Development Of Model Research Articles

Machine learning techniques for estimation of Pc5 geomagnetic pulsations observed at geostationary orbits during solar cycle 23

Pc5 geomagnetic pulsations can accelerate electrons in the radiation belts, which can pose adverse threats to both astronauts and satellites in space. The estimation of Pc5 waves in space is crucial to radiation belt dynamics studies and will help mitigate these challenges. Here, we explore the advantages of the Feed-forward Neural Network (FFNN) and Random Forest (RF) algorithm for effective estimation of Pc5 geomagnetic pulsations observed in space at geostationary orbit during solar cycle 23. The dataset used in this study is the vector magnetic field measurements retrieved from the Geostationary Operational Environmental Satellite-10 (GOES-10) and the solar wind parameters: Bz and Vx component of the solar wind in the Geocentric Solar Ecliptic (GSE) coordinate system, proton density, flow pressure, and plasma beta obtained from the OMNI Web database during part of solar cycle 23. Pc5 geomagnetic pulsations were extracted from the toroidal component of the magnetic field time series using a bandpass Butterworth filter. The continuous wavelet transform (CWT) was utilized to study the characteristics of the extracted wave in the time-frequency domain for its validation. The validated Pc5 events were used as the target in the model's development, with the solar wind parameters as the inputs. In addition to the solar wind parameters, we included an attribute of the magnetic field time series as an input variable in the model. The dataset is carefully divided to ensure effective training and testing of the models. Finally, we trained both models using the same inputs and targets and explored their estimation abilities. The model was tested during the maximum, descending, and minimum phases of solar cycle 23. Both the FFNN and RF models have a similar estimation, with average cross-correlation score (R) values of 0.74 and 0.73 and corresponding average root mean squared error (RMSEs) of 0.16 nT and 0.67 nT, respectively. The model was deployed to investigate the response of Pc5 waves during three storm days in each testing year. The machine learning (ML) model outputs showed good coherence with the observed Pc5 waves. To validate the models, we studied the correlation between the estimated Pc5 events with the Kp index, and a good correlation was seen to exist between both events. This validates the good performance of the developed models. This work will aid in the study of radiation belt dynamics and the construction of electron depletion regions in the radiation belt.

Can we accurately predict the distribution of soil microorganism presence and relative abundance?

Soil microbes play a key role in shaping terrestrial ecosystems. It is therefore essential to understand what drives their distribution. While multivariate analyses have been used to characterise microbial communities and drivers of their spatial patterns, few studies have focused on predicting the distribution of amplicon sequence variants (ASVs). Here, we evaluate the potential of species distribution models (SDMs) to predict the presence–absence and relative abundance distribution of bacteria, archaea, fungi, and protist ASVs in the western Swiss Alps. Advanced automated selection of abiotic covariates was used to circumvent the lack of knowledge on the ecology of each ASV. Presence–absence SDMs could be fitted for most ASVs, yielding better predictions than null models. Relative abundance SDMs performed less well, with low fit and predictive power overall, but displayed a good capacity to differentiate between sites with high and low relative abundance of the modelled ASV. SDMs for bacteria and archaea displayed better predictive power than for fungi and protists, suggesting a closer link of the former with the abiotic covariates used. Microorganism distributions were mostly related to edaphic covariates. In particular, pH was the most selected covariate across models. The study shows the potential of using SDM frameworks to predict the distribution of ASVs obtained from topsoil DNA. It also highlights the need for further development of precise edaphic mapping and scenario modelling to enhances prediction of microorganism distributions in the future.

