulation of thyroid cancer patients after surgery. Methods: A total of 60 thyroid cancer patients from the First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine from January 1, 2020 ~ December 31, 2023 were selected and grouped.They were divided into 30 observation groups and 30 control groups based on the principle that baseline data between groups could be compared. Patients in both groups were given routine postoperative care for thyroid cancer, and on this basis, the control group was given routine health education intervention, and the observation group was given health education intervention based on goal-setting theory. Both groups were intervened until discharge, and both groups were followed up for 1 month after discharge. Before the intervention and one week after the intervention, the self-made disease knowledge questionnaire and the self-management assessment scale of cancer patients were used to evaluate the disease knowledge, self-management ability and quality of life of the two groups. The compliance of patients with rehabilitation exercises, hoarseness, tetany and quality of life before intervention and at the end of follow-up were observed. Results: After 1 month of intervention, there were significant differences between the observation group and the normal control group in terms of disease knowledge knowledge score, self-efficacy, control of daily living habits, treatment of disease symptoms, and management of psychological adjustment (P<0.05). In the process of intervention, the compliance of the observation group was significantly higher than that of the control group, and there was a significant difference, (P<0.05). At the end of the follow-up, the symptoms of hoarseness, tetany and dyspnea in the observation group were significantly lower than those in the control group, and the difference was statistically significant (P<0.05). Finally, the two groups were significantly better than the control group in terms of physiological, psychological, functional exercise and special scores (P<0.05). Conclusion: Health education based on goal-setting theory has high application value in thyroid cancer surgery patients, which can improve patients' awareness of the disease, improve patients' rehabilitation compliance and self-management ability, and promote the recovery and improvement of postoperative living standards.