The Gulf of Corinth, Central Greece, is a highly active half-graben, characterized by seismicity which is more intense in its western part, while destructive earthquakes have also occurred towards its eastern end. We herein present an analysis of the seismicity in the Central Gulf of Corinth, for the period from June 2018 to December 2022. We applied the EQTransformer machine-learning model to enhance the initially available data, adding missing P- and S-wave arrival-times or improving existing ones. The events were initially located using a new local velocity model and then relocated using the double-difference method, including waveform cross-correlation data from local stations. The hypocenters, generally distributed at depths between 5 and 15 km, along with the focal mechanisms of significant earthquakes (1965 through 2022) and the geometry of mapped faults on the surface were co-examined to better understand their possible connection. It is shown that major outcropping north-dipping structures, such as the East Helike fault and its eastward offshore extension, match only with the southern bounds of seismicity. The Mw = 5.9, 1970 Antikira and Mw = 5.7, 1992 Galaxidi earthquakes cannot be associated with known mapped faults on the surface and likely occurred on low-angle, north-dipping planes. The variability in slip behavior of the low-angle detachment in the Gulf of Corinth, ranging from seismic slip to aseismic creep, probably accounts for the most part of the N-S extensional deformation. The spatial pattern of the 2018–2022 microseismicity delineates the edges of the rupture planes of major events that occurred during the instrumental era, including the Mw = 6.3, 1995 Aigion earthquake. The lack of aftershocks for significant earthquakes, including the Mw = 5.0, 8 October 2022 event, south of Desfina, is interpreted in terms of different pore pressure conditions, variations in fault-rock strength, and the preferred accumulation of high stress inside the upper crust.