Computational Legal Studies Comes of Age

Computational analysis techniques are transforming empirical legal scholarship. Two paradigms have emerged: law-as-code, which seeks to represent legal rules in a logical, executable format; and law-as-data, which leverages quantitative analysis of legal texts to reveal patterns and insights. This article surveys these approaches, emphasizing recent developments in large language models and generative artificial intelligence (AI). Law-as-code systems have enabled applications from tax preparation software to smart contracts, but realizing the vision of fully computational law has proven challenging. Law-as-data techniques like natural language processing and machine learning have charted the semantic relationship between courts and illuminated changes in judicial culture. Generative models showcase AI's explosive progress, with impressive feats like passing the U.S. bar example, but they also highlight limitations like factual inaccuracy and interpretability issues. Hybrid approaches integrating computational law, data science, and AI offer a promising research direction. As these tools spread, legal scholars can analyze more legal data than ever before, but they must remain cognizant of challenges like biased or low-quality data and linguistic/cultural limitations. Used judiciously alongside traditional methods, computational analysis has the potential to revolutionize empirical legal studies.

Development and validation of a clinical prediction model for glioma grade using machine learning.

Histopathological evaluation is currently the gold standard for grading gliomas; however, this technique is invasive. This study aimed to develop and validate a diagnostic prediction model for glioma by employing multiple machine learning algorithms to identify risk factors associated with high-grade glioma, facilitating the prediction of glioma grading. Data from 1114 eligible glioma patients were obtained from The Cancer Genome Atlas (TCGA) database, which was divided into a training set (n= 781) and a test set (n= 333). Fifty machine learning algorithms were employed, and the optimal algorithm was selected to construct a prediction model. The performance of the machine learning prediction model was compared to the clinical prediction model in terms of discrimination, calibration, and clinical validity to assess the performance of the prediction model. The area under the curve (AUC) values of the machine learning prediction models (training set: 0.870 vs. 0.740, test set: 0.863 vs. 0.718) were significantly improved from the clinical prediction models. Furthermore, significant improvement in discrimination was observed for the Integrated Discrimination Improvement (IDI) (training set: 0.230, test set: 0.270) and Net Reclassification Index (NRI) (training set: 0.170, test set: 0.170) from the clinical prognostic model. Both models showed a high goodness of fit and an increased net benefit. A strong prediction accuracy model can be developed using machine learning algorithms to screen for high-grade glioma risk predictors, which can serve as a non-invasive prediction tool for preoperative diagnostic grading of glioma.

Application of artificial intelligence for the classification of the clinical outcome and therapy in patients with viral infections: The case of COVID-19.

With the end of the coronavirus disease 2019 (COVID-19) pandemic, it becomes intriguing to observe the impact of innovative digital technologies on the diagnosis and management of diseases, in order to improve clinical outcomes for patients. The research aims to enhance diagnostics, prediction, and personalized treatment for patients across three classes of clinical severity (mild, moderate, and severe). What sets this study apart is its innovative approach, wherein classification extends beyond mere disease presence, encompassing the classification of disease severity. This novel perspective lays the foundation for a crucial decision support system during patient triage. An artificial neural network, as a deep learning technique, enabled the development of a complex model based on the analysis of data collected during the process of diagnosing and treating 1000 patients at the Tešanj General Hospital, Bosnia and Herzegovina. The final model achieved a classification accuracy of 82.4% on the validation data set, which testifies to the successful application of the artificial neural network in the classification of clinical outcomes and therapy in patients infected with viral infections. The results obtained show that expert systems are valuable tools for decision support in healthcare in communities with limited resources and increased demands. The research has the potential to improve patient care for future epidemics and pandemics.

Development and Validation of a Resistance Management Model for the Soybean Cyst Nematode, Heterodera glycines.

