The performance of Land Use Change (LUC) models is influenced by the regional spatial characteristics that trigger the changes. However, the literature on LUC models generally reports validation results for entire regions without considering subregions that differ significantly in their LUC drivers. This research explores how the LUC driving forces differ among subregions and whether regionalization can improve the performance of LUC models in areas undergoing rapid urbanization. We analyzed the Geomod, Cellular Automata-Markov, and Land Change Modeler models across rural and urbanized subregions on the western edge of Mexico City. Regionalization significantly enhanced the overall accuracy of the models and the concordance of spatial patterns with the reference data in rural regions but was of limited benefit in urbanized regions. This shows the need to consider regionalized modeling to improve the performance of LUC models when there are noticeable differences in LUC drivers between subregions. These findings will enhance the usefulness of LUC models for urban planning and land management policies, promoting more precise and effective decision-making.