Plant-parasitic nematodes are a key yield-limiting pest of crops around the world. Deployment of plant resistance genes are an important management tactic for many economically important plant-parasitic nematodes. The selection for virulence in nematode populations is a major threat to the effectiveness of resistance gene-based management. Little research has gone into resistance management modelling despite the importance of both plant-parasitic nematodes and resistance genes for their management. In this paper, we report on a cyst nematode resistance management model created to explore the factors which are most important for determining the durability of resistance genes to this important family of plant-parasitic nematodes. The relative dominance of virulence expression, the level of inbreeding, and the number of generations per cropping season were the most important factors in predicting resistance gene durability. Aspects of cyst nematode biology that reduce the number of generations per season for a portion of the population had a much smaller effect on the durability of resistance genes. These factors included delayed hatching within a season and early dormancy. The accuracy and utility of the model was tested using the soybean cyst nematode (SCN) rhg1-mediated resistance system. The model accurately predicted the rate at which virulence to the rhg1b resistance gene developed in Iowa over a two-decade period. The model suggested resistance gene pyramids as the most durable management solution for SCN with multiple possible avenues to obtain acceptable efficacy and durability.

FPM-WSI: Fourier ptychographic whole slide imaging via feature-domain backdiffraction

Fourier ptychographic microscopy (FPM) theoretically provides a solution to the trade-off between spatial resolution and field of view (FOV), and has promising prospects in digital pathology. However, block reconstruction and then stitching has become an unavoidable procedure for reconstruction of large FOV due to vignetting artifacts. This introduces digital stitching artifacts, as the existing image-domain optimization algorithms are highly sensitive to systematic errors. Such obstacles significantly impede the advancement and practical implementation of FPM, explaining why, despite a decade of development, FPM has not gained widespread recognition in the field of biomedicine. We report a feature-domain FPM (FD-FPM) based on the structure-aware forward model to realize stitching-free, full-FOV reconstruction. The loss function is uniquely formulated in the feature domain of images, which bypasses the troublesome vignetting effect and algorithmic vulnerability via feature-domain backdiffraction. Through massive simulations and experiments, we show that FD-FPM effectively eliminates vignetting artifacts for full-FOV reconstruction, and still achieves impressive reconstructions despite the presence of various systematic errors. We also found it has great potential in recovering the data with a lower spectrum overlapping rate, and in realizing digital refocusing without a prior defocus distance. With FD-FPM, we achieved full-color and high-throughput imaging (4.7 mm diameter FOV, 336 nm resolution in the blue channel) free of blocking-and-stitching procedures on a self-developed Fourier ptychographic microscopy whole slide imaging platform. The reported FD-FPM shows the value of FPM for various experimental circumstances, and offers physical insights useful for the developments of models for other computational imaging techniques. The reported platform demonstrates high-quality, high-speed imaging and low cost, and could find applications in many fields of biomedical research, as well as in clinical applications.

Abstract PO3-07-02: Radiomics Models for B-mode Breast Ultrasound and Strain Elastography to improve Breast Cancer Diagnosis (INSPiRED 005): An International, Multicenter Analysis

Abstract Background: Breast Elastography, a technique that quantifies tissue stiffness, has been evaluated to objectify and improve the performance of B-mode breast ultrasound. However, large prospective trials showed benefits in BI-RADS 4a breast masses only and a high operator dependency. Modern Artificial Intelligence techniques for automated image processing like radiomics, a technique where quantified features are extracted from images, may overcome these limitations. We aimed to develop and validate radiomics models based on B-mode and Strain Elastography (SE) images for patients with BI-RADS 3 or 4 breast masses and compare their performance to the respective human experts. Methods: This is a secondary analysis of an international, multicenter trial (NCT02638935), evaluating the performance of SE in women with BI-RADS 3 or 4 breast masses. Women were recruited at 12 institutions in 7 countries and underwent B-mode breast ultrasound as well as SE. B-mode images were saved and re-assed by three ultrasound readers ( >10 years of experience), resulting in three independent assessments and a final consensus assessment. SE was interpreted using the E-/B ratio. B-mode and strain images were manually segmented and quantitative radiomics features were extracted using pyradiomics. We used 10-fold cross-validation to build machine learning models (XGBoostTree, MARS) based on data of 11 of 12 study sites. The data of the 12th (largest) study site was used as external validation set. Performance metrics included sensitivity, specificity and area under the receiver operator characteristic curve (AUROC). Results: The study included a total of 1288 patients, 1206 with evaluable B-mode images and 1190 with evaluable Strain images. Mean age was 46.6 years (SD 16.02) and a total number of 29.0% (350 of 1206) and 28.9% (344 of 1190) breast masses were malignant in the B-mode and Strain cohort, respectively. Distribution of BI-RADS categories was 33.0%, 34.5%, 14.5%, and 18.0% for BI-RADS 3, 4a, 4b, and 4c, respectively. In the external validation set (n = 342), the B-mode radiomics model (XGBoostTree) achieved an AUROC of 0.86 (95% CI 0.82 to 0.90), with a sensitivity of 97.4% (95% CI 0.93 to 1.00, 113 of 116) and a specificity of 27.0% (95% CI 0.21 to 0.33, 61 of 226). The model showed equivalent performance compared to the three ultrasound readers (P = 0.133); see also Table 1. In the external validation set (n = 333), the Strain radiomics model (MARS) achieved an AUROC of 0.84 (95% CI 0.79 to 0.88), with a sensitivity of 100% (95% CI 47.0 to 58.0, 115 of 115) and a specificity of 25.5% (95% CI 0.22 to 0.34, 60 of 218). The model showed equivalent performance compared to the three ultrasound readers (P = 0.696) and performed significantly better compared to SE (P = 0.002); see also Table 1. Sensitivity of the strain model was descriptively higher (100% vs. 97.4%, see Table 1). Both models were well-calibrated. Conclusion: This is the largest development and validation study for radiomics models based on B-mode breast ultrasound and SE, to date. The radiomics models performed on par with human readers, with the strain radiomics model showing potential to identify initially missed carcinomas in BI-RADS 3 breast masses. Future implementation studies may evaluate the performance of these image analysis algorithms in clinical routine and their integration into the multi-modal breast cancer diagnostics process, including mammography and MRI. Table 1. Diagnostic performance metrics Citation Format: André Pfob, Tanja He, Lie Cai, Richard G. Barr, Volker Duda, Zaher Alwafai, Corinne Balleyguier, Dirk-André Clevert, Sarah Fastner, Christina Gomez, Manuela Goncalo, Ines Gruber, Markus Hahn, André Hennigs, Panagiotis Kapetas, Sheng-Chieh Lu, Juliane Nees, Ralf Ohlinger, Fabian Riedel, Matthieu Rutten, Benedikt Schaefgen, Anne Stieber, Riku Togawa, Mitsuhiro Tozaki, Sebastian Wojcinski, Cai Xu, Geraldine Rauch, Jörg Heil, Chris Sidey-Gibbons, Michael Golatta. Radiomics Models for B-mode Breast Ultrasound and Strain Elastography to improve Breast Cancer Diagnosis (INSPiRED 005): An International, Multicenter Analysis [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO3-07-02.

Leveraging artificial intelligence to identify high-risk patients for postoperative sore throat: An observational study.

Postoperative sore throat (POST) is a prevalent complication after general anesthesia and targeting high-risk patients helps in its prevention. This study developed and validated a machine learning model to predict POST. A total number of 834 patients who underwent general anesthesia with endotracheal intubation were included in this study. Data from a cohort of 685 patients was used for model development and validation, while a cohort of 149 patients served for external validation. The prediction performance of random forest (RF), neural network (NN), and extreme gradient boosting (XGBoost) models was compared using comprehensive performance metrics. The Local Interpretable Model-Agnostic Explanations (LIME) methods elucidated the best-performing model. POST incidences across training, validation, and testing cohorts were 41.7%, 38.4%, and 36.2%, respectively. Five predictors were age, sex, endotracheal tube cuff pressure, endotracheal tube insertion depth, and the time interval between extubation and the first drinking of water after extubation. After incorporating these variables, the NN model demonstrated superior generalization capabilities in predicting POST when compared to the XGBoost and RF models in external validation, achieving an area under the receiver operating characteristic curve (AUROC) of 0.81 (95% CI 0.74-0.89) and a precision-recall curve (AUPRC) of 0.77 (95% CI 0.66-0.86). The model also showed good calibration and clinical usage values. The NN model outperforms the XGBoost and RF models in predicting POST, with potential applications in the healthcare industry for reducing the incidence of this common postoperative complication.

Preface to the Proceedings of the 5th European Academic Symposium on EAF Steelmaking

The European Academic Symposium on EAF Steelmaking (EASES) is a series of events targeted at researchers and doctoral candidates working with different aspects of electric arc furnace (EAF) steelmaking. Previously, four events were organised in 2015, 2016, 2018, and 2021 in Aachen, Germany. The 5th European Academic Symposium on EAF Steelmaking (EASES 2023) was organised jointly by the RWTH Aachen University (Department for Industrial Furnaces and Heat Engineering) and University of Oulu (Process Metallurgy Research Unit) and held at the University of Oulu in Oulu, Finland on 5-7 June 2023. A total of 29 presentations were held at the event, out of which 13 featured an accompanying full paper. After the symposium, the authors of the full papers were invited to submit their manuscripts to be included in the proceedings. The proceedings consist of a total of 12 peer-reviewed papers published in the IOP Conference Series: Materials Science and Engineering. Based on the presentations, the development of modelling and monitoring tools for process optimization, the use of biochar to replace fossil carbon for slag foaming, and the use of hydrogen as an alternative burner fuel were identified as current hot topics. In the future, the importance of the EAF process is expected to increase further due to the increasing availability of scrap and plans for ore-based production routes based on hydrogen direct reduction.

Unraveling breast cancer prognosis: a novel model based on coagulation-related genes.

Breast cancer is highly heterogeneous, presenting challenges in prognostic assessment. Developing a universally applicable prognostic model could simplify clinical decision-making. This study aims to develop and validate a novel breast cancer prognosis model using coagulation-related genes with broad clinical applicability. A total of 203 genes related to coagulation were obtained from the KEGG database, and the mRNA data of 1,099 tumor tissue samples and 572 samples of normal tissue were retrieved from the TCGA-BRCA cohort and GTEx databases. The R package "limma" was utilized to detect variations in gene expression related to coagulation between the malignancies and normal tissue. A model was constructed in the TCGA cohort through a multivariable Cox regression analysis, followed by validation using the GSE42568 dataset as the testing set. Constructing a nomogram incorporating clinical factors to enhance the predictive capacity of the model. Utilizing the ESTIMATE algorithm to investigate the immune infiltration levels in groups with deferent risk. Performing drug sensitivity analysis using the "oncoPredict" package. A risk model consisting of six coagulation-associated genes (SERPINA1, SERPINF2, C1S, CFB, RASGRP1, and TLN2) was created and successfully tested for validation. Identified were 6 genes that serve as protective factors in the model's development. Kaplan-Meier curves revealed a worse prognosis in the high-risk group compared to the low-risk group. The ROC analysis showed that the model accurately forecasted the overall survival (OS) of breast cancer patients at 1, 3, and 5 years. Nomogram accompanied by calibration curves can also provide better guidance for clinical decision-making. The low-risk group is more likely to respond well to immunotherapy, whereas the high-risk group may show improved responses to Gemcitabine treatment. Furthermore, individuals in distinct risk categories displayed different responses to various medications within the identical therapeutic category. We established a breast cancer prognostic model incorporating six coagulation-associated genes and explored its clinical utility. This model offers valuable insights for clinical decision-making and drug selection in breast cancer patients, contributing to personalized and precise treatment advancements.

VR.net: A Real-world Dataset for Virtual Reality Motion Sickness Research.

Researchers have used machine learning approaches to identify motion sickness in VR experience. These approaches would certainly benefit from an accurately labeled, real-world, diverse dataset that enables the development of generalizable ML models. We introduce 'VR.net', a dataset comprising 165-hour gameplay videos from 100 real-world games spanning ten diverse genres, evaluated by 500 participants. VR.net accurately assigns 24 motion sickness-related labels for each video frame, such as camera/object movement, depth of field, and motion flow. Building such a dataset is challenging since manual labeling would require an infeasible amount of time. Instead, we implement a tool to automatically and precisely extract ground truth data from 3D engines' rendering pipelines without accessing VR games' source code. We illustrate the utility of VR.net through several applications, such as risk factor detection and sickness level prediction. We believe that the scale, accuracy, and diversity of VR.net can offer unparalleled opportunities for VR motion sickness research and beyond.We also provide access to our data collection tool, enabling researchers to contribute to the expansion of VR.net.

Development and external validation of a prediction model for digit replantation failure after traumatic amputations based on a prospective multicenter cohort.

Failure of digit replantation after traumatic amputation is difficult to predict. The authors aimed to develop a prognostic model to better identify factors that better predict replantation failure following traumatic digit amputation. In this multicenter prospective cohort, the authors identified patients who had received digit replantation between 1 January 2015 and 1 January 2019. Univariable and multivariable analyses were performed successively to identify independently predictive factors for failure of replanted digit. To reduce overfitting, the Bayesian information criterion was used to reduce variables in the original model. Nomograms were created with the reduced model after model selection. This model was then internally validated with bootstrap resampling and further externally validated in validation cohort. Digit replantation was failed in 101 of 1062 (9.5%) digits and 146 of 1156 digits (12.6%) in the training and validation cohorts, respectively. The authors found that six independent prognostic variables were associated with digit replantation failure: age, mechanism of injury, ischemia duration, smoking status, amputation pattern (complete or incomplete), and surgeon's experience. The prediction model achieved good discrimination, with concordance indexes of 0.81 (95% CI: 0.76-0.85) and 0.70 (95% CI: 0.65-0.74) in predicting digit failure in the training and validation cohorts, respectively. Calibration curves were well-fitted for both training and validation cohorts. The proposed prediction model effectively predicted the failure rate of digit replantation for individual digits of all patients. It could assist in selecting the most suitable surgical plan for the patient.

Development and validation of a deep learning radiomics model with clinical-radiological characteristics for the identification of occult peritoneal metastases in patients with pancreatic ductal adenocarcinoma.

Occult peritoneal metastases (OPM) in patients with pancreatic ductal adenocarcinoma (PDAC) are frequently overlooked during imaging. The authors aimed to develop and validate a computed tomography (CT)-based deep learning-based radiomics (DLR) model to identify OPM in PDAC before treatment. This retrospective, bicentric study included 302 patients with PDAC (training: n =167, OPM-positive, n =22; internal test: n =72, OPM-positive, n =9: external test, n =63, OPM-positive, n =9) who had undergone baseline CT examinations between January 2012 and October 2022. Handcrafted radiomics (HCR) and DLR features of the tumor and HCR features of peritoneum were extracted from CT images. Mutual information and least absolute shrinkage and selection operator algorithms were used for feature selection. A combined model, which incorporated the selected clinical-radiological, HCR, and DLR features, was developed using a logistic regression classifier using data from the training cohort and validated in the test cohorts. Three clinical-radiological characteristics (carcinoembryonic antigen 19-9 and CT-based T and N stages), nine HCR features of the tumor, 14 DLR features of the tumor, and three HCR features of the peritoneum were retained after feature selection. The combined model yielded satisfactory predictive performance, with an area under the curve (AUC) of 0.853 (95% CI: 0.790-0.903), 0.845 (95% CI: 0.740-0.919), and 0.852 (95% CI: 0.740-0.929) in the training, internal test, and external test cohorts, respectively (all P <0.05). The combined model showed better discrimination than the clinical-radiological model in the training (AUC=0.853 vs. 0.612, P <0.001) and the total test (AUC=0.842 vs. 0.638, P <0.05) cohorts. The decision curves revealed that the combined model had greater clinical applicability than the clinical-radiological model. The model combining CT-based DLR and clinical-radiological features showed satisfactory performance for predicting OPM in patients with PDAC.

Development of interpretable machine learning models for prediction of acute kidney injury after noncardiac surgery: a retrospective cohort study.

Early identification of patients at high-risk of postoperative acute kidney injury (AKI) can facilitate the development of preventive approaches. This study aimed to develop prediction models for postoperative AKI in noncardiac surgery using machine learning algorithms. The authors also evaluated the predictive performance of models that included only preoperative variables or only important predictors. Adult patients undergoing noncardiac surgery were retrospectively included in the study (76457 patients in the discovery cohort and 11910 patients in the validation cohort). AKI was determined using the KDIGO criteria. The prediction model was developed using 87 variables (56 preoperative variables and 31 intraoperative variables). A variety of machine learning algorithms were employed to develop the model, including logistic regression, random forest, extreme gradient boosting, and gradient boosting decision trees. The performance of different models was compared using the area under the receiver operating characteristic curve (AUROC). Shapley Additive Explanations (SHAP) analysis was employed for model interpretation. The patients in the discovery cohort had a median age of 52 years (IQR: 42-61 years), and 1179 patients (1.5%) developed AKI after surgery. The gradient boosting decision trees algorithm showed the best predictive performance using all available variables, or only preoperative variables. The AUROCs were 0.849 (95% CI: 0.835-0.863) and 0.828 (95% CI: 0.813-0.843), respectively. The SHAP analysis showed that age, surgical duration, preoperative serum creatinine, and gamma-glutamyltransferase, as well as American Society of Anesthesiologists physical status III were the most important five features. When gradually reducing the features, the AUROCs decreased from 0.852 (including the top 40 features) to 0.839 (including the top 10 features). In the validation cohort, the authors observed a similar pattern regarding the models' predictive performance. The machine learning models the authors developed had satisfactory predictive performance for identifying high-risk postoperative AKI patients. Furthermore, the authors found that model performance was only slightly affected when only preoperative variables or only the most important predictive features were included.

The Impact of Adversarial Attacks on Federated Learning: A Survey.

Federated learning (FL) has emerged as a powerful machine learning technique that enables the development of models from decentralized data sources. However, the decentralized nature of FL makes it vulnerable to adversarial attacks. In this survey, we provide a comprehensive overview of the impact of malicious attacks on FL by covering various aspects such as attack budget, visibility, and generalizability, among others. Previous surveys have primarily focused on the multiple types of attacks and defenses but failed to consider the impact of these attacks in terms of their budget, visibility, and generalizability. This survey aims to fill this gap by providing a comprehensive understanding of the attacks' effect by identifying FL attacks with low budgets, low visibility, and high impact. Additionally, we address the recent advancements in the field of adversarial defenses in FL and highlight the challenges in securing FL. The contribution of this survey is threefold: first, it provides a comprehensive and up-to-date overview of the current state of FL attacks and defenses. Second, it highlights the critical importance of considering the impact, budget, and visibility of FL attacks. Finally, we provide ten case studies and potential future directions towards improving the security and privacy of FL systems.

Exploring Scoring Function Space: Developing Computational Models for Drug Discovery.

The idea of scoring function space established a systems-level approach to address the development of models to predict the affinity of drug molecules by those interested in drug discovery. Our goal here is to review the concept of scoring function space and how to explore it to develop machine learning models to address protein-ligand binding affinity. We searched the articles available in PubMed related to the scoring function space. We also utilized crystallographic structures found in the protein data bank (PDB) to represent the protein space. The application of systems-level approaches to address receptor-drug interactions allows us to have a holistic view of the process of drug discovery. The scoring function space adds flexibility to the process since it makes it possible to see drug discovery as a relationship involving mathematical spaces. The application of the concept of scoring function space has provided us with an integrated view of drug discovery methods. This concept is useful during drug discovery, where we see the process as a computational search of the scoring function space to find an adequate model to predict receptor-drug binding affinity.

Design and Development of Mathematical and Thermal Load Modelling for Induction Heating Systems

Complex systems can be modelled and their performance can be anticipated with the help of current computers and software tools that are applicable in real-world situations. The IH system is capable of being modelled and put through analysis in two distinct domains. The modelling is compatible with the research and applications in their entirety, including the particular control circuits and converter systems under consideration. The use of electrical modelling makes it possible to analyse the features of the IH load and to examine the variations in the parameters in order to determine the impact of load variations. In order to gain an understanding of the load's flow and thermal distribution, thermal modelling is a crucial component of this study. For the purpose of analysing the performance of the coil in terms of flux and temperature from its comparable model, the COMSOL Multiphysics software that is utilised is utilised.

Recent developments in the Darcy-Forchheimer model of magnetized tetra hybrid nanofluid activation energy/joule heating in a stenotic artery

The impact of heat generation and activation energy on the Darcy-Forchheimer flow of magnetized fluid with nanoparticles in the condition of blood flowing arteries is being investigated by researchers from all over the world in an effort to understand the heat transmission component for the treatment of numerous diseases. The assessment of heat transmission has been made with the enclosure of influence like the viscous dissipation, heat source, Joules heating, and thermal radiation. Utilized is a tetra hybrid nanofluid made up of silver (Ag), gold (Au), titanium oxide (TiO2), coper (Cu), and Blood as the base fluid. The main justification for the use of gold, copper, and silver nanoparticles as drug delivery nanomaterials is their potential for drug transport and imaging. The purpose of the presented model is to assess the performance of the well-known tetra hybrid nanofluid models developed by Yamada-Ota and Xue. The main PDE are transformed into ODE via similarity renovations, and these ODE are then numerically solved using the MATLAB built-in bvp4c scheme. The arteries' internal temperature rises as a result of thermal radiation and viscous dissipation. The velocity and thermal distributions show an increasing behavior with greater variations in the flow parameter. The Yamada-Ota model outperforms the Xue tetra hybrid nanofluid model in terms of heat transmission effectiveness.

Development of Teaching Factory Learning Model in Industrial Automation in Vocational High Schools

Vocational High Schools, as schools that aim to prepare students for work in a particular field, need effectiveness in the learning process. Its effectiveness must follow the real conditions required by the industry. With the rapid devel-opment of industry, industry-based learning, often called "Teaching Factory," is one of the right role models of learning. The type of research to be carried out is development research. The purpose of this study is to determine (1) the devel-opment of the teaching factory learning model, (2) the application of the teach-ing factory learning model, (3) user response to the product, and (4) the effec-tiveness of using the developed product. The development model used in this study is the Plomp development model. The Plomp development model includes (1) the initial investigation phase, (2) the design phase, (3) the realiza-tion/construction phase, (4) the testing, evaluation, and revision phase, and (5) the field test/implementation phase. Validity by model experts about the teach-ing factory learning model gets an average score of 95.45 and is included in the very decent category. The material expert gave it a score of 93.41, and it be-longs to the very decent category. The media expert gave it a score of 95.84, which belongs to the decent category. The effectiveness test result shows a sig-nificant difference between the learning outcomes in the Industrial Automation Engineering Expertise Concentration subjects before and after applying the Teaching Factory learning model. This shows the positive influence and effectiveness of using the Teaching Factory learning model on the learning out-comes of the Industrial Automation Engineering Expertise Concentration in In-dustrial Automation Engineering Vocational School students.